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Protein Overview: cnx1

General Information:
Name(s) found: cnx1 / SPAC3C7.11c [Sanger Pombe]
Description(s) found:
Found 22 descriptions.
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  • calnexin [Sanger Pombe]
    • Organism: Schizosaccharomyces pombe
    Length: 560 amino acids

    Gene Ontology:
    Cellular Component: endoplasmic reticulum membrane [TASLink to PubMed article]
    integral to membrane [IEA]
    endoplasmic reticulum [IDALink to PubMed article]
    Biological Process: cellular response to heat [TASLink to PubMed article]
    misfolded or incompletely synthesized protein catabolic process [IMPLink to PubMed article]
    apoptosis [IMPLink to PubMed article]
    ER-associated protein catabolic process [ISS]
    protein folding in endoplasmic reticulum [IDALink to PubMed article]
    Molecular Function: protein binding [IPILink to PubMed article]
    sugar binding [IEA]
    calcium ion binding [TASLink to PubMed article]
    unfolded protein binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKYGKVSFLA LLCSLYVRGS LADPESEQEP LVFNPTEVKA PLVEQFQGAW SERWIPSHAK  60
   61 RFVNGIEEMS YVGEWTVEES SGPGALKGEA GLVMKDEAAH HAISYEFDEP INEPEKDLVV 120
  121 QYEVNPEEGL NCGGAYLKLL AEPTHGEMSN SIDYRIMFGP DKCGVNDRVH FIFKHKNPLT 180
  181 GEYSEKHLDS RPASLLKPGI TNLYTLIVKP DQTFEVRING DVVRQGSLFY DFIPPVLPPV 240
  241 EIYDPEDIKP ADWVDEPEIP DPNAVKPDDW DEDAPRMIPD PDAVKPEDWL EDEPLYIPDP 300
  301 EAQKPEDWDD EEDGDWIPSE IINPKCIEGA GCGEWKPPMI RNPNYRGPWS PPMIPNPEFI 360
  361 GEWYPRKIPN PDYFDDDHPS HFGPLYGVGF ELWTMQPNIR FSNIYVGHSI EDAERLGNET 420
  421 FLPKLKAERE LLSKQESMEK QSMHVDEESN QILEKFLDVY DIIKAKLPPN VAEKVDYYVE 480
  481 TIIETPEIGI AIVAVLGSLT AVILTCYFYF FASSSPASLS TGTTEAEKEQ QEKFKQETET 540
  541 EKIDVSYAPE TESPTAKNED

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..438] PSI-BLAST 166.0 Calnexin
    2 View Details [439..560] PSI-BLAST 11.39794 Eps15

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • complement component C1q binding
    		•  4.81971897425786 bayes_pls_golite062009
  • steroid hormone receptor binding
    		•  4.11346029337178 bayes_pls_golite062009
  • androgen receptor binding
    		•  3.88449123711676 bayes_pls_golite062009
  • zymosan binding
    		•  3.41405218556083 bayes_pls_golite062009
  • nuclear hormone receptor binding
    		•  3.3517714661273 bayes_pls_golite062009
  • binding
    		•  3.24845777545007 bayes_pls_golite062009
  • hormone receptor binding
    		•  3.2405597896178 bayes_pls_golite062009
  • structural molecule activity
    		•  3.0286932947016 bayes_pls_golite062009
  • unfolded protein binding
    		•  2.94586353433162 bayes_pls_golite062009
  • protein binding
    		•  2.62442480878692 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.5786381493734 bayes_pls_golite062009
  • transcription repressor activity
    		•  2.42862869142896 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.33705817770533 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  2.16616430987996 bayes_pls_golite062009
  • actin binding
    		•  2.0669297251683 bayes_pls_golite062009
  • DNA binding
    		•  2.05388036301171 bayes_pls_golite062009
  • carbohydrate binding
    		•  1.90829797790335 bayes_pls_golite062009
  • sugar binding
    		•  1.89824804892868 bayes_pls_golite062009
  • receptor binding
    		•  1.70102429470678 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.69567186252006 bayes_pls_golite062009
  • signal transducer activity
    		•  1.69567186252006 bayes_pls_golite062009
  • cation binding
    		•  1.67588357161378 bayes_pls_golite062009
  • metal ion binding
    		•  1.67588357161378 bayes_pls_golite062009
  • ion binding
    		•  1.66900324045723 bayes_pls_golite062009
  • NACHT domain binding
    		•  1.53382521801494 bayes_pls_golite062009
  • integrin binding
    		•  1.36513827550387 bayes_pls_golite062009
  • transporter activity
    		•  1.29150662073327 bayes_pls_golite062009
  • chaperone binding
    		•  1.28860282614448 bayes_pls_golite062009
  • glycosaminoglycan binding
    		•  1.25720635817943 bayes_pls_golite062009
  • protein complex binding
    		•  1.23240411516711 bayes_pls_golite062009
  • RNA binding
    		•  1.22339134958708 bayes_pls_golite062009
  • heparin binding
    		•  1.15897181987617 bayes_pls_golite062009
  • transcription factor activity
    		•  1.15427978494805 bayes_pls_golite062009
  • transcription activator activity
    		•  1.11465354227601 bayes_pls_golite062009
  • polysaccharide binding
    		•  1.09475063562581 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.07075219961504 bayes_pls_golite062009
  • receptor activity
    		•  0.946182305131481 bayes_pls_golite062009
  • growth factor activity
    		•  0.850395354506359 bayes_pls_golite062009
  • pattern binding
    		•  0.83687933614214 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  0.814690646803591 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.801327928563072 bayes_pls_golite062009
  • mRNA binding
    		•  0.67699218614597 bayes_pls_golite062009
  • monosaccharide binding
    		•  0.5678336426881 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.546870122670733 bayes_pls_golite062009
  • extracellular matrix structural constituent
    		•  0.52360080681204 bayes_pls_golite062009
  • calcium ion binding
    		•  0.416416901481401 bayes_pls_golite062009
  • hydrolase activity
    		•  0.374282208763552 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.160855218996334 bayes_pls_golite062009
  • growth factor binding
    		•  0.0922754536898114 bayes_pls_golite062009
  • cytokine binding
    		•  0.0273545648165503 bayes_pls_golite062009
    2
    Term Confidence Notes
  • cytoskeletal protein binding
    		•  3.49668552859347 bayes_pls_golite062009
  • structural molecule activity
    		•  3.23829457266793 bayes_pls_golite062009
  • binding
    		•  3.17556402087346 bayes_pls_golite062009
  • actin binding
    		•  2.93015079033749 bayes_pls_golite062009
  • metal ion binding
    		•  2.62077305565026 bayes_pls_golite062009
  • cation binding
    		•  2.62077305565026 bayes_pls_golite062009
  • ion binding
    		•  2.61312132078717 bayes_pls_golite062009
  • motor activity
    		•  2.57627414053278 bayes_pls_golite062009
  • microfilament motor activity
    		•  2.31015572544973 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.23156041569913 bayes_pls_golite062009
  • protein binding
    		•  2.21291432166051 bayes_pls_golite062009
  • structural constituent of muscle
    		•  2.20727612600932 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.83723964306928 bayes_pls_golite062009
  • DNA binding
    		•  1.73924929536227 bayes_pls_golite062009
  • signal transducer activity
    		•  1.56751504958972 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.56751504958972 bayes_pls_golite062009
  • myosin binding
    		•  1.52005099664686 bayes_pls_golite062009
  • tubulin binding
    		•  1.46254997073304 bayes_pls_golite062009
  • peptidase activity
    		•  1.42397628411744 bayes_pls_golite062009
  • calcium ion binding
    		•  1.40919295397643 bayes_pls_golite062009
  • actin-dependent ATPase activity
    		•  1.39855027520112 bayes_pls_golite062009
  • actin filament binding
    		•  1.39015845077273 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.24311821191924 bayes_pls_golite062009
  • transporter activity
    		•  1.15928534291452 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  1.15266823079004 bayes_pls_golite062009
  • calcium-dependent protein binding
    		•  1.07190293594284 bayes_pls_golite062009
  • microtubule binding
    		•  1.02453072828852 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.945691505472547 bayes_pls_golite062009
  • receptor binding
    		•  0.857448001471136 bayes_pls_golite062009
  • endopeptidase activity
    		•  0.833336205861396 bayes_pls_golite062009
  • G-protein beta/gamma-subunit binding
    		•  0.77824189826064 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.693724160233023 bayes_pls_golite062009
  • myosin heavy chain binding
    		•  0.61866037435065 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.45412801027969 bayes_pls_golite062009
  • hydrolase activity
    		•  0.275235036575339 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.246383459363256 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.193201281459889 bayes_pls_golite062009
  • N-terminal myristoylation domain binding
    		•  0.1721637562785 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.116648335890738 bayes_pls_golite062009
  • gated channel activity
    		•  0.0709126830279607 bayes_pls_golite062009
  • actin monomer binding
    		•  0.0701886284348601 bayes_pls_golite062009
  • protein complex binding
    		•  0.0676093357928913 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  0.0305250212662123 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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