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Protein Overview: ard-1

General Information:
Name(s) found: ard-1 / CE03127 [WormBase]
Description(s) found:
Found 18 descriptions.
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  • WBGene00000181 locus:ard-1 status:Confirmed UniProt:Q19102 protein_id:CAA92764.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 258 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IEALink to PubMed article]
    Biological Process: estrogen biosynthetic process [IEALink to PubMed article]
    locomotory behavior [IMPLink to PubMed article]
    hermaphrodite genitalia development [IMPLink to PubMed article]
    nematode larval development [IMPLink to PubMed article]
    poly-hydroxybutyrate biosynthetic process [IEALink to PubMed article]
    proteolysis [IEALink to PubMed article]
    metabolic process [IEALink to PubMed article]
    gamete generation [IMPLink to PubMed article]
    fatty acid biosynthetic process [IEALink to PubMed article]
    cellular metabolic process [IEALink to PubMed article]
    growth [IMPLink to PubMed article]
    positive regulation of locomotion [IMPLink to PubMed article]
    Molecular Function: estradiol 17-beta-dehydrogenase activity [IEALink to PubMed article]
    coenzyme binding [IEALink to PubMed article]
    3-oxoacyl-[acyl-carrier-protein] reductase activity [IEALink to PubMed article]
    catalytic activity [IEALink to PubMed article]
    oxidoreductase activity [IEALink to PubMed article]
    NAD or NADH binding [IEALink to PubMed article]
    3-hydroxybutyrate dehydrogenase activity [IEALink to PubMed article]
    cysteine-type endopeptidase activity [IEALink to PubMed article]
    acetoacetyl-CoA reductase activity [IEALink to PubMed article]
    2-deoxy-D-gluconate 3-dehydrogenase activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSALRSTKGL VALVTGGASG LGKGAAEVLA KAGAQVAILD LPQSKGADVA KEIGGIFTPA  60
   61 SVTSEEEVRA AFAKVQAEYG RLDALVNCAG IAYAFKLYSV QKKKHVDFEK IRQTIDVNVL 120
  121 GTFNVIRHGV ALMGEHEKDA NGQRGVVINT ASVAAFDGQT GQSAYSASKG AIVGMTLPLA 180
  181 RDFAGDGIRF NTIAPGLMDT PLLSSLPEKV KSFLAQLIPN PSRLGHPHEY GALVQHIIEN 240
  241 QYLNGETIRF DGALRMPA

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run hcp-2 hcp2 ip from december Cheeseman, I.M., et al. (2005)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..258] PSI-BLAST 52.154902 Abeta-bound human ABAD structure [also known as 3-hydroxyacyl-CoA dehydrogenase type II (Type II HADH), Endoplasmic reticulum-associated amyloid beta-peptide binding protein (ERAB)]

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • retinol dehydrogenase activity
    		•  4.1750549780559 bayes_pls_golite062009
  • oxidoreductase activity
    		•  3.09625241707629 bayes_pls_golite062009
  • 3-hydroxyacyl-CoA dehydrogenase activity
    		•  3.06391460989761 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-CH group of donors
    		•  3.02758902218302 bayes_pls_golite062009
  • oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor
    		•  2.66329970371321 bayes_pls_golite062009
  • ethanol binding
    		•  2.01597876952325 bayes_pls_golite062009
  • retinol binding
    		•  1.92497267707609 bayes_pls_golite062009
  • oxidoreductase activity, acting on NADH or NADPH
    		•  1.81060491890041 bayes_pls_golite062009
  • catalytic activity
    		•  1.79741889688267 bayes_pls_golite062009
  • steroid dehydrogenase activity
    		•  1.75109362865449 bayes_pls_golite062009
  • retinoid binding
    		•  1.72614743805853 bayes_pls_golite062009
  • oxidoreductase activity, acting on CH-OH group of donors
    		•  1.65338499044318 bayes_pls_golite062009
  • isoprenoid binding
    		•  1.61095405873981 bayes_pls_golite062009
  • steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
    		•  1.55012034958204 bayes_pls_golite062009
  • alcohol binding
    		•  1.51091775360793 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
    		•  1.47309297191111 bayes_pls_golite062009
  • fatty acid synthase activity
    		•  1.23679054027553 bayes_pls_golite062009
  • sorbose reductase activity
    		•  1.06293597394863 bayes_pls_golite062009
  • benzaldehyde dehydrogenase activity
    		•  1.05577641583555 bayes_pls_golite062009
  • receptor activity
    		•  1.02559644924534 bayes_pls_golite062009
  • binding
    		•  0.982999356179965 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  0.973650203491298 bayes_pls_golite062009
  • signal transducer activity
    		•  0.832324207538104 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.832324207538104 bayes_pls_golite062009
  • 7-beta-hydroxysteroid dehydrogenase (NADP+) activity
    		•  0.695969796208571 bayes_pls_golite062009
  • retinal dehydrogenase activity
    		•  0.69372321031969 bayes_pls_golite062009
  • 3-alpha(17-beta)-hydroxysteroid dehydrogenase (NAD+) activity
    		•  0.665447800395781 bayes_pls_golite062009
  • alcohol dehydrogenase (NAD) activity
    		•  0.65743456407889 bayes_pls_golite062009
  • 3-oxoacyl-[acyl-carrier-protein] reductase activity
    		•  0.604742541607263 bayes_pls_golite062009
  • testosterone 17-beta-dehydrogenase activity
    		•  0.532187027260366 bayes_pls_golite062009
  • DNA binding
    		•  0.525227236870065 bayes_pls_golite062009
  • all-trans retinal binding
    		•  0.522435200991921 bayes_pls_golite062009
  • NADPH:quinone reductase activity
    		•  0.512538385530248 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.459537641913493 bayes_pls_golite062009
  • enoyl-CoA hydratase activity
    		•  0.439912268968251 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.177044638410302 bayes_pls_golite062009
  • methylenetetrahydrofolate dehydrogenase activity
    		•  0.124826575912808 bayes_pls_golite062009
  • methenyltetrahydrofolate cyclohydrolase activity
    		•  0.118312276550651 bayes_pls_golite062009
  • monovalent inorganic cation transmembrane transporter activity
    		•  0.0868063468469216 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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