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Protein Overview: Miro-PD

General Information:
Name(s) found: Miro-PD / FBpp0083980 [FlyBase]
Description(s) found:
Found 22 descriptions.
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  • The gene Mitochondrial Rho is referred to in FlyBase by the symbol Dmel\Miro (CG5410, FBgn0039140). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:19860083..19863644. It has the cytological map location 95D8-95D9. An electronic pipeline based on InterPro domains suggests that it has the molecular function</span>: GTP binding; calcium ion binding. There is experimental evidence that it is involved in the biological process</span>: synaptic transmission; mitochondrion localization; synaptic vesicle transport; mitochondrion localization, microtubule-mediated; microtubule cytoskeleton organization; cytoplasmic microtubule organization. 11 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 652 amino acids

    Gene Ontology:
    Cellular Component: integral to mitochondrial outer membrane [ISS]
    Biological Process: cellular homeostasis [ISS]
    synaptic vesicle transport [IMP]
    small GTPase mediated signal transduction [IEA]
    mitochondrion transport along microtubule [ISS]
    apoptosis [ISS]
    synaptic transmission [IMP]
    mitochondrion localization, microtubule-mediated [IMP]
    cytoplasmic microtubule organization [IMP]
    microtubule cytoskeleton organization [IMP]
    mitochondrion localization [IMP]
    Molecular Function: GTP binding [IEA]
    calcium ion binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGQYTASQRK NVRILLVGDA GVGKTSLILS LVSEEYPEEV PPRAEEITIP ANVTPEQVPT  60
   61 SIVDFSAVEQ SEDALAAEIN KAHVVCIVYA VDDDDTLDRI TSHWLPLVRA KCNPSLDGEG 120
  121 DAEAEAEGDT QREPIRKPIV LVGNKIDLIE YSTMDSVLAI MEDYPEIESC VECSAKSLHN 180
  181 ISEMFYYAQK AVLHPTSPLY MMEEQELTSA CKKSLVRIFK ICDIDGDNLL NDYELNLFQR 240
  241 RCFNTPLQPQ ILDEVKAVIQ KNVPDGIYND AVTLKGFLFL HCLFIQRGRN ETTWAVLRRF 300
  301 GYNDQLEMCQ EYLRPPLKIP PGSSTELSHR GQQFLIAVFE RYDRDGDGAL SPEEHKMLFS 360
  361 TCPAAPWSYS TDIRKSCPIN ETTGWVTLHG WLCRWTLMTL IDVVKTMEYL AYLGFNVHEN 420
  421 DSQLAAIHVT RERRIDLAKR QSSRSVYKCH VIGPKGSGKT GMCRGFLVED MHKLIGKEFK 480
  481 TNVVNCINSV QVYGQEKHLI LRDIDVRHAL DPLQPQEVNC DVACLVYDSS NPRSFEYVAR 540
  541 IYIKYYAESK IPVMIVGTKC DMDERRQDYL MQPSEFCDKY KLLPPHLFSL KTNKKELYTK 600
  601 LATMAAFPHL RQFGLMTEDP KLWLKAGLGV AAATMLGFIV LKTISAAGAH TR

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..226] PSI-BLAST 44.39794 Crystal structure of human Rab18 in complex with Gppnhp
    2 View Details [227..440] FFAS03 3.93 No description for 2ggzA was found.
    3 View Details [441..652] PSI-BLAST 54.221849 Structure of RabGDP-dissociation inhibitor in complex with prenylated YPT1 GTPase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • microtubule motor activity
    		•  3.64858540496165 bayes_pls_golite062009
  • transporter activity
    		•  3.10463051760206 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  2.95886887664984 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  2.89122312915795 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  2.81593838944939 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  2.79724985811732 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  2.79347973548337 bayes_pls_golite062009
  • binding
    		•  2.64537357529343 bayes_pls_golite062009
  • primary active transmembrane transporter activity
    		•  2.61775212528604 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven transmembrane transporter activity
    		•  2.61467977505707 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
    		•  2.57552435627908 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of substances
    		•  2.57107347424517 bayes_pls_golite062009
  • ATPase activity, coupled to movement of substances
    		•  2.57054427875021 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  2.50494515048649 bayes_pls_golite062009
  • ATPase activity
    		•  2.44176688200537 bayes_pls_golite062009
  • ATPase activity, coupled
    		•  2.43862163407966 bayes_pls_golite062009
  • microfilament motor activity
    		•  2.38215814751368 bayes_pls_golite062009
  • motor activity
    		•  2.1532118704195 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  1.91091452720653 bayes_pls_golite062009
  • guanyl nucleotide binding
    		•  1.89320355239381 bayes_pls_golite062009
  • guanyl ribonucleotide binding
    		•  1.88721318481223 bayes_pls_golite062009
  • GTP binding
    		•  1.87900088157196 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  1.56325751172863 bayes_pls_golite062009
  • hydrolase activity
    		•  1.40217504818333 bayes_pls_golite062009
  • GTPase activity
    		•  1.23010905798386 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.13474466330485 bayes_pls_golite062009
  • signal transducer activity
    		•  1.13474466330485 bayes_pls_golite062009
  • protein transporter activity
    		•  1.05248757342537 bayes_pls_golite062009
  • actin-dependent ATPase activity
    		•  0.990320704369021 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.977237423302079 bayes_pls_golite062009
  • purine nucleotide binding
    		•  0.929901285538132 bayes_pls_golite062009
  • nucleotide binding
    		•  0.922442819194247 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  0.920987930180051 bayes_pls_golite062009
  • ribonucleotide binding
    		•  0.920926158369519 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.777787753097919 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.568484017802328 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  0.557919489256916 bayes_pls_golite062009
  • DNA binding
    		•  0.479412476059825 bayes_pls_golite062009
  • ATP binding
    		•  0.41092997612902 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  0.385813421701492 bayes_pls_golite062009
  • receptor activity
    		•  0.381142123108547 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  0.377870145186619 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  0.355770151889237 bayes_pls_golite062009
  • tubulin binding
    		•  0.326239364039846 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.312171320541728 bayes_pls_golite062009
  • macromolecule transmembrane transporter activity
    		•  0.28297830193871 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven protein transmembrane transporter activity
    		•  0.28297830193871 bayes_pls_golite062009
  • plus-end-directed microtubule motor activity
    		•  0.226790072388501 bayes_pls_golite062009
  • microtubule binding
    		•  0.225323885896927 bayes_pls_golite062009
  • hydrogen ion transporting ATP synthase activity, rotational mechanism
    		•  0.213018989352421 bayes_pls_golite062009
  • protein binding
    		•  0.170837278876362 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  0.123304946374679 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  0.0775601177068852 bayes_pls_golite062009
  • actin binding
    		•  0.0206144204131673 bayes_pls_golite062009
    2 No functions predicted.
    3
    Term Confidence Notes
  • microtubule motor activity
    		•  3.64858540496165 bayes_pls_golite062009
  • transporter activity
    		•  3.10463051760206 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  2.95886887664984 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  2.89122312915795 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  2.81593838944939 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  2.79724985811732 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  2.79347973548337 bayes_pls_golite062009
  • binding
    		•  2.64537357529343 bayes_pls_golite062009
  • primary active transmembrane transporter activity
    		•  2.61775212528604 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven transmembrane transporter activity
    		•  2.61467977505707 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
    		•  2.57552435627908 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of substances
    		•  2.57107347424517 bayes_pls_golite062009
  • ATPase activity, coupled to movement of substances
    		•  2.57054427875021 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  2.50494515048649 bayes_pls_golite062009
  • ATPase activity
    		•  2.44176688200537 bayes_pls_golite062009
  • ATPase activity, coupled
    		•  2.43862163407966 bayes_pls_golite062009
  • microfilament motor activity
    		•  2.38215814751368 bayes_pls_golite062009
  • motor activity
    		•  2.1532118704195 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  1.91091452720653 bayes_pls_golite062009
  • guanyl nucleotide binding
    		•  1.89320355239381 bayes_pls_golite062009
  • guanyl ribonucleotide binding
    		•  1.88721318481223 bayes_pls_golite062009
  • GTP binding
    		•  1.87900088157196 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  1.56325751172863 bayes_pls_golite062009
  • hydrolase activity
    		•  1.40217504818333 bayes_pls_golite062009
  • GTPase activity
    		•  1.23010905798386 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.13474466330485 bayes_pls_golite062009
  • signal transducer activity
    		•  1.13474466330485 bayes_pls_golite062009
  • protein transporter activity
    		•  1.05248757342537 bayes_pls_golite062009
  • actin-dependent ATPase activity
    		•  0.990320704369021 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.977237423302079 bayes_pls_golite062009
  • purine nucleotide binding
    		•  0.929901285538132 bayes_pls_golite062009
  • nucleotide binding
    		•  0.922442819194247 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  0.920987930180051 bayes_pls_golite062009
  • ribonucleotide binding
    		•  0.920926158369519 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.777787753097919 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.568484017802328 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  0.557919489256916 bayes_pls_golite062009
  • DNA binding
    		•  0.479412476059825 bayes_pls_golite062009
  • ATP binding
    		•  0.41092997612902 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  0.385813421701492 bayes_pls_golite062009
  • receptor activity
    		•  0.381142123108547 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  0.377870145186619 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  0.355770151889237 bayes_pls_golite062009
  • tubulin binding
    		•  0.326239364039846 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.312171320541728 bayes_pls_golite062009
  • macromolecule transmembrane transporter activity
    		•  0.28297830193871 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven protein transmembrane transporter activity
    		•  0.28297830193871 bayes_pls_golite062009
  • plus-end-directed microtubule motor activity
    		•  0.226790072388501 bayes_pls_golite062009
  • microtubule binding
    		•  0.225323885896927 bayes_pls_golite062009
  • hydrogen ion transporting ATP synthase activity, rotational mechanism
    		•  0.213018989352421 bayes_pls_golite062009
  • protein binding
    		•  0.170837278876362 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  0.123304946374679 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  0.0775601177068852 bayes_pls_golite062009
  • actin binding
    		•  0.0206144204131673 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle