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Catalysis of the reaction: sirohydrochlorin + Fe2+ = siroheme + 2 H+. Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. Catalysis of the reaction: protoporphyrin + Fe2+ = protoheme + 2 H+.

View Gene Ontology (GO) Term


Name: ferrochelatase activity
Acc: GO:0004325
Aspect: Molecular Function
Desc: Catalysis of the reaction: protoporphyrin + Fe2+ = protoheme + 2 H+.
  • heme synthetase activity
  • heme synthase activity
  • protoheme ferro-lyase (protoporphyrin-forming)
  • ferro-protoporphyrin chelatase activity
  • protoheme ferrolyase activity
  • protoheme ferro-lyase activity
  • iron chelatase activity
Proteins in PDR annotated with:
   This term: 32 [Search]
   Term or descendants: 35 [Search]


GO:0004325 - ferrochelatase activity (interactive image map)

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