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Protein Overview: Cyp18a1-PB, Cyp1...

General Information:
Name(s) found: Cyp18a1-PB / FBpp0074381 [FlyBase]
Cyp18a1-PA / FBpp0074380 [FlyBase]
Description(s) found:
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  • gi|7293499|gb|AAF48874.1| cytochrome P450-18a1, isoform B [Drosophila melanogaster] [NCBI NR]
  • gi|24643094|ref|NP_523403.2| cytochrome P450-18a1, isoform B [Drosophila melanogaster] [NCBI NR]
  • gi|24643092|ref|NP_728191.1| cytochrome P450-18a1, isoform A [Drosophila melanogaster] [NCBI NR]
  • gi|22832514|gb|AAN09473.1| cytochrome P450-18a1, isoform A [Drosophila melanogaster] [NCBI NR]
  • gi|146739343|emb|CAL69954.1| cytochrome P450 Cyp18a1 [Drosophila melanogaster] [NCBI NR]
  • gi|146739340|emb|CAL69952.1| cytochrome P450 Cyp18a1 [Drosophila melanogaster] [NCBI NR]
  • gi|146739337|emb|CAL69950.1| cytochrome P450 Cyp18a1 [Drosophila melanogaster] [NCBI NR]
  • gi|146739334|emb|CAL69948.1| cytochrome P450 Cyp18a1 [Drosophila melanogaster] [NCBI NR]
  • gi|146739331|emb|CAL69946.1| cytochrome P450 Cyp18a1 [Drosophila melanogaster] [NCBI NR]
  • gi|146739328|emb|CAL69944.1| cytochrome P450 Cyp18a1 [Drosophila melanogaster] [NCBI NR]
  • gi|146739325|emb|CAL69942.1| cytochrome P450 Cyp18a1 [Drosophila melanogaster] [NCBI NR]
  • gi|146739319|emb|CAL69938.1| cytochrome P450 Cyp18a1 [Drosophila melanogaster] [NCBI NR]
  • gi|146739316|emb|CAL69936.1| cytochrome P450 Cyp18a1 [Drosophila melanogaster] [NCBI NR]
  • gi|146739313|emb|CAL69934.1| cytochrome P450 Cyp18a1 [Drosophila melanogaster] [NCBI NR]
  • gi|146739310|emb|CAL69932.1| cytochrome P450 Cyp18a1 [Drosophila melanogaster] [NCBI NR]
  • gi|146739307|emb|CAL69930.1| cytochrome P450 Cyp18a1 [Drosophila melanogaster] [NCBI NR]
  • gi|12644471|sp|Q95078.2|CP18A_DROME RecName: Full=Cytochrome P450 18a1; AltName: Full=CYPXVIIIA1 [NCBI NR]
  • (Q95078) Cytochrome P450 18a1 (EC 1.14.-.-) (CYPXVIIIA1) [Swiss-Prot]
  • Cytochrome P450 18a1 OS=Drosophila melanogaster GN=Cyp18a1 PE=2 SV=2 [Swiss-Prot]
  • The gene Cytochrome P450-18a1 is referred to in FlyBase by the symbol Dmel\Cyp18a1 (CG6816, FBgn0010383). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:18582570..18586778. It has the cytological map location 17D1. Based on sequence similarity, it is predicted to have molecular function</span>: electron carrier activity. It is reported to be involved in the biological process</span>: steroid biosynthetic process. 4 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
  • >CG6816-PA translation from_gene[CG6816 Cyp18a1 FBgn0010383] seq_release:3 mol_weight=61950 cds_boundaries:(X:18,420,108..18,423,177[-]) aa_length:538 transcript_info:[CG6816-RA seq_release:3] gene_info:[gene symbol:Cyp18a1 FBgn0010383 gene_boundaries: [hmr_yeast5_DM3-1_pombe.fasta]
  • >CG6816-PB translation from_gene[CG6816 Cyp18a1 FBgn0010383] seq_release:3 mol_weight=61950 cds_boundaries:(X:18,420,108..18,423,177[-]) aa_length:538 transcript_info:[CG6816-RB seq_release:3] gene_info:[gene symbol:Cyp18a1 FBgn0010383 gene_boundaries: [hmr_yeast5_DM3-1_pombe.fasta]
  • (AE003509) Cyp18a1 gene product [Drosophila melanogaster] [yeastflysequest.fasta]
  • CG6816-PB, isoform B [Drosophila melanogaster]gi|22832514|gb|AAN09473.1| CG6816-PA, isoform A [Drosophila melanogaster]gi|24643092|ref|NP_728191.1| CG6816-PA [Drosophila melanogaster]gi|24643094|ref|NP_523403.2| CG6816-PB [Drosophila melanogaster]gi|1 [nrdb_11152004_Chlamydomonas]
  • type=protein; loc=X:complement(18583179..18583587,18584024..18584288,18584392..18584821,18584899..18585020,18585861..18586251); ID=FBpp0074380; name=Cyp18a1-PA; parent=FBgn0010383,FBtr0074609; dbxref=FlyBase:FBpp0074380,FlyBase_Annotation_IDs:CG6816-PA,GB [fly-100309-contam.fasta]
  • type=protein; loc=X:complement(18583179..18583587,18584024..18584288,18584392..18584821,18584899..18585020,18585861..18586251); ID=FBpp0074381; name=Cyp18a1-PB; parent=FBgn0010383,FBtr0074610; dbxref=FlyBase:FBpp0074381,FlyBase_Annotation_IDs:CG6816-PB,GB [fly-100309-contam.fasta]
  • CG6816-PB, isoform B [Drosophila melanogaster] [nr-271106-contam.fasta]
  • CG6816-PA, isoform A [Drosophila melanogaster] [nr-271106-contam.fasta]
  • Cytochrome P450-18a1 CG6816-PA, isoform A [Drosophila melanogaster] [nr-271106-contam.fasta]
  • Cytochrome P450 18a1 (CYPXVIIIA1) [nr-271106-contam.fasta]
  • Cytochrome P450-18a1 CG6816-PB, isoform B [Drosophila melanogaster] [nr-271106-contam.fasta]
  • type=protein; loc=X:complement(18583179..18583587,18584024..18584288,18584392..18584821,18584899..18585020,18585861..18586251); ID=FBpp0074380; name=Cyp18a1-PA; parent=FBgn0010383,FBtr0074609; dbxref=FlyBase:FBpp0074380,FlyBase_Annotation_IDs:CG6816-PA,GB_protein:AAN09473.1,REFSEQ:NP_728191,GB_protein:AAN09473; MD5=47ace5c3df54ffe072b4e20779caa7eb; length=538; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=X:complement(18583179..18583587,18584024..18584288,18584392..18584821,18584899..18585020,18585861..18586251); ID=FBpp0074381; name=Cyp18a1-PB; parent=FBgn0010383,FBtr0074610; dbxref=FlyBase:FBpp0074381,FlyBase_Annotation_IDs:CG6816-PB,GB_protein:AAF48874.1,REFSEQ:NP_523403,GB_protein:AAF48874; MD5=47ace5c3df54ffe072b4e20779caa7eb; length=538; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=X:complement(18583179..18583587,18584024..18584288,18584392..18584821,18584899..18585020,18585861..18586251); ID=FBpp0074380; name=Cyp18a1-PA; parent=FBgn0010383,FBtr0074609; dbxref=FlyBase:FBpp0074380,FlyBase_Annotation_IDs:CG6816-PA,GB_protein:AAN09473.1,REFSEQ:NP_728191,GB_protein:AAN09473; MD5=47ace5c3df54ffe072b4e20779caa7eb; length=538; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • type=protein; loc=X:complement(18583179..18583587,18584024..18584288,18584392..18584821,18584899..18585020,18585861..18586251); ID=FBpp0074381; name=Cyp18a1-PB; parent=FBgn0010383,FBtr0074610; dbxref=FlyBase:FBpp0074381,FlyBase_Annotation_IDs:CG6816-PB,GB_protein:AAF48874.1,REFSEQ:NP_523403,GB_protein:AAF48874; MD5=47ace5c3df54ffe072b4e20779caa7eb; length=538; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • type=protein; loc=X:complement(18583179..18583587,18584024..18584288,18584392..18584821,18584899..18585020,18585861..18586251); ID=FBpp0074380; name=Cyp18a1-PA; parent=FBgn0010383,FBtr0074609; dbxref=FlyBase:FBpp0074380,FlyBase_Annotation_IDs:CG6816-PA,GB_protein:AAN09473.1,REFSEQ:NP_728191,GB_protein:AAN09473,FlyMine:FBpp0074380,modMine:FBpp0074380; MD5=47ace5c3df54ffe072b4e20779caa7eb; length=538; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • type=protein; loc=X:complement(18583179..18583587,18584024..18584288,18584392..18584821,18584899..18585020,18585861..18586251); ID=FBpp0074381; name=Cyp18a1-PB; parent=FBgn0010383,FBtr0074610; dbxref=FlyBase:FBpp0074381,FlyBase_Annotation_IDs:CG6816-PB,GB_protein:AAF48874.1,REFSEQ:NP_523403,GB_protein:AAF48874; MD5=47ace5c3df54ffe072b4e20779caa7eb; length=538; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • type=protein; loc=X:complement(join(18691828..18692218,18690866..18690987,18690359..18690788,18689991..18690255,18689146..18689554)); ID=FBpp0074380; name=Cyp18a1-PA; parent=FBgn0010383,FBtr0074609; dbxref=FlyBase:FBpp0074380,FlyBase_Annotation_IDs:CG6816-PA,GB_protein:AAN09473.1,REFSEQ:NP_728191,GB_protein:AAN09473,FlyMine:FBpp0074380,modMine:FBpp0074380; MD5=47ace5c3df54ffe072b4e20779caa7eb; length=538; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=X:complement(join(18691828..18692218,18690866..18690987,18690359..18690788,18689991..18690255,18689146..18689554)); ID=FBpp0074381; name=Cyp18a1-PB; parent=FBgn0010383,FBtr0074610; dbxref=FlyBase:FBpp0074381,FlyBase_Annotation_IDs:CG6816-PB,GB_protein:AAF48874.1,REFSEQ:NP_523403,GB_protein:AAF48874; MD5=47ace5c3df54ffe072b4e20779caa7eb; length=538; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=X:complement(join(18691828..18692218,18690866..18690987,18690359..18690788,18689991..18690255,18689146..18689554)); ID=FBpp0074380; name=Cyp18a1-PA; parent=FBgn0010383,FBtr0074609; dbxref=FlyBase:FBpp0074380,FlyBase_Annotation_IDs:CG6816-PA,GB_protein:AAN09473.1,REFSEQ:NP_728191,GB_protein:AAN09473,FlyMine:FBpp0074380,modMine:FBpp0074380; MD5=47ace5c3df54ffe072b4e20779caa7eb; length=538; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • type=protein; loc=X:complement(join(18691828..18692218,18690866..18690987,18690359..18690788,18689991..18690255,18689146..18689554)); ID=FBpp0074381; name=Cyp18a1-PB; parent=FBgn0010383,FBtr0074610; dbxref=FlyBase:FBpp0074381,FlyBase_Annotation_IDs:CG6816-PB,GB_protein:AAF48874.1,REFSEQ:NP_523403,GB_protein:AAF48874; MD5=47ace5c3df54ffe072b4e20779caa7eb; length=538; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • FBpp0074380 type=protein; loc=X:complement(join(18691828..18692218,18690866..18690987,18690359..18690788,18689991..18690255,18689146..18689554)); ID=FBpp0074380; name=Cyp18a1-PA; parent=FBgn0010383,FBtr0074609; dbxref=FlyBase:FBpp0074380,FlyBase_Annotation_IDs:CG6816-PA,GB_protein:AAN09473.1,REFSEQ:NP_728191,GB_protein:AAN09473,FlyMine:FBpp0074380,modMine:FBpp0074380; MD5=47ace5c3df54ffe072b4e20779caa7eb; length=538; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • FBpp0074381 type=protein; loc=X:complement(join(18691828..18692218,18690866..18690987,18690359..18690788,18689991..18690255,18689146..18689554)); ID=FBpp0074381; name=Cyp18a1-PB; parent=FBgn0010383,FBtr0074610; dbxref=FlyBase:FBpp0074381,FlyBase_Annotation_IDs:CG6816-PB,GB_protein:AAF48874.1,REFSEQ:NP_523403,GB_protein:AAF48874; MD5=47ace5c3df54ffe072b4e20779caa7eb; length=538; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • [fly-122215-dmel-6-09-contam.fasta]
  • type=protein; loc=X:complement(join(18691828..18692218,18690866..18690987,18690359..18690788,18689991..18690255,18689146..18689554)); ID=FBpp0074380; name=Cyp18a1-PA; parent=FBgn0010383,FBtr0074609; dbxref=FlyBase:FBpp0074380,FlyBase_Annotation_IDs:CG6816-PA,GB_protein:AAN09473.1,REFSEQ:NP_728191,GB_protein:AAN09473,UniProt/Swiss-Prot:Q95078,FlyMine:FBpp0074380,modMine:FBpp0074380; MD5=47ace5c3df54ffe072b4e20779caa7eb; length=538; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
  • type=protein; loc=X:complement(join(18691828..18692218,18690866..18690987,18690359..18690788,18689991..18690255,18689146..18689554)); ID=FBpp0074381; name=Cyp18a1-PB; parent=FBgn0010383,FBtr0074610; dbxref=FlyBase:FBpp0074381,FlyBase_Annotation_IDs:CG6816-PB,GB_protein:AAF48874.1,REFSEQ:NP_523403,GB_protein:AAF48874,UniProt/Swiss-Prot:Q95078; MD5=47ace5c3df54ffe072b4e20779caa7eb; length=538; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
    • Organism: Drosophila melanogaster
    Length: 538 amino acids

    Gene Ontology:
    Cellular Component: membrane [NAS]
    microsome [NAS]
    Biological Process: oxidation reduction [IEA]
    steroid biosynthetic process [NAS]
    Molecular Function: electron carrier activity [IEA][ISS][NAS]
    monooxygenase activity [IEA]
    heme binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLADSYLIKF VLRQLQVQQD GDAQHLLMVF LGLLALVTLL QWLVRNYREL RKLPPGPWGL  60
   61 PVIGYLLFMG SEKHTRFMEL AKQYGSLFST RLGSQLTVVM SDYKMIRECF RREEFTGRPD 120
  121 TPFMQTLNGY GIINSTGKLW KDQRRFLHDK LRQFGMTYMG NGKQQMQKRI MTEVHEFIGH 180
  181 LHASDGQPVD MSPVISVAVS NVICSLMMST RFSIDDPKFR RFNFLIEEGM RLFGEIHTVD 240
  241 YIPTMQCFPS ISTAKNKIAQ NRAEMQRFYQ DVIDDHKRSF DPNNIRDLVD FYLCEIEKAK 300
  301 AEGTDAELFD GKNHEEQLVQ VIIDLFSAGM ETIKTTLLWI NVFMLRNPKE MRRVQDELDQ 360
  361 VVGRHRLPTI EDLQYLPITE STILESMRRS SIVPLATTHS PTRDVELNGY TIPAGSHVIP 420
  421 LINSVHMDPN LWEKPEEFRP SRFIDTEGKV RKPEYFIPFG VGRRMCLGDV LARMELFLFF 480
  481 ASFMHCFDIA LPEGQPLPSL KGNVGATITP ESFKVCLKRR PLGPTAADPH HMRNVGAN

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..538] PSI-BLAST 109.0 Crystal Structure of Human Drug Metabolizing Cytochrome P450 2C8

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • arachidonic acid monooxygenase activity
    		•  6.76823710927794 bayes_pls_golite062009
  • fatty acid (omega-1)-hydroxylase activity
    		•  6.3313834755701 bayes_pls_golite062009
  • monooxygenase activity
    		•  5.57229509004705 bayes_pls_golite062009
  • steroid hydroxylase activity
    		•  5.04794778387361 bayes_pls_golite062009
  • arachidonic acid epoxygenase activity
    		•  4.80764258881036 bayes_pls_golite062009
  • electron carrier activity
    		•  4.64931978461551 bayes_pls_golite062009
  • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen
    		•  4.64322346579269 bayes_pls_golite062009
  • steroid 17-alpha-monooxygenase activity
    		•  3.99744233006162 bayes_pls_golite062009
  • retinoic acid 4-hydroxylase activity
    		•  3.76307535769621 bayes_pls_golite062009
  • oxygen binding
    		•  3.7203678182299 bayes_pls_golite062009
  • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
    		•  3.68151610133025 bayes_pls_golite062009
  • demethylase activity
    		•  3.40807632433846 bayes_pls_golite062009
  • flavonoid 3'-monooxygenase activity
    		•  3.16634614522939 bayes_pls_golite062009
  • sterol 14-demethylase activity
    		•  2.94610675710811 bayes_pls_golite062009
  • retinoic acid binding
    		•  2.70323898361882 bayes_pls_golite062009
  • retinoid binding
    		•  2.60220937953757 bayes_pls_golite062009
  • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
    		•  2.56821164444595 bayes_pls_golite062009
  • isoprenoid binding
    		•  2.47826119804163 bayes_pls_golite062009
  • thromboxane-A synthase activity
    		•  2.45281910634006 bayes_pls_golite062009
  • oxysterol 7-alpha-hydroxylase activity
    		•  2.36480328243514 bayes_pls_golite062009
  • oxidoreductase activity
    		•  2.35847923992364 bayes_pls_golite062009
  • 1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity
    		•  2.30416050662077 bayes_pls_golite062009
  • steroid 7-alpha-hydroxylase activity
    		•  2.21042366294727 bayes_pls_golite062009
  • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen
    		•  2.15105968497418 bayes_pls_golite062009
  • arachidonic acid 11,12-epoxygenase activity
    		•  2.0071742914584 bayes_pls_golite062009
  • ecdysteroid 25-hydroxylase activity
    		•  2.0071742914584 bayes_pls_golite062009
  • vitamin D 24-hydroxylase activity
    		•  1.81919676974797 bayes_pls_golite062009
  • vitamin D3 25-hydroxylase activity
    		•  1.65825585934141 bayes_pls_golite062009
  • vitamin D 25-hydroxylase activity
    		•  1.65825585934141 bayes_pls_golite062009
  • corticosterone 18-monooxygenase activity
    		•  1.64204907906991 bayes_pls_golite062009
  • steroid 11-beta-monooxygenase activity
    		•  1.64204907906991 bayes_pls_golite062009
  • ecdysteroid 22-hydroxylase activity
    		•  1.58167166311061 bayes_pls_golite062009
  • testosterone 6-beta-hydroxylase activity
    		•  1.4661447981611 bayes_pls_golite062009
  • binding
    		•  1.2866152532988 bayes_pls_golite062009
  • 25-hydroxycholecalciferol-24-hydroxylase activity
    		•  1.06487564122685 bayes_pls_golite062009
  • transition metal ion binding
    		•  0.880940639082655 bayes_pls_golite062009
  • protein binding
    		•  0.836411857417911 bayes_pls_golite062009
  • oxidoreductase activity, acting on NADH or NADPH
    		•  0.614118857213859 bayes_pls_golite062009
  • catalytic activity
    		•  0.608111453189583 bayes_pls_golite062009
  • iron ion binding
    		•  0.529598228513719 bayes_pls_golite062009
  • cation binding
    		•  0.510556740388808 bayes_pls_golite062009
  • metal ion binding
    		•  0.510556740388808 bayes_pls_golite062009
  • ion binding
    		•  0.503326724714616 bayes_pls_golite062009
  • oxidoreductase activity, acting on diphenols and related substances as donors
    		•  0.377799149936808 bayes_pls_golite062009
  • cholesterol monooxygenase (side-chain-cleaving) activity
    		•  0.276594551871869 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
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