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Protein Overview: Nek2-PA

General Information:
Name(s) found: Nek2-PA / FBpp0071094 [FlyBase]
Description(s) found:
Found 22 descriptions.
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  • The gene Nek2 is referred to in FlyBase by the symbol Dmel\Nek2 (CG17256, FBgn0029970). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:7783099..7785605. It has the cytological map location 7C1. Based on sequence similarity, it is predicted to have molecular function</span>: protein serine/threonine kinase activity. There is experimental evidence that it is involved in the biological process</span>: mitosis; regulation of mitosis. 6 alleles are reported. The phenotypes of these alleles are annotated with: mitotic telophase; mitotic anaphase; centrosome; spindle; microtubule. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 735 amino acids

    Gene Ontology:
    Cellular Component: centrosome [IDA]
    midbody [IDA]
    Biological Process: regulation of mitosis [IMP]
    mitosis [IMP]
    protein amino acid phosphorylation [IEA][NAS]
    Molecular Function: ATP binding [IEA]
    receptor signaling protein serine/threonine kinase activity [NAS]
    protein serine/threonine kinase activity [IEA][ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSGEESAGMD FSQKTLQDYE VLAVMGNGSF GTCYKVRDKS TGELFAWKGM NYDELDEAKC  60
   61 DALVSEISVL RQLQHPNIVQ YYHHLVNREA KSVYIVMECC AGGDLAQIVQ RARSQRQRFE 120
  121 EPYIWRVLFQ LCRALQVCHN KIPNGTILHR DIKPANIFLD AAGNAKLGDF GLARMLRRDQ 180
  181 SFAASFVGTP HYMSPELVKG RKYDRKSDVW AVGCLVYEMC ALRPPFRGRA FDQLSEKIAQ 240
  241 GEFSRIPAIY STDLQEIIAF MLAVDHEQRP GIEVIIRHPL VVRNISELDG KFPILVDSGE 300
  301 DFYTLPSGAR LFEDEEEDGV HPELSSTMFT EQYSFNEGYG QRRLSVTGVF TPDLRSELFY 360
  361 SAKRKIFPAK KLQLSDPSLY ESIRREERAE ERQVELAEER RRKKDQEQQK RDQELLKEAP 420
  421 SSPRALTQNI FDEVLKTRLH AIRAQESLLQ QKLEELQTRE QELQLAEQRV QTLERQMQEK 480
  481 LLQQEKHTCS CRQPIAPPIP PRKPAKSHHD DTYCTIELNE TSPTVAKLNL ATLPAPKSLN 540
  541 TLRKVTFKSP QKFVTYGIEN MPPPAVKPAV NPPPTGVPMQ MSVSSNDSGD SQASSTRRKS 600
  601 ILSLFGLSRG SKATSKSLPS VNQVAQAAAT RVQRPPLAVK PPITQEQPAE VPPVANLWTK 660
  661 EQKKQAFELL AAMNAAEREA SGGGVVGSGP GGARRQHLRQ SVRERNSTLQ RNRMRRSLVV 720
  721 ATGHQKLTTR DQMVI

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..288] PSI-BLAST 61.154902 No description for 2javA was found.
    2 View Details [289..509] FFAS03 1.49 No description for 2i1jA was found.
    3 View Details [510..668] FFAS03 1.36 THE BLUETONGUE VIRUS (BTV) CORE BINDS DSRNA
    4 View Details [669..735] PSI-BLAST 7.69897 Solution structure of kinase associated domain 1 of mouse MAP/microtubule affinity-regulating kinase 3

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • phosphotransferase activity, alcohol group as acceptor
    		•  5.49988294224815 bayes_pls_golite062009
  • protein kinase activity
    		•  5.4586557943719 bayes_pls_golite062009
  • kinase activity
    		•  5.3287080791198 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  4.96052051118534 bayes_pls_golite062009
  • cyclin-dependent protein kinase activity
    		•  4.62392503670521 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  4.46381887831481 bayes_pls_golite062009
  • transferase activity
    		•  3.97138602499442 bayes_pls_golite062009
  • binding
    		•  2.74863538127007 bayes_pls_golite062009
  • phosphoinositide 3-kinase binding
    		•  2.41610417530517 bayes_pls_golite062009
  • protein binding
    		•  2.276111749106 bayes_pls_golite062009
  • tubulin binding
    		•  2.18641675163967 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  2.12615078788254 bayes_pls_golite062009
  • ATP binding
    		•  1.97600611746091 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  1.93596671856664 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  1.93176092222748 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  1.90928021591891 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  1.90354666768303 bayes_pls_golite062009
  • microtubule binding
    		•  1.88110801192607 bayes_pls_golite062009
  • telethonin binding
    		•  1.75733591474207 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  1.71452519680794 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  1.65732943334212 bayes_pls_golite062009
  • ribonucleotide binding
    		•  1.65726906484847 bayes_pls_golite062009
  • purine nucleotide binding
    		•  1.63763394711025 bayes_pls_golite062009
  • nucleotide binding
    		•  1.63195828048121 bayes_pls_golite062009
  • insulin receptor substrate binding
    		•  1.62657794525303 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  1.6084489855403 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.56748951434625 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  1.3898059094397 bayes_pls_golite062009
  • receptor signaling protein serine/threonine kinase activity
    		•  1.38496328649031 bayes_pls_golite062009
  • DNA binding
    		•  1.35333135345112 bayes_pls_golite062009
  • actin binding
    		•  1.33479685165255 bayes_pls_golite062009
  • gamma-tubulin binding
    		•  1.28511591054866 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  1.27291233344322 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  1.27184436658773 bayes_pls_golite062009
  • insulin receptor activity
    		•  1.22442673174261 bayes_pls_golite062009
  • catalytic activity
    		•  1.21655087018101 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.16049201286103 bayes_pls_golite062009
  • transcription factor activity
    		•  1.10928254946881 bayes_pls_golite062009
  • transcription activator activity
    		•  0.997272622653026 bayes_pls_golite062009
  • PTB domain binding
    		•  0.9900774724568 bayes_pls_golite062009
  • alpha-actinin binding
    		•  0.877087652539674 bayes_pls_golite062009
  • insulin-like growth factor receptor binding
    		•  0.872782211382796 bayes_pls_golite062009
  • MAP kinase activity
    		•  0.81943579965027 bayes_pls_golite062009
  • insulin binding
    		•  0.614254468447749 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.612883428421652 bayes_pls_golite062009
  • transporter activity
    		•  0.595111702412257 bayes_pls_golite062009
  • protein serine/threonine/tyrosine kinase activity
    		•  0.48345772948903 bayes_pls_golite062009
  • protein kinase C activity
    		•  0.41587987561486 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.41384976209545 bayes_pls_golite062009
  • magnesium ion binding
    		•  0.393328812780268 bayes_pls_golite062009
  • MAP kinase kinase kinase activity
    		•  0.37115026509016 bayes_pls_golite062009
  • MAP kinase kinase activity
    		•  0.35402045013148 bayes_pls_golite062009
  • protein complex binding
    		•  0.343240719858581 bayes_pls_golite062009
  • signal transducer activity
    		•  0.270054246024761 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.270054246024761 bayes_pls_golite062009
  • insulin receptor binding
    		•  0.266450215230107 bayes_pls_golite062009
  • cation channel activity
    		•  0.245400615103891 bayes_pls_golite062009
  • actin filament binding
    		•  0.2403700250846 bayes_pls_golite062009
  • SH2 domain binding
    		•  0.226760162354251 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.0922946791401962 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  0.0556163711947139 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  0.00652065412910241 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.0040394359628233 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle