YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

View Protein Complex Details

Complex Overview

From Publication: Gavin A.C. et al. (2006) Proteome survey reveals modularity of the yeast cell machinery. Nature. 2006 Mar 30;440(7084):631-6. Epub 2006 Jan 22.
Notes: From the published set of protein complexes (core proteins only)
Complex Size: 8 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
APC1
  • anaphase-promoting complex
  • mitotic spindle elongation
  • cyclin catabolic process
  • mitotic sister chromatid segregation
  • anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
  • mitotic metaphase/anaphase transition
  • protein ubiquitination
  • ubiquitin-protein ligase activity
  • protein binding
  • APC2
  • anaphase-promoting complex
  • mitotic spindle elongation
  • cyclin catabolic process
  • mitotic sister chromatid segregation
  • anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
  • mitotic metaphase/anaphase transition
  • protein ubiquitination
  • ubiquitin-protein ligase activity
  • protein binding
  • APC4
  • anaphase-promoting complex
  • mitotic spindle elongation
  • cyclin catabolic process
  • mitotic sister chromatid segregation
  • anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
  • mitotic metaphase/anaphase transition
  • protein ubiquitination
  • ubiquitin-protein ligase activity
  • protein binding
  • APC5
  • anaphase-promoting complex
  • mitotic spindle elongation
  • cyclin catabolic process
  • mitotic sister chromatid segregation
  • anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
  • chromatin assembly or disassembly
  • mitotic metaphase/anaphase transition
  • protein ubiquitination
  • ubiquitin-protein ligase activity
  • protein binding
  • APC9
  • anaphase-promoting complex
  • mitotic spindle elongation
  • cyclin catabolic process
  • mitotic sister chromatid segregation
  • anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
  • mitotic metaphase/anaphase transition
  • protein ubiquitination
  • ubiquitin-protein ligase activity
  • protein binding
  • CDC16
  • anaphase-promoting complex
  • mitotic spindle elongation
  • cyclin catabolic process
  • mitotic sister chromatid segregation
  • anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
  • mitotic metaphase/anaphase transition
  • protein ubiquitination
  • ubiquitin-protein ligase activity
  • protein binding
  • CDC23
  • anaphase-promoting complex
  • mitotic spindle elongation
  • cyclin catabolic process
  • mitotic sister chromatid segregation
  • anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
  • mitotic metaphase/anaphase transition
  • protein ubiquitination
  • ubiquitin-protein ligase activity
  • protein binding
  • CDC27
  • anaphase-promoting complex
  • mitotic spindle elongation
  • cyclin catabolic process
  • mitotic sister chromatid segregation
  • anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
  • mitotic metaphase/anaphase transition
  • protein ubiquitination
  • ubiquitin-protein ligase activity
  • protein binding
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    anaphase-promoting complex 1.2461E-21 8 19 8 6292
    nuclear ubiquitin ligase complex 8.0839E-21 8 23 8 6292
    ubiquitin ligase complex 2.3908E-18 8 43 8 6292
    nuclear part 8.7333E-7 8 1103 8 6292
    protein complex 1.1143E-6 8 1137 8 6292
    macromolecular complex 2.0527E-5 8 1635 8 6292
    nucleus 1.2145E-4 8 2041 8 6292
    organelle part 2.9704E-4 8 2282 8 6292
    intracellular organelle part 2.9704E-4 8 2282 8 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    cyclin catabolic process 2.1219E-23 8 13 8 6292
    anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process 2.1219E-22 8 16 8 6292
    mitotic spindle elongation 3.355E-21 8 21 8 6292
    spindle elongation 3.355E-21 8 21 8 6292
    mitotic metaphase/anaphase transition 6.3653E-19 8 37 8 6292
    mitotic spindle organization 6.2214E-18 8 48 8 6292
    spindle organization 7.4353E-18 8 49 8 6292
    protein ubiquitination 8.3217E-17 8 65 8 6292
    mitotic sister chromatid segregation 9.4695E-17 8 66 8 6292
    sister chromatid segregation 1.3786E-16 8 69 8 6292
    proteasomal protein catabolic process 1.3786E-16 8 69 8 6292
    proteasomal ubiquitin-dependent protein catabolic process 1.3786E-16 8 69 8 6292
    protein modification by small protein conjugation 8.7481E-16 8 86 8 6292
    microtubule cytoskeleton organization 2.3827E-15 8 97 8 6292
    mitosis 4.2467E-15 8 104 8 6292
    nuclear division 4.9722E-15 8 106 8 6292
    microtubule-based process 7.2795E-15 8 111 8 6292
    organelle fission 8.4368E-15 8 113 8 6292
    protein modification by small protein conjugation or removal 9.0735E-15 8 114 8 6292
    chromosome segregation 2.3572E-14 8 128 8 6292
    M phase of mitotic cell cycle 2.3572E-14 8 128 8 6292
    modification-dependent protein catabolic process 1.1951E-13 8 156 8 6292
    ubiquitin-dependent protein catabolic process 1.1951E-13 8 156 8 6292
    proteolysis involved in cellular protein catabolic process 1.3967E-13 8 159 8 6292
    modification-dependent macromolecule catabolic process 1.7992E-13 8 164 8 6292
    cellular protein catabolic process 2.5317E-13 8 171 8 6292
    proteolysis 5.4869E-13 8 188 8 6292
    protein catabolic process 5.7294E-13 8 189 8 6292
    cytoskeleton organization 2.9329E-12 8 231 8 6292
    mitotic cell cycle 6.5431E-12 8 255 8 6292
    cellular macromolecule catabolic process 8.9385E-12 8 265 8 6292
    macromolecule catabolic process 2.0734E-11 8 294 8 6292
    M phase 2.0734E-11 8 294 8 6292
    post-translational protein modification 9.9693E-11 8 357 8 6292
    cell cycle phase 1.5155E-10 8 376 8 6292
    cellular catabolic process 3.3615E-10 8 415 8 6292
    cell cycle process 1.2831E-9 8 490 8 6292
    catabolic process 1.4153E-9 8 496 8 6292
    protein modification process 1.4857E-9 8 499 8 6292
    cell cycle 2.2368E-9 8 525 8 6292
    chromosome organization 3.4991E-9 8 555 8 6292
    macromolecule modification 4.2762E-9 8 569 8 6292
    cellular protein metabolic process 7.0519E-7 8 1074 8 6292
    organelle organization 1.038E-6 8 1127 8 6292
    protein metabolic process 1.1064E-6 8 1136 8 6292
    cellular component organization 1.5761E-5 8 1582 8 6292
    cellular macromolecule metabolic process 3.0018E-4 8 2285 8 6292
    macromolecule metabolic process 3.7455E-4 8 2349 8 6292
    primary metabolic process 2.0036E-3 8 2896 8 6292
    cellular metabolic process 2.9013E-3 8 3033 8 6292
    metabolic process 3.9991E-3 8 3157 8 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    ubiquitin-protein ligase activity 2.7243E-17 8 57 8 6292
    small conjugating protein ligase activity 5.5745E-17 8 62 8 6292
    acid-amino acid ligase activity 1.7541E-16 8 71 8 6292
    ligase activity, forming carbon-nitrogen bonds 1.8353E-15 8 94 8 6292
    ligase activity 8.6676E-14 8 150 8 6292
    protein binding 7.6857E-9 8 612 8 6292
    binding 3.1454E-6 8 1294 8 6292
    catalytic activity 1.8428E-4 8 2150 8 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle