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Protein Overview: Apc2-PA

General Information:
Name(s) found: Apc2-PA / FBpp0083937 [FlyBase]
Description(s) found:
Found 26 descriptions.
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  • The gene Adenomatous polyposis coli tumor suppressor homolog 2 is referred to in FlyBase by the symbol Dmel\Apc2 (CG6193, FBgn0026598). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:19989690..19994041. It has the cytological map location 95E6. There is experimental evidence that it has the molecular function</span>: protein binding. There is experimental evidence for 15 unique biological process</span> terms, many of which group under: anatomical structure development; embryonic development via the syncytial blastoderm; cell adhesion; regulation of Wnt receptor signaling pathway; organ development; central nervous system development; regulation of biological process; embryonic development ending in birth or egg hatching; larval chitin-based cuticle development; syncytial nuclear migration. 27 alleles are reported. The phenotypes of these alleles are annotated with 17 unique terms, many of which group under: organ system; female germline cyst; cuticle; late extended germ band embryo; primordium; plasma membrane; peripheral nervous system; muscle founder cell; portion of tissue; nervous system. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1067 amino acids

    Gene Ontology:
    Cellular Component: apicolateral plasma membrane [TAS]
    nucleus [TAS]
    dendrite [IDA]
    adherens junction [TAS]
    cytoplasm [TAS]
    cleavage furrow [IDA]
    cell cortex [IDA]
    apical cortex [IDA]
    protein complex [IPI]
    neuronal cell body [IDA]
    actin filament [IDA]
    microtubule associated complex [ISS]
    Biological Process: cell-cell adhesion [IGI]
    establishment of mitotic spindle localization [TAS]
    chitin-based larval cuticle pattern formation [IGI]
    chitin-based embryonic cuticle biosynthetic process [IMP]
    head involution [IGI]
    syncytial nuclear migration [IMP]
    cytokinesis [TAS]
    axon guidance [IGI]
    cell adhesion [IMP][NAS]
    positive regulation of proteolysis [TAS]
    brain development [IGI]
    imaginal disc pattern formation [IGI]
    microtubule-based process [ISS][TAS]
    neuroblast proliferation [IGI]
    medulla oblongata development [IGI]
    negative regulation of transcription, DNA-dependent [TAS]
    Wnt receptor signaling pathway [TAS]
    negative regulation of Wnt receptor signaling pathway [IGI]
    regulation of Wnt receptor signaling pathway [IGI][IMP]
    pseudocleavage during syncytial blastoderm formation [IMP]
    oocyte localization during germarium-derived egg chamber formation [IGI][IMP]
    Molecular Function: protein binding [IPI]
    microtubule binding [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTLNESDATR LELTRNFLEL SRNPETCTAL RSSDCIQLLV QILHANDEGL STAKKYASQA  60
   61 LHNIVHNNPE EKERQREVKM LRLLDQILDY CNFLHTQLQS GGEAIADDED RHPLAAMKLL 120
  121 MKASFDEEHR QTMCELGALK AIPNLVHLDH AVHGPAAGRE QCNALRSYGL MALTNLTFGD 180
  181 ENVHNKSYLC GQRQFMEVVI AQLNTAPDEL LQVLAGVLRN LSWRADKHMK TIFNELGTVT 240
  241 SLARAAMQNK NENTLKAILS ALWNLSAHCS TNKAEFCAVD GALAFLVGML SYEGPSKTLK 300
  301 IIENAGGILR NVSSHIAVCE PYRQILRRYN CLAILLQQLK SESLTVVSNS CGTLWNLSAR 360
  361 CPEDQQYLID HNAIPLLRAL ISSKNSMIAE GSASALKNLV NFRATQELMP NGDGGSLPLD 420
  421 KEAGHGGTLP RRFSSLRLSS NPTGSLKKVR PSTVSTTGFL NRKCESRESI YSGKSDSTKY 480
  481 STKSEGAKNP FEIVTPTEEQ PIDYSMKYME HKPNSSKTFE IDLDQPTDFS ARYKERRSAQ 540
  541 TAQPELKSET NEIRSKELQL TKSSSATELR NSPGLVAVSA AKQKIATETE TETAERPINY 600
  601 CEEGTPGSFS RFDSLNSLTE KPEKCMPPKT PTKTAVLPVH VDGNTPQNID SALETPLMFS 660
  661 RRSSMDSLVG DDETVACEDN GSVISEYSRM QSGVISPSEL PDSPTQSMPQ SPRRDRKVST 720
  721 QNNLDTPEQK PSTVFEDKLN RFHVEHTPAA FSCATSLSNL SMMDDSNANA IRGQRGNDIN 780
  781 GNGDAPRSYC TEDTTAVLSK APSNSDLSIL SIPNDLNANE AQPVPAPRAD VTGMDTRMPA 840
  841 EDAISKMRCG GNALPSYLPV SDEMSKYYVE DSPCTFSVIS GLSHLTVGSA KAGPVLKLPM 900
  901 RTAEEAQAPK LPPRRSAVQG DAEPRLPPKK SDSLSSLSMD SDDDCNLLSQ AIAAGSCRPQ 960
  961 PSGASTSSSL ANASTSTLCR ENGQSKKQVE HGDKPNYSSD DSLDDDDDDA RSKSLFEQCI1020
 1021 LSGMHKSNDA LESEGEPPGQ RQEISARDRF VSNQVRQIES MLAGRQH

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..438] PSI-BLAST 98.69897 No description for 2gl7A was found.
    2 View Details [439..611] deduced N/A No confident structure predictions are available.
    3 View Details [612..850] FFAS03 2.69 Beta-catenin in complex with a phosphorylated APC 20aa repeat fragment
    4 View Details [851..979] MSA 4.197995 View MSA. No confident structure predictions are available.
    5 View Details [980..1067] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  3.0667965351474 bayes_pls_golite062009
  • protein binding
    		•  2.78733902345842 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.74745843355294 bayes_pls_golite062009
  • protein transporter activity
    		•  2.71371809786708 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  2.61566088685247 bayes_pls_golite062009
  • transporter activity
    		•  2.44584964322784 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  2.23613166876856 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.16673352512615 bayes_pls_golite062009
  • DNA binding
    		•  1.95242774903625 bayes_pls_golite062009
  • cell adhesion molecule binding
    		•  1.83254788740042 bayes_pls_golite062009
  • actin binding
    		•  1.76244772281676 bayes_pls_golite062009
  • RPTP-like protein binding
    		•  1.38347756516661 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.24772365783803 bayes_pls_golite062009
  • transcription factor activity
    		•  1.20660383756339 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  1.06768761940869 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.05960420053443 bayes_pls_golite062009
  • signal transducer activity
    		•  1.05960420053443 bayes_pls_golite062009
  • protein transmembrane transporter activity
    		•  0.77052454980864 bayes_pls_golite062009
  • structural molecule activity
    		•  0.440301695287117 bayes_pls_golite062009
  • hydrolase activity
    		•  0.42501390959416 bayes_pls_golite062009
  • RNA binding
    		•  0.40024158562931 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.222115326695668 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.221267538887804 bayes_pls_golite062009
  • primary active transmembrane transporter activity
    		•  0.196648209113174 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven transmembrane transporter activity
    		•  0.187792942463938 bayes_pls_golite062009
  • peptide binding
    		•  0.17066729499393 bayes_pls_golite062009
  • transcription activator activity
    		•  0.160275383613705 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
    		•  0.149265988041485 bayes_pls_golite062009
  • ATPase activity, coupled to movement of substances
    		•  0.145736947807635 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of substances
    		•  0.145426459009789 bayes_pls_golite062009
  • cadherin binding
    		•  0.1400783779596 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.0810031465868464 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.0443466434497628 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.0355990844321387 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.0330014214401512 bayes_pls_golite062009
  • transcription factor binding
    		•  0.0221966060394205 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  0.0149637869665291 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle