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View Structure Prediction Details

Protein: Vps4-PA, FBpp0309628
Organism: Drosophila melanogaster
Length: 442 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Vps4-PA, FBpp0309628.

Description E-value Query
Range		 Subject
Range
gi|109129052 - gi|109129052|ref|XP_001093648.1| PREDICTED: vacuolar protein sorting factor 4A [Macaca mulatta]
 336.0 [0..1] [441..80]

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Predicted Domain #1
Region A:
Residues: [1-122] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAAGTTLQKA IDLVTKATEE DRNKNYAEAL RLYEHGVEYF LHTIKYEAQG EKAKDSIRAK  60
   61 CLQYLDRAEK LKEYLKKGKK KPIKEGGESS AKDDKDKKSD SDDEDGDDPE KKKLQSKLED 120
  121 AI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 7.39794
Match: 2cptA
Description: Solution structure of MIT domain from human SKD1
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [123-149] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VIEKPKVQWS DVAGLDAAKE ALKEAVI

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.94
Match: 2qp9X
Description: No description for 2qp9X was found.

Predicted Domain #3
Region A:
Residues: [150-368] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LPIKFPQLFT GKRIPWKGIL LFGPPGTGKS YLAKAVATEA NRSTFFSVSS SDLMSKWLGE  60
   61 SEKLVKNLFE LARQHKPSII FIDEIDSMCS ARSDNENDSV RRIKTEFLVQ MQGVGNDTDG 120
  121 ILVLGATNIP WVLDSAIRRR FEKRIYIPLP EAHARLVMFK IHLGNTTHVL TEQDLKELAG 180
  181 KTEGYSGADI SIVVRDALME PVRKVQTATH FKRVSGPSP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 4.69897
Match: 1ex6A
Description: Guanylate kinase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
hydrogen ion transporting ATP synthase activity, rotational mechanism 4.45975815173802 bayes_pls_golite062009
hydrolase activity 3.63069754092699 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 3.4837867129694 bayes_pls_golite062009
ion transmembrane transporter activity 3.35436118751376 bayes_pls_golite062009
transporter activity 3.10463051760206 bayes_pls_golite062009
cation transmembrane transporter activity 3.08390071341252 bayes_pls_golite062009
transmembrane transporter activity 2.95886887664984 bayes_pls_golite062009
nucleoside-triphosphatase activity 2.95079405147356 bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity 2.9271291809464 bayes_pls_golite062009
pyrophosphatase activity 2.87427509025394 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 2.85499564954033 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 2.85178667290149 bayes_pls_golite062009
binding 2.64537357529343 bayes_pls_golite062009
hydrogen ion transmembrane transporter activity 2.63419811368692 bayes_pls_golite062009
primary active transmembrane transporter activity 2.61775212528604 bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity 2.61467977505707 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 2.57552435627908 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances 2.57107347424517 bayes_pls_golite062009
ATPase activity, coupled to movement of substances 2.57054427875021 bayes_pls_golite062009
active transmembrane transporter activity 2.50494515048649 bayes_pls_golite062009
ATPase activity, coupled 2.43862163407966 bayes_pls_golite062009
inorganic cation transmembrane transporter activity 2.40292717311506 bayes_pls_golite062009
ATPase activity 2.39535714892224 bayes_pls_golite062009
metal ion transmembrane transporter activity 2.26365379756656 bayes_pls_golite062009
nucleic acid binding 2.11222585187695 bayes_pls_golite062009
alpha-tubulin binding 2.02293807820805 bayes_pls_golite062009
substrate-specific transporter activity 1.91091452720653 bayes_pls_golite062009
voltage-gated cation channel activity 1.8621490001046 bayes_pls_golite062009
potassium channel activity 1.79629698691358 bayes_pls_golite062009
DNA binding 1.7904783386531 bayes_pls_golite062009
voltage-gated ion channel activity 1.74551765217439 bayes_pls_golite062009
voltage-gated channel activity 1.74536227612384 bayes_pls_golite062009
transcription regulator activity 1.68903321260301 bayes_pls_golite062009
microtubule-severing ATPase activity 1.51207319154707 bayes_pls_golite062009
beta-tubulin binding 1.37252692137017 bayes_pls_golite062009
cholesterol transporter activity 1.26047467122235 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of ions 1.23799860254751 bayes_pls_golite062009
peptidase activity 1.12876670227791 bayes_pls_golite062009
lipid transporter activity 1.10957173853622 bayes_pls_golite062009
sterol transporter activity 1.00610936344232 bayes_pls_golite062009
catalytic activity 1.00104173493322 bayes_pls_golite062009
purine nucleotide binding 0.929901285538132 bayes_pls_golite062009
nucleotide binding 0.922442819194247 bayes_pls_golite062009
purine ribonucleotide binding 0.920987930180051 bayes_pls_golite062009
ribonucleotide binding 0.920926158369519 bayes_pls_golite062009
motor activity 0.87979065815418 bayes_pls_golite062009
structural constituent of ribosome 0.860102064846772 bayes_pls_golite062009
di-, tri-valent inorganic cation transmembrane transporter activity 0.767424210804186 bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides 0.765442336337003 bayes_pls_golite062009
glutathione S-conjugate-exporting ATPase activity 0.719430645205088 bayes_pls_golite062009
cation channel activity 0.644849120170412 bayes_pls_golite062009
guanyl nucleotide binding 0.640772201693186 bayes_pls_golite062009
guanyl ribonucleotide binding 0.63468044350616 bayes_pls_golite062009
GTP binding 0.621689261700018 bayes_pls_golite062009
transcription factor activity 0.603758349693077 bayes_pls_golite062009
protein transporter activity 0.498432226280822 bayes_pls_golite062009
GTPase activity 0.437665353870877 bayes_pls_golite062009
anion transmembrane transporter activity 0.43332053110728 bayes_pls_golite062009
ATP binding 0.41092997612902 bayes_pls_golite062009
adenyl ribonucleotide binding 0.385813421701492 bayes_pls_golite062009
adenyl nucleotide binding 0.377870145186619 bayes_pls_golite062009
signal recognition particle binding 0.29390189699022 bayes_pls_golite062009
translation regulator activity 0.29096092258568 bayes_pls_golite062009
translation factor activity, nucleic acid binding 0.274994961137851 bayes_pls_golite062009
transition metal ion transmembrane transporter activity 0.248918847596573 bayes_pls_golite062009
proton-transporting ATPase activity, rotational mechanism 0.219473333671469 bayes_pls_golite062009
protein binding 0.170837278876362 bayes_pls_golite062009
ion channel activity 0.154779598791225 bayes_pls_golite062009
channel activity 0.134817721656507 bayes_pls_golite062009
passive transmembrane transporter activity 0.134817721656507 bayes_pls_golite062009
substrate-specific channel activity 0.126911677161968 bayes_pls_golite062009
nucleobase, nucleoside, nucleotide kinase activity 0.12351419478929 bayes_pls_golite062009
microtubule motor activity 0.11674780318211 bayes_pls_golite062009
structural molecule activity 0.11239762372728 bayes_pls_golite062009
helicase activity 0.0775311459068899 bayes_pls_golite062009
cation-transporting ATPase activity 0.0536898657672154 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [369-442] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TNHEEIVNDL LVPCSPGDQG AVEMNWMDVP SDKLFEPPVT MRDMLKSLSR TKPTVNEDDL  60
   61 KKLRKFTEDF GQEG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 77.522879
Match: 1xwiA
Description: Crystal Structure of VPS4B
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle