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View Structure Prediction Details

Protein: hsd-2
Organism: Caenorhabditis elegans
Length: 374 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for hsd-2.

Description E-value Query
Range
Subject
Range
gi|41205692 - gi|41205692|gb|AAR99612.1| dTDP-glucose 4,6-dehydratase [Geobacillus stearothermophilus]
305.0 [0..2] [357..3]

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Predicted Domain #1
Region A:
Residues: [1-374]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGHYVIVGGG GFLGAHVISA LQKIGCKERI IVVDPCPQEF KTIKIDKSNI SYIKASFLDD  60
   61 KVLENILNGA SAVVHLAAVG HTGLIAGDRK SVHNFNVNGT KQLIKQCKAL GVKRFLYASS 120
  121 VAVSFIGEPL DNVTEDDPLP DPKKYLDFYS ASKAEAETYV LSQSTPDFKT VCLRFRGIYG 180
  181 PEDPNVTLKV ANLIKNGLFI GMVSAHGRES VSCASSGVNC AKAFALADQM LQNPDGLHGR 240
  241 AYYILDGENV GQFQFWTPLV LALGKQPPSF YTPYDFIKAV VPYFQNVCYG VFKLPPLLTK 300
  301 FELSILAVDN TYSIERARRE LGYEPEPCVM TDVAKYYQDL EENEVATATT EWKSAISILI 360
  361 VFISIAFLFL FNLN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 73.045757
Match: 1lrkA
Description: Uridine diphosphogalactose-4-epimerase (UDP-galactose 4-epimerase)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
steroid dehydrogenase activity 3.70115036051018 bayes_pls_golite062009
steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 3.56748749904419 bayes_pls_golite062009
oxidoreductase activity 3.09625241707629 bayes_pls_golite062009
retinol dehydrogenase activity 3.08644105481774 bayes_pls_golite062009
3-alpha(17-beta)-hydroxysteroid dehydrogenase (NAD+) activity 1.80383455383329 bayes_pls_golite062009
catalytic activity 1.79741889688267 bayes_pls_golite062009
oxidoreductase activity, acting on CH-OH group of donors 1.65338499044318 bayes_pls_golite062009
receptor activity 1.59521607141455 bayes_pls_golite062009
transmembrane receptor activity 1.57495858691649 bayes_pls_golite062009
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 1.47309297191111 bayes_pls_golite062009
ethanol binding 1.43137718523288 bayes_pls_golite062009
retinol binding 1.36627553306209 bayes_pls_golite062009
signal transducer activity 1.28375985874563 bayes_pls_golite062009
molecular transducer activity 1.28375985874563 bayes_pls_golite062009
C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity 1.03845584151228 bayes_pls_golite062009
DNA binding 0.925435782369235 bayes_pls_golite062009
transcription regulator activity 0.830735196151903 bayes_pls_golite062009
nucleic acid binding 0.805690663404413 bayes_pls_golite062009
benzaldehyde dehydrogenase activity 0.74738022559788 bayes_pls_golite062009
fatty acid synthase activity 0.714637370305282 bayes_pls_golite062009
retinoid binding 0.67821643688355 bayes_pls_golite062009
alcohol dehydrogenase (NAD) activity 0.65743456407889 bayes_pls_golite062009
G-protein coupled receptor activity 0.648902636946461 bayes_pls_golite062009
11-beta-hydroxysteroid dehydrogenase activity 0.617411823427239 bayes_pls_golite062009
isoprenoid binding 0.56322670082984 bayes_pls_golite062009
binding 0.553666136934364 bayes_pls_golite062009
testosterone 17-beta-dehydrogenase activity 0.532187027260366 bayes_pls_golite062009
NAD or NADH binding 0.44922383360529 bayes_pls_golite062009
transcription factor activity 0.288669328257774 bayes_pls_golite062009
all-trans retinal binding 0.218888750914841 bayes_pls_golite062009
3-oxoacyl-[acyl-carrier-protein] reductase activity 0.192594057004213 bayes_pls_golite062009
NADPH:quinone reductase activity 0.0435917990586205 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle