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View Protein Complex Details

Complex Overview

From Publication: Ho Y. et al. (2002) Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature. 2002 Jan 10;415(6868):180-3.
Notes: This molecular complex record represents a population of complexes co-purified by immunoprecipitation of FLAG-tagged Erb1. The topolgies of protein complexes in this experiment are unknown.
Complex Size: 26 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
ACO1
  • mitochondrial matrix
  • mitochondrion
  • cytosol
  • mitochondrial nucleoid
  • glutamate biosynthetic process
  • response to drug
  • citrate metabolic process
  • propionate metabolic process
  • tricarboxylic acid cycle
  • mitochondrial genome maintenance
  • aconitate hydratase activity
  • CCT6
  • chaperonin-containing T-complex
  • cytoskeleton
  • cytoplasm
  • cytoskeleton organization
  • protein folding
  • unfolded protein binding
  • CDC14
  • nucleus
  • RENT complex
  • spindle pole body
  • nucleolus
  • regulation of exit from mitosis
  • protein amino acid dephosphorylation
  • phosphoprotein phosphatase activity
  • EGD2
  • nascent polypeptide-associated complex
  • 'de novo' cotranslational protein folding
  • unfolded protein binding
  • ERB1
  • nucleus
  • nucleolus
  • rRNA processing
  • molecular_function
  • GND1
  • cytoplasm
  • mitochondrion
  • response to oxidative stress
  • pentose-phosphate shunt, oxidative branch
  • phosphogluconate dehydrogenase (decarboxylating) activity
  • GUS1
  • cytoplasm
  • methionyl glutamyl tRNA synthetase complex
  • glutamyl-tRNA aminoacylation
  • glutamate-tRNA ligase activity
  • HAS1
  • nuclear envelope
  • nucleolus
  • ribosome biogenesis
  • rRNA processing
  • RNA binding
  • RNA-dependent ATPase activity
  • ATP-dependent RNA helicase activity
  • HXT7
  • mitochondrion
  • plasma membrane
  • hexose transport
  • fructose transmembrane transporter activity
  • glucose transmembrane transporter activity
  • mannose transmembrane transporter activity
  • MET6
  • cytoplasm
  • methionine biosynthetic process
  • 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity
  • MRT4
  • nucleus
  • nucleolus
  • ribosomal large subunit biogenesis
  • telomere maintenance
  • ribosome biogenesis
  • rRNA processing
  • mRNA catabolic process
  • molecular_function
  • MUB1
  • cellular_component
  • regulation of cell budding
  • molecular_function
  • NOC2
  • nucleus
  • Noc2p-Noc3p complex
  • mitochondrion
  • Noc1p-Noc2p complex
  • ribosomal subunit export from nucleus
  • ribosome biogenesis
  • ribosome assembly
  • molecular_function
  • NOC3
  • nucleus
  • Noc2p-Noc3p complex
  • nucleolus
  • DNA replication initiation
  • ribosome biogenesis
  • rRNA processing
  • protein binding
  • chromatin binding
  • NOG1
  • nuclear outer membrane
  • nucleolus
  • preribosome, large subunit precursor
  • ribosomal subunit export from nucleus
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • GTP binding
  • NSA1
  • nucleus
  • nucleolus
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • molecular_function
  • NUG1
  • nucleus
  • nucleolus
  • ribosome biogenesis
  • rRNA processing
  • GTPase activity
  • PRP43
  • mitochondrion
  • spliceosomal complex
  • nuclear outer membrane
  • maturation of SSU-rRNA
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • rRNA processing
  • processing of 27S pre-rRNA
  • ATP-dependent RNA helicase activity
  • SAH1
  • cytoplasm
  • methionine metabolic process
  • selenocysteine metabolic process
  • adenosylhomocysteinase activity
  • SCS2
  • integral to membrane
  • endoplasmic reticulum
  • inositol metabolic process
  • protein targeting to ER
  • chromatin silencing at telomere
  • protein binding
  • SEC53
  • cytosol
  • protein targeting to ER
  • phosphomannomutase activity
  • SPB4
  • nuclear outer membrane
  • nucleolus
  • ribosome biogenesis
  • ribosomal large subunit assembly
  • ATP-dependent RNA helicase activity
  • SSQ1
  • mitochondrial matrix
  • mitochondrion
  • DNA-dependent DNA replication
  • intracellular sequestering of iron ion
  • unfolded protein binding
  • TIF6
  • nucleus
  • cytoplasm
  • nuclear outer membrane
  • nucleolus
  • ribosomal subunit export from nucleus
  • ribosomal large subunit biogenesis
  • processing of 27S pre-rRNA
  • ribosomal large subunit binding
  • UBR2
  • cytoplasm
  • protein polyubiquitination
  • protein monoubiquitination
  • ubiquitin-protein ligase activity
  • YTM1
  • nucleus
  • nucleolus
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • molecular_function
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    nucleolus 9.4736E-12 26 211 12 6292
    organelle lumen 4.9692E-8 26 660 14 6292
    intracellular organelle lumen 4.9692E-8 26 660 14 6292
    nuclear lumen 6.4066E-8 26 453 12 6292
    membrane-enclosed lumen 1.0551E-7 26 700 14 6292
    preribosome, large subunit precursor 5.1771E-6 26 9 3 6292
    non-membrane-bounded organelle 5.3227E-6 26 959 14 6292
    intracellular non-membrane-bounded organelle 5.3227E-6 26 959 14 6292
    Noc2p-Noc3p complex 1.6421E-5 26 2 2 6292
    nuclear part 1.4944E-4 26 1103 13 6292
    Noc complex 1.6296E-4 26 5 2 6292
    preribosome 3.4436E-4 26 34 3 6292
    nuclear outer membrane 3.8664E-4 26 86 4 6292
    nuclear membrane 6.1168E-4 26 97 4 6292
    nucleolar part 7.9233E-4 26 45 3 6292
    nuclear envelope 1.151E-3 26 199 5 6292
    outer membrane 5.6869E-3 26 178 4 6292
    organelle outer membrane 5.6869E-3 26 178 4 6292
    Noc1p-Noc2p complex 8.248E-3 26 2 1 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    ribosome biogenesis 3.0435E-9 26 346 12 6292
    ribosomal large subunit biogenesis 5.0848E-9 26 65 7 6292
    ribonucleoprotein complex biogenesis 7.3958E-9 26 374 12 6292
    cellular component biogenesis 6.5908E-6 26 694 12 6292
    rRNA processing 1.0392E-5 26 128 6 6292
    rRNA metabolic process 1.5361E-5 26 137 6 6292
    ncRNA metabolic process 5.8975E-5 26 257 7 6292
    establishment of ribosome localization 1.5294E-4 26 26 3 6292
    ribosome localization 1.5294E-4 26 26 3 6292
    ribosomal subunit export from nucleus 1.5294E-4 26 26 3 6292
    ncRNA processing 1.9258E-4 26 215 6 6292
    cellular process 1.2541E-3 26 4426 25 6292
    establishment of organelle localization 1.4253E-3 26 55 3 6292
    processing of 27S pre-rRNA 1.9016E-3 26 16 2 6292
    RNA processing 3.8191E-3 26 380 6 6292
    regulation of cell budding 4.1322E-3 26 1 1 6292
    selenocysteine metabolic process 4.1322E-3 26 1 1 6292
    selenium metabolic process 4.1322E-3 26 1 1 6292
    methionine metabolic process 4.2858E-3 26 24 2 6292
    organelle localization 4.9433E-3 26 85 3 6292
    protein targeting to ER 8.0141E-3 26 33 2 6292
    intracellular sequestering of iron ion 8.248E-3 26 2 1 6292
    sequestering of metal ion 8.248E-3 26 2 1 6292
    cellular amino acid metabolic process 8.4061E-3 26 199 4 6292
    nuclear export 8.4267E-3 26 103 3 6292
    sulfur amino acid metabolic process 8.4934E-3 26 34 2 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    ATP-dependent RNA helicase activity 1.9165E-4 26 28 3 6292
    RNA-dependent ATPase activity 2.1318E-4 26 29 3 6292
    RNA helicase activity 6.4631E-4 26 42 3 6292
    ATP-dependent helicase activity 9.5786E-4 26 48 3 6292
    purine NTP-dependent helicase activity 9.5786E-4 26 48 3 6292
    unfolded protein binding 1.9234E-3 26 61 3 6292
    trialkylsulfonium hydrolase activity 4.1322E-3 26 1 1 6292
    ribosomal large subunit binding 4.1322E-3 26 1 1 6292
    phosphomannomutase activity 4.1322E-3 26 1 1 6292
    5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity 4.1322E-3 26 1 1 6292
    5-methyltetrahydropteroyltri-L-glutamate-dependent methyltransferase activity 4.1322E-3 26 1 1 6292
    adenosylhomocysteinase activity 4.1322E-3 26 1 1 6292
    helicase activity 4.6238E-3 26 83 3 6292
    phosphogluconate dehydrogenase (decarboxylating) activity 8.248E-3 26 2 1 6292
    aconitate hydratase activity 8.248E-3 26 2 1 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle