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Protein Overview: ERCC3_RAT

General Information:
Name(s) found: ERCC3_RAT [Swiss-Prot]
Description(s) found:
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  • gi|72255519|ref|NP_001026814.1| excision repair cross-complementing rodent repair deficiency, complementation group 3 [Rattus norvegicus] [NCBI NR]
  • gi|71051759|gb|AAH98856.1| Excision repair cross-complementing rodent repair deficiency, complementation group 3 [Rattus norvegicus] [NCBI NR]
  • ref|XP_214601.2| similar to TFIIH basal transcription factor complex helicase XPB subunit (Basic transcription factor 2 89 kDa subunit) (BTF2-p89) (TFIIH 89 kDa subunit) (DNA-repair protein complementing XP-B cells) (Xeroderma pigmentosum group B compleme [NCBI NR]
  • gi|149017136|gb|EDL76187.1| excision repair cross-complementing rodent repair deficiency, complementation group 3 [Rattus norvegicus] [NCBI NR]
  • gi|123781857|sp|Q4G005.1|ERCC3_RAT RecName: Full=TFIIH basal transcription factor complex helicase XPB subunit; AltName: Full=DNA excision repair protein ERCC-3 [NCBI NR]
  • TFIIH basal transcription factor complex helicase XPB subunit OS=Rattus norvegicus GN=Ercc3 PE=1 SV=1 [Swiss-Prot]
  • similar to TFIIH basal transcription factor complex helicase XPB subunit (Basic transcription factor 2 89 kDa subunit) (BTF2-p89) (TFIIH 89 kDa subunit) (DNA-repair protein complementing XP-B cells) (Xeroderma pigmentosum group B complementing prot... [HMR_022704-rand.fasta]
  • similar to TFIIH basal transcription factor complex helicase XPB subunit (Basic transcription factor 2 89 kDa subunit) (BTF2-p89) (TFIIH 89 kDa subunit) (DNA-repair protein complementing XP-B cells) (Xeroderma pigmentosum group B complementing prot... [Ra [nrdb_11152004_Chlamydomonas]
  • Tax_Id=10116 Excision repair cross-complementing rodent repair deficiency, complementation group 3 [EBI-IPI_rat_3.17_05-10-2006_con_reversed.fasta]
  • Tax_Id=10116 PREDICTED: similar to TFIIH basal transcription factor complex helicase XPB subunit (Basic transcription factor 2 89 kDa subunit) (BTF2-p89) (TFIIH 89 kDa subunit) (DNA-repair protein complementing XP-B cells) (Xeroderma pigmentosum group B c [EBI-IPI_rat_3.08_07-12-2005_origrev_con.fasta]
  • Tax_Id=10116 Similar to TFIIH baSal tranScription factor complex helicaSe XPB Subunit (BaSic tranScription factor 2 89 kDa Subunit) (BTF2-p89) (TFIIH 89 kDa Subunit) (DNA-repair protein complementing XP-B cellS) (Xeroderma pigmentoSum group B complementin [EBI-IPI_rat_3.05_04-04-2005_origrev.fasta]
  • TFIIH basal transcription factor complex helicase XPB subunit (DNA excision repair protein ERCC-3) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • excision repair cross-complementing rodent repair deficiency, complementation group 3 [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Excision repair cross-complementing rodent repair deficiency, complementation group 3 [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Tax_Id=10116 SIMILAR TO TFIIH BASAL TRANSCRIPTION FACTOR COMPLEX HELICASE XPB SUBUNIT (BASIC TRANSCRIPTION FACTOR 2 89 KDA SUBUNIT) (BTF2-P89) (TFIIH 89 KDA SUBUNIT) (DNA-REPAIR PROTEIN COMPLEMENTING XP-B CELLS) (XERODERMA PIGMENTOSUM GROUP B COMPLEMENTIN [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • Tax_Id=10116 Gene_Symbol=Ercc3 TFIIH basal transcription factor complex helicase XPB subunit [rat-ipi-250309-contam.fasta]
  • TFIIH basal transcription factor complex helicase XPB subunit OS=Rattus norvegicus GN=Ercc3 [011711_HMR.fasta]
  • TFIIH basal transcription factor complex helicase XPB subunit OS=Rattus norvegicus GN=Ercc3 PE=2 SV=1 [UNIPROT_RAT_07-21-2011_reversed.fasta]
    • Organism: Rattus norvegicus
    Length: 782 amino acids

    Gene Ontology:
    Cellular Component: SSL2-core TFIIH complex [IDA]
    nucleus [IEA]
    holo TFIIH complex [UNKNOWN][ISS]
    cellular_component [ND]
    nucleoplasm [UNKNOWN]
    Biological Process: DNA repair [UNKNOWN]
    biological_process [ND]
    nucleotide-excision repair, DNA damage removal [UNKNOWN]
    nucleotide-excision repair, DNA duplex unwinding [UNKNOWN][IEA]
    nucleotide-excision repair, DNA incision [UNKNOWN][IEA]
    UV protection [UNKNOWN][IEA]
    transcription-coupled nucleotide-excision repair [UNKNOWN][IEA]
    ATP catabolic process [IDA]
    protein localization [UNKNOWN][IEA]
    nucleotide-excision repair [UNKNOWN]
    transcription from RNA polymerase II promoter [UNKNOWN][ISS]
    response to UV [UNKNOWN]
    DNA topological change [UNKNOWN][IEA]
    protein amino acid phosphorylation [IDA]
    regulation of transcription [IEA]
    positive regulation of transcription from RNA polymerase II promoter [UNKNOWN][IEA]
    transcription initiation from RNA polymerase II promoter [UNKNOWN]
    RNA elongation from RNA polymerase II promoter [UNKNOWN]
    response to oxidative stress [UNKNOWN][IEA]
    cell cycle checkpoint [UNKNOWN][IEA]
    response to hypoxia [IEP]
    induction of apoptosis [UNKNOWN][IEA]
    hair cell differentiation [UNKNOWN][IEA]
    Molecular Function: ATPase activity [UNKNOWN][IDA]
    DNA-dependent ATPase activity [UNKNOWN][ISS]
    RNA polymerase II carboxy-terminal domain kinase activity [UNKNOWN][IDA][ISS]
    protein C-terminus binding [UNKNOWN][IEA]
    helicase activity [IEA]
    protein kinase activity [UNKNOWN][ISS]
    peptide binding [IDA]
    transcription factor binding [UNKNOWN][IEA]
    ATP-dependent DNA helicase activity [IDA]
    3'-5' DNA helicase activity [UNKNOWN][IEA]
    molecular_function [ND]
    nucleotide binding [IEA]
    GTP binding [IDA]
    DNA binding [IEA]
    ATP binding [IDA]
    protein binding [UNKNOWN]
    protein N-terminus binding [UNKNOWN][IEA]
    dATP binding [IDA]
    hydrolase activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGKRDRVDRD KKKSKKRQYE EEEEDEDDAP GNESQEAVPS AAGKQVDESS TKVDEYGAKD  60
   61 YRQQMPLKGD HTSRPLWVAP DGHIFLEAFS PVYKYAQDFL VAIAEPVCRP THVHEYKLTA 120
  121 YSLYAAVSVG LQTSDITEYL RKLSKTGVPD GIIQFIKLCT VSYGKVKLVL KHNRYFVESS 180
  181 HPDVIQHLLQ DPVIRECRLR NAEGEATELI TETFTSKSAI SKTVEGSGGA STSQGVDAQA 240
  241 KSDIPKDLFD FYEQMDKDEE EEEETQTVSF EVKQEMIEEL QKRCICLEYP LLAEYDFRND 300
  301 SLNPDINIDL KPTAVLRPYQ EKSLRKMFGN GRARSGVIVL PCGAGKSLVG VTAACTVRKR 360
  361 CLVLGNSAVS VEQWKAQFKM WSTIDDSQIC RFTSDAKDKP IGCSIAISTY SMLGHTTKRS 420
  421 WEAERVMEWL KTQEWGLMIL DEVHTIPAKM FRRVLTIVQA HCKLGLTATL VREDDKIVDL 480
  481 NFLIGPKLYE ANWMELQNNG YIAKVQCAEV WCPMSPEFYR EYVAIKTKKR ILLYTMNPNK 540
  541 FRACQFLIKF HERRNDKIIV FADNVFALKE YAIRLNKPYI YGPTSQGERM QILQNFKHNP 600
  601 KINTIFISKV GDTSFDLPEA NVLIQISSHG GSRRQEAQRL GRVLRAKKGM VAEEYNAFFY 660
  661 SLVSQDTQEM AYSTKRQRFL VDQGYSFKVI TKLAGMEEEE LAFSTKEEQQ QLLQKVLAAT 720
  721 DLDAEEEVVA GEFGSRSGQA SRRFGTMSSL SGADDTVYME YHSSRNKAST KHVHPLFKRF 780
  781 RK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle