YRC Public Data Repository - Protein Complex GO Analysis

Complex Overview

From Publication:	Riffle <i>et al</i>. (2010) (Unpublished Data)
Notes:	Complex predicted from the combined set of Gavin (2002), Gavin (2006), Ho (2002) and Krogan (2006); at p-value cutoff of 1E-7
Complex Size:	23 proteins

Complex Member Proteins

Protein	GO Cellular Component	GO Biological Process	GO Molecular Function
PUF4	cytoplasm	loss of chromatin silencing involved in replicative cell aging protein localization mRNA catabolic process nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	mRNA binding
RPL11B	ribonucleoprotein complex cytoplasm cytosolic large ribosomal subunit ribosome intracellular	ribosomal large subunit assembly translation	structural constituent of ribosome
RPL12B, RPL12A	ribonucleoprotein complex cytoplasm cytosolic large ribosomal subunit ribosome	regulation of translation translational termination ribosomal large subunit assembly translation	RNA binding structural constituent of ribosome
RPL16A	ribonucleoprotein complex cytoplasm large ribosomal subunit cytosolic large ribosomal subunit ribosome intracellular	translation	RNA binding structural constituent of ribosome
RPL17A	cytoplasm	translation	structural constituent of ribosome
RPL17B	ribonucleoprotein complex cytoplasm large ribosomal subunit cytosolic large ribosomal subunit ribosome intracellular	translation	structural constituent of ribosome
RPL20A		translation	structural constituent of ribosome
RPL21A	ribonucleoprotein complex cytoplasm cytosolic large ribosomal subunit ribosome intracellular	translation	structural constituent of ribosome
RPL2A, RPL2B	ribonucleoprotein complex cytoplasm cytosolic large ribosomal subunit ribosome intracellular	regulation of translation response to drug translation	RNA binding structural constituent of ribosome rRNA binding
RPL30	cytoplasm	negative regulation of nuclear mRNA splicing, via spliceosome rRNA processing negative regulation of translation translation	structural constituent of ribosome
RPL36A	ribonucleoprotein complex cytoplasm cytosolic large ribosomal subunit ribosome intracellular	translation	RNA binding structural constituent of ribosome
RPL42B, RPL42A	ribonucleoprotein complex cytoplasm cytosolic large ribosomal subunit ribosome intracellular	response to antibiotic response to cycloheximide translation	structural constituent of ribosome
RPL4A	ribonucleoprotein complex cytoplasm cytosolic large ribosomal subunit ribosome intracellular	translation	structural constituent of ribosome
RPL6A	ribonucleoprotein complex cytoplasm cytosolic large ribosomal subunit ribosome intracellular	ribosomal large subunit assembly translation	RNA binding structural constituent of ribosome
RPS11A, RPS11B	ribonucleoprotein complex cytosolic small ribosomal subunit cytoplasm ribosome 90S preribosome intracellular	regulation of translation maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ribosomal small subunit assembly translation	RNA binding structural constituent of ribosome rRNA binding
RPS14A	small nucleolar ribonucleoprotein complex	maturation of SSU-rRNA telomere maintenance ribosomal small subunit assembly translation	RNA binding structural constituent of ribosome
RPS16B, RPS16A	ribonucleoprotein complex cytosolic small ribosomal subunit cytoplasm ribosome 90S preribosome intracellular	regulation of translation maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ribosomal small subunit biogenesis translation	structural constituent of ribosome
RPS17B	ribonucleoprotein complex cytosolic small ribosomal subunit cytoplasm ribosome intracellular	telomere maintenance ribosomal small subunit assembly translation	structural constituent of ribosome
RPS22A	ribonucleoprotein complex cytoplasm cytosolic small ribosomal subunit ribosome intracellular	telomere maintenance translation	structural constituent of ribosome
RPS30B, RPS30A	stress granule ribonucleoprotein complex cytoplasm cytosolic small ribosomal subunit ribosome intracellular	translation	structural constituent of ribosome
RPS5	ribonucleoprotein complex cytosolic small ribosomal subunit cytoplasm small ribosomal subunit 90S preribosome ribosome intracellular	translation	structural constituent of ribosome
RPS8B, RPS8A	ribonucleoprotein complex cytosolic small ribosomal subunit cytoplasm 90S preribosome ribosome intracellular	regulation of translation maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) translation	structural constituent of ribosome
RPS9B	small nucleolar ribonucleoprotein complex	regulation of translational fidelity translation	structural constituent of ribosome

Cellular Component Analysis

Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

Only showing terms with a p-value less than or equal to 0.01.

GO Term	P-value	A	B	I	T
cytosolic ribosome	7.1591E-27	23	101	17	6292
cytosolic part	2.2548E-25	23	122	17	6292
ribosomal subunit	3.1397E-22	23	183	17	6292
cytosol	6.6296E-19	23	284	17	6292
ribosome	9.5031E-19	23	290	17	6292
ribonucleoprotein complex	1.0203E-17	23	514	19	6292
cytosolic large ribosomal subunit	2.9495E-15	23	60	10	6292
large ribosomal subunit	1.6683E-12	23	110	10	6292
cytosolic small ribosomal subunit	3.7394E-11	23	38	7	6292
non-membrane-bounded organelle	4.6243E-10	23	959	17	6292
intracellular non-membrane-bounded organelle	4.6243E-10	23	959	17	6292
small ribosomal subunit	4.4635E-9	23	73	7	6292
macromolecular complex	2.0241E-8	23	1635	19	6292
90S preribosome	3.1302E-7	23	17	4	6292
preribosome	5.8534E-6	23	34	4	6292
organelle part	2.6209E-4	23	2282	17	6292
intracellular organelle part	2.6209E-4	23	2282	17	6292
cytoplasmic part	8.3315E-4	23	2482	17	6292
cytoplasm	1.8805E-3	23	3552	20	6292
stress granule	3.6554E-3	23	1	1	6292

Biological Process Analysis

Only showing terms with a p-value less than or equal to 0.01.

GO Term	P-value	A	B	I	T
translation	1.4531E-26	23	376	22	6292
cellular macromolecule biosynthetic process	1.8389E-17	23	1187	23	6292
macromolecule biosynthetic process	1.9122E-17	23	1189	23	6292
gene expression	1.1179E-16	23	1283	23	6292
cellular protein metabolic process	2.0721E-16	23	1074	22	6292
protein metabolic process	7.1268E-16	23	1136	22	6292
cellular biosynthetic process	1.1521E-14	23	1567	23	6292
biosynthetic process	1.9216E-14	23	1602	23	6292
cellular macromolecule metabolic process	7.1036E-11	23	2285	23	6292
macromolecule metabolic process	1.345E-10	23	2349	23	6292
regulation of translation	7.5074E-10	23	57	7	6292
posttranscriptional regulation of gene expression	1.2278E-9	23	61	7	6292
regulation of cellular protein metabolic process	2.6857E-9	23	68	7	6292
regulation of protein metabolic process	4.9188E-9	23	74	7	6292
primary metabolic process	1.6931E-8	23	2896	23	6292
ribosomal subunit assembly	3.0372E-8	23	55	6	6292
cellular metabolic process	4.9214E-8	23	3033	23	6292
ribosome assembly	7.6919E-8	23	64	6	6292
organelle assembly	1.2156E-7	23	69	6	6292
metabolic process	1.241E-7	23	3157	23	6292
ribonucleoprotein complex assembly	6.8525E-7	23	92	6	6292
ribosome biogenesis	1.7052E-6	23	346	9	6292
ribosomal small subunit biogenesis	1.9238E-6	23	26	4	6292
ribonucleoprotein complex biogenesis	3.2649E-6	23	374	9	6292
maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	1.1918E-5	23	13	3	6292
ribosomal small subunit assembly	1.5132E-5	23	14	3	6292
cellular macromolecular complex assembly	3.6131E-5	23	182	6	6292
maturation of SSU-rRNA	5.4067E-5	23	59	4	6292
rRNA processing	8.0783E-5	23	128	5	6292
rRNA metabolic process	1.1162E-4	23	137	5	6292
regulation of gene expression	1.1169E-4	23	445	8	6292
regulation of macromolecule biosynthetic process	1.3269E-4	23	456	8	6292
regulation of cellular biosynthetic process	1.6904E-4	23	472	8	6292
regulation of biosynthetic process	1.7157E-4	23	473	8	6292
regulation of macromolecule metabolic process	2.1335E-4	23	488	8	6292
cellular macromolecular complex subunit organization	2.5645E-4	23	259	6	6292
cellular process	3.0112E-4	23	4426	23	6292
regulation of primary metabolic process	3.0571E-4	23	514	8	6292
macromolecular complex assembly	3.9879E-4	23	281	6	6292
regulation of cellular metabolic process	4.0773E-4	23	536	8	6292
ribosomal large subunit assembly	4.1551E-4	23	41	3	6292
cellular component biogenesis	4.4858E-4	23	694	9	6292
regulation of metabolic process	4.684E-4	23	547	8	6292
ncRNA processing	9.0415E-4	23	215	5	6292
macromolecular complex subunit organization	1.4152E-3	23	357	6	6292
ribosomal large subunit biogenesis	1.6079E-3	23	65	3	6292
biological regulation	1.7977E-3	23	1213	11	6292
ncRNA metabolic process	2.0084E-3	23	257	5	6292
cellular component assembly	2.0884E-3	23	385	6	6292
response to cycloalkane	3.6554E-3	23	1	1	6292
response to organic cyclic substance	3.6554E-3	23	1	1	6292
negative regulation of mRNA processing	3.6554E-3	23	1	1	6292
negative regulation of nuclear mRNA splicing, via spliceosome	3.6554E-3	23	1	1	6292
negative regulation of RNA splicing	3.6554E-3	23	1	1	6292
response to cycloheximide	3.6554E-3	23	1	1	6292
regulation of cellular process	5.41E-3	23	796	8	6292
regulation of biological process	6.6917E-3	23	824	8	6292
regulation of mRNA processing	7.2981E-3	23	2	1	6292
regulation of RNA splicing	7.2981E-3	23	2	1	6292
regulation of nuclear mRNA splicing, via spliceosome	7.2981E-3	23	2	1	6292

Molecular Function Analysis

Only showing terms with a p-value less than or equal to 0.01.

GO Term	P-value	A	B	I	T
structural constituent of ribosome	3.026E-32	23	212	22	6292
structural molecule activity	1.3957E-27	23	339	22	6292
RNA binding	2.8048E-5	23	367	8	6292
rRNA binding	1.4869E-3	23	16	2	6292
nucleic acid binding	1.7415E-3	23	666	8	6292

View Protein Complex Details

Complex Overview

Complex Member Proteins

Cellular Component Analysis

Biological Process Analysis

Molecular Function Analysis