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View Structure Prediction Details

Protein: TFP1
Organism: Saccharomyces cerevisiae
Length: 1071 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TFP1.

Description E-value Query
Range
Subject
Range
VATA_YEAST - V-type proton ATPase catalytic subunit A OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN...
TFP1 - Subunit A of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase; protein prec...
0.0 [1..1071] [1..1071]
gi|29420869 - gi|29420869|dbj|BAC66656.1| vacuolar membrane ATPase subunit a precursor [Saccharomyces pastorianus]
0.0 [16..1060] [2..1046]
gi|29420859 - gi|29420859|dbj|BAC66651.1| vacuolar membrane ATPase subunit a precursor [Saccharomyces dairenensis]
0.0 [14..1060] [2..1095]

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Predicted Domain #1
Region A:
Residues: [1-84]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAGAIENARK EIKRISLEDH AESEYGAIYS VSGPVVIAEN MIGCAMYELV KVGHDNLVGE  60
   61 VIRIDGDKAT IQVYEETAGL TVGD

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 21.886057
Match: PF02874.7
Description: No description for PF02874.7 was found.

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
hydrogen ion transmembrane transporter activity 8.99485812867371 bayes_pls_golite062009
hydrogen ion transporting ATP synthase activity, rotational mechanism 8.43809246013427 bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity 7.28612792538764 bayes_pls_golite062009
inorganic cation transmembrane transporter activity 6.56211055461575 bayes_pls_golite062009
proton-transporting ATPase activity, rotational mechanism 3.88373794136406 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 3.39040720727162 bayes_pls_golite062009
ion transmembrane transporter activity 3.28894636799771 bayes_pls_golite062009
hydrogen-exporting ATPase activity, phosphorylative mechanism 3.20056737251701 bayes_pls_golite062009
cation transmembrane transporter activity 3.03916263027565 bayes_pls_golite062009
transporter activity 2.9325438450934 bayes_pls_golite062009
transmembrane transporter activity 2.77909183361556 bayes_pls_golite062009
nucleoside-triphosphatase activity 2.67498718917813 bayes_pls_golite062009
pyrophosphatase activity 2.60251056808401 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 2.58430117129985 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 2.58115131779782 bayes_pls_golite062009
hydrolase activity 2.48023456865742 bayes_pls_golite062009
primary active transmembrane transporter activity 2.38650577592563 bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity 2.38284234201968 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 2.34368052096144 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances 2.33928814826072 bayes_pls_golite062009
ATPase activity, coupled to movement of substances 2.33884554716207 bayes_pls_golite062009
active transmembrane transporter activity 2.28786776436738 bayes_pls_golite062009
cation-transporting ATPase activity 2.2242188318911 bayes_pls_golite062009
ATPase activity, coupled 2.19267030982632 bayes_pls_golite062009
binding 2.15223415484989 bayes_pls_golite062009
ATPase activity 2.14491816112038 bayes_pls_golite062009
substrate-specific transporter activity 1.8085602148752 bayes_pls_golite062009
metal ion transmembrane transporter activity 1.53938373974092 bayes_pls_golite062009
nucleic acid binding 1.50098700711558 bayes_pls_golite062009
DNA binding 1.19194387475416 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of ions 1.12292194267086 bayes_pls_golite062009
transcription regulator activity 1.12203014375349 bayes_pls_golite062009
catalytic activity 0.942640875796745 bayes_pls_golite062009
DNA-dependent ATPase activity 0.875943780299382 bayes_pls_golite062009
structural constituent of ribosome 0.869710683000949 bayes_pls_golite062009
helicase activity 0.802129193518991 bayes_pls_golite062009
purine nucleotide binding 0.714145134870091 bayes_pls_golite062009
nucleotide binding 0.708394757192331 bayes_pls_golite062009
purine ribonucleotide binding 0.70300395089804 bayes_pls_golite062009
ribonucleotide binding 0.702990562850678 bayes_pls_golite062009
voltage-gated cation channel activity 0.630907399726593 bayes_pls_golite062009
DNA helicase activity 0.606831357648651 bayes_pls_golite062009
voltage-gated channel activity 0.520434833402482 bayes_pls_golite062009
voltage-gated ion channel activity 0.520010821042307 bayes_pls_golite062009
potassium channel activity 0.516313726033988 bayes_pls_golite062009
ATP-dependent helicase activity 0.329657633591245 bayes_pls_golite062009
purine NTP-dependent helicase activity 0.329657633591245 bayes_pls_golite062009
anion transmembrane transporter activity 0.29111329295693 bayes_pls_golite062009
cation channel activity 0.267140200199812 bayes_pls_golite062009
ATP binding 0.221274151647827 bayes_pls_golite062009
protein binding 0.201869978778282 bayes_pls_golite062009
adenyl ribonucleotide binding 0.198698067988182 bayes_pls_golite062009
adenyl nucleotide binding 0.194178388079667 bayes_pls_golite062009
structural molecule activity 0.191568396055768 bayes_pls_golite062009
ion channel activity 0.17671388431308 bayes_pls_golite062009
di-, tri-valent inorganic cation transmembrane transporter activity 0.168531365787205 bayes_pls_golite062009
translation regulator activity 0.165004576559811 bayes_pls_golite062009
channel activity 0.164130750223518 bayes_pls_golite062009
passive transmembrane transporter activity 0.164130750223518 bayes_pls_golite062009
substrate-specific channel activity 0.154272377180496 bayes_pls_golite062009
translation factor activity, nucleic acid binding 0.144513585153713 bayes_pls_golite062009
transcription factor activity 0.101575043176033 bayes_pls_golite062009
four-way junction helicase activity 0.100226648459719 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [85-189]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PVLRTGKPLS VELGPGLMET IYDGIQRPLK AIKEESQSIY IPRGIDTPAL DRTIKWQFTP  60
   61 GKFQVGDHIS GGDIYGSVFE NSLISSHKIL LPPRSRGTIT WIAPA

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [190-261]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GEYTLDEKIL EVEFDGKKSD FTLYHTWPVR VPRPVTEKLS ADYPLLTGQR VLDALFPCVQ  60
   61 GGTTCIPGAF GC

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [262-512]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GKTVISQSLS KYSNSDAIIY VGCFAKGTNV LMADGSIECI ENIEVGNKVM GKDGRPREVI  60
   61 KLPRGRETMY SVVQKSQHRA HKSDSSREVP ELLKFTCNAT HELVVRTPRS VRRLSRTIKG 120
  121 VEYFEVITFE MGQKKAPDGR IVELVKEVSK SYPISEGPER ANELVESYRK ASNKAYFEWT 180
  181 IEARDLSLLG SHVRKATYQT YAPILYENDH FFDYMQKSKF HLTIEGPKVL AYLLGLWIGD 240
  241 GLSDRATFSV D

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 80.0
Match: 1jvaA_
Description: VMA1-derived endonuclease (VDE) PI-Scei intein; VMA1-derived endonuclease (VDE) PI-SceI
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [513-1071]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SRDTSLMERV TEYAEKLNLC AEYKDRKEPQ VAKTVNLYSK VVRGNGIRNN LNTENPLWDA  60
   61 IVGLGFLKDG VKNIPSFLST DNIGTRETFL AGLIDSDGYV TDEHGIKATI KTIHTSVRDG 120
  121 LVSLARSLGL VVSVNAEPAK VDMNGTKHKI SYAIYMSGGD VLLNVLSKCA GSKKFRPAPA 180
  181 AAFARECRGF YFELQELKED DYYGITLSDD SDHQFLLANQ VVVHNCGERG NEMAEVLMEF 240
  241 PELYTEMSGT KEPIMKRTTL VANTSNMPVA AREASIYTGI TLAEYFRDQG KNVSMIADSS 300
  301 SRWAEALREI SGRLGEMPAD QGFPAYLGAK LASFYERAGK AVALGSPDRT GSVSIVAAVS 360
  361 PAGGDFSDPV TTATLGITQV FWGLDKKLAQ RKHFPSINTS VSYSKYTNVL NKFYDSNYPE 420
  421 FPVLRDRMKE ILSNAEELEQ VVQLVGKSAL SDSDKITLDV ATLIKEDFLQ QNGYSTYDAF 480
  481 CPIWKTFDMM RAFISYHDEA QKAVANGANW SKLADSTGDV KHAVSSSKFF EPSRGEKEVH 540
  541 GEFEKLLSTM QERFAESTD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 113.0
Match: 1bmfA_
Description: F1 ATP synthase alpha subunit, domain 3; F1 ATP synthase alpha subunit, domain 1; Central domain of alpha subunit of F1 ATP synthase
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle