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View Structure Prediction Details

Protein: rab-33
Organism: Caenorhabditis elegans
Length: 307 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for rab-33.

Description E-value Query
Range		 Subject
Range
gi|109105440 - gi|109105440|ref|XP_001118047.1| PREDICTED: similar to RAB1B, member RAS oncogene family [Macaca mul...
 236.0 [0..28] [307..1]

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Predicted Domain #1
Region A:
Residues: [1-94] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSEHHVNIPA PQFSTYATVI DPPKHVTATH PDELTTASHP QPTHPSAPQD PSPAVPSTPV  60
   61 RVPYPTAPPP IPPAPEAVTA GPKKMALAPS STKT

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.55
Match: 1pk8A
Description: Crystal Structure of Rat Synapsin I C Domain Complexed to Ca.ATP
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [95-307] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YKQKRTFKVI IVGNAAVGKT CLSFRFCCGR FPEHTEATIG VDFRERSCVI ENELLRVQLW  60
   61 DTAGQERYRQ SIVAHYYRNV NAVVFVYDVT CRESFNDLAL WIKECEKHGL VGDSEVPRIL 120
  121 IGNKCDVECT NRVSTDEAQM FADRNNMALF ETSAKLASEA DHVESIFLTL LHKLQQSKPM 180
  181 HVQSQDERHQ KEQERLILKA NETENVEEEG FCC

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 46.522879
Match: 1z06A
Description: GppNHp-Bound Rab33 GTPase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
microtubule motor activity 4.51968578934603 bayes_pls_golite062009
motor activity 4.04927796049806 bayes_pls_golite062009
hydrolase activity 3.63069754092699 bayes_pls_golite062009
actin binding 3.33639699088484 bayes_pls_golite062009
microfilament motor activity 3.17800963620802 bayes_pls_golite062009
signal recognition particle binding 3.10924684520019 bayes_pls_golite062009
transporter activity 3.10463051760206 bayes_pls_golite062009
transmembrane transporter activity 2.95886887664984 bayes_pls_golite062009
nucleoside-triphosphatase activity 2.95079405147356 bayes_pls_golite062009
pyrophosphatase activity 2.87427509025394 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 2.85499564954033 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 2.85178667290149 bayes_pls_golite062009
tubulin binding 2.67743463093593 bayes_pls_golite062009
binding 2.64537357529343 bayes_pls_golite062009
primary active transmembrane transporter activity 2.61775212528604 bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity 2.61467977505707 bayes_pls_golite062009
microtubule binding 2.59155206524122 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 2.57552435627908 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances 2.57107347424517 bayes_pls_golite062009
ATPase activity, coupled to movement of substances 2.57054427875021 bayes_pls_golite062009
active transmembrane transporter activity 2.50494515048649 bayes_pls_golite062009
ATPase activity, coupled 2.43862163407966 bayes_pls_golite062009
cytoskeletal protein binding 2.4101693596493 bayes_pls_golite062009
ATPase activity 2.39535714892224 bayes_pls_golite062009
actin filament binding 2.24723363507804 bayes_pls_golite062009
nucleic acid binding 2.21184938313192 bayes_pls_golite062009
DNA binding 2.12258000781149 bayes_pls_golite062009
transcription regulator activity 2.09345198747025 bayes_pls_golite062009
ribonucleoprotein binding 2.04103162399905 bayes_pls_golite062009
substrate-specific transporter activity 1.91091452720653 bayes_pls_golite062009
guanyl nucleotide binding 1.89320355239381 bayes_pls_golite062009
guanyl ribonucleotide binding 1.88721318481223 bayes_pls_golite062009
GTP binding 1.87900088157196 bayes_pls_golite062009
purine ribonucleotide binding 1.85943679361938 bayes_pls_golite062009
ribonucleotide binding 1.85937484083653 bayes_pls_golite062009
purine nucleotide binding 1.8521191028835 bayes_pls_golite062009
nucleotide binding 1.84603132945448 bayes_pls_golite062009
hydrogen ion transporting ATP synthase activity, rotational mechanism 1.81972511638668 bayes_pls_golite062009
kinase activity 1.80889641165674 bayes_pls_golite062009
structural constituent of ribosome 1.80055405467543 bayes_pls_golite062009
protein transporter activity 1.71214667007262 bayes_pls_golite062009
helicase activity 1.70242731830224 bayes_pls_golite062009
G-protein coupled receptor activity 1.63949223587737 bayes_pls_golite062009
GTPase activity 1.6309422514633 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 1.60386625568858 bayes_pls_golite062009
actin-dependent ATPase activity 1.58897222423517 bayes_pls_golite062009
ATP binding 1.5859264197035 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 1.56325751172863 bayes_pls_golite062009
adenyl ribonucleotide binding 1.55520429131224 bayes_pls_golite062009
adenyl nucleotide binding 1.53158018507951 bayes_pls_golite062009
GDP-dissociation inhibitor binding 1.53046363842187 bayes_pls_golite062009
apolipoprotein receptor activity 1.52496551152043 bayes_pls_golite062009
syntaxin-13 binding 1.52496551152043 bayes_pls_golite062009
apolipoprotein A-I binding 1.52496551152043 bayes_pls_golite062009
apolipoprotein A-I receptor activity 1.52496551152043 bayes_pls_golite062009
1.5195709747438 bayes_pls_golite062009
plus-end-directed microtubule motor activity 1.38366133153678 bayes_pls_golite062009
protein binding 1.22129154759482 bayes_pls_golite062009
DNA-dependent ATPase activity 1.2155186842031 bayes_pls_golite062009
ATP-dependent helicase activity 1.19311444180077 bayes_pls_golite062009
purine NTP-dependent helicase activity 1.19311444180077 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 1.14475274823167 bayes_pls_golite062009
peptidase activity 1.12876670227791 bayes_pls_golite062009
protein kinase activity 1.12864835254143 bayes_pls_golite062009
catalytic activity 1.00104173493322 bayes_pls_golite062009
ion transmembrane transporter activity 0.977237423302079 bayes_pls_golite062009
GMP binding 0.975301479415235 bayes_pls_golite062009
DNA-directed DNA polymerase activity 0.971476020912368 bayes_pls_golite062009
structural constituent of muscle 0.960508657568442 bayes_pls_golite062009
DNA polymerase activity 0.928091843881235 bayes_pls_golite062009
transferase activity, transferring glycosyl groups 0.889480122725603 bayes_pls_golite062009
transcription factor activity 0.887108427603557 bayes_pls_golite062009
protein methyltransferase activity 0.876296121718575 bayes_pls_golite062009
transferase activity 0.871779313294914 bayes_pls_golite062009
structural molecule activity 0.86163779946438 bayes_pls_golite062009
structure-specific DNA binding 0.782430219754236 bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides 0.765442336337003 bayes_pls_golite062009
transcription activator activity 0.739301862805678 bayes_pls_golite062009
DNA helicase activity 0.72881469450553 bayes_pls_golite062009
signal transducer activity 0.683309012097319 bayes_pls_golite062009
molecular transducer activity 0.683309012097319 bayes_pls_golite062009
transmembrane receptor activity 0.661834961742057 bayes_pls_golite062009
protein-DNA loading ATPase activity 0.650964453464311 bayes_pls_golite062009
receptor activity 0.633514002718998 bayes_pls_golite062009
histone methyltransferase activity 0.63002958837536 bayes_pls_golite062009
double-stranded DNA binding 0.6071273686445 bayes_pls_golite062009
ATP-dependent DNA helicase activity 0.5886142102548 bayes_pls_golite062009
cation transmembrane transporter activity 0.557919489256916 bayes_pls_golite062009
DNA clamp loader activity 0.543512707823441 bayes_pls_golite062009
protein transmembrane transporter activity 0.46552249844591 bayes_pls_golite062009
hydrogen ion transmembrane transporter activity 0.444874730945263 bayes_pls_golite062009
signal sequence binding 0.42240724331108 bayes_pls_golite062009
drug transmembrane transporter activity 0.38711726712063 bayes_pls_golite062009
DNA strand annealing activity 0.370730612975529 bayes_pls_golite062009
RNA helicase activity 0.34746349346164 bayes_pls_golite062009
protein serine/threonine kinase activity 0.345873656782869 bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity 0.325013574811283 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 0.312659433116074 bayes_pls_golite062009
ATP-dependent RNA helicase activity 0.30832907234141 bayes_pls_golite062009
RNA-dependent ATPase activity 0.29532978396745 bayes_pls_golite062009
myosin binding 0.274885859454447 bayes_pls_golite062009
nucleobase, nucleoside, nucleotide kinase activity 0.12351419478929 bayes_pls_golite062009
inorganic cation transmembrane transporter activity 0.123304946374679 bayes_pls_golite062009
RNA binding 0.0693163519626152 bayes_pls_golite062009
structural constituent of cytoskeleton 0.0111338193708552 bayes_pls_golite062009
P-P-bond-hydrolysis-driven protein transmembrane transporter activity 0.00571427458217011 bayes_pls_golite062009
macromolecule transmembrane transporter activity 0.00571427458217011 bayes_pls_golite062009
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