Protein Overview: lola-PN

General Information:
Name(s) found:	lola-PN / FBpp0088388 [FlyBase]
Description(s) found: Found 15 descriptions. SHOW ALL	The gene longitudinals lacking is referred to in FlyBase by the symbol Dmel\lola (CG12052, FBgn0005630). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:6369712..6430767. It has the cytological map location 47A11-47A13. There is experimental evidence that it has the molecular function</span>: protein binding. There is experimental evidence for 12 unique biological process</span> terms, many of which group under: anatomical structure development; cell projection organization; cellular component movement; behavior; sensory organ development; organ morphogenesis; immune response; programmed cell death; neuromuscular process; behavioral interaction between organisms; locomotory behavior; regulation of metabolic process. 163 alleles are reported. The phenotypes of these alleles are annotated with 40 unique terms, many of which group under: peripheral nervous system; nervous system; abdominal lateral monoscolopidial chordotonal organ lch1; embryonic neuron; embryonic nervous system; organ system; multi-cell-component structure; adult segment; abdominal longitudinal muscle; ventral longitudinal muscle. It has 26 annotated transcripts and 26 annotated polypeptides. [FlyBase]
Organism:	Drosophila melanogaster
Length:	878 amino acids
Gene Ontology:
Cellular Component:	nucleus [IDA][NAS]
Biological Process:	regulation of gene-specific transcription [IMP] R7 cell development [IMP] axon guidance [IGI][IMP][NAS] nurse cell apoptosis [IMP] brain morphogenesis [IMP] R3/R4 cell fate commitment [IMP] inter-male aggressive behavior [IMP] regulation of transcription from RNA polymerase II promoter [NAS] locomotion involved in locomotory behavior [IMP] startle response [IMP] positive regulation of transcription, DNA-dependent [ISS] axonogenesis [IMP] axon midline choice point recognition [IGI][IMP] antimicrobial humoral response [IMP]
Molecular Function:	zinc ion binding [IEA] protein binding [IPI] RNA polymerase II transcription factor activity [NAS] specific RNA polymerase II transcription factor activity [ISS][NAS] transcription activator activity [ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDDDQQFCLR WNNHQSTLIS VFDTLLENET LVDCTLAAEG KFLKAHKVVL SACSPYFATL  60
   61 LQEQYDKHPI FILKDVKYQE LRAMMDYMYR GEVNISQDQL AALLKAAESL QIKGLSDNRT 120
  121 GGGVAPKPES SGHHRGGKLS GAYTLEQTKR ARLATGGAMD TSGDVSGSRE GSSSPSRRRR 180
  181 KVRRRSMEND AHDNSNSSVL QAAASNQSIL QQTGAGLAVS ALVTTQLSSG PAAGTSSQAS 240
  241 STQQQQPLTS TNVTKKTESA KLTSSTAAPA SGASASAAVQ QAHLHQQQAQ TTSDAINTEN 300
  301 VQAQSQGGAQ GVQGDDEDID EGSAVGGPNS ATGPNPASAS ASAVHAGVVV KQLASVVDKS 360
  361 SSNHKHKIKD NSVSSVGSEM VIEPKAEYDD DAHDENVEDL TLDEEDMTME ELDQTAGTSQ 420
  421 GGEGSSQTYA TWQHDRSQDE LGLMAQDAQQ RDPQDGYWTI LETVPYSIAS AAPNQTLTTA 480
  481 TTLSNGGSSL LTGATVVVEL PPDDLGNPVG NIQYTIPALT KNATTNTNTT SLLHKPQATT 540
  541 IQIVKQQHQQ QHQQQHQHPQ QQHQPQQQQH RQHLTIQQSQ THARQEYIKI DTSRLEDKML 600
  601 LRDVMQYGAT SIAMAPQSAT TTVVSTHPVE SGLLLADADE AERELELEAM KVDQHDEEHL 660
  661 LDDEGYVIEK IHGDGETVNQ PQEKLYINGM SNIIHTATTM TLQPDDCKYA CNVCGKTYKI 720
  721 KGSLKRHKNY ECGVEPNLKC PHCPHKCKCV LAQVVNFVRH GPKNQLLCQC GRYYNTLSRL 780
  781 MLHQREECQD FKRFQCDFCL KWFKRRSHLN RHKKLHDAEL FLEPLSKQKP KTTSGQNLSH 840
  841 DANTDDEVAT TNPAATEDES NYPFTSEIKI ENEFDEFI

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Searching the YRC Public Image Repository, found results:

Currently showing to of results.

[View Search in the YRC Public Image Repository]

Searching the YRC Public Image Repository, found no results.

Ginzu Version Information

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

Gene Ontology predictions

Term	Confidence	Notes
transcription regulator activity	4.03732153795237	bayes_pls_golite062009
DNA binding	3.50992893425527	bayes_pls_golite062009
nucleic acid binding	3.39650042677839	bayes_pls_golite062009
transcription repressor activity	3.34221155527033	bayes_pls_golite062009
transcription factor activity	2.77967244868934	bayes_pls_golite062009
binding	2.73171412378045	bayes_pls_golite062009
protein binding	2.43603601331034	bayes_pls_golite062009
gated channel activity	2.31670938272069	bayes_pls_golite062009
cation channel activity	2.29487032939987	bayes_pls_golite062009
ion channel activity	2.26817638058015	bayes_pls_golite062009
potassium channel activity	1.44385468589872	bayes_pls_golite062009
voltage-gated cation channel activity	1.43775565332764	bayes_pls_golite062009
substrate-specific transporter activity	1.43014386864286	bayes_pls_golite062009
channel activity	1.41924822300643	bayes_pls_golite062009
passive transmembrane transporter activity	1.41924822300643	bayes_pls_golite062009
voltage-gated ion channel activity	1.41843723045096	bayes_pls_golite062009
substrate-specific channel activity	1.4152854884651	bayes_pls_golite062009
voltage-gated channel activity	1.40892835925684	bayes_pls_golite062009
sequence-specific DNA binding	1.3794923488776	bayes_pls_golite062009
voltage-gated potassium channel activity	1.37848954483947	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	1.36107960937272	bayes_pls_golite062009
metal ion transmembrane transporter activity	1.34347609298791	bayes_pls_golite062009
ion transmembrane transporter activity	1.32720756453806	bayes_pls_golite062009
transcription activator activity	1.3134483946218	bayes_pls_golite062009
cation transmembrane transporter activity	1.2813343017365	bayes_pls_golite062009
RNA polymerase II transcription factor activity	0.933012980583336	bayes_pls_golite062009
specific transcriptional repressor activity	0.69971422997918	bayes_pls_golite062009
transporter activity	0.14391700968389	bayes_pls_golite062009
catalytic activity	0.112500532859479	bayes_pls_golite062009
chromatin binding	0.0908724449159477	bayes_pls_golite062009
transmembrane transporter activity	0.0733959562343498	bayes_pls_golite062009

No functions predicted.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.95

Source: Reynolds et al. (2008)

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..129]	PSI-BLAST	32.0	Crystal Structure of the B-Cell Lymphoma 6 (BCL6) BTB domain to 2.2 Angstrom
2	View Details	[130..343]	deduced	N/A	No confident structure predictions are available.
3	View Details	[344..493]	deduced	N/A	No confident structure predictions are available.
4	View Details	[494..583]	MSA	1.52199	View MSA. No confident structure predictions are available.
5	View Details	[584..631]	deduced	N/A	No confident structure predictions are available.
6	View Details	[632..700]	PSI-BLAST	19.69897	Five-finger GLI1
7	View Details	[701..878]	PSI-BLAST	57.30103	No description for 2i13A was found.

Protein Overview: lola-PN

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: