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View Structure Prediction Details

Protein: fray-PC, fray-PB...
Organism: Drosophila melanogaster
Length: 552 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for fray-PC, fray-PB....

Description E-value Query
Range
Subject
Range
gi|4101730 - gi|4101730|gb|AAD01275.1| Ste20-like protein kinase [Drosophila melanogaster]
462.0 [0..1] [552..1]

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Predicted Domain #1
Region A:
Residues: [1-392]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTSIPANLSS NNVAGAATLP GAAAPPEKYT WPNSKDDYEL RDVIGVGATA VVHGAYCIPR  60
   61 NEKCAIKRIN LEKWNTSMDE LLKEIQAMSS CFHENVVTYH TSFVVREELW LVLRLLEGGS 120
  121 LLDIIKHKMR TSNCKQGVFD EATIATVLKE VLKGLEYFHS NGQIHRDIKA GNILIGDDGT 180
  181 IQIADFGVSA WLATGRDLSR QKVRHTFVGT PCWMAPEVME QDHGYDFKAD IWSFGITAIE 240
  241 MATGTAPYHK YPPMKVLMLT LQNDPPTLDT GADDKDQYKA YGKTFRKMIV ECLQKEPSKR 300
  301 PTASELLKHA FFKKAKDRKY LTQTLLQSGP SMETRVHKAA KRQPGASGRL HRTVTGEWVW 360
  361 SSEEEDNGGS ATGSGTGDRK HPSSDSDSED RP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 60.0
Match: 1u5qA
Description: Crystal Structure of the TAO2 Kinase Domain: Activation and Specifity of a Ste20p MAP3K
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
phosphotransferase activity, alcohol group as acceptor 5.49988294224815 bayes_pls_golite062009
protein kinase activity 5.4586557943719 bayes_pls_golite062009
kinase activity 5.3287080791198 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 4.96052051118534 bayes_pls_golite062009
protein serine/threonine kinase activity 4.46381887831481 bayes_pls_golite062009
protein tyrosine kinase activity 2.8153155526437 bayes_pls_golite062009
binding 2.74863538127007 bayes_pls_golite062009
molecular transducer activity 2.40586892801446 bayes_pls_golite062009
signal transducer activity 2.40586892801446 bayes_pls_golite062009
transferase activity 2.34875558765742 bayes_pls_golite062009
protein binding 2.276111749106 bayes_pls_golite062009
receptor signaling protein activity 2.10379226653669 bayes_pls_golite062009
ATP binding 1.97600611746091 bayes_pls_golite062009
adenyl ribonucleotide binding 1.93596671856664 bayes_pls_golite062009
adenyl nucleotide binding 1.90928021591891 bayes_pls_golite062009
receptor signaling protein serine/threonine kinase activity 1.81249386965144 bayes_pls_golite062009
transmembrane receptor protein kinase activity 1.7769021678395 bayes_pls_golite062009
MAP kinase kinase kinase kinase activity 1.70795227184717 bayes_pls_golite062009
transmembrane receptor activity 1.6878868450299 bayes_pls_golite062009
purine ribonucleotide binding 1.65732943334212 bayes_pls_golite062009
ribonucleotide binding 1.65726906484847 bayes_pls_golite062009
purine nucleotide binding 1.63763394711025 bayes_pls_golite062009
nucleotide binding 1.63195828048121 bayes_pls_golite062009
receptor activity 1.57112777506542 bayes_pls_golite062009
transmembrane receptor protein tyrosine kinase activity 1.4571078357189 bayes_pls_golite062009
MAP kinase kinase activity 1.42275431028856 bayes_pls_golite062009
kinase binding 1.26086833316556 bayes_pls_golite062009
JUN kinase kinase kinase kinase activity 1.23861359579123 bayes_pls_golite062009
cytoskeletal protein binding 1.22172815474021 bayes_pls_golite062009
catalytic activity 1.21655087018101 bayes_pls_golite062009
structural constituent of muscle 1.19908793854422 bayes_pls_golite062009
transporter activity 1.11833481501707 bayes_pls_golite062009
protein kinase binding 1.06030596516506 bayes_pls_golite062009
receptor binding 0.990272341309676 bayes_pls_golite062009
transmembrane transporter activity 0.97575992765505 bayes_pls_golite062009
MAP kinase activity 0.81943579965027 bayes_pls_golite062009
substrate-specific transporter activity 0.705905455086486 bayes_pls_golite062009
nucleic acid binding 0.655396214040669 bayes_pls_golite062009
transcription regulator activity 0.631882811427766 bayes_pls_golite062009
DNA binding 0.599969415455862 bayes_pls_golite062009
cyclin-dependent protein kinase activity 0.499492353295369 bayes_pls_golite062009
protein serine/threonine/tyrosine kinase activity 0.48345772948903 bayes_pls_golite062009
enzyme binding 0.46284745266176 bayes_pls_golite062009
transcription factor activity 0.457173041568166 bayes_pls_golite062009
actin binding 0.456340967230669 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.450699332958421 bayes_pls_golite062009
protein kinase C activity 0.41587987561486 bayes_pls_golite062009
magnesium ion binding 0.393328812780268 bayes_pls_golite062009
MAP kinase kinase kinase activity 0.37115026509016 bayes_pls_golite062009
transforming growth factor beta receptor activity 0.26602283402868 bayes_pls_golite062009
transmembrane receptor protein serine/threonine kinase activity 0.26602283402868 bayes_pls_golite062009
ion transmembrane transporter activity 0.148194101970458 bayes_pls_golite062009
cytokine receptor binding 0.143315390473442 bayes_pls_golite062009
growth factor binding 0.0526340287295695 bayes_pls_golite062009
transforming growth factor beta receptor activity, type I 0.0506751594607393 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [393-458]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNRLERADSS DSDREEPSPE ITHSVSSATV TPGAPAAAGA GAAQELTAGI AQLPLPSEAA  60
   61 GEAPPV

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [459-552]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NLVLRMRNLR RELHDIRFEF VVGKDTAEGI ATELVDAGLV DALDTQPMAT HLDQLIAASA  60
   61 TMKTITFQLS SGVQPGEVPD ERSLVGYAQI SITD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 31.221849
Match: 2v3sA
Description: No description for 2v3sA was found.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle