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Protein Overview: grk-2

General Information:
Name(s) found: grk-2 / CE32946 [WormBase]
Description(s) found:
Found 19 descriptions.
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  • WBGene00001709 locus:grk-2 G protein-coupled receptor kinase 2 status:Partially_confirmed UniProt:Q09639 protein_id:CCD63981.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 707 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: chemotaxis [IMPLink to PubMed article]
    positive regulation of growth rate [IGILink to PubMed article]
    olfactory behavior [IMPLink to PubMed article]
    protein amino acid phosphorylation [IEALink to PubMed article]
    hyperosmotic response [IMPLink to PubMed article]
    multicellular organismal process [IGILink to PubMed article]
    Molecular Function: magnesium ion binding [IEALink to PubMed article]
    ATP binding [IEALink to PubMed article]
    protein tyrosine kinase activity [IEALink to PubMed article]
    zinc ion binding [IEALink to PubMed article]
    protein kinase activity [IEALink to PubMed article]
    protein serine/threonine kinase activity [IEALink to PubMed article]
    signal transducer activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MADLEAVLAD VSYLMAMEKS RSQPAARASK RIVLPDPSVR SIMQKFLEKS GDMKFDKIFN  60
   61 QKLGFLLLKD YAENVSESPC PQIKFYEAIK EYEKMETPDE RLTKAREIYD HHIMVEMLAH 120
  121 AHNYSKESLQ HVQYHLLKQN VPPDLFHRYV LEICDQLRGD IFQRFLESDK FTRFCQWKNL 180
  181 ELNMQLTMND FSVHRIIGRG GFGEVYGCRK ADTGKMYAMK CLDKKRIKMK QGETLALNER 240
  241 IMLSLVSTGQ DCPFIVCMTY AFQSPDKLCF ILDLMNGGDL HYHLSQHGVF TEQEMIFYAS 300
  301 EVILGLEHMH NRFVVYRDLK PANILLDENG HVRVSDLGLA CDYSKKKPHA SVGTHGYMAP 360
  361 EVLAKGVAYD SSADWFSLGC MLYKLLKGHS PFRQHKSKDK NEIDKMTLTQ DIELPNEGLS 420
  421 KDCRDLLEGL LKRDVPDRLG CRGKGPTEVK EHPFFKDVDW QTVYLRRMTP PLIPPRGEVN 480
  481 AADAFDIGNF DDDEVKGVKL QDGDSDLYKN FNIVISERWQ NEIAETIFEV VNQDADKAES 540
  541 KKRSKQKIKV AVEEKDSDVI VHGYIKKLGG PFTSAWQTKY GKLYPSRLEL YPESLTAKPE 600
  601 LVFMDQIEDV CAEMQTIKGE TAIIVKLRDG FKEPKICLTN SDEISLKEWH TSLRTAHKVS 660
  661 QELLQRMGRK AIKIYGVNHD PMLSESERPG SVTRAFLNRA SSVDSGV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..707] PSI-BLAST 153.0 G-protein coupled receptor kinase 2, N-terminal domain; G-protein coupled receptor kinase 2 (beta-adrenergic receptor kinase 1); G-protein coupled receptor kinase 2

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • cyclic nucleotide-dependent protein kinase activity
    		•  4.97855712164511 bayes_pls_golite062009
  • insulin-like growth factor receptor binding
    		•  4.68588428747284 bayes_pls_golite062009
  • cAMP-dependent protein kinase activity
    		•  4.66277812893755 bayes_pls_golite062009
  • structural molecule activity
    		•  4.25992091947152 bayes_pls_golite062009
  • SH2 domain binding
    		•  4.2225235101534 bayes_pls_golite062009
  • actin binding
    		•  3.72754591832642 bayes_pls_golite062009
  • phosphoinositide 3-kinase binding
    		•  3.48970773098023 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  3.48744511411671 bayes_pls_golite062009
  • binding
    		•  3.29080729281876 bayes_pls_golite062009
  • insulin receptor activity
    		•  3.256741381527 bayes_pls_golite062009
  • protein binding
    		•  3.17213698546013 bayes_pls_golite062009
  • PTB domain binding
    		•  3.02789234463297 bayes_pls_golite062009
  • insulin receptor binding
    		•  2.87341016128079 bayes_pls_golite062009
  • tau-protein kinase activity
    		•  2.37138140221719 bayes_pls_golite062009
  • tubulin binding
    		•  2.18641675163967 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.10584700564436 bayes_pls_golite062009
  • actin filament binding
    		•  2.03444575838575 bayes_pls_golite062009
  • microtubule binding
    		•  1.88110801192607 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  1.8384977631304 bayes_pls_golite062009
  • acetylcholine receptor activator activity
    		•  1.83545227594542 bayes_pls_golite062009
  • receptor signaling protein serine/threonine kinase activity
    		•  1.81249386965144 bayes_pls_golite062009
  • DNA binding
    		•  1.77960272183811 bayes_pls_golite062009
  • armadillo repeat domain binding
    		•  1.70850996351356 bayes_pls_golite062009
  • insulin receptor substrate binding
    		•  1.62657794525303 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.55319485371003 bayes_pls_golite062009
  • signal transducer activity
    		•  1.55319485371003 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.55295906221034 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.53043443218632 bayes_pls_golite062009
  • kinase activity
    		•  1.49733072352288 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.36365892826676 bayes_pls_golite062009
  • ErbB-3 class receptor binding
    		•  1.34841233233438 bayes_pls_golite062009
  • protein kinase activity
    		•  1.34246406302496 bayes_pls_golite062009
  • ErbB-2 class receptor binding
    		•  1.33825339298024 bayes_pls_golite062009
  • transporter activity
    		•  1.28986800087234 bayes_pls_golite062009
  • gamma-tubulin binding
    		•  1.28511591054866 bayes_pls_golite062009
  • brain-derived neurotrophic factor binding
    		•  1.28495809513039 bayes_pls_golite062009
  • insulin binding
    		•  1.23861703046323 bayes_pls_golite062009
  • receptor activity
    		•  1.1755016270537 bayes_pls_golite062009
  • enzyme binding
    		•  1.17212675145623 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  1.1152029796159 bayes_pls_golite062009
  • transcription factor activity
    		•  1.10928254946881 bayes_pls_golite062009
  • phospholipid binding
    		•  1.09683218092034 bayes_pls_golite062009
  • Ran GTPase binding
    		•  1.07023555877478 bayes_pls_golite062009
  • transferase activity
    		•  1.05502123133116 bayes_pls_golite062009
  • receptor binding
    		•  1.00859318603128 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  1.00400540041137 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.97575992765505 bayes_pls_golite062009
  • oxidoreductase activity
    		•  0.965872107791437 bayes_pls_golite062009
  • kinase binding
    		•  0.961706066143 bayes_pls_golite062009
  • cyclin-dependent protein kinase activity
    		•  0.959360414036299 bayes_pls_golite062009
  • protein domain specific binding
    		•  0.90578029954417 bayes_pls_golite062009
  • JUN kinase kinase kinase kinase activity
    		•  0.886904175966993 bayes_pls_golite062009
  • growth factor binding
    		•  0.86076618871384 bayes_pls_golite062009
  • insulin-like growth factor II binding
    		•  0.856861384729301 bayes_pls_golite062009
  • MAP kinase activity
    		•  0.81943579965027 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.79883446648737 bayes_pls_golite062009
  • phosphoinositide binding
    		•  0.71817045430443 bayes_pls_golite062009
  • structural constituent of muscle
    		•  0.70794260327482 bayes_pls_golite062009
  • protein kinase binding
    		•  0.67284191028382 bayes_pls_golite062009
  • profilin binding
    		•  0.66906205737225 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.611829373978789 bayes_pls_golite062009
  • Janus kinase activity
    		•  0.580310109637219 bayes_pls_golite062009
  • I-SMAD binding
    		•  0.568054578050901 bayes_pls_golite062009
  • protein complex binding
    		•  0.55916857709427 bayes_pls_golite062009
  • protein serine/threonine/tyrosine kinase activity
    		•  0.48345772948903 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.450699332958421 bayes_pls_golite062009
  • protein kinase C activity
    		•  0.41587987561486 bayes_pls_golite062009
  • magnesium ion binding
    		•  0.393328812780268 bayes_pls_golite062009
  • 3-phosphoinositide-dependent protein kinase binding
    		•  0.372842462336059 bayes_pls_golite062009
  • MAP kinase kinase kinase activity
    		•  0.37115026509016 bayes_pls_golite062009
  • mRNA binding
    		•  0.369721687873392 bayes_pls_golite062009
  • GTPase regulator activity
    		•  0.355387992614734 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.35466574267734 bayes_pls_golite062009
  • MAP kinase kinase activity
    		•  0.35402045013148 bayes_pls_golite062009
  • nucleoside-triphosphatase regulator activity
    		•  0.335498703113274 bayes_pls_golite062009
  • RNA binding
    		•  0.324381862881119 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase signaling protein activity
    		•  0.28468123649303 bayes_pls_golite062009
  • transmembrane receptor protein serine/threonine kinase activity
    		•  0.20643152368029 bayes_pls_golite062009
  • transforming growth factor beta receptor activity
    		•  0.20643152368029 bayes_pls_golite062009
  • enzyme regulator activity
    		•  0.189879136353541 bayes_pls_golite062009
  • photoreceptor activity
    		•  0.187612589250841 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.148194101970458 bayes_pls_golite062009
  • G-protein-coupled receptor binding
    		•  0.12466518799375 bayes_pls_golite062009
  • peptide binding
    		•  0.118578378753757 bayes_pls_golite062009
  • alpha-catenin binding
    		•  0.102004310679969 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.0611639610381174 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.0524559849408587 bayes_pls_golite062009
  • transforming growth factor beta receptor activity, type I
    		•  0.0506751594607393 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.0498422520006935 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.0040394359628233 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle