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Protein Overview: S6kII-PA, FBpp03...

General Information:
Name(s) found: FBpp0305864 [FlyBase]
S6kII-PA / FBpp0077052 [FlyBase]
Description(s) found:
Found 27 descriptions.
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  • type=protein; loc=X:join(21932187..21934338,21934692..21935275); ID=FBpp0305864; name=S6kII-PB; parent=FBgn0262866,FBtr0333715; dbxref=REFSEQ:NP_001259779,GB_protein:AGB95617,FlyBase:FBpp0305864,FlyBase_Annotation_IDs:CG17596-PB; MD5=05f79e2a7437fc2aa869c94e97cf56ce; length=911; release=r5.56; species=Dmel; [FlyBase]
  • The gene RPS6-protein kinase-II is referred to in FlyBase by the symbol Dmel\S6kII (CG17596, FBgn0011285). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:21931813..21935929. It has the cytological map location 20C1. There is experimental evidence that it has the molecular function</span>: protein binding; ribosomal protein S6 kinase activity. There is experimental evidence for 11 unique biological process</span> terms, many of which group under: regulation of developmental process; regulation of biological process; anatomical structure development; learning; learning or memory; organ development; system process; negative regulation of small GTPase mediated signal transduction; associative learning; regulation of protein transport; determination of adult lifespan; locomotory behavior; regulation of neurogenesis. 20 alleles are reported. The phenotypes of these alleles are annotated with: rhabdomere; retina; interommatidial bristle; cone cell; eye photoreceptor cell; ommatidial precursor cluster; ommatidium; wing vein; pigment cell. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 911 amino acids

    Gene Ontology:
    Cellular Component: neuromuscular junction [IDA]
    ribosome [ISS][NAS]
    Biological Process: neuromuscular junction development [IMP]
    negative regulation of Ras protein signal transduction [IGI]
    negative regulation of protein import into nucleus [IDA]
    locomotor rhythm [IMP]
    determination of adult lifespan [IMP]
    negative regulation of compound eye cone cell fate specification [IMP]
    imaginal disc-derived wing vein specification [IMP]
    negative regulation of photoreceptor cell differentiation [IMP]
    protein amino acid phosphorylation [IEA][ISS][NAS]
    associative learning [IMP][TAS]
    operant conditioning [IMP][TAS]
    negative regulation of pigment cell differentiation [IMP]
    Molecular Function: ribosomal protein S6 kinase activity [IDA][ISS][NAS]
    ATP binding [IEA]
    protein binding [IPI]
    protein serine/threonine kinase activity [NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPLADSQKDL RQQPQQQQQQ QHVSSTSSSN NAEQQCSSSG LGLQLRQRMQ ITSSGCSSLA  60
   61 VTPMEHTPTE DDESGGGNSG VTSSVTTVTS SQRRQQLQQV QQQSALQAAL EQHHISPTAD 120
  121 LDSARKRPTH RTLCPPPELM ELSDSESQGG VETGGRREGA TGRSAPDLED TEPLYETENE 180
  181 FELKEVIKEG HDKADPSQFE LLRVLGEGSF GKVFLVRKII GKDAGTLYAM KVLKKATLKV 240
  241 KDRVRSTNER KILADVGHAF IVRLHYAFQT PGKLYLILDF LRGGDLFTRL SKEVMFTEED 300
  301 VKFYLAELAL AMNHLHTLGI IYRDLKPENI LLDEHGHIAL TDFGLSKQPL DGSKTYSFCG 360
  361 TVEYMAPEIV NRKGHDFAAD WWSFGVLMYE MLTGNLPFHG QTRQETMNQI LRSKLGMPEN 420
  421 LSPEAQSLLR ALFKRNPQNR LGAGAQGILD IKAHCFFATI DWVRLERKQV RPPFIPAVSR 480
  481 DDAFYFDVEY TSKSPRDSPG GPISASAHEI FRGFSFVAPV LLEGQCAGSN MCSTSASPLH 540
  541 SIAPIPAAPV GAPRTLPGVL PGNFHAEYNL LQELGRGTFS VCRLCEHRAS KKHYAVKVIE 600
  601 KAAVAAASTS TSADCWEEVE IMLRYGNHPN IVTLYSVYED AGSAYLVMEL LKGGELLDRI 660
  661 LAVGQMCESE ASAVLRTIAS AVAYLHEHGV VHRDLKPSNM IYASMRQTPE TLKLCDLGFA 720
  721 KQLRADNGLL MTPCYTANFV APEVLKRQGY DLACDIWSLG VLLYIMLSGR TPFASTPNDS 780
  781 PDVILKRIGS GQIDFTSSRW ALISVPAKEL LRQMLHIVPE NRPTAARILE HDWLREQFAG 840
  841 GVQLTEYAVA PGSQLSLGAQ QQQQNHISMA LRGAVDATFR AIAIPQAANV GPVELSMLAK 900
  901 RRAKDRANLH S

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..180] deduced N/A No confident structure predictions are available.
    2 View Details [181..551] PSI-BLAST 80.522879 Catalytic and ubiqutin-associated domains of MARK2/PAR-1: Wild type
    3 View Details [552..911] PSI-BLAST 92.221849 No description for 2jdoA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • phosphotransferase activity, alcohol group as acceptor
    		•  5.49988294224815 bayes_pls_golite062009
  • protein kinase activity
    		•  5.4586557943719 bayes_pls_golite062009
  • kinase activity
    		•  5.3287080791198 bayes_pls_golite062009
  • cyclic nucleotide-dependent protein kinase activity
    		•  4.97855712164511 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  4.96052051118534 bayes_pls_golite062009
  • cAMP-dependent protein kinase activity
    		•  4.66277812893755 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  4.46381887831481 bayes_pls_golite062009
  • calmodulin-dependent protein kinase activity
    		•  4.31938467136214 bayes_pls_golite062009
  • transferase activity
    		•  3.97138602499442 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase activity
    		•  3.41480681854114 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  3.40140621607334 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  2.8153155526437 bayes_pls_golite062009
  • binding
    		•  2.74863538127007 bayes_pls_golite062009
  • structural molecule activity
    		•  2.60280308499348 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  2.59526003830791 bayes_pls_golite062009
  • signal transducer activity
    		•  2.40586892801446 bayes_pls_golite062009
  • molecular transducer activity
    		•  2.40586892801446 bayes_pls_golite062009
  • receptor activity
    		•  2.39311927684508 bayes_pls_golite062009
  • protein binding
    		•  2.276111749106 bayes_pls_golite062009
  • tubulin binding
    		•  2.18641675163967 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  2.12615078788254 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  2.10379226653669 bayes_pls_golite062009
  • ATP binding
    		•  1.97600611746091 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  1.93596671856664 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  1.90928021591891 bayes_pls_golite062009
  • microtubule binding
    		•  1.88110801192607 bayes_pls_golite062009
  • actin binding
    		•  1.87817875565699 bayes_pls_golite062009
  • receptor signaling protein serine/threonine kinase activity
    		•  1.81249386965144 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  1.65732943334212 bayes_pls_golite062009
  • ribonucleotide binding
    		•  1.65726906484847 bayes_pls_golite062009
  • purine nucleotide binding
    		•  1.63763394711025 bayes_pls_golite062009
  • nucleotide binding
    		•  1.63195828048121 bayes_pls_golite062009
  • insulin receptor substrate binding
    		•  1.62657794525303 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.56748951434625 bayes_pls_golite062009
  • growth factor binding
    		•  1.53863828216563 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.46547714006072 bayes_pls_golite062009
  • DNA binding
    		•  1.35333135345112 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  1.32254739984688 bayes_pls_golite062009
  • gamma-tubulin binding
    		•  1.28511591054866 bayes_pls_golite062009
  • kinase binding
    		•  1.26086833316556 bayes_pls_golite062009
  • ErbB-3 class receptor binding
    		•  1.25765701903393 bayes_pls_golite062009
  • phosphoinositide 3-kinase binding
    		•  1.25285260301349 bayes_pls_golite062009
  • catalytic activity
    		•  1.21655087018101 bayes_pls_golite062009
  • acetylcholine receptor activator activity
    		•  1.13856518303051 bayes_pls_golite062009
  • transporter activity
    		•  1.11833481501707 bayes_pls_golite062009
  • transcription factor activity
    		•  1.10928254946881 bayes_pls_golite062009
  • transmembrane receptor protein serine/threonine kinase activity
    		•  1.10045286406485 bayes_pls_golite062009
  • transforming growth factor beta receptor activity
    		•  1.10045286406485 bayes_pls_golite062009
  • protein kinase binding
    		•  1.06030596516506 bayes_pls_golite062009
  • transcription activator activity
    		•  0.997272622653026 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.97575992765505 bayes_pls_golite062009
  • cyclin-dependent protein kinase activity
    		•  0.959360414036299 bayes_pls_golite062009
  • MAP kinase activity
    		•  0.81943579965027 bayes_pls_golite062009
  • actin filament binding
    		•  0.794152600084 bayes_pls_golite062009
  • fibroblast growth factor receptor activity
    		•  0.75189004129952 bayes_pls_golite062009
  • stem cell factor receptor activity
    		•  0.717202429138068 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.705905455086486 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.612883428421652 bayes_pls_golite062009
  • ErbB-2 class receptor binding
    		•  0.547121592096699 bayes_pls_golite062009
  • activin binding
    		•  0.510364757301021 bayes_pls_golite062009
  • protein serine/threonine/tyrosine kinase activity
    		•  0.48345772948903 bayes_pls_golite062009
  • enzyme binding
    		•  0.46284745266176 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.450699332958421 bayes_pls_golite062009
  • structural constituent of muscle
    		•  0.399773397398032 bayes_pls_golite062009
  • magnesium ion binding
    		•  0.393328812780268 bayes_pls_golite062009
  • MAP kinase kinase kinase activity
    		•  0.37115026509016 bayes_pls_golite062009
  • MAP kinase kinase activity
    		•  0.35402045013148 bayes_pls_golite062009
  • RNA binding
    		•  0.245748631571068 bayes_pls_golite062009
  • protein complex binding
    		•  0.239339759110451 bayes_pls_golite062009
  • insulin receptor activity
    		•  0.237134032032089 bayes_pls_golite062009
  • SH2 domain binding
    		•  0.226760162354251 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.148194101970458 bayes_pls_golite062009
  • transforming growth factor beta receptor activity, type I
    		•  0.0506751594607393 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.0040394359628233 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.95

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle