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Protein Overview: FKBP3_YEAST

General Information:
Name(s) found: FKBP3_YEAST [Swiss-Prot]
Description(s) found:
  • FK506-binding nuclear protein OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=FPR3 PE=1 SV=2 [Swiss-Prot]
    • Organism: Saccharomyces cerevisiae S288c
    Length: 411 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDLLPLATY SLNVEPYTPV PAIDVTMPIT VRITMAALNP EAIDEENKPS TLRIIKRNPD  60
   61 FEDDDFLGGD FDEDEIDEES SEEEEEEKTQ KKKKSKGKKA ESESEDDEED DDEDDEFQES 120
  121 VLLTLSPEAQ YQQSLDLTIT PEEEVQFIVT GSYAISLSGN YVKHPFDTPM GVEGEDEDED 180
  181 ADIYDSEDYD LTPDEDEIIG DDMDDLDDEE EEEVRIEEVQ EEDEEDNDGE EEQEEEEEEE 240
  241 QKEEVKPEPK KSKKEKKRKH EEKEEEKKAK KVKKVEFKKD LEEGPTKPKS KKEQDKHKPK 300
  301 SKVLEGGIVI EDRTIGDGPQ AKRGARVGMR YIGKLKNGKV FDKNTSGKPF AFKLGRGEVI 360
  361 KGWDIGVAGM SVGGERRIII PAPYAYGKQA LPGIPANSEL TFDVKLVSMK N

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..89] ORFEUS 8.75 No description for 1l8mA was found.
    2 View Details [90..168] ORFEUS 8.75 No description for 1l8mA was found.
    3 View Details [169..238] ORFEUS 8.75 No description for 1l8mA was found.
    4 View Details [239..307] ORFEUS 8.75 No description for 1l8mA was found.
    5 View Details [308..411] PSI-BLAST 250.218487 Calcineurin (FKBP12.6)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • histone binding
    		•  3.35045437512493 bayes_pls_golite062009
  • binding
    		•  2.31105760892804 bayes_pls_golite062009
  • protein binding
    		•  2.12153134547445 bayes_pls_golite062009
  • unfolded protein binding
    		•  1.82337497151874 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.64766838528772 bayes_pls_golite062009
  • DNA binding
    		•  1.44751295983711 bayes_pls_golite062009
  • transcription activator activity
    		•  1.24287805928534 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.22112424514163 bayes_pls_golite062009
  • transcription factor binding
    		•  0.771629017736754 bayes_pls_golite062009
  • enzyme binding
    		•  0.420979974123408 bayes_pls_golite062009
  • hydrolase activity
    		•  0.319361545733709 bayes_pls_golite062009
  • catalytic activity
    		•  0.290929394811364 bayes_pls_golite062009
  • ribonucleoprotein binding
    		•  0.290017406252516 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.237741029116502 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.196866743343878 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.186970052809736 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.1843930975799 bayes_pls_golite062009
  • ATPase activity, coupled
    		•  0.0973531211151839 bayes_pls_golite062009
  • NF-kappaB binding
    		•  0.00132024988427304 bayes_pls_golite062009
    2
    Term Confidence Notes
  • ryanodine-sensitive calcium-release channel activity
    		•  10.9968443145942 bayes_pls_golite062009
  • intracellular ligand-gated calcium channel activity
    		•  10.9968443145942 bayes_pls_golite062009
  • macrolide binding
    		•  7.31599503004442 bayes_pls_golite062009
  • FK506 binding
    		•  7.22442625476031 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  6.74926751944787 bayes_pls_golite062009
  • calcium channel activity
    		•  6.4374377859142 bayes_pls_golite062009
  • cation channel activity
    		•  6.06732269872248 bayes_pls_golite062009
  • ion channel activity
    		•  5.45007096522107 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  5.32426176964634 bayes_pls_golite062009
  • channel activity
    		•  5.32426176964634 bayes_pls_golite062009
  • substrate-specific channel activity
    		•  5.28960420749143 bayes_pls_golite062009
  • gated channel activity
    		•  5.28074654906904 bayes_pls_golite062009
  • peptidyl-prolyl cis-trans isomerase activity
    		•  4.0615867467963 bayes_pls_golite062009
  • cis-trans isomerase activity
    		•  3.99265212272703 bayes_pls_golite062009
  • ligand-gated channel activity
    		•  3.34717828007833 bayes_pls_golite062009
  • ligand-gated ion channel activity
    		•  3.34717828007833 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  2.6566793500337 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  2.61794461605199 bayes_pls_golite062009
  • calcium-release channel activity
    		•  2.58969194870156 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  2.47257819150887 bayes_pls_golite062009
  • isomerase activity
    		•  2.31710030777753 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.85589011277711 bayes_pls_golite062009
  • receptor activity
    		•  1.78361575899771 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  1.7459556028988 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.68688812199737 bayes_pls_golite062009
  • kinase activity
    		•  1.67904764195462 bayes_pls_golite062009
  • binding
    		•  1.63170667962375 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.57898291235576 bayes_pls_golite062009
  • signal transducer activity
    		•  1.53711974553033 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.53711974553033 bayes_pls_golite062009
  • protein kinase activity
    		•  1.45320632553313 bayes_pls_golite062009
  • drug binding
    		•  1.39643621593407 bayes_pls_golite062009
  • transferase activity
    		•  1.34122735969662 bayes_pls_golite062009
  • receptor serine/threonine kinase binding
    		•  1.32709321745178 bayes_pls_golite062009
  • transmembrane receptor protein serine/threonine kinase binding
    		•  1.32470025150272 bayes_pls_golite062009
  • transforming growth factor beta receptor binding
    		•  1.32470025150272 bayes_pls_golite062009
  • transporter activity
    		•  1.25197125648774 bayes_pls_golite062009
  • protein binding
    		•  1.08765413491791 bayes_pls_golite062009
  • SMAD binding
    		•  1.04905381164355 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.03909235910355 bayes_pls_golite062009
  • catalytic activity
    		•  0.885282592863018 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.789390402522536 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  0.780499202755666 bayes_pls_golite062009
  • transmembrane receptor protein serine/threonine kinase activity
    		•  0.763739321802433 bayes_pls_golite062009
  • transforming growth factor beta receptor activity
    		•  0.763739321802433 bayes_pls_golite062009
  • intracellular ligand-gated ion channel activity
    		•  0.727019445105701 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.671059013500415 bayes_pls_golite062009
  • activin binding
    		•  0.33489895389042 bayes_pls_golite062009
  • unfolded protein binding
    		•  0.27473817613726 bayes_pls_golite062009
  • histone binding
    		•  0.221748741603068 bayes_pls_golite062009
  • transcription elongation regulator activity
    		•  0.21145105012677 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle