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View Protein Complex Details

Complex Overview

From Publication: Riffle <i>et al</i>. (2010) (Unpublished Data)
Notes: Complex predicted from the combined set of Gavin (2002), Gavin (2006), Ho (2002) and Krogan (2006); at p-value cutoff of 1E-7
Complex Size: 20 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
CSE2
  • nucleus
  • mediator complex
  • mitotic sister chromatid segregation
  • transcription from RNA polymerase II promoter
  • RNA polymerase II transcription mediator activity
  • GAL11
  • nucleus
  • mediator complex
  • telomere maintenance
  • transcription from RNA polymerase II promoter
  • RNA polymerase II transcription mediator activity
  • MED1
  • nucleus
  • mediator complex
  • telomere maintenance
  • transcription from RNA polymerase II promoter
  • RNA polymerase II transcription mediator activity
  • MED11
  • mediator complex
  • transcription from RNA polymerase II promoter
  • structural molecule activity
  • RNA polymerase II transcription mediator activity
  • MED4
  • nucleus
  • mediator complex
  • transcription from RNA polymerase II promoter
  • RNA polymerase II transcription mediator activity
  • MED6
  • mediator complex
  • transcription from RNA polymerase II promoter
  • RNA polymerase II transcription mediator activity
  • MED7
  • nucleus
  • mediator complex
  • transcription from RNA polymerase II promoter
  • RNA polymerase II transcription mediator activity
  • MED8
  • mediator complex
  • transcription from RNA polymerase II promoter
  • RNA polymerase II transcription mediator activity
  • NUT1
  • nucleus
  • mitochondrion
  • regulation of transcription from RNA polymerase II promoter
  • molecular_function
  • NUT2
  • nucleus
  • mediator complex
  • transcription from RNA polymerase II promoter
  • RNA polymerase II transcription mediator activity
  • PGD1
  • nucleus
  • mediator complex
  • response to drug
  • telomere maintenance
  • transcription from RNA polymerase II promoter
  • RNA polymerase II transcription mediator activity
  • RGR1
  • nucleus
  • mediator complex
  • transcription from RNA polymerase II promoter
  • RNA polymerase II transcription mediator activity
  • SIN4
  • nucleus
  • mediator complex
  • transcription from RNA polymerase II promoter
  • RNA polymerase II transcription mediator activity
  • SRB2
  • mediator complex
  • telomere maintenance
  • transcription from RNA polymerase II promoter
  • RNA polymerase II transcription mediator activity
  • SRB4
  • mediator complex
  • transcription from RNA polymerase II promoter
  • RNA polymerase II transcription mediator activity
  • SRB5
  • mediator complex
  • telomere maintenance
  • transcription from RNA polymerase II promoter
  • RNA polymerase II transcription mediator activity
  • SRB8
  • transcription factor complex
  • negative regulation of transcription from RNA polymerase II promoter
  • telomere maintenance
  • RNA polymerase II transcription mediator activity
  • SSN2
  • transcription factor complex
  • negative regulation of transcription from RNA polymerase II promoter
  • telomere maintenance
  • general RNA polymerase II transcription factor activity
  • SSN3
  • transcription factor complex
  • negative regulation of transcription from RNA polymerase II promoter
  • telomere maintenance
  • protein amino acid phosphorylation
  • regulation of transcription
  • meiosis
  • general RNA polymerase II transcription factor activity
  • cyclin-dependent protein kinase activity
  • YAP1
  • nucleus
  • cytoplasm
  • response to heat
  • transcription
  • response to arsenic
  • response to drug
  • response to singlet oxygen
  • transcription factor activity
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    mediator complex 1.7502E-38 20 18 15 6292
    nucleoplasm part 4.0542E-24 20 245 18 6292
    nucleoplasm 1.6206E-23 20 264 18 6292
    nuclear lumen 3.2604E-19 20 453 18 6292
    organelle lumen 2.9701E-16 20 660 18 6292
    intracellular organelle lumen 2.9701E-16 20 660 18 6292
    membrane-enclosed lumen 8.566E-16 20 700 18 6292
    nuclear part 2.8943E-12 20 1103 18 6292
    protein complex 4.9584E-12 20 1137 18 6292
    nucleus 1.5619E-10 20 2041 20 6292
    macromolecular complex 2.9554E-9 20 1635 18 6292
    organelle part 9.3013E-7 20 2282 18 6292
    intracellular organelle part 9.3013E-7 20 2282 18 6292
    membrane-bounded organelle 3.504E-5 20 3771 20 6292
    intracellular membrane-bounded organelle 3.504E-5 20 3771 20 6292
    intracellular organelle 1.6178E-4 20 4070 20 6292
    organelle 1.6258E-4 20 4071 20 6292
    transcription factor complex 1.3679E-3 20 71 3 6292
    intracellular part 7.7919E-3 20 4938 20 6292
    intracellular 9.0491E-3 20 4975 20 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    transcription from RNA polymerase II promoter 7.3203E-24 20 335 19 6292
    transcription 5.3071E-22 20 552 20 6292
    transcription, DNA-dependent 1.9191E-20 20 503 19 6292
    RNA biosynthetic process 2.322E-20 20 508 19 6292
    cellular macromolecule biosynthetic process 2.8607E-15 20 1187 20 6292
    macromolecule biosynthetic process 2.9594E-15 20 1189 20 6292
    RNA metabolic process 4.0051E-15 20 954 19 6292
    gene expression 1.3717E-14 20 1283 20 6292
    nucleic acid metabolic process 9.8605E-14 20 1415 20 6292
    nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 7.5906E-13 20 1566 20 6292
    cellular biosynthetic process 7.6887E-13 20 1567 20 6292
    biosynthetic process 1.1992E-12 20 1602 20 6292
    cellular nitrogen compound metabolic process 8.9131E-12 20 1770 20 6292
    nitrogen compound metabolic process 1.1299E-11 20 1791 20 6292
    cellular macromolecule metabolic process 1.5096E-9 20 2285 20 6292
    macromolecule metabolic process 2.629E-9 20 2349 20 6292
    primary metabolic process 1.757E-7 20 2896 20 6292
    cellular metabolic process 4.4416E-7 20 3033 20 6292
    metabolic process 9.9232E-7 20 3157 20 6292
    anatomical structure homeostasis 1.2921E-6 20 286 8 6292
    telomere organization 1.2921E-6 20 286 8 6292
    telomere maintenance 1.2921E-6 20 286 8 6292
    homeostatic process 1.8396E-5 20 408 8 6292
    chromosome organization 2.0959E-5 20 555 9 6292
    regulation of biological quality 1.6021E-4 20 551 8 6292
    DNA metabolic process 2.4387E-4 20 585 8 6292
    negative regulation of transcription from RNA polymerase II promoter 8.3744E-4 20 60 3 6292
    cellular process 8.6878E-4 20 4426 20 6292
    organelle organization 4.6468E-3 20 1127 9 6292
    regulation of transcription from RNA polymerase II promoter 5.1479E-3 20 228 4 6292
    biological regulation 7.7066E-3 20 1213 9 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    RNA polymerase II transcription mediator activity 1.273E-39 20 22 16 6292
    general RNA polymerase II transcription factor activity 1.8532E-35 20 64 18 6292
    RNA polymerase II transcription factor activity 2.5796E-29 20 130 18 6292
    transcription regulator activity 9.2239E-24 20 339 19 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle