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Protein Overview: gad8

General Information:
Name(s) found: gad8 / SPCC24B10.07 [Sanger Pombe]
Description(s) found:
Found 21 descriptions.
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  • serine/threonine protein kinase Gad8 [Sanger Pombe]
    • Organism: Schizosaccharomyces pombe
    Length: 569 amino acids

    Gene Ontology:
    Cellular Component: cellular_component [ND]
    Biological Process: induction of conjugation upon nitrogen starvation [IGILink to PubMed article]
    TOR signaling pathway [TASLink to PubMed article]
    protein amino acid phosphorylation [ICLink to PubMed article]
    Molecular Function: ATP binding [ICLink to PubMed article]
    protein binding [IPILink to PubMed article]
    protein serine/threonine kinase activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSWKLTKKLK ETHLASAIGL NSGGSSFTRG LKNSTLSSTS SRKSSDEKSR KSSEDKRSPQ  60
   61 STVVQPGLLQ VTIIEARNLK LPSGHVPANY GVSIDNSLLA PPLSNGSGHA RSRSHAWWLP 120
  121 YIVVEFDKNE ILVDALNTAS LENPCWDYQA TFDVSRYSKL SLNIYLRSSS SRSRNGMGND 180
  181 AFLGGIKLSP SFIVNKLTDE WVPLHGGSGE LRVQMLYKPN QSTPLTIDAF ELLKVVGKGS 240
  241 FGKVMQVRKR DTSRIYALKT MKKAHIVSRS EVDHTLAERT VLAQVNNPFI VPLKFSFQSP 300
  301 GKLYLVLAFV NGGELFHHLQ REGCFDTYRA KFYIAELLVA LECLHEFNVI YRDLKPENIL 360
  361 LDYTGHIALC DFGLCKLNMA KTDRTNTFCG TPEYLAPELL LGHGYTKVVD WWTLGVLLYE 420
  421 MITGLPPFYD ENINEMYRKI LQDPLRFPDN IDEKAKDLLS GLLTRAPEKR LGSGGAQEIK 480
  481 NHPFFDDIDW KKLCAKKIQP PFKPSVESAI DTSNFDSEFT SEIPMDSVVA DSHLSETVQQ 540
  541 RFANWSYQRP TTIDTSDDIN TIAPGSVIR

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..112] PSI-BLAST 8.154902 Polygalacturonase inhibiting protein PGIP
    2 View Details [113..224] FFAS03 3.27 Domain from protein kinase C epsilon
    3 View Details [225..496] PSI-BLAST 61.09691 3-phosphoinositide dependent protein kinase-1 Pdk1
    4 View Details [497..569] PSI-BLAST 79.69897 Pkb kinase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • calcium-dependent phospholipid binding
    		•  3.39159423075195 bayes_pls_golite062009
  • binding
    		•  2.69807173453705 bayes_pls_golite062009
  • phospholipid binding
    		•  2.34381497997352 bayes_pls_golite062009
  • protein binding
    		•  2.30382591804018 bayes_pls_golite062009
  • neurexin binding
    		•  1.53016354357112 bayes_pls_golite062009
  • lipid binding
    		•  1.45204823180714 bayes_pls_golite062009
  • receptor activity
    		•  1.32994295600591 bayes_pls_golite062009
  • transporter activity
    		•  1.27490249434763 bayes_pls_golite062009
  • signal transducer activity
    		•  1.11725807163488 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.11725807163488 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.82381389185441 bayes_pls_golite062009
  • SNARE binding
    		•  0.0797557025734419 bayes_pls_golite062009
  • calmodulin binding
    		•  0.0726445139314009 bayes_pls_golite062009
  • profilin binding
    		•  3.38774728102731E-4 bayes_pls_golite062009
    3
    Term Confidence Notes
  • phosphotransferase activity, alcohol group as acceptor
    		•  5.49988294224815 bayes_pls_golite062009
  • protein kinase activity
    		•  5.4586557943719 bayes_pls_golite062009
  • kinase activity
    		•  5.3287080791198 bayes_pls_golite062009
  • cyclic nucleotide-dependent protein kinase activity
    		•  4.97855712164511 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  4.96052051118534 bayes_pls_golite062009
  • cAMP-dependent protein kinase activity
    		•  4.66277812893755 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  4.46381887831481 bayes_pls_golite062009
  • transferase activity
    		•  3.97138602499442 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  2.8153155526437 bayes_pls_golite062009
  • binding
    		•  2.74863538127007 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  2.59526003830791 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  2.54265774272269 bayes_pls_golite062009
  • molecular transducer activity
    		•  2.40586892801446 bayes_pls_golite062009
  • signal transducer activity
    		•  2.40586892801446 bayes_pls_golite062009
  • receptor activity
    		•  2.39311927684508 bayes_pls_golite062009
  • protein binding
    		•  2.276111749106 bayes_pls_golite062009
  • tubulin binding
    		•  2.18641675163967 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase activity
    		•  2.16831387024372 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  2.12615078788254 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  2.10379226653669 bayes_pls_golite062009
  • ATP binding
    		•  1.97600611746091 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  1.93596671856664 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  1.90928021591891 bayes_pls_golite062009
  • microtubule binding
    		•  1.88110801192607 bayes_pls_golite062009
  • actin binding
    		•  1.87817875565699 bayes_pls_golite062009
  • acetylcholine receptor activator activity
    		•  1.83545227594542 bayes_pls_golite062009
  • phosphoinositide 3-kinase binding
    		•  1.82515074380651 bayes_pls_golite062009
  • receptor signaling protein serine/threonine kinase activity
    		•  1.81249386965144 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  1.65732943334212 bayes_pls_golite062009
  • ribonucleotide binding
    		•  1.65726906484847 bayes_pls_golite062009
  • purine nucleotide binding
    		•  1.63763394711025 bayes_pls_golite062009
  • nucleotide binding
    		•  1.63195828048121 bayes_pls_golite062009
  • insulin receptor substrate binding
    		•  1.62657794525303 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.56748951434625 bayes_pls_golite062009
  • DNA binding
    		•  1.35333135345112 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  1.32254739984688 bayes_pls_golite062009
  • gamma-tubulin binding
    		•  1.28511591054866 bayes_pls_golite062009
  • kinase binding
    		•  1.26086833316556 bayes_pls_golite062009
  • ErbB-3 class receptor binding
    		•  1.25765701903393 bayes_pls_golite062009
  • catalytic activity
    		•  1.21655087018101 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.16049201286103 bayes_pls_golite062009
  • transporter activity
    		•  1.11833481501707 bayes_pls_golite062009
  • transcription factor activity
    		•  1.10928254946881 bayes_pls_golite062009
  • protein kinase binding
    		•  1.06030596516506 bayes_pls_golite062009
  • ErbB-2 class receptor binding
    		•  1.02996109010965 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.97575992765505 bayes_pls_golite062009
  • cyclin-dependent protein kinase activity
    		•  0.959360414036299 bayes_pls_golite062009
  • growth factor binding
    		•  0.86076618871384 bayes_pls_golite062009
  • MAP kinase activity
    		•  0.81943579965027 bayes_pls_golite062009
  • actin filament binding
    		•  0.794152600084 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.705905455086486 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.612883428421652 bayes_pls_golite062009
  • protein serine/threonine/tyrosine kinase activity
    		•  0.48345772948903 bayes_pls_golite062009
  • enzyme binding
    		•  0.46284745266176 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.450699332958421 bayes_pls_golite062009
  • protein kinase C activity
    		•  0.41587987561486 bayes_pls_golite062009
  • magnesium ion binding
    		•  0.393328812780268 bayes_pls_golite062009
  • MAP kinase kinase kinase activity
    		•  0.37115026509016 bayes_pls_golite062009
  • MAP kinase kinase activity
    		•  0.35402045013148 bayes_pls_golite062009
  • insulin receptor binding
    		•  0.266450215230107 bayes_pls_golite062009
  • protein complex binding
    		•  0.239339759110451 bayes_pls_golite062009
  • insulin receptor activity
    		•  0.237134032032089 bayes_pls_golite062009
  • SH2 domain binding
    		•  0.226760162354251 bayes_pls_golite062009
  • transmembrane receptor protein serine/threonine kinase activity
    		•  0.20643152368029 bayes_pls_golite062009
  • transforming growth factor beta receptor activity
    		•  0.20643152368029 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.148194101970458 bayes_pls_golite062009
  • peptide binding
    		•  0.118578378753757 bayes_pls_golite062009
  • transforming growth factor beta receptor activity, type I
    		•  0.0506751594607393 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.0040394359628233 bayes_pls_golite062009
    4 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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