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View Structure Prediction Details

Protein: Apc2-PA
Organism: Drosophila melanogaster
Length: 1067 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Apc2-PA.

Description E-value Query
Range
Subject
Range
gi|15291749 - gi|15291749|gb|AAK93143.1| LD24920p [Drosophila melanogaster]
612.0 [0..1] [1067..1]

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Predicted Domain #1
Region A:
Residues: [1-438]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTLNESDATR LELTRNFLEL SRNPETCTAL RSSDCIQLLV QILHANDEGL STAKKYASQA  60
   61 LHNIVHNNPE EKERQREVKM LRLLDQILDY CNFLHTQLQS GGEAIADDED RHPLAAMKLL 120
  121 MKASFDEEHR QTMCELGALK AIPNLVHLDH AVHGPAAGRE QCNALRSYGL MALTNLTFGD 180
  181 ENVHNKSYLC GQRQFMEVVI AQLNTAPDEL LQVLAGVLRN LSWRADKHMK TIFNELGTVT 240
  241 SLARAAMQNK NENTLKAILS ALWNLSAHCS TNKAEFCAVD GALAFLVGML SYEGPSKTLK 300
  301 IIENAGGILR NVSSHIAVCE PYRQILRRYN CLAILLQQLK SESLTVVSNS CGTLWNLSAR 360
  361 CPEDQQYLID HNAIPLLRAL ISSKNSMIAE GSASALKNLV NFRATQELMP NGDGGSLPLD 420
  421 KEAGHGGTLP RRFSSLRL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 98.69897
Match: 2gl7A
Description: No description for 2gl7A was found.

Predicted functions:

Term Confidence Notes
binding 3.0667965351474 bayes_pls_golite062009
protein binding 2.78733902345842 bayes_pls_golite062009
nucleic acid binding 2.74745843355294 bayes_pls_golite062009
protein transporter activity 2.71371809786708 bayes_pls_golite062009
cytoskeletal protein binding 2.61566088685247 bayes_pls_golite062009
transporter activity 2.44584964322784 bayes_pls_golite062009
substrate-specific transporter activity 2.23613166876856 bayes_pls_golite062009
transcription regulator activity 2.16673352512615 bayes_pls_golite062009
DNA binding 1.95242774903625 bayes_pls_golite062009
cell adhesion molecule binding 1.83254788740042 bayes_pls_golite062009
actin binding 1.76244772281676 bayes_pls_golite062009
RPTP-like protein binding 1.38347756516661 bayes_pls_golite062009
transmembrane transporter activity 1.24772365783803 bayes_pls_golite062009
transcription factor activity 1.20660383756339 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 1.06768761940869 bayes_pls_golite062009
molecular transducer activity 1.05960420053443 bayes_pls_golite062009
signal transducer activity 1.05960420053443 bayes_pls_golite062009
protein transmembrane transporter activity 0.77052454980864 bayes_pls_golite062009
structural molecule activity 0.440301695287117 bayes_pls_golite062009
hydrolase activity 0.42501390959416 bayes_pls_golite062009
RNA binding 0.40024158562931 bayes_pls_golite062009
ion transmembrane transporter activity 0.222115326695668 bayes_pls_golite062009
active transmembrane transporter activity 0.221267538887804 bayes_pls_golite062009
primary active transmembrane transporter activity 0.196648209113174 bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity 0.187792942463938 bayes_pls_golite062009
peptide binding 0.17066729499393 bayes_pls_golite062009
transcription activator activity 0.160275383613705 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 0.149265988041485 bayes_pls_golite062009
ATPase activity, coupled to movement of substances 0.145736947807635 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances 0.145426459009789 bayes_pls_golite062009
cadherin binding 0.1400783779596 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.0810031465868464 bayes_pls_golite062009
pyrophosphatase activity 0.0443466434497628 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 0.0355990844321387 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.0330014214401512 bayes_pls_golite062009
transcription factor binding 0.0221966060394205 bayes_pls_golite062009
cation transmembrane transporter activity 0.0149637869665291 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [439-611]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SSNPTGSLKK VRPSTVSTTG FLNRKCESRE SIYSGKSDST KYSTKSEGAK NPFEIVTPTE  60
   61 EQPIDYSMKY MEHKPNSSKT FEIDLDQPTD FSARYKERRS AQTAQPELKS ETNEIRSKEL 120
  121 QLTKSSSATE LRNSPGLVAV SAAKQKIATE TETETAERPI NYCEEGTPGS FSR

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [612-850]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FDSLNSLTEK PEKCMPPKTP TKTAVLPVHV DGNTPQNIDS ALETPLMFSR RSSMDSLVGD  60
   61 DETVACEDNG SVISEYSRMQ SGVISPSELP DSPTQSMPQS PRRDRKVSTQ NNLDTPEQKP 120
  121 STVFEDKLNR FHVEHTPAAF SCATSLSNLS MMDDSNANAI RGQRGNDING NGDAPRSYCT 180
  181 EDTTAVLSKA PSNSDLSILS IPNDLNANEA QPVPAPRADV TGMDTRMPAE DAISKMRCG

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 2.69
Match: 1th1C
Description: Beta-catenin in complex with a phosphorylated APC 20aa repeat fragment
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [851-979]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GNALPSYLPV SDEMSKYYVE DSPCTFSVIS GLSHLTVGSA KAGPVLKLPM RTAEEAQAPK  60
   61 LPPRRSAVQG DAEPRLPPKK SDSLSSLSMD SDDDCNLLSQ AIAAGSCRPQ PSGASTSSSL 120
  121 ANASTSTLC

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [980-1067]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RENGQSKKQV EHGDKPNYSS DDSLDDDDDD ARSKSLFEQC ILSGMHKSND ALESEGEPPG  60
   61 QRQEISARDR FVSNQVRQIE SMLAGRQH

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle