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View Structure Prediction Details

Protein: cnx1
Organism: Schizosaccharomyces pombe
Length: 560 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for cnx1.

Description E-value Query
Range
Subject
Range
gi|109080100 - gi|109080100|ref|XP_001100506.1| PREDICTED: similar to calnexin precursor isoform 1 [Macaca mulatta]
648.0 [0..18] [482..41]
gi|114603821 - gi|114603821|ref|XP_001150707.1| PREDICTED: similar to Calnexin precursor isoform 1 [Pan troglodytes...
646.0 [0..18] [482..41]
gi|145229911 - gi|145229911|ref|XP_001389264.1| hypothetical protein An01g08420 [Aspergillus niger]
gi|134055377, gi... - gi|18564808|emb|CAC82717.1| calnexin [Aspergillus niger], gi|134055377|emb|CAK43931.1| unnamed prote...
642.0 [0..1] [553..1]
gi|61373028 - gi|61373028|gb|AAX43960.1| calnexin [synthetic construct]
639.0 [0..18] [481..41]
gi|55731977 - gi|55731977|emb|CAH92697.1| hypothetical protein [Pongo abelii]
gi|55731977|emb|... - hypothetical protein [Pongo pygmaeus]
638.0 [0..18] [481..41]
CANX - calnexin
gi|123994237, gi... - gi|60655615|gb|AAX32371.1| calnexin [synthetic construct], gi|124126943|gb|ABM92244.1| calnexin [syn...
638.0 [0..18] [481..41]

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Predicted Domain #1
Region A:
Residues: [1-438]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKYGKVSFLA LLCSLYVRGS LADPESEQEP LVFNPTEVKA PLVEQFQGAW SERWIPSHAK  60
   61 RFVNGIEEMS YVGEWTVEES SGPGALKGEA GLVMKDEAAH HAISYEFDEP INEPEKDLVV 120
  121 QYEVNPEEGL NCGGAYLKLL AEPTHGEMSN SIDYRIMFGP DKCGVNDRVH FIFKHKNPLT 180
  181 GEYSEKHLDS RPASLLKPGI TNLYTLIVKP DQTFEVRING DVVRQGSLFY DFIPPVLPPV 240
  241 EIYDPEDIKP ADWVDEPEIP DPNAVKPDDW DEDAPRMIPD PDAVKPEDWL EDEPLYIPDP 300
  301 EAQKPEDWDD EEDGDWIPSE IINPKCIEGA GCGEWKPPMI RNPNYRGPWS PPMIPNPEFI 360
  361 GEWYPRKIPN PDYFDDDHPS HFGPLYGVGF ELWTMQPNIR FSNIYVGHSI EDAERLGNET 420
  421 FLPKLKAERE LLSKQESM

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 166.0
Match: 1jhnA
Description: Calnexin
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
complement component C1q binding 4.81971897425786 bayes_pls_golite062009
steroid hormone receptor binding 4.11346029337178 bayes_pls_golite062009
androgen receptor binding 3.88449123711676 bayes_pls_golite062009
zymosan binding 3.41405218556083 bayes_pls_golite062009
nuclear hormone receptor binding 3.3517714661273 bayes_pls_golite062009
binding 3.24845777545007 bayes_pls_golite062009
hormone receptor binding 3.2405597896178 bayes_pls_golite062009
structural molecule activity 3.0286932947016 bayes_pls_golite062009
unfolded protein binding 2.94586353433162 bayes_pls_golite062009
protein binding 2.62442480878692 bayes_pls_golite062009
transcription regulator activity 2.5786381493734 bayes_pls_golite062009
transcription repressor activity 2.42862869142896 bayes_pls_golite062009
nucleic acid binding 2.33705817770533 bayes_pls_golite062009
cytoskeletal protein binding 2.16616430987996 bayes_pls_golite062009
actin binding 2.0669297251683 bayes_pls_golite062009
DNA binding 2.05388036301171 bayes_pls_golite062009
carbohydrate binding 1.90829797790335 bayes_pls_golite062009
sugar binding 1.89824804892868 bayes_pls_golite062009
receptor binding 1.70102429470678 bayes_pls_golite062009
molecular transducer activity 1.69567186252006 bayes_pls_golite062009
signal transducer activity 1.69567186252006 bayes_pls_golite062009
cation binding 1.67588357161378 bayes_pls_golite062009
metal ion binding 1.67588357161378 bayes_pls_golite062009
ion binding 1.66900324045723 bayes_pls_golite062009
NACHT domain binding 1.53382521801494 bayes_pls_golite062009
integrin binding 1.36513827550387 bayes_pls_golite062009
transporter activity 1.29150662073327 bayes_pls_golite062009
chaperone binding 1.28860282614448 bayes_pls_golite062009
glycosaminoglycan binding 1.25720635817943 bayes_pls_golite062009
protein complex binding 1.23240411516711 bayes_pls_golite062009
RNA binding 1.22339134958708 bayes_pls_golite062009
heparin binding 1.15897181987617 bayes_pls_golite062009
transcription factor activity 1.15427978494805 bayes_pls_golite062009
transcription activator activity 1.11465354227601 bayes_pls_golite062009
polysaccharide binding 1.09475063562581 bayes_pls_golite062009
transmembrane transporter activity 1.07075219961504 bayes_pls_golite062009
receptor activity 0.946182305131481 bayes_pls_golite062009
growth factor activity 0.850395354506359 bayes_pls_golite062009
pattern binding 0.83687933614214 bayes_pls_golite062009
transmembrane receptor activity 0.814690646803591 bayes_pls_golite062009
substrate-specific transporter activity 0.801327928563072 bayes_pls_golite062009
mRNA binding 0.67699218614597 bayes_pls_golite062009
monosaccharide binding 0.5678336426881 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.546870122670733 bayes_pls_golite062009
extracellular matrix structural constituent 0.52360080681204 bayes_pls_golite062009
calcium ion binding 0.416416901481401 bayes_pls_golite062009
hydrolase activity 0.374282208763552 bayes_pls_golite062009
structural constituent of cytoskeleton 0.160855218996334 bayes_pls_golite062009
growth factor binding 0.0922754536898114 bayes_pls_golite062009
cytokine binding 0.0273545648165503 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [439-560]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EKQSMHVDEE SNQILEKFLD VYDIIKAKLP PNVAEKVDYY VETIIETPEI GIAIVAVLGS  60
   61 LTAVILTCYF YFFASSSPAS LSTGTTEAEK EQQEKFKQET ETEKIDVSYA PETESPTAKN 120
  121 ED

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 11.39794
Match: 1qjtA
Description: Eps15
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
cytoskeletal protein binding 3.49668552859347 bayes_pls_golite062009
structural molecule activity 3.23829457266793 bayes_pls_golite062009
binding 3.17556402087346 bayes_pls_golite062009
actin binding 2.93015079033749 bayes_pls_golite062009
metal ion binding 2.62077305565026 bayes_pls_golite062009
cation binding 2.62077305565026 bayes_pls_golite062009
ion binding 2.61312132078717 bayes_pls_golite062009
motor activity 2.57627414053278 bayes_pls_golite062009
microfilament motor activity 2.31015572544973 bayes_pls_golite062009
transcription regulator activity 2.23156041569913 bayes_pls_golite062009
protein binding 2.21291432166051 bayes_pls_golite062009
structural constituent of muscle 2.20727612600932 bayes_pls_golite062009
nucleic acid binding 1.83723964306928 bayes_pls_golite062009
DNA binding 1.73924929536227 bayes_pls_golite062009
signal transducer activity 1.56751504958972 bayes_pls_golite062009
molecular transducer activity 1.56751504958972 bayes_pls_golite062009
myosin binding 1.52005099664686 bayes_pls_golite062009
tubulin binding 1.46254997073304 bayes_pls_golite062009
peptidase activity 1.42397628411744 bayes_pls_golite062009
calcium ion binding 1.40919295397643 bayes_pls_golite062009
actin-dependent ATPase activity 1.39855027520112 bayes_pls_golite062009
actin filament binding 1.39015845077273 bayes_pls_golite062009
transcription repressor activity 1.24311821191924 bayes_pls_golite062009
transporter activity 1.15928534291452 bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides 1.15266823079004 bayes_pls_golite062009
calcium-dependent protein binding 1.07190293594284 bayes_pls_golite062009
microtubule binding 1.02453072828852 bayes_pls_golite062009
transmembrane transporter activity 0.945691505472547 bayes_pls_golite062009
receptor binding 0.857448001471136 bayes_pls_golite062009
endopeptidase activity 0.833336205861396 bayes_pls_golite062009
G-protein beta/gamma-subunit binding 0.77824189826064 bayes_pls_golite062009
substrate-specific transporter activity 0.693724160233023 bayes_pls_golite062009
myosin heavy chain binding 0.61866037435065 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.45412801027969 bayes_pls_golite062009
hydrolase activity 0.275235036575339 bayes_pls_golite062009
active transmembrane transporter activity 0.246383459363256 bayes_pls_golite062009
ion transmembrane transporter activity 0.193201281459889 bayes_pls_golite062009
N-terminal myristoylation domain binding 0.1721637562785 bayes_pls_golite062009
structural constituent of cytoskeleton 0.116648335890738 bayes_pls_golite062009
gated channel activity 0.0709126830279607 bayes_pls_golite062009
actin monomer binding 0.0701886284348601 bayes_pls_golite062009
protein complex binding 0.0676093357928913 bayes_pls_golite062009
cation transmembrane transporter activity 0.0305250212662123 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle