Protein Overview: VIK1

General Information:
Name(s) found:	VIK1 / YPL253C [SGD]
Description(s) found: Found 25 descriptions. SHOW ALL	Protein that forms a complex with Kar3p at the spindle pole body, possible regulator of Kar3p function in microtubule-mediated processes; required for sister chromatid cohesion; has similarity to Cik1p [SGD]
Organism:	Saccharomyces cerevisiae
Length:	647 amino acids
Gene Ontology:
Cellular Component:	spindle pole body [IDA ] kinesin complex [IDA]
Biological Process:	mitotic sister chromatid cohesion [IGI][IMP] microtubule-based process [IMP][IPI]
Molecular Function:	microtubule motor activity [ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MASQQNKHAF LSKNRIFHNP DNVSSSKSRN LMDITNTTNT MNGSRPSSMK SSLALPPVKD  60
   61 SFPSVSRSAS LNINMSKIKD LKDRQDKIRF QRHTLRTQLI ECEREIKTIK FRDLNKSRFE 120
  121 LYKKKSKQAK YLKQVRDLTQ NLNSKDGERA DLIKKNKSAL ATLQAELDQN LILKRQESQE 180
  181 LYNNKLIFWE NELQIMENVE PDHEITEEIS QLKKTLQELN INWANLQKQN LERQVNHESQ 240
  241 LRKDFIAFKE AKLKSMENLT NKHRELLDQI ATLQSESEKL HKEIMDIDRQ AEYSEQNISE 300
  301 INENIKQLEL ANNPLISKSL QNSQDLEHLQ NQMENLKEMA SKQEKFYNDT YNTVEKELLR 360
  361 SRRLENSIIE QKGTMRCYAY VMEQNLPENL LFDYENGVIT QGLSEHVYKF NRVIPHLKVS 420
  421 EDKFFTQEYS VYHDMCLNQK KNFNLISLST TPHGSLRESL IKFLAEKDTI YQKQYVITLQ 480
  481 FVFLSDDEFS QDMLLDYSHN DKDSIKLKFE KHSISLDSKL VIIENGLEDL PLNFSCDEHP 540
  541 NLPHSGMGII KVQFFPRDSK SDGNNDPVPV DFYFIELNNL KSIEQFDKSI FKKESCETPI 600
  601 ALVLKKLISD TKSFFLLNLN DSKNVNKLLT ISEEVQTQLC KRKKKLT

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Qiu et al. (2008)		CIK1 CIN8 DYN1 DYN3 KAR3 KIP1 KIP2 STU1 VIK1

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	NSL1	No Comments	Hazbun TR, et al. (2003)
View Run	CEP3	sample cbf3 from feb 2005	Sandall S, et all (2006)
View Run	RPA135	No Comments	Schneider, DA, et al. (2006)

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	VIK1	YER159C-A, YDR31...	2	Uetz P, et al. (2000)

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..345]	PSI-BLAST	20.0	Heavy meromyosin subfragment
2	View Details	[346..406]	PSI-BLAST	9.69897	Tropomyosin
3	View Details	[407..466]	PSI-BLAST	9.69897	Tropomyosin
4	View Details	[467..564]	PSI-BLAST	9.69897	Tropomyosin
5	View Details	[565..647]	deduced	N/A	No confident structure predictions are available.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2