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Protein Overview: daf-4

General Information:
Name(s) found: daf-4 / CE16827 [WormBase]
Description(s) found:
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  • WBGene00000900 locus:daf-4 Cell surface receptor daf-4 status:Confirmed UniProt:P50488 protein_id:CCD63118.1 [WormBase]
  • gi|32470609|sp|P50488.2|DAF4_CAEEL RecName: Full=Cell surface receptor daf-4; AltName: Full=Abnormal dauer formation protein 4; Flags: Precursor [NCBI NR]
  • gi|2873385|gb|AAC02726.1| Abnormal dauer formation protein 4, isoform a [Caenorhabditis elegans] [NCBI NR]
  • pir||D88462 protein daf-4 [imported] - Caenorhabditis elegans [NCBI NR]
  • gi|17552830|ref|NP_498211.1| abnormal DAuer Formation family member (daf-4) [Caenorhabditis elegans] [NCBI NR]
  • Cell surface receptor daf-4 OS=Caenorhabditis elegans GN=daf-4 PE=1 SV=2 [Swiss-Prot]
  • [wormpep67.fasta]
  • CE16827 WBGene00000900 locus:daf-4 status:Confirmed SW:P50488 protein_id:AAC02726.1 [wormpep150.fasta]
  • 16827 WBGene00000900 locus:daf-4 status:Confirmed SW:P50488 protein_id:AAC02726.1 [wormpep130-phg-ecoli-orf-rand.fasta]
  • abnormal DAuer Formation DAF-4, activin/BMP cell-surface receptor, regulates dauer larva development (84.4 kD) (daf-4) [Caenorhabditis elegans]gi|2873385|gb|AAC02726.1| Abnormal dauer formation protein 4, isoform a [Caenorhabditis elegans]gi|25387061|pi [nrdb_11152004_Chlamydomonas]
  • locus:daf-4 status:Confirmed SW:P50488 protein_id:AAC02726.1 [wormpep115.fasta.reversed]
  • CE16827 locus:daf-4 status:Confirmed [wormpep80.hongbin]
  • CE16827 WBGene00000900 locus:daf-4 status:Confirmed UniProt:P50488 protein_id:AAC02726.1 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta]
  • CE16827 WBGene00000900 locus:daf-4 status:Confirmed UniProt:P50488 protein_id:AAC02726.1| [wormORF-contam.fasta]
  • Abnormal dauer formation protein 4, isoform a [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • Cell-surface receptor daf-4 precursor (Abnormal dauer formation protein 4) [nr-271106-contam.fasta]
  • abnormal DAuer Formation family member (daf-4) [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr]
  • CE16827 WBGene00000900 locus:daf-4 status:Confirmed UniProt:P50488 protein_id:CCD63118.1 [wormbase_c_elegans_ws231_03-13-2012_reversed.fasta]
  • CE16827 WBGene00000900 locus:daf-4 status:Confirmed UniProt:P50488 protein_id:CCD63118.1 Cell surface receptor daf-4 [wormpep246-ecoli-contam.fasta]
    • Organism: Caenorhabditis elegans
    Length: 744 amino acids

    Gene Ontology:
    Cellular Component: membrane [IEALink to PubMed article]
    integral to membrane [IEALink to PubMed article]
    Biological Process: negative regulation of BMP signaling pathway [IMPLink to PubMed article]
    positive regulation of BMP signaling pathway [IMPLink to PubMed article]
    dauer larval development [IGILink to PubMed article][IMPLink to PubMed articleLink to PubMed articleLink to PubMed articleLink to PubMed articleLink to PubMed article]
    nematode larval development [IMPLink to PubMed article]
    oviposition [IMPLink to PubMed article]
    positive regulation of transcription from RNA polymerase II promoter [IMPLink to PubMed article]
    protein amino acid phosphorylation [IEALink to PubMed article]
    positive regulation of multicellular organism growth [IMPLink to PubMed articleLink to PubMed article]
    Molecular Function: ATP binding [IEALink to PubMed article]
    growth factor binding [IPILink to PubMed article]
    protein tyrosine kinase activity [IEALink to PubMed article]
    protein kinase activity [IEALink to PubMed article]
    protein serine/threonine kinase activity [IEALink to PubMed article]
    transmembrane receptor protein serine/threonine kinase activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNQKGTVRLK ALVLICLPLF LIATPVPVAV TEDDRQDRIE SEAAEKEWAN TLVSKVAQSN  60
   61 GTGTIKVSAP AKPTLRRMDN EEDEVISIEC VYYDEMECEK SGDCEITKKT CYSEAHLKAV 120
  121 GCLAVFGLPT QEINSTEPYL KVDKPQYKSL GCMPYQHADS MNCENESSCR QGRSFRGGIG 180
  181 MCCCSTNNCN MPDLIEMVNP SLKKDSDNSA LLWASTPSNM DLESLDKFPF YWIIIIALSV 240
  241 ILCIALLILA YVGWKFQQNK KEEIKKQQKI KFDMEKTDAL EAGNVPLVEP EEEMIEMVET 300
  301 PKELPITDFQ LISKGRFGKV FKAQYTPDSG EKRLVAVKKL NEFQKASFLA EKRIFDELNE 360
  361 YPKWYKSIVE FVCAEKIGDE YWIVTEFHER LSLYELLKNN VISITSANRI IMSMIDGLQF 420
  421 LHDDRPYFFG HPKKPIIHRD IKSKNILVKS DMTTCIADFG LARIYSYDIE QSDLLGQVGT 480
  481 KRYMSPEMLE GATEFTPTAF KAMDVYSMGL VMWEVISRTK LHQTDEPPNY QMPFQVIGFD 540
  541 PTIGLMRNYV VSKKERPQWR DEIIKHEYMS LLKKVTEEMW DPEACARITA GCAFARVWNH 600
  601 IMSSPDSSEG YHSGSSMKNR GVDDVEQSEK PEGIEEMQHY HASSPSKRQH PSPNPFFDSC 660
  661 PPPPPIPVIL ENGGILQPDN AEPEPEELPD LPIVEKIYDI ATNMLFSREE LDLMNAQRQV 720
  721 EYEAGADTRA STPTPSGTFG TFTT

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..261] PSI-BLAST 15.0 EGF receptor extracellular domain; EGF receptor Cys-rich domains
    2 View Details [262..610] PSI-BLAST 53.522879 Type I TGF-beta receptor R4
    3 View Details [611..744] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • growth factor binding
    		•  6.33296746316446 bayes_pls_golite062009
  • insulin-like growth factor binding
    		•  4.68807086347794 bayes_pls_golite062009
  • binding
    		•  3.10942625145915 bayes_pls_golite062009
  • protein binding
    		•  3.04595153576805 bayes_pls_golite062009
  • insulin-like growth factor I binding
    		•  2.64764959452188 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  2.11274485218746 bayes_pls_golite062009
  • receptor activity
    		•  2.04770371945982 bayes_pls_golite062009
  • insulin-like growth factor II binding
    		•  1.94025491221585 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.83752933098717 bayes_pls_golite062009
  • kinase activity
    		•  1.80864815034082 bayes_pls_golite062009
  • signal transducer activity
    		•  1.716940423168 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.716940423168 bayes_pls_golite062009
  • enzyme regulator activity
    		•  1.68559458458962 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.6818630115957 bayes_pls_golite062009
  • protein kinase activity
    		•  1.64316913174221 bayes_pls_golite062009
  • enzyme activator activity
    		•  1.49158544951255 bayes_pls_golite062009
  • glycoprotein binding
    		•  1.41359665103303 bayes_pls_golite062009
  • transferase activity
    		•  1.3977021765186 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  0.625443680166071 bayes_pls_golite062009
  • catalytic activity
    		•  0.271811389148807 bayes_pls_golite062009
  • phosphatase activator activity
    		•  0.234175951765568 bayes_pls_golite062009
  • protein tyrosine phosphatase activator activity
    		•  0.193211593927368 bayes_pls_golite062009
    2
    Term Confidence Notes
  • activin receptor activity
    		•  7.18922615745589 bayes_pls_golite062009
  • activin binding
    		•  7.11944534332244 bayes_pls_golite062009
  • receptor signaling protein serine/threonine kinase activity
    		•  6.41728494915949 bayes_pls_golite062009
  • activin receptor activity, type I
    		•  6.1393596497059 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  5.49988294224815 bayes_pls_golite062009
  • protein kinase activity
    		•  5.4586557943719 bayes_pls_golite062009
  • kinase activity
    		•  5.3287080791198 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  4.96052051118534 bayes_pls_golite062009
  • cyclin-dependent protein kinase activity
    		•  4.62392503670521 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  4.46381887831481 bayes_pls_golite062009
  • transferase activity
    		•  3.97138602499442 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  3.40140621607334 bayes_pls_golite062009
  • transmembrane receptor protein serine/threonine kinase activity
    		•  3.37600307408153 bayes_pls_golite062009
  • transforming growth factor beta receptor activity
    		•  3.37600307408153 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  3.1965684217331 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase activity
    		•  2.97315540587667 bayes_pls_golite062009
  • receptor activity
    		•  2.96273889901429 bayes_pls_golite062009
  • molecular transducer activity
    		•  2.85730457922199 bayes_pls_golite062009
  • signal transducer activity
    		•  2.85730457922199 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  2.8153155526437 bayes_pls_golite062009
  • binding
    		•  2.74863538127007 bayes_pls_golite062009
  • growth factor binding
    		•  2.61235080252818 bayes_pls_golite062009
  • transforming growth factor beta receptor activity, type I
    		•  2.57601476622612 bayes_pls_golite062009
  • protein binding
    		•  2.276111749106 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  2.10379226653669 bayes_pls_golite062009
  • insulin receptor activity
    		•  2.08642574110801 bayes_pls_golite062009
  • fibroblast growth factor binding
    		•  2.00819948109978 bayes_pls_golite062009
  • ATP binding
    		•  1.97600611746091 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  1.93596671856664 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  1.90928021591891 bayes_pls_golite062009
  • phosphoinositide 3-kinase binding
    		•  1.90879495821405 bayes_pls_golite062009
  • fibroblast growth factor 1 binding
    		•  1.82118598657067 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  1.65732943334212 bayes_pls_golite062009
  • ribonucleotide binding
    		•  1.65726906484847 bayes_pls_golite062009
  • purine nucleotide binding
    		•  1.63763394711025 bayes_pls_golite062009
  • nucleotide binding
    		•  1.63195828048121 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.56748951434625 bayes_pls_golite062009
  • transforming growth factor beta binding
    		•  1.46877913443522 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.46547714006072 bayes_pls_golite062009
  • MAP kinase kinase activity
    		•  1.42275431028856 bayes_pls_golite062009
  • DNA binding
    		•  1.35333135345112 bayes_pls_golite062009
  • catalytic activity
    		•  1.21655087018101 bayes_pls_golite062009
  • transporter activity
    		•  1.11833481501707 bayes_pls_golite062009
  • transcription factor activity
    		•  1.10928254946881 bayes_pls_golite062009
  • insulin binding
    		•  1.03564126441771 bayes_pls_golite062009
  • SMAD binding
    		•  1.02108562119195 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  0.99838484913572 bayes_pls_golite062009
  • transcription activator activity
    		•  0.997272622653026 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.97575992765505 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.959888295228949 bayes_pls_golite062009
  • MAP kinase activity
    		•  0.81943579965027 bayes_pls_golite062009
  • amine binding
    		•  0.783881819862438 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.748533008006377 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.705905455086486 bayes_pls_golite062009
  • insulin receptor substrate binding
    		•  0.57617745233877 bayes_pls_golite062009
  • protein serine/threonine/tyrosine kinase activity
    		•  0.48345772948903 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.450699332958421 bayes_pls_golite062009
  • follistatin binding
    		•  0.407208295811976 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.401250804041384 bayes_pls_golite062009
  • structural constituent of muscle
    		•  0.399773397398032 bayes_pls_golite062009
  • magnesium ion binding
    		•  0.393328812780268 bayes_pls_golite062009
  • PTB domain binding
    		•  0.384625387464921 bayes_pls_golite062009
  • insulin receptor binding
    		•  0.379040209226037 bayes_pls_golite062009
  • MAP kinase kinase kinase activity
    		•  0.37115026509016 bayes_pls_golite062009
  • transforming growth factor beta receptor activity, type II
    		•  0.365530951355731 bayes_pls_golite062009
  • fibroblast growth factor receptor activity
    		•  0.34434685718027 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.318153468064373 bayes_pls_golite062009
  • peptide hormone binding
    		•  0.312169974523858 bayes_pls_golite062009
  • glycoprotein binding
    		•  0.2984932537448 bayes_pls_golite062009
  • glycosaminoglycan binding
    		•  0.294256794094724 bayes_pls_golite062009
  • kinase binding
    		•  0.26752427107238 bayes_pls_golite062009
  • protein complex binding
    		•  0.239339759110451 bayes_pls_golite062009
  • polysaccharide binding
    		•  0.229808864843639 bayes_pls_golite062009
  • cytokine binding
    		•  0.17817111033393 bayes_pls_golite062009
  • cell adhesion molecule binding
    		•  0.150740450460731 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.148194101970458 bayes_pls_golite062009
  • cytokine receptor binding
    		•  0.144440612194652 bayes_pls_golite062009
  • protein kinase C activity
    		•  0.0795689006739899 bayes_pls_golite062009
  • tubulin binding
    		•  0.0510156114567444 bayes_pls_golite062009
  • receptor serine/threonine kinase binding
    		•  0.0123645889643007 bayes_pls_golite062009
  • protein kinase binding
    		•  0.00674998152095019 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.0040394359628233 bayes_pls_golite062009
  • SH2 domain binding
    		•  2.96656737540424E-4 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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