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View Structure Prediction Details

Protein: TPK3
Organism: Saccharomyces cerevisiae
Length: 398 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TPK3.

Description E-value Query
Range		 Subject
Range
TPK3 - cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients...
KAPC_YEAST - cAMP-dependent protein kinase type 3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TPK...
gi|151941752 - gi|151941752|gb|EDN60113.1| cAMP-dependent protein kinase catalytic subunit [Saccharomyces cerevisia...
 0.0 [1..398] [1..398]
gi|183396893, gi... - gi|183396893|gb|AAI65948.1| Protein kinase C, epsilon [synthetic construct], gi|117616658|gb|ABK4234...
KPCE_MOUSE - Protein kinase C epsilon type OS=Mus musculus GN=Prkce PE=1 SV=1
 0.0 [4..398] [311..728]
PRKCE - protein kinase C, epsilon
gi|168279093 - gi|168279093|dbj|BAG11426.1| protein kinase C epsilon type [synthetic construct]
 0.0 [4..398] [311..728]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
 0.0 [4..398] [311..727]
KPCE_RABIT - Protein kinase C epsilon type OS=Oryctolagus cuniculus GN=PRKCE PE=2 SV=1
 0.0 [4..398] [311..727]

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Predicted Domain #1
Region A:
Residues: [1-78] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MYVDPMNNNE IRKLSITAKT ETTPDNVGQD IPVNAHSVHE ECSSNTPVEI NGRNSGKLKE  60
   61 EASAGICLVK KPMLQYRD

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
phosphotransferase activity, alcohol group as acceptor 5.49988294224815 bayes_pls_golite062009
protein kinase activity 5.4586557943719 bayes_pls_golite062009
kinase activity 5.3287080791198 bayes_pls_golite062009
cyclic nucleotide-dependent protein kinase activity 4.97855712164511 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 4.96052051118534 bayes_pls_golite062009
cAMP-dependent protein kinase activity 4.66277812893755 bayes_pls_golite062009
protein serine/threonine kinase activity 4.46381887831481 bayes_pls_golite062009
transferase activity 3.97138602499442 bayes_pls_golite062009
protein tyrosine kinase activity 2.8153155526437 bayes_pls_golite062009
binding 2.74863538127007 bayes_pls_golite062009
transmembrane receptor activity 2.59526003830791 bayes_pls_golite062009
transmembrane receptor protein kinase activity 2.54265774272269 bayes_pls_golite062009
signal transducer activity 2.40586892801446 bayes_pls_golite062009
molecular transducer activity 2.40586892801446 bayes_pls_golite062009
receptor activity 2.39311927684508 bayes_pls_golite062009
telethonin binding 2.27062712605521 bayes_pls_golite062009
tubulin binding 2.18641675163967 bayes_pls_golite062009
transmembrane receptor protein tyrosine kinase activity 2.16831387024372 bayes_pls_golite062009
cytoskeletal protein binding 2.12615078788254 bayes_pls_golite062009
receptor signaling protein activity 2.10379226653669 bayes_pls_golite062009
ATP binding 1.97600611746091 bayes_pls_golite062009
adenyl ribonucleotide binding 1.93596671856664 bayes_pls_golite062009
adenyl nucleotide binding 1.90928021591891 bayes_pls_golite062009
microtubule binding 1.88110801192607 bayes_pls_golite062009
actin binding 1.87817875565699 bayes_pls_golite062009
acetylcholine receptor activator activity 1.83545227594542 bayes_pls_golite062009
phosphoinositide 3-kinase binding 1.82515074380651 bayes_pls_golite062009
receptor signaling protein serine/threonine kinase activity 1.81249386965144 bayes_pls_golite062009
purine ribonucleotide binding 1.65732943334212 bayes_pls_golite062009
ribonucleotide binding 1.65726906484847 bayes_pls_golite062009
purine nucleotide binding 1.63763394711025 bayes_pls_golite062009
nucleotide binding 1.63195828048121 bayes_pls_golite062009
insulin receptor substrate binding 1.62657794525303 bayes_pls_golite062009
transcription regulator activity 1.56748951434625 bayes_pls_golite062009
JUN kinase kinase kinase activity 1.41172362253967 bayes_pls_golite062009
alpha-actinin binding 1.38861866085902 bayes_pls_golite062009
DNA binding 1.35333135345112 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 1.32254739984688 bayes_pls_golite062009
gamma-tubulin binding 1.28511591054866 bayes_pls_golite062009
kinase binding 1.26086833316556 bayes_pls_golite062009
ErbB-3 class receptor binding 1.25765701903393 bayes_pls_golite062009
protein binding 1.22565748038754 bayes_pls_golite062009
catalytic activity 1.21655087018101 bayes_pls_golite062009
nucleic acid binding 1.16049201286103 bayes_pls_golite062009
transporter activity 1.11833481501707 bayes_pls_golite062009
transcription factor activity 1.10928254946881 bayes_pls_golite062009
protein kinase binding 1.06030596516506 bayes_pls_golite062009
ErbB-2 class receptor binding 1.02996109010965 bayes_pls_golite062009
transmembrane transporter activity 0.97575992765505 bayes_pls_golite062009
cyclin-dependent protein kinase activity 0.959360414036299 bayes_pls_golite062009
growth factor binding 0.86076618871384 bayes_pls_golite062009
ligase activity, forming aminoacyl-tRNA and related compounds 0.835012681606991 bayes_pls_golite062009
ligase activity, forming carbon-oxygen bonds 0.835012681606991 bayes_pls_golite062009
aminoacyl-tRNA ligase activity 0.832111648073981 bayes_pls_golite062009
MAP kinase activity 0.81943579965027 bayes_pls_golite062009
actin filament binding 0.794152600084 bayes_pls_golite062009
substrate-specific transporter activity 0.705905455086486 bayes_pls_golite062009
ligase activity 0.665445021164512 bayes_pls_golite062009
structural constituent of cytoskeleton 0.612883428421652 bayes_pls_golite062009
protein serine/threonine/tyrosine kinase activity 0.48345772948903 bayes_pls_golite062009
enzyme binding 0.46284745266176 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.450699332958421 bayes_pls_golite062009
protein kinase C activity 0.41587987561486 bayes_pls_golite062009
magnesium ion binding 0.393328812780268 bayes_pls_golite062009
MAP kinase kinase kinase activity 0.37115026509016 bayes_pls_golite062009
MAP kinase kinase activity 0.35402045013148 bayes_pls_golite062009
insulin receptor binding 0.266450215230107 bayes_pls_golite062009
protein complex binding 0.239339759110451 bayes_pls_golite062009
insulin receptor activity 0.237134032032089 bayes_pls_golite062009
SH2 domain binding 0.226760162354251 bayes_pls_golite062009
transmembrane receptor protein serine/threonine kinase activity 0.20643152368029 bayes_pls_golite062009
transforming growth factor beta receptor activity 0.20643152368029 bayes_pls_golite062009
receptor binding 0.197402253061255 bayes_pls_golite062009
ion transmembrane transporter activity 0.148194101970458 bayes_pls_golite062009
peptide binding 0.118578378753757 bayes_pls_golite062009
transforming growth factor beta receptor activity, type I 0.0506751594607393 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.0040394359628233 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [79-137] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TSGKYSLSDF QILRTLGTGS FGRVHLIRSN HNGRFYALKT LKKHTIVKLK QVEHTNDER

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [151-167] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MWGTFQDSQQ VFMVMDY

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [363-398] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IQQGQGDTSQ FDRYPEEEFN YGIQGEDPYM DLMKEF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1860.0
Match: 1fotA_
Description: cAMP-dependent PK, catalytic subunit
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [138-150] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RMLSIVSHPF IIR

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [168-362] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IEGGELFSLL RKSQRFPNPV AKFYAAEVCL ALEYLHSKDI IYRDLKPENI LLDKNGHIKI  60
   61 TDFGFAKYVP DVTYTLCGTP DYIAPEVVST KPYNKSVDWW SFGVLIYEML AGYTPFYNSN 120
  121 TMKTYENILN AELKFPPFFH PDAQDLLKKL ITRDLSERLG NLQNGSEDVK NHPWFNEVIW 180
  181 EKLLARYIET PYEPP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1860.0
Match: 1fotA_
Description: cAMP-dependent PK, catalytic subunit
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle