Protein Overview: E2AK3_RAT

General Information:
Name(s) found:	E2AK3_RAT [Swiss-Prot]
Description(s) found: SHOW ONLY BEST	pir\|\|T17455 translation initiation factor eIF-2 alpha chain kinase (EC 2.7.1.-) - rat [NCBI NR] gi\|3983101\|gb\|AAC83801.1\| pancreatic eukaryotic initiation factor 2 alpha-subunit kinase [Rattus norvegicus] [NCBI NR] gi\|17374701\|sp\|Q9Z1Z1.1\|E2AK3_RAT RecName: Full=Eukaryotic translation initiation factor 2-alpha kinase 3; AltName: Full=PRKR-like endoplasmic reticulum kinase; AltName: Full=Pancreatic eIF2-alpha kinase; Flags: Precursor [NCBI NR] gi\|149036360\|gb\|EDL90978.1\| eukaryotic translation initiation factor 2 alpha kinase 3, isoform CRA_a [Rattus norvegicus] [NCBI NR] gi\|13928816\|ref\|NP_113787.1\| eukaryotic translation initiation factor 2-alpha kinase 3 [Rattus norvegicus] [NCBI NR] (Q9Z1Z1) Eukaryotic translation initiation factor 2-alpha kinase 3 precursor (EC 2.7.1.-) (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase) [Swiss-Prot] Eukaryotic translation initiation factor 2-alpha kinase 3 OS=Rattus norvegicus GN=Eif2ak3 PE=1 SV=1 [Swiss-Prot] eukaryotic translation initiation factor 2 alpha kinase 3 [HMR_022704-rand.fasta] eukaryotic translation initiation factor 2 alpha kinase 3 [Rattus norvegicus]gi\|17374701\|sp\|Q9Z1Z1\|E2K3_RAT Eukaryotic translation initiation factor 2-alpha kinase 3 precursor (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase)gi\|398 [nrdb_11152004_Chlamydomonas] Tax_Id=10116 Eukaryotic translation initiation factor 2-alpha kinase 3 precursor [EBI-IPI_rat_3.17_05-10-2006_con_reversed.fasta] (NM_031599) eukaryotic translation initiation factor 2 alpha kinase 3 [Rattus norvegicus] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta] Eukaryotic translation initiation factor 2-alpha kinase 3 precursor (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] eukaryotic translation initiation factor 2 alpha kinase 3 [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] eukaryotic translation initiation factor 2 alpha kinase 3, isoform CRA_a [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] pancreatic eukaryotic initiation factor 2 alpha-subunit kinase [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Tax_Id=10116 EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE 3 PRECURSOR [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta] Tax_Id=10116 Gene_Symbol=Eif2ak3 Eukaryotic translation initiation factor 2-alpha kinase 3 [rat-ipi-250309-contam.fasta] Eukaryotic translation initiation factor 2-alpha kinase 3 OS=Rattus norvegicus GN=Eif2ak3 [011711_HMR.fasta]
Organism:	Rattus norvegicus
Length:	1108 amino acids
Gene Ontology:
Cellular Component:	endoplasmic reticulum membrane [UNKNOWN][IEA] cell [IDA] cytoplasm [UNKNOWN][IEA] membrane [IEA] integral to membrane [IEA] endoplasmic reticulum [UNKNOWN][IEA]
Biological Process:	positive regulation of protein binding [UNKNOWN][IEA] insulin secretion [UNKNOWN][IEA] negative regulation of translation in response to stress [IDA] chondrocyte development [UNKNOWN][IEA] protein amino acid autophosphorylation [UNKNOWN][IDA][IMP][ISS] lactation [UNKNOWN][IEA] fat cell differentiation [UNKNOWN][IEA] protein amino acid phosphorylation [UNKNOWN][IDA][IMP] response to unfolded protein [IEA] ER overload response [UNKNOWN][ISS] skeletal system development [UNKNOWN][IEA] ossification [UNKNOWN][ISS] endoplasmic reticulum unfolded protein response [UNKNOWN][ISS] apoptosis [UNKNOWN] activation of caspase activity [UNKNOWN][IEA] calcium-mediated signaling [UNKNOWN][IEA] negative regulation of translation [UNKNOWN] endocrine pancreas development [UNKNOWN][ISS] pancreas development [UNKNOWN] bone mineralization [UNKNOWN][IEA] insulin-like growth factor receptor signaling pathway [UNKNOWN][IEA] protein homooligomerization [UNKNOWN][ISS] endoplasmic reticulum organization [UNKNOWN][IEA] positive regulation of signal transduction [UNKNOWN][IEA] translation [UNKNOWN] SREBP-mediated signaling pathway [UNKNOWN][IEA] virus-infected cell apoptosis [UNKNOWN][IEA] negative regulation of translational initiation in response to stress [TAS] negative regulation of myelination [UNKNOWN][IEA] response to endoplasmic reticulum stress [UNKNOWN] regulation of fatty acid metabolic process [UNKNOWN][IEA]
Molecular Function:	nucleotide binding [IEA] ATP binding [IEA] identical protein binding [UNKNOWN][IEA] protein binding [UNKNOWN] protein kinase activity [UNKNOWN] eukaryotic translation initiation factor 2alpha kinase activity [UNKNOWN][IDA][IMP][ISS] protein serine/threonine kinase activity [UNKNOWN][IDA] transferase activity [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MERATQPRPR ALLLLFLLLG CAAGISAVAR ARSLLAPTSD TAFGLGAAAA PTSAARVPAV  60
   61 ATAEVTVEDA EALPAASGEQ ESRATESDDD VELRPRGRSL VIISTLDGRI AALDAENHGK 120
  121 KQWDLDVGSG SLVSSSLSKP EVFGNKMIIP SLDGDLFQWD RDRESMEAVP FTVESLLESS 180
  181 YKFGDDVVLV GGKSLTTYGL SAYSGKLRYI CSALGCRRWD SDEMEEEEDI LLLQRTQKTV 240
  241 RAVGPRSGSE KWNFSVGHFE LRYIPDMETR AGFIESTFKL GGNKEDSKII SDVEEQDVDT 300
  301 VIKVSVADWK VMAFSKKGGR LEWEYQFCTP IASAWLVRDG KVIPISLFDD TSYTANEEVL 360
  361 EDEEDIVEAA RGATENSVYL GMYRGQLYLQ SSVRVSEKFP TRPKALESVN GESAIIPLPT 420
  421 IKWKPLIHSP SRTPVLVGSD EFDKCLSNDK YSHEEYSNGA LSILQYPYDN GYYLPYYKRE 480
  481 RNKRSTQITV RFLDSPHYSK NIRKKDPILL LHWWKEIFGT ILLCIVATTF IVRRLFHPQP 540
  541 HRQRKESETQ CQTESKYDSV SADNSDNSWN DIKHSGYVSR YLTDFEPIQC MGRGGFGVVF 600
  601 EAKNKVDDCN YAIKRIRLPN RELAREKVMR EVKALAKLEH PGIVRYFNAW LETPPEKWQE 660
  661 EMDEIWLKDE STDWPLSSPS PMDAPSVKIR QMDPFSTKEQ IEVIAPSPER SRSFSVGISC 720
  721 GRTSSSESQF SPLEFSGTDC GDNSDSEDAA HNLQDSCLTD CDMEDGTVDG DDEGHSFELC 780
  781 PSEASPYTRS REGTSSSIVF EDSGCDNASS KEDPRMNRLH NGHHYVNKLT EFKHSSSRSS 840
  841 SEATLSTSPT RPTTLSLDFT RNTVDRLQPS SPKVYLYIQM QLCRKENLKD WMNRRCSMED 900
  901 REHRVCLHIF LQIAEAVQFL HSKGLMHRDL KPSNIFFTMD DVVKVGDFGL VTAMDQDEEE 960
  961 QTVLTPMPAY ATHTGQVGTK LYMSPEQIHG NNYSHKVDIF SLGLILFELL YPFSTQMERV1020
 1021 RTLTDVRNLK FPPLFTQKYP QEHMMVQDML SPSPMERPEA TDIIENAVFE NLEFPGKTVL1080
 1081 RQRSRSLSSS GTKHSRQPSS TFSPLPGN

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein Overview: E2AK3_RAT

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: