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View Structure Prediction Details

Protein: daf-9
Organism: Caenorhabditis elegans
Length: 572 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for daf-9.

Description E-value Query
Range		 Subject
Range
CYP2C8 - cytochrome P450, family 2, subfamily C, polypeptide 8
 402.0 [0..82] [565..4]

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Predicted Domain #1
Region A:
Residues: [1-75] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MHLENRVLSS VLDYASKFYK RMSSLVFFSA NSIQVQMNIS QSSWIKCRDW MAFALSHHII  60
   61 MGIYLLILRN FLPQV

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [76-572] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VPDFEWQHYF MRVFIVHIIY IIISYFIRIT RYPPGPPPMA VFGNSPFVNI LTPEQTFLEY  60
   61 REIYGPIFTL HLSQPTIILA EYKTIQEALV KNGQQTSGRS SAESFVLFTG DRLNGDGVIL 120
  121 AMRQKWKDMR HEISRFMNKW YGAPMDELVL HHTRCLEQEL AKIAETKSLI DLRDPLAGAI 180
  181 ANVIQQITIG RNYMYQDQEF QTQLRDINAV VKEIMTAEVF FVNCYPWLRY LPEGILRKWT 240
  241 NYKRSGFRLQ QWFRTILEEH HVNRHQGDFM SHMIDLQESK QEQFRDLSII LTCGDMWTGG 300
  301 METTVTTLRW GIIYLLNNPE VQAKCQMEIL DVFGNDIPDM GKMNQTPYVR ATLSEIQRLA 360
  361 NVLPWAIPHK TIEECNIGGY DIPVNTEIIP ALGAVLFDPN VFESPKQFKP ERFLDEEGKY 420
  421 RVMEEFRPFG LGPRVCLGER IARTELYLIF ASLLQNFRFY LNRGDPIPVA ERVIGGITAP 480
  481 PKPYATRVEY LGNRLIN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 108.0
Match: 1pq2A
Description: Crystal Structure of Human Drug Metabolizing Cytochrome P450 2C8
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
arachidonic acid monooxygenase activity 6.76823710927794 bayes_pls_golite062009
fatty acid (omega-1)-hydroxylase activity 6.3313834755701 bayes_pls_golite062009
monooxygenase activity 5.57229509004705 bayes_pls_golite062009
steroid hydroxylase activity 5.04794778387361 bayes_pls_golite062009
oxysterol 7-alpha-hydroxylase activity 5.03099580095037 bayes_pls_golite062009
arachidonic acid epoxygenase activity 4.80764258881036 bayes_pls_golite062009
electron carrier activity 4.64931978461551 bayes_pls_golite062009
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen 4.64322346579269 bayes_pls_golite062009
steroid 17-alpha-monooxygenase activity 3.99744233006162 bayes_pls_golite062009
retinoic acid 4-hydroxylase activity 3.76307535769621 bayes_pls_golite062009
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 3.68151610133025 bayes_pls_golite062009
demethylase activity 3.40807632433846 bayes_pls_golite062009
oxygen binding 3.29945075872446 bayes_pls_golite062009
flavonoid 3'-monooxygenase activity 3.16634614522939 bayes_pls_golite062009
fluorene oxygenase activity 3.16634614522939 bayes_pls_golite062009
sterol 14-demethylase activity 2.94610675710811 bayes_pls_golite062009
retinoic acid binding 2.70323898361882 bayes_pls_golite062009
retinoid binding 2.60220937953757 bayes_pls_golite062009
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 2.56821164444595 bayes_pls_golite062009
isoprenoid binding 2.47826119804163 bayes_pls_golite062009
thromboxane-A synthase activity 2.45281910634006 bayes_pls_golite062009
oxidoreductase activity 2.35847923992364 bayes_pls_golite062009
steroid 7-alpha-hydroxylase activity 2.29989218606587 bayes_pls_golite062009
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen 2.15105968497418 bayes_pls_golite062009
ecdysteroid 25-hydroxylase activity 2.0071742914584 bayes_pls_golite062009
vitamin D 24-hydroxylase activity 1.81919676974797 bayes_pls_golite062009
vitamin D 25-hydroxylase activity 1.65825585934141 bayes_pls_golite062009
vitamin D3 25-hydroxylase activity 1.65825585934141 bayes_pls_golite062009
corticosterone 18-monooxygenase activity 1.64204907906991 bayes_pls_golite062009
steroid 11-beta-monooxygenase activity 1.64204907906991 bayes_pls_golite062009
arachidonic acid 11,12-epoxygenase activity 1.48500938886158 bayes_pls_golite062009
testosterone 6-beta-hydroxylase activity 1.4661447981611 bayes_pls_golite062009
binding 1.2866152532988 bayes_pls_golite062009
25-hydroxycholecalciferol-24-hydroxylase activity 1.06487564122685 bayes_pls_golite062009
protein binding 0.836411857417911 bayes_pls_golite062009
ecdysteroid 22-hydroxylase activity 0.7601272997427 bayes_pls_golite062009
catalytic activity 0.608111453189583 bayes_pls_golite062009
iron ion binding 0.529598228513719 bayes_pls_golite062009
cation binding 0.510556740388808 bayes_pls_golite062009
metal ion binding 0.510556740388808 bayes_pls_golite062009
ion binding 0.503326724714616 bayes_pls_golite062009
transition metal ion binding 0.450436868179747 bayes_pls_golite062009
cholesterol monooxygenase (side-chain-cleaving) activity 0.276594551871869 bayes_pls_golite062009
1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity 0.203772707673481 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle