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Protein Overview: rad-51

General Information:
Name(s) found: rad-51 / CE29064 [WormBase]
Description(s) found:
Found 16 descriptions.
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  • WBGene00004297 locus:rad-51 status:Confirmed UniProt:Q95Q25 protein_id:CAB61038.2 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 395 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article][IEALink to PubMed article]
    germ cell nucleus [IDALink to PubMed article]
    intracellular [IEALink to PubMed article]
    condensed nuclear chromosome [IDALink to PubMed article]
    Biological Process: DNA repair [IEALink to PubMed article]
    meiotic chromosome condensation [IMPLink to PubMed article]
    reciprocal meiotic recombination [IEALink to PubMed article]
    embryonic development ending in birth or egg hatching [IMPLink to PubMed articleLink to PubMed articleLink to PubMed articleLink to PubMed article]
    negative regulation of apoptosis [IMPLink to PubMed article]
    DNA recombination [IEALink to PubMed article]
    DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis [IGILink to PubMed article]
    chromosome segregation [IMPLink to PubMed article]
    response to DNA damage stimulus [IMPLink to PubMed article]
    DNA metabolic process [IEALink to PubMed article]
    Molecular Function: nucleotide binding [IEALink to PubMed article]
    DNA binding [IEALink to PubMed article]
    ATP binding [IEALink to PubMed article]
    DNA-dependent ATPase activity [IEALink to PubMed article]
    nucleoside-triphosphatase activity [IEALink to PubMed article]
    sequence-specific DNA binding [IEALink to PubMed article]
    damaged DNA binding [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGQSWGYEGI AKRSLCTHKW LYNLNLHSIN LFLPIESKMS AQASRQKKSD QEQRAADQAL  60
   61 LNAAIEDNAM EQDENFTVID KLESSGISSG DISKLKEAGY YTYESLAFTT RRELRNVKGI 120
  121 SDQKAEKIMK EAMKFVQMGF TTGAEVHVKR SQLVQIRTGS ASLDRLLGGG IETGSITEVY 180
  181 GEYRTGKTQL CHSLAVLCQL PIDMGGGEGK CMYIDTNATF RPERIIAIAQ RYNMDSAHVL 240
  241 ENIAVARAYN SEHLMALIIR AGAMMSESRY AVVIVDCATA HFRNEYTGRG DLAERQMKLS 300
  301 AFLKCLAKLA DEYGVAVIIT NQVVAQVDGG ASMFQADAKK PIGGHIIAHM STTRLYLRKG 360
  361 KGENRVAKMV QSPNLPEAEA TYSITNHGIE DARED

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..74] PSI-BLAST 17.522879 N-terminal domain of DnaB helicase
    2 View Details [75..395] PSI-BLAST 76.0 A Crystal Structure of the Rad51 Filament

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • DNA helicase activity
    		•  9.26997966081452 bayes_pls_golite062009
  • DNA-dependent ATPase activity
    		•  6.08870471440355 bayes_pls_golite062009
  • ATP-dependent DNA helicase activity
    		•  5.45262775532714 bayes_pls_golite062009
  • helicase activity
    		•  4.28397455986496 bayes_pls_golite062009
  • purine NTP-dependent helicase activity
    		•  3.663510450664 bayes_pls_golite062009
  • ATP-dependent helicase activity
    		•  3.663510450664 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  2.97659021862014 bayes_pls_golite062009
  • ATPase activity, coupled
    		•  2.94159549461095 bayes_pls_golite062009
  • hydrolase activity
    		•  2.93824265320761 bayes_pls_golite062009
  • ATPase activity
    		•  2.91512649893171 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  2.90294890063489 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  2.88373077621612 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  2.88156619844481 bayes_pls_golite062009
  • binding
    		•  1.9180887037845 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.9087142423581 bayes_pls_golite062009
  • DNA binding
    		•  1.87185414119548 bayes_pls_golite062009
  • catalytic activity
    		•  1.58067730905989 bayes_pls_golite062009
  • protein binding
    		•  1.45202848418786 bayes_pls_golite062009
    2
    Term Confidence Notes
  • four-way junction helicase activity
    		•  6.34056703603795 bayes_pls_golite062009
  • DNA helicase activity
    		•  5.64236969551706 bayes_pls_golite062009
  • DNA clamp loader activity
    		•  3.22518920754305 bayes_pls_golite062009
  • protein-DNA loading ATPase activity
    		•  3.19273435123154 bayes_pls_golite062009
  • transporter activity
    		•  3.13325129560423 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  2.92327745911863 bayes_pls_golite062009
  • motor activity
    		•  2.79327761685782 bayes_pls_golite062009
  • microtubule motor activity
    		•  2.74365461017633 bayes_pls_golite062009
  • DNA-dependent ATPase activity
    		•  2.72462789867829 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  2.69246499202248 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  2.66107861968804 bayes_pls_golite062009
  • binding
    		•  2.64537357529343 bayes_pls_golite062009
  • bubble DNA binding
    		•  2.62179925837003 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  2.61582393123755 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  2.59641929642359 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  2.59333672868803 bayes_pls_golite062009
  • hydrolase activity
    		•  2.55157966585974 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.21184938313192 bayes_pls_golite062009
  • ATPase activity
    		•  2.11122403732968 bayes_pls_golite062009
  • double-strand/single-strand DNA junction binding
    		•  2.02697209084624 bayes_pls_golite062009
  • telomeric DNA binding
    		•  1.98044285764127 bayes_pls_golite062009
  • DNA binding
    		•  1.94055378599526 bayes_pls_golite062009
  • ATPase activity, coupled
    		•  1.8908019270286 bayes_pls_golite062009
  • ATP-dependent DNA helicase activity
    		•  1.88455339138556 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.83584389083042 bayes_pls_golite062009
  • helicase activity
    		•  1.70242731830224 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  1.40488517180956 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  1.37694050923424 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  1.2539059700735 bayes_pls_golite062009
  • protein transporter activity
    		•  1.25342367751911 bayes_pls_golite062009
  • protein binding
    		•  1.22129154759482 bayes_pls_golite062009
  • purine NTP-dependent helicase activity
    		•  1.19311444180077 bayes_pls_golite062009
  • ATP-dependent helicase activity
    		•  1.19311444180077 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  1.117585097627 bayes_pls_golite062009
  • catalytic activity
    		•  1.00104173493322 bayes_pls_golite062009
  • tubulin binding
    		•  0.979946830272106 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.97700154207756 bayes_pls_golite062009
  • DNA-directed DNA polymerase activity
    		•  0.971476020912368 bayes_pls_golite062009
  • DNA polymerase activity
    		•  0.928091843881235 bayes_pls_golite062009
  • microtubule binding
    		•  0.907162506177187 bayes_pls_golite062009
  • actin binding
    		•  0.883285269827407 bayes_pls_golite062009
  • single-stranded telomeric DNA binding
    		•  0.847538346941812 bayes_pls_golite062009
  • double-stranded telomeric DNA binding
    		•  0.75018916645383 bayes_pls_golite062009
  • transcription activator activity
    		•  0.739301862805678 bayes_pls_golite062009
  • purine nucleotide binding
    		•  0.725611289205392 bayes_pls_golite062009
  • nucleotide binding
    		•  0.717697610309727 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  0.713814218071151 bayes_pls_golite062009
  • ribonucleotide binding
    		•  0.713752628021599 bayes_pls_golite062009
  • transcription factor activity
    		•  0.697256579145077 bayes_pls_golite062009
  • guanyl nucleotide binding
    		•  0.656009904481476 bayes_pls_golite062009
  • guanyl ribonucleotide binding
    		•  0.64416740142962 bayes_pls_golite062009
  • GTP binding
    		•  0.643084645864898 bayes_pls_golite062009
  • single-stranded DNA binding
    		•  0.568457189190858 bayes_pls_golite062009
  • recombinase activity
    		•  0.45851158693664 bayes_pls_golite062009
  • GTPase activity
    		•  0.437665353870877 bayes_pls_golite062009
  • RNA helicase activity
    		•  0.34746349346164 bayes_pls_golite062009
  • histone acetyltransferase activity
    		•  0.328186246219424 bayes_pls_golite062009
  • lysine N-acetyltransferase activity
    		•  0.328186246219424 bayes_pls_golite062009
  • centromeric DNA binding
    		•  0.322818640526369 bayes_pls_golite062009
  • mismatched DNA binding
    		•  0.31144582840038 bayes_pls_golite062009
  • ATP-dependent RNA helicase activity
    		•  0.30832907234141 bayes_pls_golite062009
  • RNA-dependent ATPase activity
    		•  0.29532978396745 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  0.208665086324262 bayes_pls_golite062009
  • ATP binding
    		•  0.19169045543599 bayes_pls_golite062009
  • exodeoxyribonuclease V activity
    		•  0.185603938981231 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  0.165732470448462 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  0.162060759063149 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.114463153989353 bayes_pls_golite062009
  • microfilament motor activity
    		•  0.10236059675512 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.081265446432119 bayes_pls_golite062009
  • 3'-5' DNA helicase activity
    		•  0.0769112340058804 bayes_pls_golite062009
  • protein transmembrane transporter activity
    		•  0.0378638259240902 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.96

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle