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Protein Overview: hsd-2

General Information:
Name(s) found: hsd-2 / CE07577 [WormBase]
Description(s) found:
Found 19 descriptions.
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  • WBGene00022498 locus:hsd-2 status:Confirmed UniProt:Q23086 protein_id:CCD73127.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 374 amino acids

    Gene Ontology:
    Cellular Component: integral to membrane [IEALink to PubMed article]
    Biological Process: carbohydrate metabolic process [IEALink to PubMed article]
    steroid biosynthetic process [IEALink to PubMed article]
    galactose metabolic process [IEALink to PubMed article]
    cellular metabolic process [IEALink to PubMed article]
    Molecular Function: 3-beta-hydroxy-delta5-steroid dehydrogenase activity [IEALink to PubMed article]
    NADP or NADPH binding [IEALink to PubMed article]
    coenzyme binding [IEALink to PubMed article]
    catalytic activity [IEALink to PubMed article]
    UDP-glucose 4-epimerase activity [IEALink to PubMed article]
    steroid delta-isomerase activity [IEALink to PubMed article]
    ADP-glyceromanno-heptose 6-epimerase activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGHYVIVGGG GFLGAHVISA LQKIGCKERI IVVDPCPQEF KTIKIDKSNI SYIKASFLDD  60
   61 KVLENILNGA SAVVHLAAVG HTGLIAGDRK SVHNFNVNGT KQLIKQCKAL GVKRFLYASS 120
  121 VAVSFIGEPL DNVTEDDPLP DPKKYLDFYS ASKAEAETYV LSQSTPDFKT VCLRFRGIYG 180
  181 PEDPNVTLKV ANLIKNGLFI GMVSAHGRES VSCASSGVNC AKAFALADQM LQNPDGLHGR 240
  241 AYYILDGENV GQFQFWTPLV LALGKQPPSF YTPYDFIKAV VPYFQNVCYG VFKLPPLLTK 300
  301 FELSILAVDN TYSIERARRE LGYEPEPCVM TDVAKYYQDL EENEVATATT EWKSAISILI 360
  361 VFISIAFLFL FNLN

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..374] PSI-BLAST 73.045757 Uridine diphosphogalactose-4-epimerase (UDP-galactose 4-epimerase)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • steroid dehydrogenase activity
    		•  3.70115036051018 bayes_pls_golite062009
  • steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
    		•  3.56748749904419 bayes_pls_golite062009
  • oxidoreductase activity
    		•  3.09625241707629 bayes_pls_golite062009
  • retinol dehydrogenase activity
    		•  3.08644105481774 bayes_pls_golite062009
  • 3-alpha(17-beta)-hydroxysteroid dehydrogenase (NAD+) activity
    		•  1.80383455383329 bayes_pls_golite062009
  • catalytic activity
    		•  1.79741889688267 bayes_pls_golite062009
  • oxidoreductase activity, acting on CH-OH group of donors
    		•  1.65338499044318 bayes_pls_golite062009
  • receptor activity
    		•  1.59521607141455 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  1.57495858691649 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
    		•  1.47309297191111 bayes_pls_golite062009
  • ethanol binding
    		•  1.43137718523288 bayes_pls_golite062009
  • retinol binding
    		•  1.36627553306209 bayes_pls_golite062009
  • signal transducer activity
    		•  1.28375985874563 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.28375985874563 bayes_pls_golite062009
  • C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity
    		•  1.03845584151228 bayes_pls_golite062009
  • DNA binding
    		•  0.925435782369235 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.830735196151903 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.805690663404413 bayes_pls_golite062009
  • benzaldehyde dehydrogenase activity
    		•  0.74738022559788 bayes_pls_golite062009
  • fatty acid synthase activity
    		•  0.714637370305282 bayes_pls_golite062009
  • retinoid binding
    		•  0.67821643688355 bayes_pls_golite062009
  • alcohol dehydrogenase (NAD) activity
    		•  0.65743456407889 bayes_pls_golite062009
  • G-protein coupled receptor activity
    		•  0.648902636946461 bayes_pls_golite062009
  • 11-beta-hydroxysteroid dehydrogenase activity
    		•  0.617411823427239 bayes_pls_golite062009
  • isoprenoid binding
    		•  0.56322670082984 bayes_pls_golite062009
  • binding
    		•  0.553666136934364 bayes_pls_golite062009
  • testosterone 17-beta-dehydrogenase activity
    		•  0.532187027260366 bayes_pls_golite062009
  • NAD or NADH binding
    		•  0.44922383360529 bayes_pls_golite062009
  • transcription factor activity
    		•  0.288669328257774 bayes_pls_golite062009
  • all-trans retinal binding
    		•  0.218888750914841 bayes_pls_golite062009
  • 3-oxoacyl-[acyl-carrier-protein] reductase activity
    		•  0.192594057004213 bayes_pls_golite062009
  • NADPH:quinone reductase activity
    		•  0.0435917990586205 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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