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Complex Overview

From Publication: Riffle <i>et al</i>. (2010) (Unpublished Data)
Notes: Complex predicted from the combined set of Gavin (2002), Gavin (2006), Ho (2002) and Krogan (2006); at p-value cutoff of 1E-7
Complex Size: 15 proteins

Complex Member Proteins

Protein

 GO Cellular Component GO Biological Process GO Molecular Function
RPB10
  • DNA-directed RNA polymerase I complex
  • DNA-directed RNA polymerase III complex
  • DNA-directed RNA polymerase II, core complex
    		•
  • transcription from RNA polymerase III promoter
  • transcription from RNA polymerase I promoter
  • transcription from RNA polymerase II promoter
    		•
  • DNA-directed RNA polymerase activity
    		•
    RPB11
  • DNA-directed RNA polymerase II, core complex
    		•
  • transcription from RNA polymerase II promoter
    		•
  • DNA-directed RNA polymerase activity
    		•
    RPB2
  • mitochondrion
  • DNA-directed RNA polymerase II, core complex
    		•
  • transcription from RNA polymerase II promoter
    		•
  • DNA-directed RNA polymerase activity
    		•
    RPB3
  • DNA-directed RNA polymerase II, core complex
    		•
  • transcription from RNA polymerase II promoter
    		•
  • DNA-directed RNA polymerase activity
    		•
    RPB4
  • nucleus
  • cytoplasm
  • cytoplasmic mRNA processing body
  • DNA-directed RNA polymerase II, core complex
    		•
  • mRNA export from nucleus
  • telomere maintenance
  • transcription from RNA polymerase II promoter
  • nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
    		•
  • DNA-directed RNA polymerase activity
    		•
    RPB5
  • DNA-directed RNA polymerase I complex
  • DNA-directed RNA polymerase III complex
  • DNA-directed RNA polymerase II, core complex
    		•
  • transcription from RNA polymerase III promoter
  • transcription from RNA polymerase I promoter
  • transcription from RNA polymerase II promoter
    		•
  • DNA-directed RNA polymerase activity
    		•
    RPB7
  • DNA-directed RNA polymerase II, core complex
    		•
  • transcription from RNA polymerase II promoter
    		•
  • DNA-directed RNA polymerase activity
    		•
    RPB8
  • DNA-directed RNA polymerase I complex
  • DNA-directed RNA polymerase III complex
  • DNA-directed RNA polymerase II, core complex
    		•
  • transcription from RNA polymerase III promoter
  • transcription from RNA polymerase I promoter
  • transcription from RNA polymerase II promoter
    		•
  • DNA-directed RNA polymerase activity
    		•
    RPB9
  • DNA-directed RNA polymerase II, core complex
    		•
  • response to drug
  • transcription-coupled nucleotide-excision repair
  • telomere maintenance
  • transcription from RNA polymerase II promoter
  • response to DNA damage stimulus
    		•
  • DNA-directed RNA polymerase activity
    		•
    RPO21
  • mitochondrion
  • DNA-directed RNA polymerase II, core complex
    		•
  • transcription from RNA polymerase II promoter
    		•
  • DNA-directed RNA polymerase activity
    		•
    RPO26
  • DNA-directed RNA polymerase I complex
  • DNA-directed RNA polymerase III complex
  • DNA-directed RNA polymerase II, core complex
    		•
  • transcription from RNA polymerase III promoter
  • transcription from RNA polymerase I promoter
  • transcription from RNA polymerase II promoter
    		•
  • DNA-directed RNA polymerase activity
    		•
    SPT4
  • nucleus
  • transcription elongation factor complex
  • DSIF complex
  • kinetochore
  • nuclear chromosome, telomeric region
    		•
  • regulation of transcription, DNA-dependent
  • chromosome segregation
  • chromatin silencing
  • chromatin organization
  • RNA elongation from RNA polymerase II promoter
    		•
  • RNA polymerase II transcription elongation factor activity
    		•
    SPT5
  • nucleus
  • transcription elongation factor complex
  • DSIF complex
  • mitochondrion
    		•
  • regulation of transcription, DNA-dependent
  • chromatin organization
  • RNA elongation from RNA polymerase II promoter
    		•
  • RNA polymerase II transcription elongation factor activity
    		•
    TFG1
  • transcription factor TFIIF complex
    		•
  • transcription initiation from RNA polymerase II promoter
    		•
  • general RNA polymerase II transcription factor activity
    		•
    TFG2
  • transcription factor TFIIF complex
    		•
  • transcription initiation from RNA polymerase II promoter
    		•
  • general RNA polymerase II transcription factor activity
    		•

    Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    DNA-directed RNA polymerase II, core complex 1.0773E-30 15 12 11 6292
    DNA-directed RNA polymerase II, holoenzyme 5.0992E-26 15 56 13 6292
    DNA-directed RNA polymerase complex 7.5175E-24 15 31 11 6292
    RNA polymerase complex 7.5175E-24 15 31 11 6292
    nuclear DNA-directed RNA polymerase complex 7.5175E-24 15 31 11 6292
    nucleoplasm part 4.7098E-22 15 245 15 6292
    nucleoplasm 1.4911E-21 15 264 15 6292
    nuclear lumen 5.8229E-18 15 453 15 6292
    organelle lumen 1.7741E-15 15 660 15 6292
    intracellular organelle lumen 1.7741E-15 15 660 15 6292
    membrane-enclosed lumen 4.3281E-15 15 700 15 6292
    nuclear part 4.193E-12 15 1103 15 6292
    protein complex 6.6306E-12 15 1137 15 6292
    macromolecular complex 1.5857E-9 15 1635 15 6292
    DNA-directed RNA polymerase I complex 2.0652E-8 15 14 4 6292
    nucleus 4.4738E-8 15 2041 15 6292
    DNA-directed RNA polymerase III complex 4.8896E-8 15 17 4 6292
    intracellular organelle part 2.3996E-7 15 2282 15 6292
    organelle part 2.3996E-7 15 2282 15 6292
    nucleolar part 2.9431E-6 15 45 4 6292
    DSIF complex 5.3053E-6 15 2 2 6292
    transcription factor TFIIF complex 1.5894E-5 15 3 2 6292
    membrane-bounded organelle 4.5726E-4 15 3771 15 6292
    intracellular membrane-bounded organelle 4.5726E-4 15 3771 15 6292
    nucleolus 1.2539E-3 15 211 4 6292
    transcription elongation factor complex 1.304E-3 15 23 2 6292
    intracellular organelle 1.4392E-3 15 4070 15 6292
    organelle 1.4445E-3 15 4071 15 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    transcription from RNA polymerase II promoter 5.7938E-20 15 335 15 6292
    transcription, DNA-dependent 2.8668E-17 15 503 15 6292
    RNA biosynthetic process 3.3323E-17 15 508 15 6292
    transcription 1.1781E-16 15 552 15 6292
    RNA metabolic process 4.6839E-13 15 954 15 6292
    cellular macromolecule biosynthetic process 1.2694E-11 15 1187 15 6292
    macromolecule biosynthetic process 1.3021E-11 15 1189 15 6292
    gene expression 4.1034E-11 15 1283 15 6292
    nucleic acid metabolic process 1.7965E-10 15 1415 15 6292
    nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 8.2811E-10 15 1566 15 6292
    cellular biosynthetic process 8.3612E-10 15 1567 15 6292
    biosynthetic process 1.1663E-9 15 1602 15 6292
    cellular nitrogen compound metabolic process 5.2383E-9 15 1770 15 6292
    nitrogen compound metabolic process 6.2564E-9 15 1791 15 6292
    cellular macromolecule metabolic process 2.4475E-7 15 2285 15 6292
    macromolecule metabolic process 3.7086E-7 15 2349 15 6292
    transcription from RNA polymerase I promoter 5.5285E-7 15 30 4 6292
    transcription from RNA polymerase III promoter 1.4725E-6 15 38 4 6292
    primary metabolic process 8.6423E-6 15 2896 15 6292
    cellular metabolic process 1.7316E-5 15 3033 15 6292
    metabolic process 3.1628E-5 15 3157 15 6292
    RNA elongation from RNA polymerase II promoter 3.7359E-3 15 39 2 6292
    transcription-coupled nucleotide-excision repair 4.7627E-3 15 2 1 6292
    RNA elongation 4.9503E-3 15 45 2 6292
    cellular process 5.0732E-3 15 4426 15 6292
    transcription initiation from RNA polymerase II promoter 5.3904E-3 15 47 2 6292
    transcription initiation 8.119E-3 15 58 2 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    RNA polymerase activity 2.5356E-23 15 34 11 6292
    DNA-directed RNA polymerase activity 2.5356E-23 15 34 11 6292
    nucleotidyltransferase activity 4.4173E-15 15 168 11 6292
    transferase activity, transferring phosphorus-containing groups 1.1061E-10 15 420 11 6292
    transferase activity 1.0636E-7 15 797 11 6292
    RNA polymerase II transcription elongation factor activity 4.0759E-4 15 13 2 6292
    transcription elongation regulator activity 8.862E-4 15 19 2 6292
    catalytic activity 2.247E-3 15 2150 11 6292
    transcription regulator activity 7.0355E-3 15 339 4 6292
    general RNA polymerase II transcription factor activity 9.8206E-3 15 64 2 6292
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle