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View Structure Prediction Details

Protein: Miro-PD
Organism: Drosophila melanogaster
Length: 652 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Miro-PD.

Description E-value Query
Range		 Subject
Range
MIRO_DROPS - Mitochondrial Rho GTPase OS=Drosophila pseudoobscura pseudoobscura GN=Miro PE=3 SV=1
MIRO_DROPS - Mitochondrial Rho GTPase - Drosophila pseudoobscura (Fruit fly)
 656.0 [0..1] [652..1]

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Predicted Domain #1
Region A:
Residues: [1-226] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGQYTASQRK NVRILLVGDA GVGKTSLILS LVSEEYPEEV PPRAEEITIP ANVTPEQVPT  60
   61 SIVDFSAVEQ SEDALAAEIN KAHVVCIVYA VDDDDTLDRI TSHWLPLVRA KCNPSLDGEG 120
  121 DAEAEAEGDT QREPIRKPIV LVGNKIDLIE YSTMDSVLAI MEDYPEIESC VECSAKSLHN 180
  181 ISEMFYYAQK AVLHPTSPLY MMEEQELTSA CKKSLVRIFK ICDIDG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 44.39794
Match: 1x3sA
Description: Crystal structure of human Rab18 in complex with Gppnhp
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
microtubule motor activity 3.64858540496165 bayes_pls_golite062009
transporter activity 3.10463051760206 bayes_pls_golite062009
transmembrane transporter activity 2.95886887664984 bayes_pls_golite062009
nucleoside-triphosphatase activity 2.89122312915795 bayes_pls_golite062009
pyrophosphatase activity 2.81593838944939 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 2.79724985811732 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 2.79347973548337 bayes_pls_golite062009
binding 2.64537357529343 bayes_pls_golite062009
primary active transmembrane transporter activity 2.61775212528604 bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity 2.61467977505707 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 2.57552435627908 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances 2.57107347424517 bayes_pls_golite062009
ATPase activity, coupled to movement of substances 2.57054427875021 bayes_pls_golite062009
active transmembrane transporter activity 2.50494515048649 bayes_pls_golite062009
ATPase activity 2.44176688200537 bayes_pls_golite062009
ATPase activity, coupled 2.43862163407966 bayes_pls_golite062009
microfilament motor activity 2.38215814751368 bayes_pls_golite062009
motor activity 2.1532118704195 bayes_pls_golite062009
substrate-specific transporter activity 1.91091452720653 bayes_pls_golite062009
guanyl nucleotide binding 1.89320355239381 bayes_pls_golite062009
guanyl ribonucleotide binding 1.88721318481223 bayes_pls_golite062009
GTP binding 1.87900088157196 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 1.56325751172863 bayes_pls_golite062009
hydrolase activity 1.40217504818333 bayes_pls_golite062009
GTPase activity 1.23010905798386 bayes_pls_golite062009
molecular transducer activity 1.13474466330485 bayes_pls_golite062009
signal transducer activity 1.13474466330485 bayes_pls_golite062009
protein transporter activity 1.05248757342537 bayes_pls_golite062009
actin-dependent ATPase activity 0.990320704369021 bayes_pls_golite062009
ion transmembrane transporter activity 0.977237423302079 bayes_pls_golite062009
purine nucleotide binding 0.929901285538132 bayes_pls_golite062009
nucleotide binding 0.922442819194247 bayes_pls_golite062009
purine ribonucleotide binding 0.920987930180051 bayes_pls_golite062009
ribonucleotide binding 0.920926158369519 bayes_pls_golite062009
nucleic acid binding 0.777787753097919 bayes_pls_golite062009
cytoskeletal protein binding 0.568484017802328 bayes_pls_golite062009
cation transmembrane transporter activity 0.557919489256916 bayes_pls_golite062009
DNA binding 0.479412476059825 bayes_pls_golite062009
ATP binding 0.41092997612902 bayes_pls_golite062009
adenyl ribonucleotide binding 0.385813421701492 bayes_pls_golite062009
receptor activity 0.381142123108547 bayes_pls_golite062009
adenyl nucleotide binding 0.377870145186619 bayes_pls_golite062009
transmembrane receptor activity 0.355770151889237 bayes_pls_golite062009
tubulin binding 0.326239364039846 bayes_pls_golite062009
transcription regulator activity 0.312171320541728 bayes_pls_golite062009
macromolecule transmembrane transporter activity 0.28297830193871 bayes_pls_golite062009
P-P-bond-hydrolysis-driven protein transmembrane transporter activity 0.28297830193871 bayes_pls_golite062009
plus-end-directed microtubule motor activity 0.226790072388501 bayes_pls_golite062009
microtubule binding 0.225323885896927 bayes_pls_golite062009
hydrogen ion transporting ATP synthase activity, rotational mechanism 0.213018989352421 bayes_pls_golite062009
protein binding 0.170837278876362 bayes_pls_golite062009
inorganic cation transmembrane transporter activity 0.123304946374679 bayes_pls_golite062009
metal ion transmembrane transporter activity 0.0775601177068852 bayes_pls_golite062009
actin binding 0.0206144204131673 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [227-440] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DNLLNDYELN LFQRRCFNTP LQPQILDEVK AVIQKNVPDG IYNDAVTLKG FLFLHCLFIQ  60
   61 RGRNETTWAV LRRFGYNDQL EMCQEYLRPP LKIPPGSSTE LSHRGQQFLI AVFERYDRDG 120
  121 DGALSPEEHK MLFSTCPAAP WSYSTDIRKS CPINETTGWV TLHGWLCRWT LMTLIDVVKT 180
  181 MEYLAYLGFN VHENDSQLAA IHVTRERRID LAKR

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 3.93
Match: 2ggzA
Description: No description for 2ggzA was found.

Predicted Domain #3
Region A:
Residues: [441-652] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QSSRSVYKCH VIGPKGSGKT GMCRGFLVED MHKLIGKEFK TNVVNCINSV QVYGQEKHLI  60
   61 LRDIDVRHAL DPLQPQEVNC DVACLVYDSS NPRSFEYVAR IYIKYYAESK IPVMIVGTKC 120
  121 DMDERRQDYL MQPSEFCDKY KLLPPHLFSL KTNKKELYTK LATMAAFPHL RQFGLMTEDP 180
  181 KLWLKAGLGV AAATMLGFIV LKTISAAGAH TR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 54.221849
Match: 1ukvY
Description: Structure of RabGDP-dissociation inhibitor in complex with prenylated YPT1 GTPase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
microtubule motor activity 3.64858540496165 bayes_pls_golite062009
transporter activity 3.10463051760206 bayes_pls_golite062009
transmembrane transporter activity 2.95886887664984 bayes_pls_golite062009
nucleoside-triphosphatase activity 2.89122312915795 bayes_pls_golite062009
pyrophosphatase activity 2.81593838944939 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 2.79724985811732 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 2.79347973548337 bayes_pls_golite062009
binding 2.64537357529343 bayes_pls_golite062009
primary active transmembrane transporter activity 2.61775212528604 bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity 2.61467977505707 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 2.57552435627908 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances 2.57107347424517 bayes_pls_golite062009
ATPase activity, coupled to movement of substances 2.57054427875021 bayes_pls_golite062009
active transmembrane transporter activity 2.50494515048649 bayes_pls_golite062009
ATPase activity 2.44176688200537 bayes_pls_golite062009
ATPase activity, coupled 2.43862163407966 bayes_pls_golite062009
microfilament motor activity 2.38215814751368 bayes_pls_golite062009
motor activity 2.1532118704195 bayes_pls_golite062009
substrate-specific transporter activity 1.91091452720653 bayes_pls_golite062009
guanyl nucleotide binding 1.89320355239381 bayes_pls_golite062009
guanyl ribonucleotide binding 1.88721318481223 bayes_pls_golite062009
GTP binding 1.87900088157196 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 1.56325751172863 bayes_pls_golite062009
hydrolase activity 1.40217504818333 bayes_pls_golite062009
GTPase activity 1.23010905798386 bayes_pls_golite062009
molecular transducer activity 1.13474466330485 bayes_pls_golite062009
signal transducer activity 1.13474466330485 bayes_pls_golite062009
protein transporter activity 1.05248757342537 bayes_pls_golite062009
actin-dependent ATPase activity 0.990320704369021 bayes_pls_golite062009
ion transmembrane transporter activity 0.977237423302079 bayes_pls_golite062009
purine nucleotide binding 0.929901285538132 bayes_pls_golite062009
nucleotide binding 0.922442819194247 bayes_pls_golite062009
purine ribonucleotide binding 0.920987930180051 bayes_pls_golite062009
ribonucleotide binding 0.920926158369519 bayes_pls_golite062009
nucleic acid binding 0.777787753097919 bayes_pls_golite062009
cytoskeletal protein binding 0.568484017802328 bayes_pls_golite062009
cation transmembrane transporter activity 0.557919489256916 bayes_pls_golite062009
DNA binding 0.479412476059825 bayes_pls_golite062009
ATP binding 0.41092997612902 bayes_pls_golite062009
adenyl ribonucleotide binding 0.385813421701492 bayes_pls_golite062009
receptor activity 0.381142123108547 bayes_pls_golite062009
adenyl nucleotide binding 0.377870145186619 bayes_pls_golite062009
transmembrane receptor activity 0.355770151889237 bayes_pls_golite062009
tubulin binding 0.326239364039846 bayes_pls_golite062009
transcription regulator activity 0.312171320541728 bayes_pls_golite062009
macromolecule transmembrane transporter activity 0.28297830193871 bayes_pls_golite062009
P-P-bond-hydrolysis-driven protein transmembrane transporter activity 0.28297830193871 bayes_pls_golite062009
plus-end-directed microtubule motor activity 0.226790072388501 bayes_pls_golite062009
microtubule binding 0.225323885896927 bayes_pls_golite062009
hydrogen ion transporting ATP synthase activity, rotational mechanism 0.213018989352421 bayes_pls_golite062009
protein binding 0.170837278876362 bayes_pls_golite062009
inorganic cation transmembrane transporter activity 0.123304946374679 bayes_pls_golite062009
metal ion transmembrane transporter activity 0.0775601177068852 bayes_pls_golite062009
actin binding 0.0206144204131673 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle