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Protein Overview: Nrg-PB, Nrg-PE, ...

General Information:
Name(s) found: FBpp0305703 [FlyBase]
Nrg-PE / FBpp0290977 [FlyBase]
Nrg-PB / FBpp0071155 [FlyBase]
Description(s) found:
Found 34 descriptions.
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  • type=protein; loc=X:join(8425980..8426052,8426368..8426497,8438883..8441696,8441771..8441938,8442011..8442388,8442455..8442558,8445783..8446024); ID=FBpp0305703; name=Nrg-PI; parent=FBgn0264975,FBtr0333523; dbxref=REFSEQ:NP_001259337,GB_protein:AGB95181,FlyBase:FBpp0305703,FlyBase_Annotation_IDs:CG1634-PI; MD5=4ac52627944fd89dc9bdf650f05f3d9b; length=1302; release=r5.56; species=Dmel; [FlyBase]
  • The gene Neuroglian is referred to in FlyBase by the symbol Dmel\Nrg (CG1634, FBgn0002968). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:8411406..8446152. It has the cytological map location 7F2-7F4. There is experimental evidence that it has the molecular function</span>: calcium ion binding. There is experimental evidence for 13 unique biological process</span> terms, many of which group under: anatomical structure development; cell projection organization; neuron differentiation; organ development; synapse organization; cell adhesion; regulation of biological process; cell junction organization; cell morphogenesis; nerve development; extracellular structure organization; cell-cell adhesion; transmembrane receptor protein tyrosine kinase signaling pathway; central nervous system development; organ morphogenesis; cellular ion homeostasis; dendrite morphogenesis; glial cell development; cell-cell junction assembly; regulation of anatomical structure size. 57 alleles are reported. The phenotypes of these alleles are annotated with 27 unique terms, many of which group under: nervous system; organ system; multi-cell-component structure; adult segment; peripheral nervous system; embryonic nervous system; mushroom body; adult brain; embryonic glial cell; embryonic neuron; FBbt:00003689; abdominal segmental nerve; synapse; embryonic dorsal trunk; external compound sense organ; plasma membrane part; embryonic trachea. It has 6 annotated transcripts and 6 annotated polypeptides. [FlyBase]
  • The gene Neuroglian is referred to in FlyBase by the symbol Dmel\Nrg (CG1634, FBgn0002968). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:8411406..8446152. It has the cytological map location 7F2-7F4. There is experimental evidence that it has the molecular function</span>: calcium ion binding. There is experimental evidence for 13 unique biological process</span> terms, many of which group under: anatomical structure development; cell projection organization; neuron differentiation; organ development; synapse organization; cell adhesion; regulation of biological process; cell junction organization; cell morphogenesis; nerve development; extracellular structure organization; cell-cell adhesion; transmembrane receptor protein tyrosine kinase signaling pathway; central nervous system development; organ morphogenesis; cellular ion homeostasis; dendrite morphogenesis; glial cell development; cell-cell junction assembly; regulation of anatomical structure size. 57 alleles are reported. The phenotypes of these alleles are annotated with 27 unique terms, many of which group under: nervous system; organ system; multi-cell-component structure; adult segment; peripheral nervous system; embryonic nervous system; mushroom body; adult brain; embryonic glial cell; embryonic neuron; FBbt:00003689; abdominal segmental nerve; synapse; embryonic dorsal trunk; external compound sense organ; plasma membrane part; embryonic trachea. It has 6 annotated transcripts and 6 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1302 amino acids

    Gene Ontology:
    Cellular Component: lateral plasma membrane [TAS]
    septate junction [IDA]
    pleated septate junction [IDA]
    plasma membrane [IDA][NAS]
    Biological Process: imaginal disc morphogenesis [IMP]
    mushroom body development [IMP][NAS]
    regulation of tube size, open tracheal system [IMP]
    synapse organization [IMP]
    epidermal growth factor receptor signaling pathway [IMP]
    neuron cell-cell adhesion [IMP][ISS][NAS]
    establishment of glial blood-brain barrier [IMP]
    axon ensheathment [IMP]
    dendrite morphogenesis [IMP]
    nerve maturation [IMP]
    axon extension [IMP]
    central complex development [NAS]
    axonogenesis [IMP]
    septate junction assembly [IMP]
    Molecular Function: calcium ion binding [IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MWRQSTILAA LLVALLCAGS AESKGNRPPR ITKQPAPGEL LFKVAQQNKE SDNPFIIECE  60
   61 ADGQPEPEYS WIKNGKKFDW QAYDNRMLRQ PGRGTLVITI PKDEDRGHYQ CFASNEFGTA 120
  121 TSNSVYVRKA ELNAFKDEAA KTLEAVEGEP FMLKCAAPDG FPSPTVNWMI QESIDGSIKS 180
  181 INNSRMTLDP EGNLWFSNVT REDASSDFYY ACSATSVFRS EYKIGNKVLL DVKQMGVSAS 240
  241 QNKHPPVRQY VSRRQSLALR GKRMELFCIY GGTPLPQTVW SKDGQRIQWS DRITQGHYGK 300
  301 SLVIRQTNFD DAGTYTCDVS NGVGNAQSFS IILNVNSVPY FTKEPEIATA AEDEEVVFEC 360
  361 RAAGVPEPKI SWIHNGKPIE QSTPNPRRTV TDNTIRIINL VKGDTGNYGC NATNSLGYVY 420
  421 KDVYLNVQAE PPTISEAPAA VSTVDGRNVT IKCRVNGSPK PLVKWLRASN WLTGGRYNVQ 480
  481 ANGDLEIQDV TFSDAGKYTC YAQNKFGEIQ ADGSLVVKEH TRITQEPQNY EVAAGQSATF 540
  541 RCNEAHDDTL EIEIDWWKDG QSIDFEAQPR FVKTNDNSLT IAKTMELDSG EYTCVARTRL 600
  601 DEATARANLI VQDVPNAPKL TGITCQADKA EIHWEQQGDN RSPILHYTIQ FNTSFTPASW 660
  661 DAAYEKVPNT DSSFVVQMSP WANYTFRVIA FNKIGASPPS AHSDSCTTQP DVPFKNPDNV 720
  721 VGQGTEPNNL VISWTPMPEI EHNAPNFHYY VSWKRDIPAA AWENNNIFDW RQNNIVIADQ 780
  781 PTFVKYLIKV VAINDRGESN VAAEEVVGYS GEDRPLDAPT NFTMRQITSS TSGYMAWTPV 840
  841 SEESVRGHFK GYKIQTWTEN EGEEGLREIH VKGDTHNALV TQFKPDSKNY ARILAYNGRF 900
  901 NGPPSAVIDF DTPEGVPSPV QGLDAYPLGS SAFMLHWKKP LYPNGKLTGY KIYYEEVKES 960
  961 YVGERREYDP HITDPRVTRM KMAGLKPNSK YRISITATTK MGEGSEHYIE KTTLKDAVNV1020
 1021 APATPSFSWE QLPSDNGLAK FRINWLPSTE GHPGTHFFTM HRIKGETQWI RENEEKNSDY1080
 1081 QEVGGLDPET AYEFRVVSVD GHFNTESATQ EIDTNTVEGP IMVANETVAN AGWFIGMMLA1140
 1141 LAFIIILFII ICIIRRNRGG KYDVHDRELA NGRRDYPEEG GFHEYSQPLD NKSAGRQSVS1200
 1201 SANKPGVESD TDSMAEYGDG DTGQFTEDGS FIGQYVPGKL QPPVSPQPLN NSAAAHQAAP1260
 1261 TAGGSGAAGS AAAAGASGGA SSAGGAAASN GGAAAGAVAT YV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..131] PSI-BLAST 59.30103 Hemolin
    2 View Details [132..614] PSI-BLAST 18.221849 No description for 2ocwA was found.
    3 View Details [615..711] PSI-BLAST 31.0 No description for 2nziA was found.
    4 View Details [712..792] PSI-BLAST 30.522879 CRYSTAL STRUCTURE OF TANDEM TYPE III FIBRONECTIN DOMAINS FROM DROSOPHILA NEUROGLIAN AT 2.0 ANGSTROMS
    5 View Details [793..1119] PSI-BLAST 12.221849 Common beta-chain in the GM-CSF, IL-3 and IL-5 receptors
    6 View Details [1120..1302] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • fibroblast growth factor 1 binding
    		•  6.68503380812062 bayes_pls_golite062009
  • telethonin binding
    		•  6.64811984458494 bayes_pls_golite062009
  • alpha-actinin binding
    		•  5.77350124471385 bayes_pls_golite062009
  • actinin binding
    		•  5.69539760434923 bayes_pls_golite062009
  • structural constituent of muscle
    		•  4.93896503565413 bayes_pls_golite062009
  • olfactory receptor activity
    		•  4.21057154107121 bayes_pls_golite062009
  • receptor activity
    		•  4.00123250685257 bayes_pls_golite062009
  • antigen binding
    		•  3.82355200401222 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  3.81769911097805 bayes_pls_golite062009
  • peptide antigen binding
    		•  3.67780971105726 bayes_pls_golite062009
  • fibroblast growth factor binding
    		•  3.54458347746523 bayes_pls_golite062009
  • fibroblast growth factor receptor activity
    		•  3.20458334492494 bayes_pls_golite062009
  • binding
    		•  3.17641566810715 bayes_pls_golite062009
  • signal transducer activity
    		•  3.10913345555941 bayes_pls_golite062009
  • molecular transducer activity
    		•  3.10913345555941 bayes_pls_golite062009
  • IgG binding
    		•  2.37772196119887 bayes_pls_golite062009
  • growth factor binding
    		•  2.28613301180608 bayes_pls_golite062009
  • protein binding
    		•  2.22855404705168 bayes_pls_golite062009
  • IgE receptor activity
    		•  1.73481096568834 bayes_pls_golite062009
  • IgE binding
    		•  1.73481096568834 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  1.58610597245454 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase activity
    		•  1.52958974617075 bayes_pls_golite062009
  • actin binding
    		•  1.42681407553255 bayes_pls_golite062009
  • cell adhesion molecule binding
    		•  1.36789541796983 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.32330470851159 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  1.30657787244536 bayes_pls_golite062009
  • sugar binding
    		•  1.26337823485694 bayes_pls_golite062009
  • DNA binding
    		•  1.19412627500732 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.16252234499274 bayes_pls_golite062009
  • G-protein coupled receptor activity
    		•  1.02428106476324 bayes_pls_golite062009
  • myosin light chain kinase activity
    		•  0.87238163212 bayes_pls_golite062009
  • protein complex binding
    		•  0.83543827718565 bayes_pls_golite062009
  • immunoglobulin receptor activity
    		•  0.803684061893919 bayes_pls_golite062009
  • actin filament binding
    		•  0.760856470721016 bayes_pls_golite062009
  • collagen binding
    		•  0.729893120256353 bayes_pls_golite062009
  • peptide binding
    		•  0.729048089532569 bayes_pls_golite062009
  • immunoglobulin binding
    		•  0.64138121404685 bayes_pls_golite062009
  • receptor binding
    		•  0.632627479346393 bayes_pls_golite062009
  • cytokine binding
    		•  0.631436442105379 bayes_pls_golite062009
  • titin binding
    		•  0.599892148302011 bayes_pls_golite062009
  • integrin binding
    		•  0.599569390248921 bayes_pls_golite062009
  • protein kinase activity
    		•  0.589015157128768 bayes_pls_golite062009
  • transcription factor activity
    		•  0.54549168007511 bayes_pls_golite062009
  • monosaccharide binding
    		•  0.533047672054027 bayes_pls_golite062009
  • IgG receptor activity
    		•  0.50231877534761 bayes_pls_golite062009
  • myosin heavy chain binding
    		•  0.49788128784685 bayes_pls_golite062009
  • cell surface binding
    		•  0.477483205369537 bayes_pls_golite062009
  • cytokine receptor activity
    		•  0.34165331857492 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.300034766861208 bayes_pls_golite062009
  • kinase activity
    		•  0.232190923918901 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.182775558017364 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.0579247757286607 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.026512949804781 bayes_pls_golite062009
  • structural molecule activity
    		•  0.00139730528977644 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5
    Term Confidence Notes
  • telethonin binding
    		•  5.81747667416248 bayes_pls_golite062009
  • structural constituent of muscle
    		•  5.71979489668015 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  4.81256300373074 bayes_pls_golite062009
  • ankyrin binding
    		•  4.69755754047169 bayes_pls_golite062009
  • receptor activity
    		•  4.66147271961356 bayes_pls_golite062009
  • alpha-actinin binding
    		•  4.57951951779666 bayes_pls_golite062009
  • actinin binding
    		•  4.57900103206288 bayes_pls_golite062009
  • cytokine binding
    		•  4.43581512268554 bayes_pls_golite062009
  • cytokine receptor activity
    		•  4.08668869714207 bayes_pls_golite062009
  • growth factor binding
    		•  4.06808996928726 bayes_pls_golite062009
  • molecular transducer activity
    		•  3.69234048247377 bayes_pls_golite062009
  • signal transducer activity
    		•  3.69234048247377 bayes_pls_golite062009
  • protein binding
    		•  3.24522318184038 bayes_pls_golite062009
  • binding
    		•  3.12471204223368 bayes_pls_golite062009
  • interleukin-2 binding
    		•  2.38131482184802 bayes_pls_golite062009
  • cell adhesion molecule binding
    		•  2.32179186005318 bayes_pls_golite062009
  • prolactin receptor activity
    		•  2.15346920063421 bayes_pls_golite062009
  • ciliary neurotrophic factor receptor activity
    		•  2.15011619378442 bayes_pls_golite062009
  • peptide hormone binding
    		•  2.12033076929638 bayes_pls_golite062009
  • axon guidance receptor activity
    		•  2.01367445237355 bayes_pls_golite062009
  • interleukin-6 receptor activity
    		•  1.9781930293417 bayes_pls_golite062009
  • interleukin-6 binding
    		•  1.9781930293417 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  1.85720106085239 bayes_pls_golite062009
  • polysaccharide binding
    		•  1.69642470905172 bayes_pls_golite062009
  • glycosaminoglycan binding
    		•  1.6158868405814 bayes_pls_golite062009
  • interleukin-11 receptor activity
    		•  1.57103867592521 bayes_pls_golite062009
  • interleukin-11 binding
    		•  1.57103867592521 bayes_pls_golite062009
  • heparin binding
    		•  1.40418056272895 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.32813363771214 bayes_pls_golite062009
  • receptor binding
    		•  1.31676259534833 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.31663344632755 bayes_pls_golite062009
  • leukemia inhibitory factor receptor activity
    		•  1.27120658254426 bayes_pls_golite062009
  • oncostatin-M receptor activity
    		•  1.27120658254426 bayes_pls_golite062009
  • actin binding
    		•  1.21472460452555 bayes_pls_golite062009
  • DNA binding
    		•  1.2006039770643 bayes_pls_golite062009
  • myosin light chain kinase activity
    		•  1.18611050638993 bayes_pls_golite062009
  • cell surface binding
    		•  1.05599555585797 bayes_pls_golite062009
  • ciliary neurotrophic factor binding
    		•  1.02710126648804 bayes_pls_golite062009
  • sialic acid binding
    		•  0.992369242781511 bayes_pls_golite062009
  • interleukin-7 binding
    		•  0.992216255634359 bayes_pls_golite062009
  • peptide binding
    		•  0.92031154055894 bayes_pls_golite062009
  • protein dimerization activity
    		•  0.86564366658585 bayes_pls_golite062009
  • interleukin-2 receptor activity
    		•  0.817385502041609 bayes_pls_golite062009
  • collagen binding
    		•  0.688581536921572 bayes_pls_golite062009
  • kinase binding
    		•  0.65927255037265 bayes_pls_golite062009
  • protein kinase activity
    		•  0.651225820536084 bayes_pls_golite062009
  • enzyme binding
    		•  0.60195860585095 bayes_pls_golite062009
  • identical protein binding
    		•  0.564711394496051 bayes_pls_golite062009
  • transcription factor activity
    		•  0.557290274937694 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase activity
    		•  0.554350228628563 bayes_pls_golite062009
  • sugar binding
    		•  0.525326551675751 bayes_pls_golite062009
  • hormone binding
    		•  0.49524185948356 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  0.46168925186147 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.436168003057537 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.425601964126369 bayes_pls_golite062009
  • kinase activity
    		•  0.412589450700334 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.40600177052491 bayes_pls_golite062009
  • protein kinase binding
    		•  0.405060010394646 bayes_pls_golite062009
  • structural molecule activity
    		•  0.37617823184103 bayes_pls_golite062009
  • monosaccharide binding
    		•  0.356315624949755 bayes_pls_golite062009
  • ciliary neurotrophic factor receptor binding
    		•  0.338520586013721 bayes_pls_golite062009
  • pattern binding
    		•  0.16768253393396 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.16524109571346 bayes_pls_golite062009
  • protein heterodimerization activity
    		•  0.1430595594485 bayes_pls_golite062009
  • transcription activator activity
    		•  0.135753557343301 bayes_pls_golite062009
  • actin filament binding
    		•  0.135484838710405 bayes_pls_golite062009
  • protein homodimerization activity
    		•  0.116391819218123 bayes_pls_golite062009
  • integrin binding
    		•  0.0873424694168858 bayes_pls_golite062009
  • transcription factor binding
    		•  0.075900818564989 bayes_pls_golite062009
  • cytokine receptor binding
    		•  0.0682540643558203 bayes_pls_golite062009
  • growth factor activity
    		•  0.0477008672713168 bayes_pls_golite062009
    6 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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