YRC Public Data Repository - Protein Structure Prediction

Protein:	gad8
Organism:	Schizosaccharomyces pombe
Length:	569 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gad8.

Description	E-value	Query Range	Subject Range
gi\|71003930, gi\|... - gi\|71003930\|ref\|XP_756631.1\| hypothetical protein UM00484.1 [Ustilago maydis 521], ref\|XP_398099.1\| ...	328.0	[0..1]	[559..1]
KPCL_MOUSE - Protein kinase C eta type OS=Mus musculus GN=Prkch PE=2 SV=1	321.0	[0..126]	[552..251]
KPCL_RAT - Protein kinase C eta type OS=Rattus norvegicus GN=Prkch PE=1 SV=1	320.0	[0..126]	[552..251]
gi\|42551497, gi\|... - gi\|46122935\|ref\|XP_386021.1\| hypothetical protein FG05845.1 [Gibberella zeae PH-1], gi\|42551497\|gb\|E...	318.0	[0..1]	[550..1]
PRKCH - protein kinase C, eta gi\|168279095, gi... - gi\|61363815\|gb\|AAX42448.1\| protein kinase C eta [synthetic construct], gi\|168279095\|dbj\|BAG11427.1\| ... HGNC:9403\|MIM:60... - kinase C, eta	318.0	[0..104]	[552..229]
gi\|114653377, gi... - gi\|114653389\|ref\|XP_001168392.1\| PREDICTED: protein kinase C, eta isoform 9 [Pan troglodytes], gi\|11...	318.0	[0..104]	[552..68]

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Predicted Domain #1

Region A:
Residues: [1-112]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSWKLTKKLK ETHLASAIGL NSGGSSFTRG LKNSTLSSTS SRKSSDEKSR KSSEDKRSPQ  60
   61 STVVQPGLLQ VTIIEARNLK LPSGHVPANY GVSIDNSLLA PPLSNGSGHA RS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	8.154902
Match:	1ogqA
Description:	Polygalacturonase inhibiting protein PGIP
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [113-224]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RSHAWWLPYI VVEFDKNEIL VDALNTASLE NPCWDYQATF DVSRYSKLSL NIYLRSSSSR  60
   61 SRNGMGNDAF LGGIKLSPSF IVNKLTDEWV PLHGGSGELR VQMLYKPNQS TP

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	3.27
Match:	1gmiA
Description:	Domain from protein kinase C epsilon
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
calcium-dependent phospholipid binding	3.39159423075195	bayes_pls_golite062009
binding	2.69807173453705	bayes_pls_golite062009
phospholipid binding	2.34381497997352	bayes_pls_golite062009
protein binding	2.30382591804018	bayes_pls_golite062009
neurexin binding	1.53016354357112	bayes_pls_golite062009
lipid binding	1.45204823180714	bayes_pls_golite062009
receptor activity	1.32994295600591	bayes_pls_golite062009
transporter activity	1.27490249434763	bayes_pls_golite062009
signal transducer activity	1.11725807163488	bayes_pls_golite062009
molecular transducer activity	1.11725807163488	bayes_pls_golite062009
substrate-specific transporter activity	0.82381389185441	bayes_pls_golite062009
SNARE binding	0.0797557025734419	bayes_pls_golite062009
calmodulin binding	0.0726445139314009	bayes_pls_golite062009
profilin binding	3.38774728102731E-4	bayes_pls_golite062009

Predicted Domain #3

Region A:
Residues: [225-496]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LTIDAFELLK VVGKGSFGKV MQVRKRDTSR IYALKTMKKA HIVSRSEVDH TLAERTVLAQ  60
   61 VNNPFIVPLK FSFQSPGKLY LVLAFVNGGE LFHHLQREGC FDTYRAKFYI AELLVALECL 120
  121 HEFNVIYRDL KPENILLDYT GHIALCDFGL CKLNMAKTDR TNTFCGTPEY LAPELLLGHG 180
  181 YTKVVDWWTL GVLLYEMITG LPPFYDENIN EMYRKILQDP LRFPDNIDEK AKDLLSGLLT 240
  241 RAPEKRLGSG GAQEIKNHPF FDDIDWKKLC AK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	61.09691
Match:	1h1wA
Description:	3-phosphoinositide dependent protein kinase-1 Pdk1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
phosphotransferase activity, alcohol group as acceptor	5.49988294224815	bayes_pls_golite062009
protein kinase activity	5.4586557943719	bayes_pls_golite062009
kinase activity	5.3287080791198	bayes_pls_golite062009
cyclic nucleotide-dependent protein kinase activity	4.97855712164511	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	4.96052051118534	bayes_pls_golite062009
cAMP-dependent protein kinase activity	4.66277812893755	bayes_pls_golite062009
protein serine/threonine kinase activity	4.46381887831481	bayes_pls_golite062009
transferase activity	3.97138602499442	bayes_pls_golite062009
protein tyrosine kinase activity	2.8153155526437	bayes_pls_golite062009
binding	2.74863538127007	bayes_pls_golite062009
transmembrane receptor activity	2.59526003830791	bayes_pls_golite062009
transmembrane receptor protein kinase activity	2.54265774272269	bayes_pls_golite062009
molecular transducer activity	2.40586892801446	bayes_pls_golite062009
signal transducer activity	2.40586892801446	bayes_pls_golite062009
receptor activity	2.39311927684508	bayes_pls_golite062009
protein binding	2.276111749106	bayes_pls_golite062009
tubulin binding	2.18641675163967	bayes_pls_golite062009
transmembrane receptor protein tyrosine kinase activity	2.16831387024372	bayes_pls_golite062009
cytoskeletal protein binding	2.12615078788254	bayes_pls_golite062009
receptor signaling protein activity	2.10379226653669	bayes_pls_golite062009
ATP binding	1.97600611746091	bayes_pls_golite062009
adenyl ribonucleotide binding	1.93596671856664	bayes_pls_golite062009
adenyl nucleotide binding	1.90928021591891	bayes_pls_golite062009
microtubule binding	1.88110801192607	bayes_pls_golite062009
actin binding	1.87817875565699	bayes_pls_golite062009
acetylcholine receptor activator activity	1.83545227594542	bayes_pls_golite062009
phosphoinositide 3-kinase binding	1.82515074380651	bayes_pls_golite062009
receptor signaling protein serine/threonine kinase activity	1.81249386965144	bayes_pls_golite062009
purine ribonucleotide binding	1.65732943334212	bayes_pls_golite062009
ribonucleotide binding	1.65726906484847	bayes_pls_golite062009
purine nucleotide binding	1.63763394711025	bayes_pls_golite062009
nucleotide binding	1.63195828048121	bayes_pls_golite062009
insulin receptor substrate binding	1.62657794525303	bayes_pls_golite062009
transcription regulator activity	1.56748951434625	bayes_pls_golite062009
DNA binding	1.35333135345112	bayes_pls_golite062009
general RNA polymerase II transcription factor activity	1.32254739984688	bayes_pls_golite062009
gamma-tubulin binding	1.28511591054866	bayes_pls_golite062009
kinase binding	1.26086833316556	bayes_pls_golite062009
ErbB-3 class receptor binding	1.25765701903393	bayes_pls_golite062009
catalytic activity	1.21655087018101	bayes_pls_golite062009
nucleic acid binding	1.16049201286103	bayes_pls_golite062009
transporter activity	1.11833481501707	bayes_pls_golite062009
transcription factor activity	1.10928254946881	bayes_pls_golite062009
protein kinase binding	1.06030596516506	bayes_pls_golite062009
ErbB-2 class receptor binding	1.02996109010965	bayes_pls_golite062009
transmembrane transporter activity	0.97575992765505	bayes_pls_golite062009
cyclin-dependent protein kinase activity	0.959360414036299	bayes_pls_golite062009
growth factor binding	0.86076618871384	bayes_pls_golite062009
MAP kinase activity	0.81943579965027	bayes_pls_golite062009
actin filament binding	0.794152600084	bayes_pls_golite062009
substrate-specific transporter activity	0.705905455086486	bayes_pls_golite062009
structural constituent of cytoskeleton	0.612883428421652	bayes_pls_golite062009
protein serine/threonine/tyrosine kinase activity	0.48345772948903	bayes_pls_golite062009
enzyme binding	0.46284745266176	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	0.450699332958421	bayes_pls_golite062009
protein kinase C activity	0.41587987561486	bayes_pls_golite062009
magnesium ion binding	0.393328812780268	bayes_pls_golite062009
MAP kinase kinase kinase activity	0.37115026509016	bayes_pls_golite062009
MAP kinase kinase activity	0.35402045013148	bayes_pls_golite062009
insulin receptor binding	0.266450215230107	bayes_pls_golite062009
protein complex binding	0.239339759110451	bayes_pls_golite062009
insulin receptor activity	0.237134032032089	bayes_pls_golite062009
SH2 domain binding	0.226760162354251	bayes_pls_golite062009
transmembrane receptor protein serine/threonine kinase activity	0.20643152368029	bayes_pls_golite062009
transforming growth factor beta receptor activity	0.20643152368029	bayes_pls_golite062009
ion transmembrane transporter activity	0.148194101970458	bayes_pls_golite062009
peptide binding	0.118578378753757	bayes_pls_golite062009
transforming growth factor beta receptor activity, type I	0.0506751594607393	bayes_pls_golite062009
nucleoside-triphosphatase activity	0.0040394359628233	bayes_pls_golite062009

Predicted Domain #4

Region A:
Residues: [497-569]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KIQPPFKPSV ESAIDTSNFD SEFTSEIPMD SVVADSHLSE TVQQRFANWS YQRPTTIDTS  60
   61 DDINTIAPGS VIR

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	79.69897
Match:	1gznA
Description:	Pkb kinase
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: