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Protein Overview: ima-3

General Information:
Name(s) found: ima-3 / CE20745 [WormBase]
Description(s) found:
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  • WBGene00002074 locus:ima-3 Importin subunit alpha-3 status:Confirmed UniProt:Q19969 protein_id:CCD70435.1 [WormBase]
  • pir||T42402 importin alpha 1 - Caenorhabditis elegans [NCBI NR]
  • gi|4883510|gb|AAA83354.2| Importin alpha family protein 3 [Caenorhabditis elegans] [NCBI NR]
  • gi|2795929|gb|AAB97171.1| importin alpha 3 [Caenorhabditis elegans] [NCBI NR]
  • gi|17540124|ref|NP_501227.1| IMportin Alpha family member (ima-3) [Caenorhabditis elegans] [NCBI NR]
  • gi|10720392|sp|Q19969.2|IMA3_CAEEL RecName: Full=Importin subunit alpha-3; AltName: Full=Karyopherin subunit alpha-3 [NCBI NR]
  • Importin subunit alpha-3 OS=Caenorhabditis elegans GN=ima-3 PE=1 SV=2 [Swiss-Prot]
  • [wormpep67.fasta]
  • CE20745 WBGene00002074 locus:ima-3 importin alpha, nuclear transport factor status:Confirmed SW:Q19969 protein_id:AAA83354.2 [wormpep150.fasta]
  • 20745 WBGene00002074 locus:ima-3 importin alpha, nuclear transport factor status:Confirmed SW:Q19969 protein_id:AAA83354.2 [wormpep130-phg-ecoli-orf-rand.fasta]
  • IMportin Alpha (56.2 kD) (ima-3) [Caenorhabditis elegans]gi|4883510|gb|AAA83354.2| Importin alpha family protein 3 [Caenorhabditis elegans]gi|2795929|gb|AAB97171.1| importin alpha 3 [Caenorhabditis elegans]gi|7511453|pir||T42402 importin alpha 1 - Caen [nrdb_11152004_Chlamydomonas]
  • locus:ima-3 importin alpha, nuclear transport factor status:Confirmed SW:Q19969 protein_id:AAA83354.2 [wormpep115.fasta.reversed]
  • CE20745 locus:ima-3 serine-rich RNA polymerase I suppressor protein (SRP1) status:Confirmed [wormpep80.hongbin]
  • CE20745 WBGene00002074 locus:ima-3 importin alpha, nuclear transport factor status:Confirmed UniProt:Q19969 protein_id:AAA83354.2 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta]
  • CE20745 WBGene00002074 locus:ima-3 importin alpha, nuclear transport factor status:Confirmed UniProt:Q19969 protein_id:AAA83354.2| [wormORF-contam.fasta]
  • importin alpha 3 [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • Importin alpha family protein 3 [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • Importin alpha-3 subunit (Karyopherin alpha-3 subunit) [nr-271106-contam.fasta]
  • IMportin Alpha family member (ima-3) [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr]
  • CE20745 WBGene00002074 locus:ima-3 importin alpha, nuclear transport factor status:Confirmed UniProt:Q19969 protein_id:CCD70435.1 [wormbase_c_elegans_ws231_03-13-2012_reversed.fasta]
  • CE20745 WBGene00002074 locus:ima-3 status:Confirmed UniProt:Q19969 protein_id:CCD70435.1 Importin subunit alpha-3 [wormpep246-ecoli-contam.fasta]
    • Organism: Caenorhabditis elegans
    Length: 514 amino acids

    Gene Ontology:
    Cellular Component: nuclear envelope [IDALink to PubMed article]
    nucleus [IEALink to PubMed article]
    cytoplasm [IDALink to PubMed article][IEALink to PubMed article]
    nuclear pore [IEALink to PubMed article]
    Biological Process: nuclear pore organization [IMPLink to PubMed article]
    locomotory behavior [IMPLink to PubMed article]
    oogenesis [IMPLink to PubMed article]
    nematode larval development [IMPLink to PubMed articleLink to PubMed article]
    embryonic development ending in birth or egg hatching [IMPLink to PubMed articleLink to PubMed articleLink to PubMed articleLink to PubMed article]
    protein import into nucleus [IEALink to PubMed article]
    gamete generation [IMPLink to PubMed article]
    meiotic prophase I [IMPLink to PubMed article]
    intracellular protein transport [IEALink to PubMed article]
    reproduction [IMPLink to PubMed article]
    growth [IMPLink to PubMed article]
    Molecular Function: protein binding [IPILink to PubMed article]
    protein transporter activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSNRQAYYK NNAKEQIGKE KRNEEVVSIR KDKREEAISK RRNINTQIED DSETSTTPPG  60
   61 PFDANLLRLT VAAAQSSDPA EQLTAVQQAR KMLSTDRNPP IDDLIGSGIL PVLVQCLSST 120
  121 DPNLQFEAAW ALTNIASGTS EQTQAVVNAG AVPLFLQLLS CGNLNVCEQS VWALGNIIGD 180
  181 GPHFRDYCLE LGILQPLLQF INPEIPIGFL RNVTWVIVNL CRCKDPAPSP AVVRTILPAL 240
  241 SLLIHHQDTN ILIDTVWALS YLTDGGNEHI QMVIEAQVVT HLVPLLGHVD VKVQTAALRA 300
  301 VGNIVTGTDE QTQLVLDSGV LRFMPGLLAH YKEKINKEAV WFVSNITAGN QQQVQDVFDA 360
  361 GIMPMIIHLL DRGDFPTQKE AAWAISNVTI SGRPNQVEQM VKLGVLRPFC AMLSCTDSQI 420
  421 IQVVLDGINN ILKMAGEAAE QVTSEIEECG GLDKIENLQN HENEDIYKLA FEIIDNFFSS 480
  481 DDETGNVEGA QSSAFGGDVP PVPDAPNGGW NFGK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..514] PSI-BLAST 101.0 Crystal structure of the exportin Cse1p complexed with its cargo ( Kap60p) and RanGTP

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • protein transporter activity
    		•  4.58709163830613 bayes_pls_golite062009
  • nuclear export signal receptor activity
    		•  3.48172991171337 bayes_pls_golite062009
  • binding
    		•  3.0667965351474 bayes_pls_golite062009
  • actin binding
    		•  2.8014924948341 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.74745843355294 bayes_pls_golite062009
  • protein transmembrane transporter activity
    		•  2.74547353635661 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  2.61566088685247 bayes_pls_golite062009
  • transporter activity
    		•  2.48700774379895 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  2.26725422172281 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.16673352512615 bayes_pls_golite062009
  • DNA binding
    		•  1.95242774903625 bayes_pls_golite062009
  • nuclear localization sequence binding
    		•  1.91487015967262 bayes_pls_golite062009
  • protein binding
    		•  1.73688475473996 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.32874350341969 bayes_pls_golite062009
  • signal transducer activity
    		•  1.32874350341969 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.28481004323799 bayes_pls_golite062009
  • transcription factor activity
    		•  1.20660383756339 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  1.09652988954158 bayes_pls_golite062009
  • signal sequence binding
    		•  0.57106697498903 bayes_pls_golite062009
  • RNA binding
    		•  0.40024158562931 bayes_pls_golite062009
  • structural molecule activity
    		•  0.279926218252647 bayes_pls_golite062009
  • importin-alpha export receptor activity
    		•  0.259676026705859 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.252495966234234 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.248585912061178 bayes_pls_golite062009
  • primary active transmembrane transporter activity
    		•  0.226380819487924 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven transmembrane transporter activity
    		•  0.217517113570989 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
    		•  0.178770060806735 bayes_pls_golite062009
  • ATPase activity, coupled to movement of substances
    		•  0.175241020572885 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of substances
    		•  0.174922130116569 bayes_pls_golite062009
  • transcription activator activity
    		•  0.160275383613705 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.100181463251306 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.0635404099346928 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.0548082069333885 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.052195223119721 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  0.0405268469927988 bayes_pls_golite062009
  • transcription factor binding
    		•  0.0221966060394205 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle