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Protein Overview: lola-PN

General Information:
Name(s) found: lola-PN / FBpp0088388 [FlyBase]
Description(s) found:
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  • gi|73920874|sp|Q9V5M3.3|LOLA6_DROME RecName: Full=Longitudinals lacking protein, isoforms N/O/W/X/Y [NCBI NR]
  • gi|45552047|ref|NP_788308.2| longitudinals lacking, isoform N [Drosophila melanogaster] [NCBI NR]
  • gi|45445596|gb|AAF58781.3| longitudinals lacking, isoform N [Drosophila melanogaster] [NCBI NR]
  • Longitudinals lacking protein, isoforms N/O/W/X/Y OS=Drosophila melanogaster GN=lola PE=1 SV=3 [Swiss-Prot]
  • The gene longitudinals lacking is referred to in FlyBase by the symbol Dmel\lola (CG12052, FBgn0005630). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:6369712..6430767. It has the cytological map location 47A11-47A13. There is experimental evidence that it has the molecular function</span>: protein binding. There is experimental evidence for 12 unique biological process</span> terms, many of which group under: anatomical structure development; cell projection organization; cellular component movement; behavior; sensory organ development; organ morphogenesis; immune response; programmed cell death; neuromuscular process; behavioral interaction between organisms; locomotory behavior; regulation of metabolic process. 163 alleles are reported. The phenotypes of these alleles are annotated with 40 unique terms, many of which group under: peripheral nervous system; nervous system; abdominal lateral monoscolopidial chordotonal organ lch1; embryonic neuron; embryonic nervous system; organ system; multi-cell-component structure; adult segment; abdominal longitudinal muscle; ventral longitudinal muscle. It has 26 annotated transcripts and 26 annotated polypeptides. [FlyBase]
  • (AAF58781) CG12052-PN [DrosMelano7227.FASTAC.txt]
  • CG12052-PN, isoform N [Drosophila melanogaster]gi|45552047|ref|NP_788308.2| CG12052-PN [Drosophila melanogaster] [nrdb_11152004_Chlamydomonas]
  • type=protein; loc=2R:complement(6376278..6376648,6377290..6377312,6377677..6378556,6419544..6419624,6419686..6420399,6420623..6421016,6421081..6421254); ID=FBpp0088388; name=lola-PN; parent=FBgn0005630,FBtr0089354; dbxref=FlyBase_Annotation_IDs:CG12052-PN [fly-100309-contam.fasta]
  • CG12052-PN, isoform N [Drosophila melanogaster] [nr-271106-contam.fasta]
  • Longitudinals lacking protein, isoforms N/O/W/X/Y [nr-271106-contam.fasta]
  • longitudinals lacking CG12052-PN, isoform N [Drosophila melanogaster] [nr-271106-contam.fasta]
  • type=protein; loc=2R:complement(6376278..6376648,6377290..6377312,6377677..6378556,6419544..6419624,6419686..6420399,6420623..6421016,6421081..6421254); ID=FBpp0088388; name=lola-PN; parent=FBgn0005630,FBtr0089354; dbxref=FlyBase_Annotation_IDs:CG12052-PN,FlyBase:FBpp0088388,GB_protein:AAF58781.3,REFSEQ:NP_788308,GB_protein:AAF58781; MD5=028d301920d4bc6995a05dc284cbd8a4; length=878; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=2R:complement(6376278..6376648,6377290..6377312,6377677..6378556,6419544..6419624,6419686..6420399,6420623..6421016,6421081..6421254); ID=FBpp0088388; name=lola-PN; parent=FBgn0005630,FBtr0089354; dbxref=FlyBase_Annotation_IDs:CG12052-PN,FlyBase:FBpp0088388,GB_protein:AAF58781.3,REFSEQ:NP_788308,GB_protein:AAF58781; MD5=028d301920d4bc6995a05dc284cbd8a4; length=878; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • type=protein; loc=2R:complement(6376278..6376648,6377290..6377312,6377677..6378556,6419544..6419624,6419686..6420399,6420623..6421016,6421081..6421254); ID=FBpp0088388; name=lola-PN; parent=FBgn0005630,FBtr0089354; dbxref=FlyBase_Annotation_IDs:CG12052-PN,FlyBase:FBpp0088388,GB_protein:AAF58781.3,REFSEQ:NP_788308,GB_protein:AAF58781,FlyMine:FBpp0088388,modMine:FBpp0088388; MD5=028d301920d4bc6995a05dc284cbd8a4; length=878; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • Isoform of Q867Z4, Longitudinals lacking protein, isoforms N/O/W/X/Y OS=Drosophila melanogaster GN=lola PE=1 SV=3 [DROME.fasta.20160308]
    • Organism: Drosophila melanogaster
    Length: 878 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDA][NAS]
    Biological Process: regulation of gene-specific transcription [IMP]
    R7 cell development [IMP]
    axon guidance [IGI][IMP][NAS]
    nurse cell apoptosis [IMP]
    brain morphogenesis [IMP]
    R3/R4 cell fate commitment [IMP]
    inter-male aggressive behavior [IMP]
    regulation of transcription from RNA polymerase II promoter [NAS]
    locomotion involved in locomotory behavior [IMP]
    startle response [IMP]
    positive regulation of transcription, DNA-dependent [ISS]
    axonogenesis [IMP]
    axon midline choice point recognition [IGI][IMP]
    antimicrobial humoral response [IMP]
    Molecular Function: zinc ion binding [IEA]
    protein binding [IPI]
    RNA polymerase II transcription factor activity [NAS]
    specific RNA polymerase II transcription factor activity [ISS][NAS]
    transcription activator activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDDDQQFCLR WNNHQSTLIS VFDTLLENET LVDCTLAAEG KFLKAHKVVL SACSPYFATL  60
   61 LQEQYDKHPI FILKDVKYQE LRAMMDYMYR GEVNISQDQL AALLKAAESL QIKGLSDNRT 120
  121 GGGVAPKPES SGHHRGGKLS GAYTLEQTKR ARLATGGAMD TSGDVSGSRE GSSSPSRRRR 180
  181 KVRRRSMEND AHDNSNSSVL QAAASNQSIL QQTGAGLAVS ALVTTQLSSG PAAGTSSQAS 240
  241 STQQQQPLTS TNVTKKTESA KLTSSTAAPA SGASASAAVQ QAHLHQQQAQ TTSDAINTEN 300
  301 VQAQSQGGAQ GVQGDDEDID EGSAVGGPNS ATGPNPASAS ASAVHAGVVV KQLASVVDKS 360
  361 SSNHKHKIKD NSVSSVGSEM VIEPKAEYDD DAHDENVEDL TLDEEDMTME ELDQTAGTSQ 420
  421 GGEGSSQTYA TWQHDRSQDE LGLMAQDAQQ RDPQDGYWTI LETVPYSIAS AAPNQTLTTA 480
  481 TTLSNGGSSL LTGATVVVEL PPDDLGNPVG NIQYTIPALT KNATTNTNTT SLLHKPQATT 540
  541 IQIVKQQHQQ QHQQQHQHPQ QQHQPQQQQH RQHLTIQQSQ THARQEYIKI DTSRLEDKML 600
  601 LRDVMQYGAT SIAMAPQSAT TTVVSTHPVE SGLLLADADE AERELELEAM KVDQHDEEHL 660
  661 LDDEGYVIEK IHGDGETVNQ PQEKLYINGM SNIIHTATTM TLQPDDCKYA CNVCGKTYKI 720
  721 KGSLKRHKNY ECGVEPNLKC PHCPHKCKCV LAQVVNFVRH GPKNQLLCQC GRYYNTLSRL 780
  781 MLHQREECQD FKRFQCDFCL KWFKRRSHLN RHKKLHDAEL FLEPLSKQKP KTTSGQNLSH 840
  841 DANTDDEVAT TNPAATEDES NYPFTSEIKI ENEFDEFI

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..129] PSI-BLAST 32.0 Crystal Structure of the B-Cell Lymphoma 6 (BCL6) BTB domain to 2.2 Angstrom
    2 View Details [130..343] deduced N/A No confident structure predictions are available.
    3 View Details [344..493] deduced N/A No confident structure predictions are available.
    4 View Details [494..583] MSA 1.52199 View MSA. No confident structure predictions are available.
    5 View Details [584..631] deduced N/A No confident structure predictions are available.
    6 View Details [632..700] PSI-BLAST 19.69897 Five-finger GLI1
    7 View Details [701..878] PSI-BLAST 57.30103 No description for 2i13A was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • transcription regulator activity
    		•  4.03732153795237 bayes_pls_golite062009
  • DNA binding
    		•  3.50992893425527 bayes_pls_golite062009
  • nucleic acid binding
    		•  3.39650042677839 bayes_pls_golite062009
  • transcription repressor activity
    		•  3.34221155527033 bayes_pls_golite062009
  • transcription factor activity
    		•  2.77967244868934 bayes_pls_golite062009
  • binding
    		•  2.73171412378045 bayes_pls_golite062009
  • protein binding
    		•  2.43603601331034 bayes_pls_golite062009
  • gated channel activity
    		•  2.31670938272069 bayes_pls_golite062009
  • cation channel activity
    		•  2.29487032939987 bayes_pls_golite062009
  • ion channel activity
    		•  2.26817638058015 bayes_pls_golite062009
  • potassium channel activity
    		•  1.44385468589872 bayes_pls_golite062009
  • voltage-gated cation channel activity
    		•  1.43775565332764 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  1.43014386864286 bayes_pls_golite062009
  • channel activity
    		•  1.41924822300643 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  1.41924822300643 bayes_pls_golite062009
  • voltage-gated ion channel activity
    		•  1.41843723045096 bayes_pls_golite062009
  • substrate-specific channel activity
    		•  1.4152854884651 bayes_pls_golite062009
  • voltage-gated channel activity
    		•  1.40892835925684 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  1.3794923488776 bayes_pls_golite062009
  • voltage-gated potassium channel activity
    		•  1.37848954483947 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  1.36107960937272 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  1.34347609298791 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  1.32720756453806 bayes_pls_golite062009
  • transcription activator activity
    		•  1.3134483946218 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  1.2813343017365 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.933012980583336 bayes_pls_golite062009
  • specific transcriptional repressor activity
    		•  0.69971422997918 bayes_pls_golite062009
  • transporter activity
    		•  0.14391700968389 bayes_pls_golite062009
  • catalytic activity
    		•  0.112500532859479 bayes_pls_golite062009
  • chromatin binding
    		•  0.0908724449159477 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.0733959562343498 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.
    7 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.95

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle