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View Structure Prediction Details

Protein: gi|25404164, gi|...
Organism: Arabidopsis thaliana
Length: 686 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|25404164, gi|....

Description E-value Query
Range
Subject
Range
gi|3482933, gi|2... - gi|3482933|gb|AAC33218.1| Similar to cdc2 protein kinases [Arabidopsis thaliana], pir||G86229 hypoth...
392.0 [0..1] [686..1]

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Predicted Domain #1
Region A:
Residues: [1-140]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGCICSKGVR TNDDYIETNH VSIGKENPKA SKKQSDSEET SVNGNEATLR LIPDDVKDTF  60
   61 SDEEVEELEE KKESSFEMKS CESVLQKGNV LEIVDNVGPL QPRMSRIGSV SNGDRAAKVI 120
  121 AGWPSWLVSV AGEAINGWIP 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [141-475]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RSADSFEKLE MIGQGTYSSV YRARDLETNQ IVALKKVRFA NMDPESVRFM AREIIILRRL  60
   61 NHPNVMKLEG LIISKASGSM YLIFEYMDHD LAGLASTPGI KFSQAQQLLL GLEHCHSCGV 120
  121 LHRDIKCSNL LLDRNNNLKI GDFGLSNFYR GQRKQPLTSR VVTLWYRPPE LLLGSTDYGV 180
  181 TVDLWSTGCI LAELFTGKPL LPGRTEVEQM HKIFKLCGSP SEEYWRRSRL RHATIFKPQH 240
  241 PYKRCVADTF KDLPSSALAL LEVLLAVEPD ARGTASSALQ SEFFTTKPFP SEPSSLPRYQ 300
  301 PRKEFDAKLR EEEARRRKGS SSKQNEQKRL ARESK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 84.69897
Match: 1vywA
Description: Structure of CDK2/Cyclin A with PNU-292137
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
general RNA polymerase II transcription factor activity 5.68265749805481 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 5.49988294224815 bayes_pls_golite062009
protein kinase activity 5.4586557943719 bayes_pls_golite062009
kinase activity 5.3287080791198 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 4.96052051118534 bayes_pls_golite062009
cyclin-dependent protein kinase activity 4.62392503670521 bayes_pls_golite062009
protein serine/threonine kinase activity 4.46381887831481 bayes_pls_golite062009
transferase activity 3.97138602499442 bayes_pls_golite062009
acetylcholine receptor activator activity 3.57683141337465 bayes_pls_golite062009
binding 2.74863538127007 bayes_pls_golite062009
protein binding 2.276111749106 bayes_pls_golite062009
ATP binding 1.97600611746091 bayes_pls_golite062009
ubiquitin-protein ligase activity 1.94085498993561 bayes_pls_golite062009
adenyl ribonucleotide binding 1.93596671856664 bayes_pls_golite062009
adenyl nucleotide binding 1.90928021591891 bayes_pls_golite062009
signal transducer activity 1.79921740914853 bayes_pls_golite062009
molecular transducer activity 1.79921740914853 bayes_pls_golite062009
small conjugating protein ligase activity 1.74206248731815 bayes_pls_golite062009
transmembrane receptor protein tyrosine kinase activity 1.70788499622067 bayes_pls_golite062009
transmembrane receptor protein kinase activity 1.68012041942855 bayes_pls_golite062009
purine ribonucleotide binding 1.65732943334212 bayes_pls_golite062009
ribonucleotide binding 1.65726906484847 bayes_pls_golite062009
purine nucleotide binding 1.63763394711025 bayes_pls_golite062009
nucleotide binding 1.63195828048121 bayes_pls_golite062009
transcription regulator activity 1.56748951434625 bayes_pls_golite062009
phosphoinositide 3-kinase binding 1.47162554695064 bayes_pls_golite062009
nucleic acid binding 1.46547714006072 bayes_pls_golite062009
MAP kinase kinase activity 1.42275431028856 bayes_pls_golite062009
protein tyrosine kinase activity 1.3898059094397 bayes_pls_golite062009
receptor signaling protein serine/threonine kinase activity 1.38496328649031 bayes_pls_golite062009
DNA binding 1.35333135345112 bayes_pls_golite062009
receptor signaling protein activity 1.27291233344322 bayes_pls_golite062009
acid-amino acid ligase activity 1.2266791546014 bayes_pls_golite062009
cytoskeletal protein binding 1.22172815474021 bayes_pls_golite062009
catalytic activity 1.21655087018101 bayes_pls_golite062009
transcription elongation regulator activity 1.16995153203536 bayes_pls_golite062009
transcription factor activity 1.10928254946881 bayes_pls_golite062009
transcription activator activity 0.997272622653026 bayes_pls_golite062009
insulin receptor substrate binding 0.98689034826741 bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds 0.938271345744087 bayes_pls_golite062009
transmembrane receptor activity 0.913893847407112 bayes_pls_golite062009
MAP kinase activity 0.81943579965027 bayes_pls_golite062009
receptor activity 0.775180603313375 bayes_pls_golite062009
hormone receptor binding 0.705067960165986 bayes_pls_golite062009
transporter activity 0.595111702412257 bayes_pls_golite062009
transcription repressor activity 0.568332175782799 bayes_pls_golite062009
cyclin-dependent protein kinase activating kinase activity 0.529121666062889 bayes_pls_golite062009
tubulin binding 0.525721160726465 bayes_pls_golite062009
steroid hormone receptor binding 0.505233004492768 bayes_pls_golite062009
protein serine/threonine/tyrosine kinase activity 0.48345772948903 bayes_pls_golite062009
enzyme binding 0.46284745266176 bayes_pls_golite062009
actin binding 0.456340967230669 bayes_pls_golite062009
kinase binding 0.443916188551908 bayes_pls_golite062009
transmembrane transporter activity 0.41384976209545 bayes_pls_golite062009
cyclin-dependent protein kinase regulator activity 0.406297251827056 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.401250804041384 bayes_pls_golite062009
structural constituent of muscle 0.399773397398032 bayes_pls_golite062009
magnesium ion binding 0.393328812780268 bayes_pls_golite062009
MAP kinase kinase kinase activity 0.37115026509016 bayes_pls_golite062009
axon guidance receptor activity 0.330635248803668 bayes_pls_golite062009
structure-specific DNA binding 0.318153468064373 bayes_pls_golite062009
protein kinase binding 0.285611963740145 bayes_pls_golite062009
nuclear hormone receptor binding 0.240883589532225 bayes_pls_golite062009
transforming growth factor beta receptor activity 0.19622756073807 bayes_pls_golite062009
transmembrane receptor protein serine/threonine kinase activity 0.19622756073807 bayes_pls_golite062009
microtubule binding 0.191960933574742 bayes_pls_golite062009
growth factor binding 0.153144089598532 bayes_pls_golite062009
substrate-specific transporter activity 0.0922946791401962 bayes_pls_golite062009
protein kinase C activity 0.0795689006739899 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.0040394359628233 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [476-686]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AVPAPSANAE LLASIQKRLG ETNRTSISEK FNPEGDSGNG FRIEPLKGNT AQNPYPIYTN  60
   61 GDNHPNGSSQ LRTQRSYVQR GSGQLSRFSN SMAPTRDGSQ FGSMRDAIVN QRWLEDGSEN 120
  121 FNLSQRLLEK PNGIRKDDPS SSSKESIMGY DGEKRGRIQY SGPLIPGEGN LDEMLKEHER 180
  181 QILLAVRRAQ ADKAKRDDNR QAQTLFPANG R

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle