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View Structure Prediction Details

Protein: cyp-13A11
Organism: Caenorhabditis elegans
Length: 517 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for cyp-13A11.

Description E-value Query
Range		 Subject
Range
cyp-13A12 - cytochrome P450 status:Partially_confirmed UniProt:O17807 protein_id:CAB04113.1
 399.0 [0..2] [517..3]

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Predicted Domain #1
Region A:
Residues: [1-517] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIILLFVVSS VVGIVSYYFW TWTYWRRCGI PGPQGYPFLG SALDMMDHEN PPFLQLKKWT  60
   61 SQYGKVYGIT EGLLRTLVIS DTNLIHEVFV KQYDNFYGRN LNPIQGDPNR EKRVTLFSAQ 120
  121 GHRWKRLRTI ANPTFSSNNL RKIQVTVEDS ALELLRHIEQ HTAGGKAIDV LEYFQEFTMD 180
  181 VIGRIAMGQP DSLMFKNPLL PCARDVFGKP RTALFLSGIL FPWIGPMIRK VVFYFTNVFN 240
  241 NPAAQIMYQT ANAVEQRIKQ RMAEEKAGID PGEPQDFIDL FLDAKSDDME LENNEDFTKA 300
  301 GVKVTRQLTK DEVVGQCFVF LIAGFDTTAL SLSYSSFLLA THPKAQKKLQ EEIDRECADP 360
  361 EVTFDQLSKL KYMECVIKET LRMYPLGALA NSRRCMRSTK IGNYEIEKGV DILCDTWTLH 420
  421 YDKSIWGEDA EEFKPERWES GDEHFYQKGG YIPFGLGPRQ CIGMRLAYME EKLLLSHILR 480
  481 KYTLEVCNKT QIPLKLIGSR TTQPESVWLN LTPRDDN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 95.154902
Match: 1tqnA
Description: Crystal Structure of Human Microsomal P450 3A4
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
arachidonic acid monooxygenase activity 6.76823710927794 bayes_pls_golite062009
fatty acid (omega-1)-hydroxylase activity 6.3313834755701 bayes_pls_golite062009
monooxygenase activity 5.57229509004705 bayes_pls_golite062009
steroid hydroxylase activity 5.04794778387361 bayes_pls_golite062009
arachidonic acid epoxygenase activity 4.80764258881036 bayes_pls_golite062009
electron carrier activity 4.64931978461551 bayes_pls_golite062009
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen 4.64322346579269 bayes_pls_golite062009
steroid 17-alpha-monooxygenase activity 3.99744233006162 bayes_pls_golite062009
retinoic acid 4-hydroxylase activity 3.76307535769621 bayes_pls_golite062009
oxygen binding 3.7203678182299 bayes_pls_golite062009
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 3.68151610133025 bayes_pls_golite062009
demethylase activity 3.40807632433846 bayes_pls_golite062009
flavonoid 3'-monooxygenase activity 3.16634614522939 bayes_pls_golite062009
retinoic acid binding 3.04897926497756 bayes_pls_golite062009
sterol 14-demethylase activity 2.94610675710811 bayes_pls_golite062009
retinoid binding 2.60220937953757 bayes_pls_golite062009
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 2.56821164444595 bayes_pls_golite062009
isoprenoid binding 2.47826119804163 bayes_pls_golite062009
thromboxane-A synthase activity 2.45281910634006 bayes_pls_golite062009
oxysterol 7-alpha-hydroxylase activity 2.36480328243514 bayes_pls_golite062009
oxidoreductase activity 2.35847923992364 bayes_pls_golite062009
1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity 2.30416050662077 bayes_pls_golite062009
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen 2.15105968497418 bayes_pls_golite062009
ecdysteroid 25-hydroxylase activity 2.0071742914584 bayes_pls_golite062009
vitamin D 24-hydroxylase activity 1.81919676974797 bayes_pls_golite062009
vitamin D3 25-hydroxylase activity 1.65825585934141 bayes_pls_golite062009
vitamin D 25-hydroxylase activity 1.65825585934141 bayes_pls_golite062009
corticosterone 18-monooxygenase activity 1.64204907906991 bayes_pls_golite062009
steroid 11-beta-monooxygenase activity 1.64204907906991 bayes_pls_golite062009
arachidonic acid 11,12-epoxygenase activity 1.48500938886158 bayes_pls_golite062009
testosterone 6-beta-hydroxylase activity 1.4661447981611 bayes_pls_golite062009
binding 1.2866152532988 bayes_pls_golite062009
25-hydroxycholecalciferol-24-hydroxylase activity 1.06487564122685 bayes_pls_golite062009
iron ion binding 1.05714805569149 bayes_pls_golite062009
transition metal ion binding 0.964356154057827 bayes_pls_golite062009
cation binding 0.934330913850428 bayes_pls_golite062009
metal ion binding 0.934330913850428 bayes_pls_golite062009
ion binding 0.927080243591876 bayes_pls_golite062009
protein binding 0.836411857417911 bayes_pls_golite062009
ecdysteroid 22-hydroxylase activity 0.7601272997427 bayes_pls_golite062009
catalytic activity 0.608111453189583 bayes_pls_golite062009
cholesterol monooxygenase (side-chain-cleaving) activity 0.276594551871869 bayes_pls_golite062009
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