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View Protein Complex Details

Complex Overview

From Publication: Ho Y. et al. (2002) Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature. 2002 Jan 10;415(6868):180-3.
Notes: This molecular complex record represents a population of complexes co-purified by immunoprecipitation of FLAG-tagged Pph21. The topolgies of protein complexes in this experiment are unknown.
Complex Size: 9 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
HEM15
  • mitochondrion
  • mitochondrial inner membrane
  • heme biosynthetic process
  • ferrochelatase activity
  • PPE1
  • soluble fraction
  • sinus venosus formation
  • protein modification process
  • telomere maintenance
  • carboxylesterase activity
  • hydrolase activity
  • PPH21
  • protein phosphatase type 2A complex
  • mitotic cell cycle spindle assembly checkpoint
  • G1/S transition of mitotic cell cycle
  • protein amino acid dephosphorylation
  • actin filament organization
  • budding cell bud growth
  • translation
  • protein serine/threonine phosphatase activity
  • phosphoprotein phosphatase activity
  • metal ion binding
  • hydrolase activity
  • PPH22
  • condensed nuclear chromosome, centromeric region
  • protein phosphatase type 2A complex
  • mitotic cell cycle spindle assembly checkpoint
  • G1/S transition of mitotic cell cycle
  • protein amino acid dephosphorylation
  • actin filament organization
  • budding cell bud growth
  • translation
  • protein serine/threonine phosphatase activity
  • phosphoprotein phosphatase activity
  • metal ion binding
  • hydrolase activity
  • RPC40
  • DNA-directed RNA polymerase I complex
  • DNA-directed RNA polymerase III complex
  • transcription from RNA polymerase III promoter
  • transcription from RNA polymerase I promoter
  • ribosome biogenesis
  • DNA-directed RNA polymerase activity
  • RTS1
  • nucleus
  • condensed nuclear chromosome, centromeric region
  • cytoplasm
  • cellular bud neck
  • spindle pole body
  • protein phosphatase type 2A complex
  • protein amino acid dephosphorylation
  • meiotic sister chromatid cohesion, centromeric
  • translation
  • protein serine/threonine phosphatase activity
  • protein phosphatase type 2A regulator activity
  • RTS3
  • nucleus
  • cytoplasm
  • protein phosphatase type 2A complex
  • protein amino acid dephosphorylation
  • molecular_function
  • TAP42
  • cellular_component
  • signal transduction
  • protein binding
  • TPD3
  • nucleus
  • cellular bud tip
  • cytoplasm
  • cellular bud neck
  • spindle pole body
  • mating projection tip
  • protein phosphatase type 2A complex
  • mitotic cell cycle spindle assembly checkpoint
  • protein amino acid dephosphorylation
  • actin filament organization
  • budding cell bud growth
  • translation
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    protein phosphatase type 2A complex 9.2092E-15 9 6 5 6292
    protein serine/threonine phosphatase complex 9.4424E-12 9 17 5 6292
    protein complex 1.7541E-3 9 1137 6 6292
    condensed chromosome, centromeric region 2.5969E-3 9 55 2 6292
    condensed nuclear chromosome, centromeric region 2.5969E-3 9 55 2 6292
    microtubule organizing center 3.3951E-3 9 63 2 6292
    spindle pole body 3.3951E-3 9 63 2 6292
    chromosome, centromeric region 3.8322E-3 9 67 2 6292
    spindle pole 3.9454E-3 9 68 2 6292
    condensed nuclear chromosome 6.2461E-3 9 86 2 6292
    spindle 6.6772E-3 9 89 2 6292
    condensed chromosome 7.4253E-3 9 94 2 6292
    microtubule cytoskeleton 9.3697E-3 9 106 2 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    protein amino acid dephosphorylation 1.4909E-10 9 28 5 6292
    dephosphorylation 9.9186E-10 9 40 5 6292
    mitotic cell cycle spindle assembly checkpoint 2.6578E-6 9 21 3 6292
    negative regulation of nuclear division 2.6578E-6 9 21 3 6292
    negative regulation of mitosis 2.6578E-6 9 21 3 6292
    negative regulation of mitotic metaphase/anaphase transition 2.6578E-6 9 21 3 6292
    spindle assembly checkpoint 2.6578E-6 9 21 3 6292
    negative regulation of cell cycle 3.0753E-6 9 22 3 6292
    spindle checkpoint 4.5831E-6 9 25 3 6292
    regulation of mitotic metaphase/anaphase transition 4.5831E-6 9 25 3 6292
    mitotic cell cycle spindle checkpoint 4.5831E-6 9 25 3 6292
    mitotic cell cycle checkpoint 6.5138E-6 9 28 3 6292
    phosphorus metabolic process 6.8376E-6 9 229 5 6292
    phosphate metabolic process 6.8376E-6 9 229 5 6292
    negative regulation of cellular component organization 7.2602E-6 9 29 3 6292
    regulation of nuclear division 7.2602E-6 9 29 3 6292
    negative regulation of organelle organization 7.2602E-6 9 29 3 6292
    regulation of mitosis 7.2602E-6 9 29 3 6292
    negative regulation of cell cycle process 9.834E-6 9 32 3 6292
    budding cell bud growth 1.1847E-5 9 34 3 6292
    mitotic metaphase/anaphase transition 1.535E-5 9 37 3 6292
    protein modification process 1.6502E-5 9 499 6 6292
    macromolecule modification 3.5308E-5 9 569 6 6292
    regulation of organelle organization 4.3192E-5 9 52 3 6292
    post-translational protein modification 5.9621E-5 9 357 5 6292
    cell cycle checkpoint 6.0045E-5 9 58 3 6292
    actin filament organization 9.6826E-5 9 68 3 6292
    regulation of mitotic cell cycle 1.1019E-4 9 71 3 6292
    regulation of cellular component organization 1.298E-4 9 75 3 6292
    signal transduction 1.4334E-4 9 214 4 6292
    signal transmission 1.5131E-4 9 217 4 6292
    signaling process 1.5131E-4 9 217 4 6292
    regulation of cell cycle process 1.6331E-4 9 81 3 6292
    cell budding 2.2341E-4 9 90 3 6292
    asexual reproduction 2.2341E-4 9 90 3 6292
    signaling 2.7002E-4 9 252 4 6292
    mitosis 3.4282E-4 9 104 3 6292
    nuclear division 3.6266E-4 9 106 3 6292
    organelle fission 4.3792E-4 9 113 3 6292
    actin cytoskeleton organization 4.3792E-4 9 113 3 6292
    actin filament-based process 4.8514E-4 9 117 3 6292
    M phase 4.8835E-4 9 294 4 6292
    M phase of mitotic cell cycle 6.3162E-4 9 128 3 6292
    regulation of cell cycle 6.7598E-4 9 131 3 6292
    growth 9.0949E-4 9 145 3 6292
    cell division 9.0949E-4 9 145 3 6292
    cell cycle phase 1.2433E-3 9 376 4 6292
    translation 1.2433E-3 9 376 4 6292
    cellular protein metabolic process 1.283E-3 9 1074 6 6292
    meiotic sister chromatid cohesion, centromeric 1.4304E-3 9 1 1 6292
    protein metabolic process 1.7457E-3 9 1136 6 6292
    G1/S transition of mitotic cell cycle 2.1502E-3 9 50 2 6292
    meiotic sister chromatid cohesion 2.859E-3 9 2 1 6292
    reproduction of a single-celled organism 2.9133E-3 9 217 3 6292
    cell cycle process 3.3362E-3 9 490 4 6292
    cytoskeleton organization 3.4816E-3 9 231 3 6292
    cardiac chamber development 4.2857E-3 9 3 1 6292
    cardiac chamber morphogenesis 4.2857E-3 9 3 1 6292
    cardiac chamber formation 4.2857E-3 9 3 1 6292
    heart development 4.2857E-3 9 3 1 6292
    heart morphogenesis 4.2857E-3 9 3 1 6292
    organ morphogenesis 4.2857E-3 9 3 1 6292
    sinus venosus development 4.2857E-3 9 3 1 6292
    sinus venosus morphogenesis 4.2857E-3 9 3 1 6292
    sinus venosus formation 4.2857E-3 9 3 1 6292
    cell cycle 4.2978E-3 9 525 4 6292
    negative regulation of cellular process 4.3569E-3 9 250 3 6292
    negative regulation of biological process 4.5064E-3 9 253 3 6292
    mitotic cell cycle 4.6079E-3 9 255 3 6292
    interphase of mitotic cell cycle 7.8919E-3 9 97 2 6292
    interphase 7.8919E-3 9 97 2 6292
    organ development 8.5551E-3 9 6 1 6292
    system development 8.5551E-3 9 6 1 6292
    reproduction 9.3205E-3 9 328 3 6292
    cellular biosynthetic process 9.7492E-3 9 1567 6 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    protein serine/threonine phosphatase activity 5.1771E-6 9 26 3 6292
    phosphoprotein phosphatase activity 2.4275E-5 9 43 3 6292
    phosphatase activity 2.02E-4 9 87 3 6292
    phosphoric ester hydrolase activity 3.237E-4 9 102 3 6292
    hydrolase activity, acting on ester bonds 8.5934E-4 9 341 4 6292
    metal ion binding 2.5969E-3 9 55 2 6292
    ion binding 2.6911E-3 9 56 2 6292
    cation binding 2.6911E-3 9 56 2 6292
    ferrochelatase activity 2.859E-3 9 2 1 6292
    protein phosphatase type 2A regulator activity 5.7106E-3 9 4 1 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle