Protein Overview: fray-PC, fray-PB...

General Information:
Name(s) found:	FBpp0310694 [FlyBase] fray-PF / FBpp0288649 [FlyBase] fray-PE / FBpp0288648 [FlyBase] fray-PC / FBpp0288546 [FlyBase] fray-PB / FBpp0083058 [FlyBase] fray-PA / FBpp0083057 [FlyBase]
Description(s) found: Found 78 descriptions. SHOW ALL	type=protein; loc=3R:14412432..14414090; ID=FBpp0310694; name=fray-PG; parent=FBgn0023083,FBtr0344290; dbxref=FlyBase:FBpp0310694,FlyBase_Annotation_IDs:CG7693-PG; MD5=a92aff94b9c43da23aad9ed67135c3eb; length=552; release=r5.56; species=Dmel; [FlyBase] The gene frayed is referred to in FlyBase by the symbol Dmel\fray (CG7693, FBgn0023083). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:14398817..14415175. It has the cytological map location 91B4-91B5. Based on sequence similarity, it is predicted to have molecular function</span>: protein serine/threonine kinase activity. There is experimental evidence that it is involved in the biological process</span>: establishment of blood-nerve barrier; axonal fasciculation; axon ensheathment; chitin-based embryonic cuticle biosynthetic process. 28 alleles are reported. The phenotypes of these alleles are annotated with: embryonic/first instar larval cuticle; larval peripheral nervous system. It has 5 annotated transcripts and 5 annotated polypeptides. [FlyBase] The gene frayed is referred to in FlyBase by the symbol Dmel\fray (CG7693, FBgn0023083). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:14398817..14415175. It has the cytological map location 91B4-91B5. Based on sequence similarity, it is predicted to have molecular function</span>: protein serine/threonine kinase activity. There is experimental evidence that it is involved in the biological process</span>: establishment of blood-nerve barrier; axonal fasciculation; axon ensheathment; chitin-based embryonic cuticle biosynthetic process. 28 alleles are reported. The phenotypes of these alleles are annotated with: embryonic/first instar larval cuticle; larval peripheral nervous system. It has 5 annotated transcripts and 5 annotated polypeptides. [FlyBase] The gene frayed is referred to in FlyBase by the symbol Dmel\fray (CG7693, FBgn0023083). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:14398817..14415175. It has the cytological map location 91B4-91B5. Based on sequence similarity, it is predicted to have molecular function</span>: protein serine/threonine kinase activity. There is experimental evidence that it is involved in the biological process</span>: establishment of blood-nerve barrier; axonal fasciculation; axon ensheathment; chitin-based embryonic cuticle biosynthetic process. 28 alleles are reported. The phenotypes of these alleles are annotated with: embryonic/first instar larval cuticle; larval peripheral nervous system. It has 5 annotated transcripts and 5 annotated polypeptides. [FlyBase] The gene frayed is referred to in FlyBase by the symbol Dmel\fray (CG7693, FBgn0023083). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:14398817..14415175. It has the cytological map location 91B4-91B5. Based on sequence similarity, it is predicted to have molecular function</span>: protein serine/threonine kinase activity. There is experimental evidence that it is involved in the biological process</span>: establishment of blood-nerve barrier; axonal fasciculation; axon ensheathment; chitin-based embryonic cuticle biosynthetic process. 28 alleles are reported. The phenotypes of these alleles are annotated with: embryonic/first instar larval cuticle; larval peripheral nervous system. It has 5 annotated transcripts and 5 annotated polypeptides. [FlyBase] The gene frayed is referred to in FlyBase by the symbol Dmel\fray (CG7693, FBgn0023083). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:14398817..14415175. It has the cytological map location 91B4-91B5. Based on sequence similarity, it is predicted to have molecular function</span>: protein serine/threonine kinase activity. There is experimental evidence that it is involved in the biological process</span>: establishment of blood-nerve barrier; axonal fasciculation; axon ensheathment; chitin-based embryonic cuticle biosynthetic process. 28 alleles are reported. The phenotypes of these alleles are annotated with: embryonic/first instar larval cuticle; larval peripheral nervous system. It has 5 annotated transcripts and 5 annotated polypeptides. [FlyBase]
Organism:	Drosophila melanogaster
Length:	552 amino acids
Gene Ontology:
Cellular Component:	NONE FOUND
Biological Process:	chitin-based embryonic cuticle biosynthetic process [IMP] establishment of blood-nerve barrier [IMP] axon ensheathment [IMP] protein amino acid phosphorylation [IEA][ISS][NAS] axonal fasciculation [IMP]
Molecular Function:	ATP binding [IEA] receptor signaling protein serine/threonine kinase activity [NAS] protein serine/threonine kinase activity [IEA][ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTSIPANLSS NNVAGAATLP GAAAPPEKYT WPNSKDDYEL RDVIGVGATA VVHGAYCIPR  60
   61 NEKCAIKRIN LEKWNTSMDE LLKEIQAMSS CFHENVVTYH TSFVVREELW LVLRLLEGGS 120
  121 LLDIIKHKMR TSNCKQGVFD EATIATVLKE VLKGLEYFHS NGQIHRDIKA GNILIGDDGT 180
  181 IQIADFGVSA WLATGRDLSR QKVRHTFVGT PCWMAPEVME QDHGYDFKAD IWSFGITAIE 240
  241 MATGTAPYHK YPPMKVLMLT LQNDPPTLDT GADDKDQYKA YGKTFRKMIV ECLQKEPSKR 300
  301 PTASELLKHA FFKKAKDRKY LTQTLLQSGP SMETRVHKAA KRQPGASGRL HRTVTGEWVW 360
  361 SSEEEDNGGS ATGSGTGDRK HPSSDSDSED RPMNRLERAD SSDSDREEPS PEITHSVSSA 420
  421 TVTPGAPAAA GAGAAQELTA GIAQLPLPSE AAGEAPPVNL VLRMRNLRRE LHDIRFEFVV 480
  481 GKDTAEGIAT ELVDAGLVDA LDTQPMATHL DQLIAASATM KTITFQLSSG VQPGEVPDER 540
  541 SLVGYAQISI TD

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Searching the YRC Public Image Repository, found results:

Currently showing to of results.

[View Search in the YRC Public Image Repository]

Searching the YRC Public Image Repository, found no results.

Ginzu Version Information

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

Gene Ontology predictions

Term	Confidence	Notes
phosphotransferase activity, alcohol group as acceptor	5.49988294224815	bayes_pls_golite062009
protein kinase activity	5.4586557943719	bayes_pls_golite062009
kinase activity	5.3287080791198	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	4.96052051118534	bayes_pls_golite062009
protein serine/threonine kinase activity	4.46381887831481	bayes_pls_golite062009
protein tyrosine kinase activity	2.8153155526437	bayes_pls_golite062009
binding	2.74863538127007	bayes_pls_golite062009
molecular transducer activity	2.40586892801446	bayes_pls_golite062009
signal transducer activity	2.40586892801446	bayes_pls_golite062009
transferase activity	2.34875558765742	bayes_pls_golite062009
protein binding	2.276111749106	bayes_pls_golite062009
receptor signaling protein activity	2.10379226653669	bayes_pls_golite062009
ATP binding	1.97600611746091	bayes_pls_golite062009
adenyl ribonucleotide binding	1.93596671856664	bayes_pls_golite062009
adenyl nucleotide binding	1.90928021591891	bayes_pls_golite062009
receptor signaling protein serine/threonine kinase activity	1.81249386965144	bayes_pls_golite062009
transmembrane receptor protein kinase activity	1.7769021678395	bayes_pls_golite062009
MAP kinase kinase kinase kinase activity	1.70795227184717	bayes_pls_golite062009
transmembrane receptor activity	1.6878868450299	bayes_pls_golite062009
purine ribonucleotide binding	1.65732943334212	bayes_pls_golite062009
ribonucleotide binding	1.65726906484847	bayes_pls_golite062009
purine nucleotide binding	1.63763394711025	bayes_pls_golite062009
nucleotide binding	1.63195828048121	bayes_pls_golite062009
receptor activity	1.57112777506542	bayes_pls_golite062009
transmembrane receptor protein tyrosine kinase activity	1.4571078357189	bayes_pls_golite062009
MAP kinase kinase activity	1.42275431028856	bayes_pls_golite062009
kinase binding	1.26086833316556	bayes_pls_golite062009
JUN kinase kinase kinase kinase activity	1.23861359579123	bayes_pls_golite062009
cytoskeletal protein binding	1.22172815474021	bayes_pls_golite062009
catalytic activity	1.21655087018101	bayes_pls_golite062009
structural constituent of muscle	1.19908793854422	bayes_pls_golite062009
transporter activity	1.11833481501707	bayes_pls_golite062009
protein kinase binding	1.06030596516506	bayes_pls_golite062009
receptor binding	0.990272341309676	bayes_pls_golite062009
transmembrane transporter activity	0.97575992765505	bayes_pls_golite062009
MAP kinase activity	0.81943579965027	bayes_pls_golite062009
substrate-specific transporter activity	0.705905455086486	bayes_pls_golite062009
nucleic acid binding	0.655396214040669	bayes_pls_golite062009
transcription regulator activity	0.631882811427766	bayes_pls_golite062009
DNA binding	0.599969415455862	bayes_pls_golite062009
cyclin-dependent protein kinase activity	0.499492353295369	bayes_pls_golite062009
protein serine/threonine/tyrosine kinase activity	0.48345772948903	bayes_pls_golite062009
enzyme binding	0.46284745266176	bayes_pls_golite062009
transcription factor activity	0.457173041568166	bayes_pls_golite062009
actin binding	0.456340967230669	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	0.450699332958421	bayes_pls_golite062009
protein kinase C activity	0.41587987561486	bayes_pls_golite062009
magnesium ion binding	0.393328812780268	bayes_pls_golite062009
MAP kinase kinase kinase activity	0.37115026509016	bayes_pls_golite062009
transforming growth factor beta receptor activity	0.26602283402868	bayes_pls_golite062009
transmembrane receptor protein serine/threonine kinase activity	0.26602283402868	bayes_pls_golite062009
ion transmembrane transporter activity	0.148194101970458	bayes_pls_golite062009
cytokine receptor binding	0.143315390473442	bayes_pls_golite062009
growth factor binding	0.0526340287295695	bayes_pls_golite062009
transforming growth factor beta receptor activity, type I	0.0506751594607393	bayes_pls_golite062009

No functions predicted.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.51

Source: Reynolds et al. (2008)

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..392]	PSI-BLAST	60.0	Crystal Structure of the TAO2 Kinase Domain: Activation and Specifity of a Ste20p MAP3K
2	View Details	[393..458]	deduced	N/A	No confident structure predictions are available.
3	View Details	[459..552]	PSI-BLAST	31.221849	No description for 2v3sA was found.

Protein Overview: fray-PC, fray-PB...

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: