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View Protein Complex Details

Complex Overview

From Publication: Krogan N. J. et al. (2006) Global landscape of protein complexes in the yeast Saccharomyces cerevisiae. Nature. 2006 Mar 30;440(7084):637-43. Epub 2006 Mar 22.
Notes: From the published set of core protein complex predictions.
Complex Size: 17 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
ARC15
  • mitochondrial envelope
  • Arp2/3 protein complex
  • mitochondrion inheritance
  • actin cortical patch assembly
  • actin binding
  • structural molecule activity
  • ASR1
  • nucleus
  • cytoplasm
  • response to ethanol
  • molecular_function
  • CAJ1
  • nucleus
  • biological_process
  • chaperone regulator activity
  • CDC7
  • nucleus
  • Dbf4-dependent protein kinase complex
  • DNA replication initiation
  • protein amino acid phosphorylation
  • protein serine/threonine kinase activity
  • CRN1
  • actin cortical patch
  • actin filament organization
  • microtubule-based process
  • actin filament binding
  • protein binding, bridging
  • microtubule binding
  • INP52
  • membrane fraction
  • actin cortical patch
  • cellular cell wall organization
  • inositol lipid-mediated signaling
  • endocytosis
  • phosphoinositide dephosphorylation
  • phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
  • inositol-polyphosphate 5-phosphatase activity
  • IRC22
  • endoplasmic reticulum
  • biological_process
  • molecular_function
  • MSK1
  • mitochondrion
  • lysyl-tRNA aminoacylation
  • lysine-tRNA ligase activity
  • PNO1
  • nucleus
  • nuclear outer membrane
  • nucleolus
  • protein complex assembly
  • ribosome biogenesis
  • rRNA processing
  • unfolded protein binding
  • PST2
  • cytoplasm
  • mitochondrion
  • biological_process
  • molecular_function
  • RAD34
  • nucleus
  • nucleotide-excision repair
  • molecular_function
  • SAC6
  • actin cortical patch
  • bipolar cellular bud site selection
  • response to osmotic stress
  • actin filament organization
  • endocytosis
  • actin filament binding
  • protein binding, bridging
  • SAR1
  • COPII vesicle coat
  • ER to Golgi vesicle-mediated transport
  • GTPase activity
  • SLM1
  • TORC2 complex
  • cytoplasm
  • mitochondrion
  • plasma membrane
  • regulation of cell growth
  • establishment or maintenance of actin cytoskeleton polarity
  • actin cytoskeleton organization
  • phosphoinositide binding
  • TCP1
  • chaperonin-containing T-complex
  • cytoskeleton
  • cytoplasm
  • cytoskeleton organization
  • protein folding
  • unfolded protein binding
  • TED1
  • endoplasmic reticulum
  • response to drug
  • molecular_function
  • YPP1
  • cytoplasm
  • ribosome
  • plasma membrane
  • MAPKKK cascade
  • molecular_function
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    actin cytoskeleton 6.4573E-5 17 85 4 6292
    actin cortical patch 1.6394E-4 17 41 3 6292
    cytoskeleton 2.0094E-4 17 216 5 6292
    cortical actin cytoskeleton 3.3367E-4 17 52 3 6292
    cortical cytoskeleton 3.3367E-4 17 52 3 6292
    intracellular organelle 6.0057E-4 17 4070 17 6292
    organelle 6.0308E-4 17 4071 17 6292
    cytoskeletal part 1.7342E-3 17 201 4 6292
    cell cortex part 2.0042E-3 17 96 3 6292
    cell cortex 2.8814E-3 17 109 3 6292
    Dbf4-dependent protein kinase complex 5.3968E-3 17 2 1 6292
    non-membrane-bounded organelle 8.9507E-3 17 959 7 6292
    intracellular non-membrane-bounded organelle 8.9507E-3 17 959 7 6292
    cytoplasmic part 9.2429E-3 17 2482 12 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    actin cytoskeleton organization 1.9599E-4 17 113 4 6292
    actin filament-based process 2.2416E-4 17 117 4 6292
    cytoskeleton organization 2.7518E-4 17 231 5 6292
    lysyl-tRNA aminoacylation 5.3968E-3 17 2 1 6292
    response to ethanol 5.3968E-3 17 2 1 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    actin binding 2.1149E-5 17 21 3 6292
    actin filament binding 4.4637E-4 17 12 2 6292
    cytoskeletal protein binding 4.8512E-4 17 59 3 6292
    protein binding, bridging 1.2688E-3 17 20 2 6292
    lysine-tRNA ligase activity 5.3968E-3 17 2 1 6292
    inositol-polyphosphate 5-phosphatase activity 8.0849E-3 17 3 1 6292
    inositol trisphosphate phosphatase activity 8.0849E-3 17 3 1 6292

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