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Protein Overview: cyp-14A4

General Information:
Name(s) found: cyp-14A4 / CE06222 [WormBase]
Description(s) found:
Found 22 descriptions.
SHOW ALL
  • WBGene00011009 locus:cyp-14A4 status:Partially_confirmed UniProt:G5ED86 protein_id:CAA94168.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 491 amino acids

    Gene Ontology:
    Cellular Component: integral to membrane [IEALink to PubMed article]
    Biological Process: electron transport [IEALink to PubMed article]
    Molecular Function: iron ion binding [IEALink to PubMed article]
    oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [IEALink to PubMed article]
    monooxygenase activity [IEALink to PubMed article]
    heme binding [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSPLLILAFF VATVGYLVHF YLKVRKYPKG PFPLPVIGNL HQIPGGNLEI WFDELAKIYG  60
   61 PCYTVWSPLP CVVLTDFDHI KNAFVTQGEF NNRAHKPPES LLHVHDNTGI LNSSGENWQL 120
  121 QRRTSLKILR DFGMGKNLME EQIVKSVQEM MTQLEKTDDK KKADIFWPVQ LCVGNVINQV 180
  181 LFGYHFKYDD CERFQKFVSV IDFHLRTLLG KCSLLVSAFP MLRHVPIIGE YGYQRIKRNI 240
  241 KSYQYFIEEE VATQMKSFEE ENEPENFVHA YMQQMKQNGH PGLDVKNLRA CALDFWLAGM 300
  301 ETTSNSLRWH IAYMMKHPDI QDKVRKEILD VVGNSRFPSM SDKPNMPYTQ AVIHEVQRHS 360
  361 NMVPFLGTHQ SNKDTNVLGQ NIPAGTNVLV QAWSVMRNDP IFINQLSFNP DRYLMADGKS 420
  421 FDKNILEKTI PFSVGKRSCI GEGLARMELF LIFSALIQKY EFIANGPVDM SYDFGAVLTI 480
  481 KPYTCQLKAQ F

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..491] PSI-BLAST 105.0 Crystal Structure of Human Drug Metabolizing Cytochrome P450 2C8

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • arachidonic acid monooxygenase activity
    		•  6.76823710927794 bayes_pls_golite062009
  • fatty acid (omega-1)-hydroxylase activity
    		•  6.3313834755701 bayes_pls_golite062009
  • monooxygenase activity
    		•  5.57229509004705 bayes_pls_golite062009
  • steroid hydroxylase activity
    		•  5.04794778387361 bayes_pls_golite062009
  • arachidonic acid epoxygenase activity
    		•  4.80764258881036 bayes_pls_golite062009
  • electron carrier activity
    		•  4.64931978461551 bayes_pls_golite062009
  • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen
    		•  4.64322346579269 bayes_pls_golite062009
  • steroid 17-alpha-monooxygenase activity
    		•  3.99744233006162 bayes_pls_golite062009
  • retinoic acid 4-hydroxylase activity
    		•  3.76307535769621 bayes_pls_golite062009
  • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
    		•  3.68151610133025 bayes_pls_golite062009
  • demethylase activity
    		•  3.40807632433846 bayes_pls_golite062009
  • oxygen binding
    		•  3.29945075872446 bayes_pls_golite062009
  • flavonoid 3'-monooxygenase activity
    		•  3.16634614522939 bayes_pls_golite062009
  • sterol 14-demethylase activity
    		•  2.94610675710811 bayes_pls_golite062009
  • retinoic acid binding
    		•  2.70323898361882 bayes_pls_golite062009
  • retinoid binding
    		•  2.60220937953757 bayes_pls_golite062009
  • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
    		•  2.56821164444595 bayes_pls_golite062009
  • isoprenoid binding
    		•  2.47826119804163 bayes_pls_golite062009
  • thromboxane-A synthase activity
    		•  2.45281910634006 bayes_pls_golite062009
  • oxysterol 7-alpha-hydroxylase activity
    		•  2.36480328243514 bayes_pls_golite062009
  • oxidoreductase activity
    		•  2.35847923992364 bayes_pls_golite062009
  • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen
    		•  2.15105968497418 bayes_pls_golite062009
  • ecdysteroid 25-hydroxylase activity
    		•  2.0071742914584 bayes_pls_golite062009
  • vitamin D 24-hydroxylase activity
    		•  1.81919676974797 bayes_pls_golite062009
  • vitamin D3 25-hydroxylase activity
    		•  1.65825585934141 bayes_pls_golite062009
  • vitamin D 25-hydroxylase activity
    		•  1.65825585934141 bayes_pls_golite062009
  • corticosterone 18-monooxygenase activity
    		•  1.64204907906991 bayes_pls_golite062009
  • steroid 11-beta-monooxygenase activity
    		•  1.64204907906991 bayes_pls_golite062009
  • arachidonic acid 11,12-epoxygenase activity
    		•  1.48500938886158 bayes_pls_golite062009
  • testosterone 6-beta-hydroxylase activity
    		•  1.4661447981611 bayes_pls_golite062009
  • binding
    		•  1.2866152532988 bayes_pls_golite062009
  • 25-hydroxycholecalciferol-24-hydroxylase activity
    		•  1.06487564122685 bayes_pls_golite062009
  • protein binding
    		•  0.836411857417911 bayes_pls_golite062009
  • ecdysteroid 22-hydroxylase activity
    		•  0.7601272997427 bayes_pls_golite062009
  • catalytic activity
    		•  0.608111453189583 bayes_pls_golite062009
  • iron ion binding
    		•  0.529598228513719 bayes_pls_golite062009
  • cation binding
    		•  0.510556740388808 bayes_pls_golite062009
  • metal ion binding
    		•  0.510556740388808 bayes_pls_golite062009
  • ion binding
    		•  0.503326724714616 bayes_pls_golite062009
  • transition metal ion binding
    		•  0.450436868179747 bayes_pls_golite062009
  • cholesterol monooxygenase (side-chain-cleaving) activity
    		•  0.276594551871869 bayes_pls_golite062009
  • 1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity
    		•  0.203772707673481 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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