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View Protein Complex Details

Complex Overview

From Publication: Riffle <i>et al</i>. (2010) (Unpublished Data)
Notes: Complex predicted from the combined set of Gavin (2002), Gavin (2006), Ho (2002) and Krogan (2006); at p-value cutoff of 1E-7
Complex Size: 19 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
PUF4
  • cytoplasm
  • loss of chromatin silencing involved in replicative cell aging
  • protein localization
  • mRNA catabolic process
  • nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
  • mRNA binding
  • RPL17A
  • cytoplasm
  • translation
  • structural constituent of ribosome
  • RPL17B
  • ribonucleoprotein complex
  • cytoplasm
  • large ribosomal subunit
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • structural constituent of ribosome
  • RPL18A, RPL18B
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • regulation of translation
  • translation
  • structural constituent of ribosome
  • RPL24A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • RNA binding
  • structural constituent of ribosome
  • RPL2A, RPL2B
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • regulation of translation
  • response to drug
  • translation
  • RNA binding
  • structural constituent of ribosome
  • rRNA binding
  • RPL3
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • ribosomal large subunit assembly
  • translation
  • structural constituent of ribosome
  • RPL30
  • cytoplasm
  • negative regulation of nuclear mRNA splicing, via spliceosome
  • rRNA processing
  • negative regulation of translation
  • translation
  • structural constituent of ribosome
  • RPL32
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • structural constituent of ribosome
  • RPL36A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • RNA binding
  • structural constituent of ribosome
  • RPL42B, RPL42A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • response to antibiotic
  • response to cycloheximide
  • translation
  • structural constituent of ribosome
  • RPL4A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • structural constituent of ribosome
  • RPL6A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • ribosomal large subunit assembly
  • translation
  • RNA binding
  • structural constituent of ribosome
  • RPS16B, RPS16A
  • ribonucleoprotein complex
  • cytosolic small ribosomal subunit
  • cytoplasm
  • ribosome
  • 90S preribosome
  • intracellular
  • regulation of translation
  • maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
  • ribosomal small subunit biogenesis
  • translation
  • structural constituent of ribosome
  • RPS17B
  • ribonucleoprotein complex
  • cytosolic small ribosomal subunit
  • cytoplasm
  • ribosome
  • intracellular
  • telomere maintenance
  • ribosomal small subunit assembly
  • translation
  • structural constituent of ribosome
  • RPS1A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic small ribosomal subunit
  • ribosome
  • 90S preribosome
  • intracellular
  • translation
  • structural constituent of ribosome
  • RPS30B, RPS30A
  • stress granule
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic small ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • structural constituent of ribosome
  • RPS9B
  • small nucleolar ribonucleoprotein complex
  • regulation of translational fidelity
  • translation
  • structural constituent of ribosome
  • YHI9
  • cellular_component
  • biological_process
  • molecular_function
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    cytosolic ribosome 3.2432E-22 19 101 14 6292
    cytosolic part 5.3215E-21 19 122 14 6292
    ribosomal subunit 1.9334E-18 19 183 14 6292
    cytosolic large ribosomal subunit 2.4519E-16 19 60 10 6292
    cytosol 1.0112E-15 19 284 14 6292
    ribosome 1.358E-15 19 290 14 6292
    ribonucleoprotein complex 1.1329E-13 19 514 15 6292
    large ribosomal subunit 1.428E-13 19 110 10 6292
    non-membrane-bounded organelle 1.8386E-8 19 959 14 6292
    intracellular non-membrane-bounded organelle 1.8386E-8 19 959 14 6292
    macromolecular complex 2.0339E-6 19 1635 15 6292
    cytosolic small ribosomal subunit 4.1093E-6 19 38 4 6292
    small ribosomal subunit 5.6665E-5 19 73 4 6292
    organelle part 9.9948E-4 19 2282 14 6292
    intracellular organelle part 9.9948E-4 19 2282 14 6292
    90S preribosome 1.1437E-3 19 17 2 6292
    cytoplasm 2.2204E-3 19 3552 17 6292
    cytoplasmic part 2.5936E-3 19 2482 14 6292
    stress granule 3.0197E-3 19 1 1 6292
    preribosome 4.5757E-3 19 34 2 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    translation 1.712E-19 19 376 17 6292
    cellular macromolecule biosynthetic process 1.2901E-12 19 1187 18 6292
    macromolecule biosynthetic process 1.3296E-12 19 1189 18 6292
    gene expression 5.1894E-12 19 1283 18 6292
    cellular protein metabolic process 9.6453E-12 19 1074 17 6292
    protein metabolic process 2.4661E-11 19 1136 17 6292
    cellular biosynthetic process 1.8369E-10 19 1567 18 6292
    biosynthetic process 2.7208E-10 19 1602 18 6292
    cellular macromolecule metabolic process 1.4452E-7 19 2285 18 6292
    macromolecule metabolic process 2.3456E-7 19 2349 18 6292
    regulation of translation 5.3866E-7 19 57 5 6292
    posttranscriptional regulation of gene expression 7.5965E-7 19 61 5 6292
    regulation of cellular protein metabolic process 1.3138E-6 19 68 5 6292
    regulation of protein metabolic process 2.0076E-6 19 74 5 6292
    primary metabolic process 8.9719E-6 19 2896 18 6292
    cellular metabolic process 1.991E-5 19 3033 18 6292
    metabolic process 3.9626E-5 19 3157 18 6292
    ribosomal subunit assembly 5.5471E-4 19 55 3 6292
    ribosome assembly 8.6593E-4 19 64 3 6292
    organelle assembly 1.0786E-3 19 69 3 6292
    regulation of gene expression 1.484E-3 19 445 6 6292
    regulation of macromolecule biosynthetic process 1.6849E-3 19 456 6 6292
    regulation of cellular biosynthetic process 2.0138E-3 19 472 6 6292
    regulation of biosynthetic process 2.0359E-3 19 473 6 6292
    regulation of macromolecule metabolic process 2.3901E-3 19 488 6 6292
    ribonucleoprotein complex assembly 2.4741E-3 19 92 3 6292
    ribosomal small subunit biogenesis 2.6892E-3 19 26 2 6292
    ribosome biogenesis 2.9935E-3 19 346 5 6292
    response to cycloalkane 3.0197E-3 19 1 1 6292
    response to organic cyclic substance 3.0197E-3 19 1 1 6292
    negative regulation of mRNA processing 3.0197E-3 19 1 1 6292
    negative regulation of nuclear mRNA splicing, via spliceosome 3.0197E-3 19 1 1 6292
    negative regulation of RNA splicing 3.0197E-3 19 1 1 6292
    response to cycloheximide 3.0197E-3 19 1 1 6292
    regulation of primary metabolic process 3.1141E-3 19 514 6 6292
    regulation of cellular metabolic process 3.8479E-3 19 536 6 6292
    ribonucleoprotein complex biogenesis 4.1966E-3 19 374 5 6292
    regulation of metabolic process 4.2606E-3 19 547 6 6292
    regulation of mRNA processing 6.0308E-3 19 2 1 6292
    regulation of RNA splicing 6.0308E-3 19 2 1 6292
    regulation of nuclear mRNA splicing, via spliceosome 6.0308E-3 19 2 1 6292
    ribosomal large subunit assembly 6.6046E-3 19 41 2 6292
    response to antibiotic 9.0332E-3 19 3 1 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    structural constituent of ribosome 7.9194E-24 19 212 17 6292
    structural molecule activity 2.8583E-20 19 339 17 6292
    RNA binding 3.8677E-3 19 367 5 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle