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Protein Overview: UBC12

General Information:
Name(s) found: UBC12 / YLR306W [SGD]
Description(s) found:
Found 26 descriptions.
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  • Enzyme that mediates the conjugation of Rub1p, a ubiquitin-like protein, to other proteins; related to E2 ubiquitin-conjugating enzymes [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 188 amino acids

    Gene Ontology:
    Cellular Component: cellular_component [ND]
    Biological Process: protein neddylation [IDALink to PubMed article][IMPLink to PubMed article][ISSLink to PubMed article]
    Molecular Function: nucleotide binding [IEA]
    ATP binding [IEA]
    ubiquitin-protein ligase activity [RCA]
    acid-amino acid ligase activity [IEA]
    NEDD8 ligase activity [IDA][IMP][ISS]
    small conjugating protein ligase activity [IEA]
    ligase activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLKLRQLQKK KQKENENSSS IQPNLSAARI RLKRDLDSLD LPPTVTLNVI TSPDSADRSQ  60
   61 SPKLEVIVRP DEGYYNYGSI NFNLDFNEVY PIEPPKVVCL KKIFHPNIDL KGNVCLNILR 120
  121 EDWSPALDLQ SIITGLLFLF LEPNPNDPLN KDAAKLLCEG EKEFAEAVRL TMSGGSIEHV 180
  181 KYDNIVSP

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Ho Y, et al. (2002) ARP2 CPR6 IDH2 LHS1 MDN1 MKT1 NAS6 RPN1 RPN11 RPN12 RPN14 RPN3 RPN5 RPN6 RPN7 RPN8 RPN9 RPT1 RPT2 RPT3 RPT4 RPT5 STI1 UBC12 ULA1

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen UBC12 SIP1 2 Unpublished Fields Lab Data
    View Screen UBC12 YBR137W 1 Unpublished Fields Lab Data
    View Screen UBC12 YIR020C 1 Unpublished Fields Lab Data
    View Screen UBC12 YLR169W 1 Unpublished Fields Lab Data
    View Screen UBC12 YOL131W 1 Unpublished Fields Lab Data
    View Screen UBC12 SRO9 1 Unpublished Fields Lab Data
    View Screen UBC12 MNN11 1 Unpublished Fields Lab Data
    View Screen UBC12 CTF3 1 Unpublished Fields Lab Data
    View Screen UBC12 ALG8 1 Unpublished Fields Lab Data
    View Screen UBC12 RPS14A 1 Unpublished Fields Lab Data
    View Screen UBC12 RSM26 1 Unpublished Fields Lab Data
    View Screen UBC12 TUS1 1 Unpublished Fields Lab Data
    View Screen UBC12 DCS2 1 Unpublished Fields Lab Data
    View Screen UBC12 YDR090C 1 Unpublished Fields Lab Data
    View Screen UBC12 XPT1 1 Unpublished Fields Lab Data
    View Screen UBC12 RPS17A 1 Unpublished Fields Lab Data
    View Screen UBC12 YOR186W 1 Unpublished Fields Lab Data
    View Screen UBC12 TAF10 1 Unpublished Fields Lab Data
    View Screen UBC12 PMT4 1 Unpublished Fields Lab Data
    View Screen UBC12 IMP2 1 Unpublished Fields Lab Data
    View Screen UBC12 CDC31 1 Unpublished Fields Lab Data
    View Screen UBC12 DFM1 1 Unpublished Fields Lab Data
    View Screen UBC12 ELM1 1 Unpublished Fields Lab Data
    View Screen UBC12 MIH1 1 Unpublished Fields Lab Data
    View Screen UBC12 YOR302W 1 Unpublished Fields Lab Data
    View Screen UBC12 YKL107W 1 Unpublished Fields Lab Data
    View Screen UBC12 YMR114C 1 Unpublished Fields Lab Data
    View Screen UBC12 HSP33 1 Unpublished Fields Lab Data
    View Screen UBC12 YEL023C 1 Unpublished Fields Lab Data
    View Screen UBC12 YKL147C 1 Unpublished Fields Lab Data
    View Screen UBC12 TRS130 1 Unpublished Fields Lab Data
    View Screen UBC12 YOR392W 1 Unpublished Fields Lab Data
    View Screen UBC12 PAB1 1 Unpublished Fields Lab Data
    View Screen UBC12 FAS1 1 Unpublished Fields Lab Data
    View Screen UBC12 PUB1 1 Unpublished Fields Lab Data
    View Screen UBC12 YPL062W 1 Unpublished Fields Lab Data
    View Screen UBC12 UBR1 1 Unpublished Fields Lab Data
    View Screen UBC12 HYM1 1 Unpublished Fields Lab Data
    View Screen UBC12 PGA1 1 Unpublished Fields Lab Data
    View Screen UBC12 GUP2 1 Unpublished Fields Lab Data
    View Screen UBC12 PMT6 1 Unpublished Fields Lab Data
    View Screen UBC12 YKL225W 1 Unpublished Fields Lab Data
    View Screen UBC12 YRF1-6 1 Unpublished Fields Lab Data
    View Screen UBC12 CET1 1 Unpublished Fields Lab Data
    View Screen UBC12 YHR078W 1 Unpublished Fields Lab Data
    View Screen UBC12 YKR032W 1 Unpublished Fields Lab Data
    View Screen UBC12 YNR005C 1 Unpublished Fields Lab Data
    View Screen UBC12 VIK1 1 Unpublished Fields Lab Data
    View Screen UBC12 RTT107 1 Unpublished Fields Lab Data
    View Screen UBC12 SPC34 1 Unpublished Fields Lab Data
    View Screen UBC12 AIM38 1 Unpublished Fields Lab Data
    View Screen UBC12 YPL264C 1 Unpublished Fields Lab Data
    View Screen UBC12 SVP26 1 Unpublished Fields Lab Data
    View Screen UBC12 YKR041W 1 Unpublished Fields Lab Data
    View Screen UBC12 PDR18 1 Unpublished Fields Lab Data
    View Screen UBC12 YPR172W 1 Unpublished Fields Lab Data
    View Screen UBC12 YAL066W 1 Unpublished Fields Lab Data
    View Screen UBC12 YHR202W 1 Unpublished Fields Lab Data
    View Screen UBC12 PAU17 1 Unpublished Fields Lab Data
    View Screen UBC12 RPB11 1 Unpublished Fields Lab Data
    View Screen UBC12 SHP1 1 Unpublished Fields Lab Data
    View Screen UBC12 NAS2 1 Unpublished Fields Lab Data
    View Screen UBC12 HRT3 1 Unpublished Fields Lab Data
    View Screen UBC12 GAS5 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..188] PSI-BLAST 246.522879 Ubiquitin conjugating enzyme, UBC

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • ubiquitin-protein ligase activity
    		•  11.3486134076304 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  11.2964721480824 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  10.2401422444624 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  8.93602533934698 bayes_pls_golite062009
  • ligase activity
    		•  5.89730943108033 bayes_pls_golite062009
  • SUMO ligase activity
    		•  3.88357560284404 bayes_pls_golite062009
  • ISG15 ligase activity
    		•  3.37361650623694 bayes_pls_golite062009
  • NEDD8 ligase activity
    		•  3.30521803258995 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.21355731489173 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.13970605403492 bayes_pls_golite062009
  • DNA binding
    		•  1.95596447916631 bayes_pls_golite062009
  • protein binding
    		•  1.77678273247394 bayes_pls_golite062009
  • binding
    		•  1.75350658654805 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.5236035191291 bayes_pls_golite062009
  • transcription activator activity
    		•  1.19240180311941 bayes_pls_golite062009
  • HLH domain binding
    		•  0.944642883331201 bayes_pls_golite062009
  • catalytic activity
    		•  0.891402822028799 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.58835335751383 bayes_pls_golite062009
  • kinase activity
    		•  0.519703305315987 bayes_pls_golite062009
  • protein kinase activity
    		•  0.443948654247666 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.373779304908933 bayes_pls_golite062009
  • small protein activating enzyme activity
    		•  0.36227294335656 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.182854082413338 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.122859425935324 bayes_pls_golite062009
  • transferase activity
    		•  0.0984525836903841 bayes_pls_golite062009
  • transcription factor binding
    		•  0.0104967529560147 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle