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View Structure Prediction Details

Protein: vps-4
Organism: Caenorhabditis elegans
Length: 430 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for vps-4.

Description E-value Query
Range		 Subject
Range
gi|109129052 - gi|109129052|ref|XP_001093648.1| PREDICTED: vacuolar protein sorting factor 4A [Macaca mulatta]
 343.0 [0..1] [427..80]

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Predicted Domain #1
Region A:
Residues: [1-352] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSVPALQKAI ELVTKATEED TAGRYDQALR LYDQAIEYFL HAIKYESQGD KQRNAIRDKV  60
   61 GQYLNRAEQI KTHLKDGKTQ KKPVKDGKDD SDEDEDKKKF QDKLSGAIVM EKPNVKWTDI 120
  121 AGLEGAKEAL KEAVILPIKF PQLFTGNRKP WQGILLFGPP GTGKSYIAKA VATEAGESTF 180
  181 FSISSSDLMS KWLGESEKLV KNLFALAREH KPSIIFIDEI DSLCSARSDN ESESARRIKT 240
  241 EFMVQMQGVG LNNDGILVLG ATNIPWILDS AIRRRFEKRI YIPLPDIHAR KEMFRIDVGK 300
  301 NYNTLTDQDF KVLAERCEGY SGYDISILVK DALMQPVRRV QSATHFKHVS GP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 25.69897
Match: 1ksfX
Description: N-terminal, ClpS-binding domain of ClpA, an Hsp100 chaperone; ClpA, an Hsp100 chaperone, AAA+ modules
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
hydrogen ion transporting ATP synthase activity, rotational mechanism 4.45975815173802 bayes_pls_golite062009
hydrolase activity 3.63069754092699 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 3.4837867129694 bayes_pls_golite062009
ion transmembrane transporter activity 3.35436118751376 bayes_pls_golite062009
transporter activity 3.10463051760206 bayes_pls_golite062009
cation transmembrane transporter activity 3.08390071341252 bayes_pls_golite062009
transmembrane transporter activity 2.95886887664984 bayes_pls_golite062009
nucleoside-triphosphatase activity 2.95079405147356 bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity 2.9271291809464 bayes_pls_golite062009
pyrophosphatase activity 2.87427509025394 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 2.85499564954033 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 2.85178667290149 bayes_pls_golite062009
binding 2.64537357529343 bayes_pls_golite062009
hydrogen ion transmembrane transporter activity 2.63419811368692 bayes_pls_golite062009
primary active transmembrane transporter activity 2.61775212528604 bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity 2.61467977505707 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 2.57552435627908 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances 2.57107347424517 bayes_pls_golite062009
ATPase activity, coupled to movement of substances 2.57054427875021 bayes_pls_golite062009
active transmembrane transporter activity 2.50494515048649 bayes_pls_golite062009
ATPase activity, coupled 2.43862163407966 bayes_pls_golite062009
inorganic cation transmembrane transporter activity 2.40292717311506 bayes_pls_golite062009
ATPase activity 2.39535714892224 bayes_pls_golite062009
metal ion transmembrane transporter activity 2.26365379756656 bayes_pls_golite062009
nucleic acid binding 2.11222585187695 bayes_pls_golite062009
alpha-tubulin binding 2.02293807820805 bayes_pls_golite062009
substrate-specific transporter activity 1.91091452720653 bayes_pls_golite062009
voltage-gated cation channel activity 1.8621490001046 bayes_pls_golite062009
potassium channel activity 1.79629698691358 bayes_pls_golite062009
DNA binding 1.7904783386531 bayes_pls_golite062009
voltage-gated ion channel activity 1.74551765217439 bayes_pls_golite062009
voltage-gated channel activity 1.74536227612384 bayes_pls_golite062009
transcription regulator activity 1.68903321260301 bayes_pls_golite062009
microtubule-severing ATPase activity 1.51207319154707 bayes_pls_golite062009
beta-tubulin binding 1.37252692137017 bayes_pls_golite062009
cholesterol transporter activity 1.26047467122235 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of ions 1.23799860254751 bayes_pls_golite062009
peptidase activity 1.12876670227791 bayes_pls_golite062009
lipid transporter activity 1.10957173853622 bayes_pls_golite062009
sterol transporter activity 1.00610936344232 bayes_pls_golite062009
catalytic activity 1.00104173493322 bayes_pls_golite062009
purine nucleotide binding 0.929901285538132 bayes_pls_golite062009
nucleotide binding 0.922442819194247 bayes_pls_golite062009
purine ribonucleotide binding 0.920987930180051 bayes_pls_golite062009
ribonucleotide binding 0.920926158369519 bayes_pls_golite062009
motor activity 0.87979065815418 bayes_pls_golite062009
structural constituent of ribosome 0.860102064846772 bayes_pls_golite062009
di-, tri-valent inorganic cation transmembrane transporter activity 0.767424210804186 bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides 0.765442336337003 bayes_pls_golite062009
glutathione S-conjugate-exporting ATPase activity 0.719430645205088 bayes_pls_golite062009
cation channel activity 0.644849120170412 bayes_pls_golite062009
guanyl nucleotide binding 0.640772201693186 bayes_pls_golite062009
guanyl ribonucleotide binding 0.63468044350616 bayes_pls_golite062009
GTP binding 0.621689261700018 bayes_pls_golite062009
transcription factor activity 0.603758349693077 bayes_pls_golite062009
protein transporter activity 0.498432226280822 bayes_pls_golite062009
GTPase activity 0.437665353870877 bayes_pls_golite062009
anion transmembrane transporter activity 0.43332053110728 bayes_pls_golite062009
ATP binding 0.41092997612902 bayes_pls_golite062009
adenyl ribonucleotide binding 0.385813421701492 bayes_pls_golite062009
adenyl nucleotide binding 0.377870145186619 bayes_pls_golite062009
signal recognition particle binding 0.29390189699022 bayes_pls_golite062009
translation regulator activity 0.29096092258568 bayes_pls_golite062009
translation factor activity, nucleic acid binding 0.274994961137851 bayes_pls_golite062009
transition metal ion transmembrane transporter activity 0.248918847596573 bayes_pls_golite062009
proton-transporting ATPase activity, rotational mechanism 0.219473333671469 bayes_pls_golite062009
protein binding 0.170837278876362 bayes_pls_golite062009
ion channel activity 0.154779598791225 bayes_pls_golite062009
channel activity 0.134817721656507 bayes_pls_golite062009
passive transmembrane transporter activity 0.134817721656507 bayes_pls_golite062009
substrate-specific channel activity 0.126911677161968 bayes_pls_golite062009
nucleobase, nucleoside, nucleotide kinase activity 0.12351419478929 bayes_pls_golite062009
microtubule motor activity 0.11674780318211 bayes_pls_golite062009
structural molecule activity 0.11239762372728 bayes_pls_golite062009
helicase activity 0.0775311459068899 bayes_pls_golite062009
cation-transporting ATPase activity 0.0536898657672154 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [353-430] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SPKDPNVIAH DLLTPCSPGD PHAIAMNWLD VPGDKLANPP LSMQDISRSL ASVKPTVNNT  60
   61 DLDRLEAFKN DFGQDGQE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 81.0
Match: 1xwiA
Description: Crystal Structure of VPS4B
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle