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View Protein Complex Details

Complex Overview

From Publication: Riffle <i>et al</i>. (2010) (Unpublished Data)
Notes: Complex predicted from the combined set of Gavin (2002), Gavin (2006), Ho (2002) and Krogan (2006); at p-value cutoff of 1E-7
Complex Size: 21 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
PUF4
  • cytoplasm
  • loss of chromatin silencing involved in replicative cell aging
  • protein localization
  • mRNA catabolic process
  • nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
  • mRNA binding
  • RPL11B
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • ribosomal large subunit assembly
  • translation
  • structural constituent of ribosome
  • RPL16A
  • ribonucleoprotein complex
  • cytoplasm
  • large ribosomal subunit
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • RNA binding
  • structural constituent of ribosome
  • RPL17A
  • cytoplasm
  • translation
  • structural constituent of ribosome
  • RPL17B
  • ribonucleoprotein complex
  • cytoplasm
  • large ribosomal subunit
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • structural constituent of ribosome
  • RPL20A
  • translation
  • structural constituent of ribosome
  • RPL21A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • structural constituent of ribosome
  • RPL2A, RPL2B
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • regulation of translation
  • response to drug
  • translation
  • RNA binding
  • structural constituent of ribosome
  • rRNA binding
  • RPL30
  • cytoplasm
  • negative regulation of nuclear mRNA splicing, via spliceosome
  • rRNA processing
  • negative regulation of translation
  • translation
  • structural constituent of ribosome
  • RPL36A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • RNA binding
  • structural constituent of ribosome
  • RPL42B, RPL42A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • response to antibiotic
  • response to cycloheximide
  • translation
  • structural constituent of ribosome
  • RPL4A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • structural constituent of ribosome
  • RPL6A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • ribosomal large subunit assembly
  • translation
  • RNA binding
  • structural constituent of ribosome
  • RPL8B
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • translation
  • structural constituent of ribosome
  • RPS11A, RPS11B
  • ribonucleoprotein complex
  • cytosolic small ribosomal subunit
  • cytoplasm
  • ribosome
  • 90S preribosome
  • intracellular
  • regulation of translation
  • maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
  • ribosomal small subunit assembly
  • translation
  • RNA binding
  • structural constituent of ribosome
  • rRNA binding
  • RPS16B, RPS16A
  • ribonucleoprotein complex
  • cytosolic small ribosomal subunit
  • cytoplasm
  • ribosome
  • 90S preribosome
  • intracellular
  • regulation of translation
  • maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
  • ribosomal small subunit biogenesis
  • translation
  • structural constituent of ribosome
  • RPS17B
  • ribonucleoprotein complex
  • cytosolic small ribosomal subunit
  • cytoplasm
  • ribosome
  • intracellular
  • telomere maintenance
  • ribosomal small subunit assembly
  • translation
  • structural constituent of ribosome
  • RPS22A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic small ribosomal subunit
  • ribosome
  • intracellular
  • telomere maintenance
  • translation
  • structural constituent of ribosome
  • RPS30B, RPS30A
  • stress granule
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic small ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • structural constituent of ribosome
  • RPS8B, RPS8A
  • ribonucleoprotein complex
  • cytosolic small ribosomal subunit
  • cytoplasm
  • 90S preribosome
  • ribosome
  • intracellular
  • regulation of translation
  • maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
  • translation
  • structural constituent of ribosome
  • RPS9B
  • small nucleolar ribonucleoprotein complex
  • regulation of translational fidelity
  • translation
  • structural constituent of ribosome
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    cytosolic ribosome 1.0786E-25 21 101 16 6292
    cytosolic part 2.7331E-24 21 122 16 6292
    ribosomal subunit 2.4387E-21 21 183 16 6292
    cytosol 3.2606E-18 21 284 16 6292
    ribosome 4.5758E-18 21 290 16 6292
    cytosolic large ribosomal subunit 9.2265E-16 21 60 10 6292
    ribonucleoprotein complex 1.1021E-15 21 514 17 6292
    large ribosomal subunit 5.2956E-13 21 110 10 6292
    non-membrane-bounded organelle 7.2426E-10 21 959 16 6292
    intracellular non-membrane-bounded organelle 7.2426E-10 21 959 16 6292
    cytosolic small ribosomal subunit 1.6318E-9 21 38 6 6292
    small ribosomal subunit 9.3631E-8 21 73 6 6292
    macromolecular complex 2.0726E-7 21 1635 17 6292
    90S preribosome 2.1149E-5 21 17 3 6292
    preribosome 1.7944E-4 21 34 3 6292
    organelle part 2.2313E-4 21 2282 16 6292
    intracellular organelle part 2.2313E-4 21 2282 16 6292
    cytoplasmic part 6.8308E-4 21 2482 16 6292
    cytoplasm 8.5364E-4 21 3552 19 6292
    stress granule 3.3376E-3 21 1 1 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    translation 4.129E-24 21 376 20 6292
    cellular macromolecule biosynthetic process 5.3227E-16 21 1187 21 6292
    macromolecule biosynthetic process 5.5159E-16 21 1189 21 6292
    gene expression 2.7621E-15 21 1283 21 6292
    cellular protein metabolic process 6.7083E-15 21 1074 20 6292
    protein metabolic process 2.058E-14 21 1136 20 6292
    cellular biosynthetic process 1.8964E-13 21 1567 21 6292
    biosynthetic process 3.0247E-13 21 1602 21 6292
    cellular macromolecule metabolic process 5.4516E-10 21 2285 21 6292
    macromolecule metabolic process 9.7623E-10 21 2349 21 6292
    regulation of translation 2.0628E-8 21 57 6 6292
    posttranscriptional regulation of gene expression 3.1304E-8 21 61 6 6292
    regulation of cellular protein metabolic process 6.0825E-8 21 68 6 6292
    primary metabolic process 8.0566E-8 21 2896 21 6292
    regulation of protein metabolic process 1.0168E-7 21 74 6 6292
    cellular metabolic process 2.1337E-7 21 3033 21 6292
    metabolic process 4.9632E-7 21 3157 21 6292
    maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 8.9718E-6 21 13 3 6292
    ribosomal subunit assembly 2.8013E-5 21 55 4 6292
    ribosome assembly 5.1177E-5 21 64 4 6292
    organelle assembly 6.8881E-5 21 69 4 6292
    ribosomal small subunit biogenesis 7.9315E-5 21 26 3 6292
    ribosome biogenesis 8.5078E-5 21 346 7 6292
    ribonucleoprotein complex biogenesis 1.3923E-4 21 374 7 6292
    ribonucleoprotein complex assembly 2.1178E-4 21 92 4 6292
    regulation of gene expression 4.1042E-4 21 445 7 6292
    regulation of macromolecule biosynthetic process 4.7663E-4 21 456 7 6292
    regulation of cellular biosynthetic process 5.8812E-4 21 472 7 6292
    regulation of biosynthetic process 5.9573E-4 21 473 7 6292
    cellular process 6.1031E-4 21 4426 21 6292
    regulation of macromolecule metabolic process 7.1974E-4 21 488 7 6292
    rRNA processing 7.4771E-4 21 128 4 6292
    maturation of SSU-rRNA 9.2387E-4 21 59 3 6292
    ribosomal small subunit assembly 9.4251E-4 21 14 2 6292
    rRNA metabolic process 9.6524E-4 21 137 4 6292
    regulation of primary metabolic process 9.8332E-4 21 514 7 6292
    regulation of cellular metabolic process 1.2622E-3 21 536 7 6292
    regulation of metabolic process 1.4235E-3 21 547 7 6292
    cellular macromolecular complex assembly 2.7559E-3 21 182 4 6292
    response to cycloalkane 3.3376E-3 21 1 1 6292
    response to organic cyclic substance 3.3376E-3 21 1 1 6292
    negative regulation of mRNA processing 3.3376E-3 21 1 1 6292
    negative regulation of nuclear mRNA splicing, via spliceosome 3.3376E-3 21 1 1 6292
    negative regulation of RNA splicing 3.3376E-3 21 1 1 6292
    response to cycloheximide 3.3376E-3 21 1 1 6292
    ncRNA processing 5.02E-3 21 215 4 6292
    cellular component biogenesis 5.5911E-3 21 694 7 6292
    regulation of mRNA processing 6.6645E-3 21 2 1 6292
    regulation of RNA splicing 6.6645E-3 21 2 1 6292
    regulation of nuclear mRNA splicing, via spliceosome 6.6645E-3 21 2 1 6292
    ribosomal large subunit assembly 8.0445E-3 21 41 2 6292
    ncRNA metabolic process 9.3948E-3 21 257 4 6292
    cellular macromolecular complex subunit organization 9.6502E-3 21 259 4 6292
    response to antibiotic 9.9809E-3 21 3 1 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    structural constituent of ribosome 2.9628E-29 21 212 20 6292
    structural molecule activity 4.9407E-25 21 339 20 6292
    RNA binding 9.6933E-4 21 367 6 6292
    rRNA binding 1.2379E-3 21 16 2 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle