YRC Public Data Repository - Protein Complex GO Analysis

Complex Overview

From Publication:	Mewes, H. W. et al. MIPS: Analysis and annotation of proteins from whole genomes. Nucleic Acids Res. 32, D41-D44
Notes:	MIPS hand-curated complex set. MIPS complex ID: 500.40.20
Complex Size:	48 proteins

Complex Member Proteins

Protein	GO Cellular Component	GO Biological Process	GO Molecular Function
ASC1	cytoplasm	telomere maintenance negative regulation of translation	molecular_function
RPS0A	ribonucleoprotein complex cytoplasm cytosolic small ribosomal subunit small ribosomal subunit ribosome 90S preribosome intracellular	ribosomal small subunit assembly translation	structural constituent of ribosome
RPS0B	ribonucleoprotein complex cytoplasm cytosolic small ribosomal subunit small ribosomal subunit ribosome intracellular	ribosomal small subunit assembly translation	structural constituent of ribosome
RPS10A	ribonucleoprotein complex cytoplasm cytosolic small ribosomal subunit ribosome	translation	structural constituent of ribosome
RPS10B	ribonucleoprotein complex cytoplasm cytosolic small ribosomal subunit ribosome	translation	structural constituent of ribosome
RPS11A, RPS11B	ribonucleoprotein complex cytosolic small ribosomal subunit cytoplasm ribosome 90S preribosome intracellular	regulation of translation maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ribosomal small subunit assembly translation	RNA binding structural constituent of ribosome rRNA binding
RPS12	ribonucleoprotein complex cytosolic small ribosomal subunit cytoplasm ribosome intracellular	translation	structural constituent of ribosome
RPS13	ribonucleoprotein complex cytosolic small ribosomal subunit cytoplasm 90S preribosome ribosome intracellular	translation	structural constituent of ribosome
RPS14A	small nucleolar ribonucleoprotein complex	maturation of SSU-rRNA telomere maintenance ribosomal small subunit assembly translation	RNA binding structural constituent of ribosome
RPS14B	small nucleolar ribonucleoprotein complex	maturation of SSU-rRNA ribosomal small subunit assembly translation	RNA binding structural constituent of ribosome
RPS15	ribonucleoprotein complex cytoplasm cytosolic small ribosomal subunit small ribosomal subunit ribosome intracellular	ribosomal small subunit export from nucleus translation	structural constituent of ribosome
RPS16B, RPS16A	ribonucleoprotein complex cytosolic small ribosomal subunit cytoplasm ribosome 90S preribosome intracellular	regulation of translation maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ribosomal small subunit biogenesis translation	structural constituent of ribosome
RPS17A	ribonucleoprotein complex cytosolic small ribosomal subunit cytoplasm ribosome intracellular	telomere maintenance ribosomal small subunit assembly translation	structural constituent of ribosome
RPS17B	ribonucleoprotein complex cytosolic small ribosomal subunit cytoplasm ribosome intracellular	telomere maintenance ribosomal small subunit assembly translation	structural constituent of ribosome
RPS18B, RPS18A	ribonucleoprotein complex cytosolic small ribosomal subunit cytoplasm mitochondrion ribosome intracellular	rRNA export from nucleus endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) translation	nucleic acid binding RNA binding structural constituent of ribosome rRNA binding
RPS19A	ribonucleoprotein complex cytosolic small ribosomal subunit cytoplasm ribosome intracellular	ribosomal small subunit export from nucleus ribosomal small subunit biogenesis telomere maintenance rRNA processing translation	structural constituent of ribosome
RPS19B	ribonucleoprotein complex cytoplasm cytosolic small ribosomal subunit ribosome intracellular	ribosomal small subunit export from nucleus ribosomal small subunit biogenesis rRNA processing translation	structural constituent of ribosome
RPS1A	ribonucleoprotein complex cytoplasm cytosolic small ribosomal subunit ribosome 90S preribosome intracellular	translation	structural constituent of ribosome
RPS1B	ribonucleoprotein complex cytoplasm cytosolic small ribosomal subunit ribosome 90S preribosome intracellular	translation	structural constituent of ribosome
RPS2	small nucleolar ribonucleoprotein complex	regulation of translational fidelity translation	structural constituent of ribosome
RPS20	ribonucleoprotein complex cytosolic small ribosomal subunit cytoplasm small ribosomal subunit ribosome intracellular	translation	structural constituent of ribosome
RPS21A	ribonucleoprotein complex cytosolic small ribosomal subunit cytoplasm ribosome intracellular	telomere maintenance translation	structural constituent of ribosome
RPS21B	ribonucleoprotein complex cytoplasm cytosolic small ribosomal subunit ribosome intracellular	translation	structural constituent of ribosome
RPS22A	ribonucleoprotein complex cytoplasm cytosolic small ribosomal subunit ribosome intracellular	telomere maintenance translation	structural constituent of ribosome
RPS22B	ribonucleoprotein complex cytosolic small ribosomal subunit cytoplasm ribosome nucleolus intracellular	translation	structural constituent of ribosome
RPS23B, RPS23A	ribonucleoprotein complex cytosolic small ribosomal subunit cytoplasm small ribosomal subunit ribosome intracellular	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) regulation of translational fidelity translation	structural constituent of ribosome
RPS24A, RPS24B	ribonucleoprotein complex cytoplasm cytosolic small ribosomal subunit mitochondrion ribosome intracellular	regulation of translation maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) translation	nucleotide binding structural constituent of ribosome
RPS25A	ribonucleoprotein complex cytoplasm cytosolic small ribosomal subunit ribosome	translation	structural constituent of ribosome
RPS25B	ribonucleoprotein complex cytoplasm cytosolic small ribosomal subunit ribosome	translation	structural constituent of ribosome
RPS26A	ribonucleoprotein complex cytosolic small ribosomal subunit cytoplasm ribosome intracellular	translation	structural constituent of ribosome
RPS26B	ribonucleoprotein complex cytoplasm cytosolic small ribosomal subunit ribosome intracellular	translation	structural constituent of ribosome
RPS27A	cytoplasm	translation	structural constituent of ribosome
RPS27B	ribonucleoprotein complex cytoplasm cytosolic small ribosomal subunit ribosome intracellular	telomere maintenance translation	structural constituent of ribosome
RPS28A	ribonucleoprotein complex cytosolic small ribosomal subunit cytoplasm ribosome intracellular	translation	structural constituent of ribosome
RPS28B	ribonucleoprotein complex cytoplasm cytosolic small ribosomal subunit ribosome intracellular	telomere maintenance translation	structural constituent of ribosome
RPS29A	ribonucleoprotein complex cytoplasm cytosolic small ribosomal subunit ribosome intracellular	translation	structural constituent of ribosome
RPS29B	ribonucleoprotein complex cytoplasm cytosolic small ribosomal subunit ribosome intracellular	translation	structural constituent of ribosome
RPS3	preribosome, small subunit precursor	response to DNA damage stimulus translation	structural constituent of ribosome
RPS30B, RPS30A	stress granule ribonucleoprotein complex cytoplasm cytosolic small ribosomal subunit ribosome intracellular	translation	structural constituent of ribosome
RPS31	cytoplasm	ribosome biogenesis ribosomal small subunit assembly translation protein ubiquitination	structural constituent of ribosome protein tag
RPS4B, RPS4A	ribonucleoprotein complex cytosolic small ribosomal subunit cytoplasm ribosome 90S preribosome intracellular	regulation of translation translation	RNA binding structural constituent of ribosome rRNA binding
RPS5	ribonucleoprotein complex cytosolic small ribosomal subunit cytoplasm small ribosomal subunit 90S preribosome ribosome intracellular	translation	structural constituent of ribosome
RPS6A, RPS6B	small-subunit processome nucleus ribonucleoprotein complex cytoplasm cytosolic small ribosomal subunit ribosome nucleolus 90S preribosome intracellular	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ribosome biogenesis rRNA processing translation	structural constituent of ribosome
RPS7A	small nucleolar ribonucleoprotein complex	translation	structural constituent of ribosome
RPS7B	small nucleolar ribonucleoprotein complex	translation	structural constituent of ribosome
RPS8B, RPS8A	ribonucleoprotein complex cytosolic small ribosomal subunit cytoplasm 90S preribosome ribosome intracellular	regulation of translation maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) translation	structural constituent of ribosome
RPS9A	cytoplasm small nucleolar ribonucleoprotein complex	regulation of translational fidelity translation	structural constituent of ribosome
RPS9B	small nucleolar ribonucleoprotein complex	regulation of translational fidelity translation	structural constituent of ribosome

Cellular Component Analysis

Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

Only showing terms with a p-value less than or equal to 0.01.

GO Term	P-value	A	B	I	T
cytosolic small ribosomal subunit	3.6532E-86	48	38	37	6292
small ribosomal subunit	7.9033E-67	48	73	37	6292
cytosolic ribosome	4.6551E-60	48	101	37	6292
cytosolic part	2.1181E-56	48	122	37	6292
ribosomal subunit	5.5992E-49	48	183	37	6292
ribonucleoprotein complex	2.4727E-46	48	514	45	6292
cytosol	2.318E-41	48	284	37	6292
ribosome	5.2417E-41	48	290	37	6292
macromolecular complex	2.1419E-23	48	1635	45	6292
non-membrane-bounded organelle	1.3378E-21	48	959	37	6292
intracellular non-membrane-bounded organelle	1.3378E-21	48	959	37	6292
90S preribosome	4.5995E-18	48	17	10	6292
preribosome	3.7554E-16	48	34	11	6292
organelle part	8.4008E-9	48	2282	37	6292
intracellular organelle part	8.4008E-9	48	2282	37	6292
cytoplasmic part	1.1265E-7	48	2482	37	6292
small nucleolar ribonucleoprotein complex	9.6784E-7	48	72	7	6292
intracellular part	8.4552E-6	48	4938	48	6292
intracellular	1.2119E-5	48	4975	48	6292
cytoplasm	1.7093E-5	48	3552	41	6292
cell part	6.1443E-4	48	5397	48	6292
cell	6.2551E-4	48	5399	48	6292
stress granule	7.6287E-3	48	1	1	6292

Biological Process Analysis

Only showing terms with a p-value less than or equal to 0.01.

GO Term	P-value	A	B	I	T
translation	9.6319E-61	48	376	48	6292
cellular protein metabolic process	5.7729E-38	48	1074	48	6292
protein metabolic process	9.0569E-37	48	1136	48	6292
cellular macromolecule biosynthetic process	7.7894E-36	48	1187	48	6292
macromolecule biosynthetic process	8.4589E-36	48	1189	48	6292
gene expression	3.5031E-34	48	1283	48	6292
cellular biosynthetic process	6.0768E-30	48	1567	48	6292
biosynthetic process	1.7829E-29	48	1602	48	6292
cellular macromolecule metabolic process	5.5827E-22	48	2285	48	6292
macromolecule metabolic process	2.1311E-21	48	2349	48	6292
ribosomal small subunit biogenesis	1.0592E-17	48	26	11	6292
primary metabolic process	5.4005E-17	48	2896	48	6292
cellular metabolic process	5.0548E-16	48	3033	48	6292
metabolic process	3.5109E-15	48	3157	48	6292
ribosomal small subunit assembly	1.8057E-14	48	14	8	6292
maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	1.5813E-12	48	13	7	6292
regulation of translation	8.1867E-12	48	57	10	6292
posttranscriptional regulation of gene expression	1.6721E-11	48	61	10	6292
regulation of cellular protein metabolic process	5.1861E-11	48	68	10	6292
regulation of protein metabolic process	1.2395E-10	48	74	10	6292
ribosome biogenesis	2.3179E-10	48	346	17	6292
maturation of SSU-rRNA	3.7583E-10	48	59	9	6292
ribonucleoprotein complex biogenesis	7.8195E-10	48	374	17	6292
rRNA processing	1.9127E-9	48	128	11	6292
rRNA metabolic process	3.9608E-9	48	137	11	6292
ribosomal subunit assembly	5.7992E-9	48	55	8	6292
ribosome assembly	2.0028E-8	48	64	8	6292
organelle assembly	3.6773E-8	48	69	8	6292
cellular process	4.3019E-8	48	4426	48	6292
ribonucleoprotein complex assembly	3.5904E-7	48	92	8	6292
regulation of translational fidelity	3.6539E-7	48	9	4	6292
ncRNA processing	4.2662E-7	48	215	11	6292
regulation of translational elongation	2.0274E-6	48	13	4	6292
ncRNA metabolic process	2.5123E-6	48	257	11	6292
cellular component biogenesis	6.8213E-6	48	694	17	6292
ribosomal small subunit export from nucleus	1.4278E-5	48	7	3	6292
cellular macromolecular complex assembly	5.8872E-5	48	182	8	6292
translational elongation	6.1571E-5	48	29	4	6292
RNA processing	1.0014E-4	48	380	11	6292
regulation of biological quality	1.6875E-4	48	551	13	6292
anatomical structure homeostasis	2.561E-4	48	286	9	6292
telomere organization	2.561E-4	48	286	9	6292
telomere maintenance	2.561E-4	48	286	9	6292
cellular macromolecular complex subunit organization	6.6654E-4	48	259	8	6292
establishment of ribosome localization	9.5786E-4	48	26	3	6292
ribosome localization	9.5786E-4	48	26	3	6292
ribosomal subunit export from nucleus	9.5786E-4	48	26	3	6292
macromolecular complex assembly	1.137E-3	48	281	8	6292
regulation of gene expression	1.6115E-3	48	445	10	6292
regulation of macromolecule biosynthetic process	1.9363E-3	48	456	10	6292
biological regulation	2.4162E-3	48	1213	18	6292
regulation of cellular biosynthetic process	2.5023E-3	48	472	10	6292
regulation of biosynthetic process	2.5417E-3	48	473	10	6292
regulation of macromolecule metabolic process	3.1958E-3	48	488	10	6292
homeostatic process	3.2299E-3	48	408	9	6292
regulation of primary metabolic process	4.6464E-3	48	514	10	6292
macromolecular complex subunit organization	5.0845E-3	48	357	8	6292
regulation of cellular metabolic process	6.2471E-3	48	536	10	6292
regulation of metabolic process	7.196E-3	48	547	10	6292
nuclear export	7.588E-3	48	103	4	6292
cellular component assembly	7.9574E-3	48	385	8	6292
establishment of organelle localization	8.2805E-3	48	55	3	6292

Molecular Function Analysis

Only showing terms with a p-value less than or equal to 0.01.

GO Term	P-value	A	B	I	T
structural constituent of ribosome	1.3883E-70	48	212	47	6292
structural molecule activity	4.5611E-60	48	339	47	6292
rRNA binding	2.1767E-4	48	16	3	6292

View Protein Complex Details

Complex Overview

Complex Member Proteins

Cellular Component Analysis

Biological Process Analysis

Molecular Function Analysis