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Protein Overview: FBpp0306147, put-PA

General Information:
Name(s) found: FBpp0306147 [FlyBase]
put-PA / FBpp0082436 [FlyBase]
Description(s) found:
Found 31 descriptions.
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  • type=protein; loc=3R:complement(10446756..10446935,10446996..10447811,10447880..10448025,10448965..10449141,10449209..10449394,10450922..10450967); ID=FBpp0306147; name=put-PC; parent=FBgn0003169,FBtr0334030; dbxref=FlyBase:FBpp0306147,FlyBase_Annotation_IDs:CG7904-PC,REFSEQ:NP_001262574,GB_protein:AGB95955; MD5=ba46197936e63d89e6fdaa629dd4a224; length=516; release=r5.56; species=Dmel; [FlyBase]
  • The gene punt is referred to in FlyBase by the symbol Dmel\put (CG7904, FBgn0003169). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:10446052..10451421. It has the cytological map location 88C9. There is experimental evidence that it has the molecular function</span>: activin receptor activity; specific transcriptional repressor activity; activin binding; transforming growth factor beta receptor activity. There is experimental evidence for 12 unique biological process</span> terms, many of which group under: anatomical structure development; regulation of biological process; organ morphogenesis; open tracheal system development; enzyme linked receptor protein signaling pathway; embryonic development via the syncytial blastoderm; neuron differentiation; regulation of developmental process; regionalization; reproductive process in a multicellular organism. 40 alleles are reported. The phenotypes of these alleles are annotated with 38 unique terms, many of which group under: organ system; adult segment; adult mesothoracic segment; peripheral nervous system; nervous system; external compound sense organ; embryonic/larval tracheal system; embryonic nervous system; embryonic/larval dorsal branch; embryonic/larval hemocoel. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 516 amino acids

    Gene Ontology:
    Cellular Component: activin receptor complex [IPI]
    plasma membrane [UNKNOWN][ISS]
    Biological Process: dorsal closure [IMP][TAS]
    negative regulation of salivary gland boundary specification [TAS]
    head involution [IMP]
    transforming growth factor beta receptor signaling pathway [IGI][IMP][NAS]
    Malpighian tubule morphogenesis [IMP]
    germ-line stem cell division [IMP][TAS]
    axon guidance [IMP]
    neuron development [IMP]
    protein amino acid phosphorylation [IEA][NAS]
    dorsal/ventral pattern formation [IMP]
    open tracheal system development [IMP][TAS]
    dendrite morphogenesis [NAS]
    activin receptor signaling pathway [IDA]
    primary branching, open tracheal system [IMP]
    compound eye morphogenesis [NAS]
    germ-line stem cell maintenance [IMP]
    Molecular Function: ATP binding [IEA]
    activin binding [IDA]
    activin receptor activity [IDA]
    transforming growth factor beta receptor activity [IGI]
    protein kinase activity [NAS]
    transforming growth factor beta receptor activity, type II [ISS][NAS]
    specific transcriptional repressor activity [IMP]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSKYDLLYLT AQLTLVCCLI GIHGSILPGS HGIIECEHFD EKMCNTTQQC ETRIEHCKME  60
   61 ADKFPSCYVL WSVNETTGIL RIKMKGCFTD MHECNQTECV TSAEPRQGNI HFCCCKGSRC 120
  121 NSNQKYIKST TEATTQVPKE KTQDGSNLIY IYIGTSVFSV LMVIVGMGLL LYRRRKQAHF 180
  181 NEIPTHEAEI TNSSPLLSNR PIQLLEQKAS GRFGDVWQAK LNNQDVAVKI FRMQEKESWT 240
  241 TEHDIYKLPR MRHPNILEFL GVEKHMDKPE YWLISTYQHN GSLCDYLKSH TISWPELCRI 300
  301 AESMANGLAH LHEEIPASKT DGLKPSIAHR DFKSKNVLLK SDLTACIADF GLAMIFQPGK 360
  361 PCGDTHGQVG TRRYMAPEVL EGAINFNRDA FLRIDVYACG LVLWEMVSRC DFAGPVGEFQ 420
  421 LPFEAELGLR PSLDEVQESV VMKKLRPRLL NSWRAHPGLN VFCDTMEECW DHDAEARLSS 480
  481 SCVMERFAQL NKYPSTQLLI KNHTNIDDAK ESTNCL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..199] PSI-BLAST 5.0 Type II activin receptor
    2 View Details [200..516] PSI-BLAST 60.30103 Crystal Structure of TGF-beta receptor I kinase with inhibitor

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • transforming growth factor beta binding
    		•  2.91714500246524 bayes_pls_golite062009
  • receptor activity
    		•  2.74055213309696 bayes_pls_golite062009
  • receptor serine/threonine kinase binding
    		•  2.63843756028069 bayes_pls_golite062009
  • signal transducer activity
    		•  2.51859905018984 bayes_pls_golite062009
  • molecular transducer activity
    		•  2.51859905018984 bayes_pls_golite062009
  • binding
    		•  2.42849959483419 bayes_pls_golite062009
  • protein binding
    		•  2.27773193148456 bayes_pls_golite062009
  • growth factor binding
    		•  2.11370016324137 bayes_pls_golite062009
  • SMAD binding
    		•  2.11166655078306 bayes_pls_golite062009
  • glycosaminoglycan binding
    		•  1.93573786819729 bayes_pls_golite062009
  • U-plasminogen activator receptor activity
    		•  1.87257816307638 bayes_pls_golite062009
  • type I transforming growth factor beta receptor binding
    		•  1.8615627852658 bayes_pls_golite062009
  • polysaccharide binding
    		•  1.72562399286061 bayes_pls_golite062009
  • cytokine binding
    		•  1.30600639196836 bayes_pls_golite062009
  • receptor binding
    		•  0.899783960746717 bayes_pls_golite062009
  • transmembrane receptor protein serine/threonine kinase binding
    		•  0.897552923016526 bayes_pls_golite062009
  • transforming growth factor beta receptor binding
    		•  0.897552923016526 bayes_pls_golite062009
  • enzyme binding
    		•  0.61951403712284 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  0.227519165953748 bayes_pls_golite062009
  • pattern binding
    		•  0.21003196804615 bayes_pls_golite062009
    2
    Term Confidence Notes
  • activin receptor activity
    		•  9.43409082112081 bayes_pls_golite062009
  • activin binding
    		•  7.11944534332244 bayes_pls_golite062009
  • receptor signaling protein serine/threonine kinase activity
    		•  6.41728494915949 bayes_pls_golite062009
  • activin receptor activity, type I
    		•  6.1393596497059 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  5.49988294224815 bayes_pls_golite062009
  • protein kinase activity
    		•  5.4586557943719 bayes_pls_golite062009
  • kinase activity
    		•  5.3287080791198 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  4.96052051118534 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  4.46381887831481 bayes_pls_golite062009
  • transferase activity
    		•  3.97138602499442 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  3.40140621607334 bayes_pls_golite062009
  • transmembrane receptor protein serine/threonine kinase activity
    		•  3.37600307408153 bayes_pls_golite062009
  • transforming growth factor beta receptor activity
    		•  3.37600307408153 bayes_pls_golite062009
  • follistatin binding
    		•  3.25716461198789 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  3.1965684217331 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase activity
    		•  2.97315540587667 bayes_pls_golite062009
  • receptor activity
    		•  2.96273889901429 bayes_pls_golite062009
  • molecular transducer activity
    		•  2.85730457922199 bayes_pls_golite062009
  • signal transducer activity
    		•  2.85730457922199 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  2.8153155526437 bayes_pls_golite062009
  • binding
    		•  2.74863538127007 bayes_pls_golite062009
  • growth factor binding
    		•  2.61235080252818 bayes_pls_golite062009
  • transforming growth factor beta receptor activity, type I
    		•  2.57601476622612 bayes_pls_golite062009
  • protein binding
    		•  2.276111749106 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  2.10379226653669 bayes_pls_golite062009
  • fibroblast growth factor binding
    		•  2.00819948109978 bayes_pls_golite062009
  • ATP binding
    		•  1.97600611746091 bayes_pls_golite062009
  • activin receptor activity, type II
    		•  1.93639573827674 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  1.93596671856664 bayes_pls_golite062009
  • insulin receptor activity
    		•  1.91768456749814 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  1.90928021591891 bayes_pls_golite062009
  • fibroblast growth factor 1 binding
    		•  1.82118598657067 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  1.65732943334212 bayes_pls_golite062009
  • ribonucleotide binding
    		•  1.65726906484847 bayes_pls_golite062009
  • purine nucleotide binding
    		•  1.63763394711025 bayes_pls_golite062009
  • nucleotide binding
    		•  1.63195828048121 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.56748951434625 bayes_pls_golite062009
  • transforming growth factor beta binding
    		•  1.46877913443522 bayes_pls_golite062009
  • MAP kinase kinase activity
    		•  1.42275431028856 bayes_pls_golite062009
  • DNA binding
    		•  1.35333135345112 bayes_pls_golite062009
  • phosphoinositide 3-kinase binding
    		•  1.30850950497296 bayes_pls_golite062009
  • amine binding
    		•  1.3051205627964 bayes_pls_golite062009
  • kinase binding
    		•  1.26086833316556 bayes_pls_golite062009
  • catalytic activity
    		•  1.21655087018101 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.16049201286103 bayes_pls_golite062009
  • PTB domain binding
    		•  1.14009984975509 bayes_pls_golite062009
  • transporter activity
    		•  1.11833481501707 bayes_pls_golite062009
  • transcription factor activity
    		•  1.10928254946881 bayes_pls_golite062009
  • cytokine receptor binding
    		•  1.08904623349766 bayes_pls_golite062009
  • protein kinase binding
    		•  1.06030596516506 bayes_pls_golite062009
  • insulin binding
    		•  1.03564126441771 bayes_pls_golite062009
  • SMAD binding
    		•  1.02108562119195 bayes_pls_golite062009
  • transcription activator activity
    		•  0.997272622653026 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.97575992765505 bayes_pls_golite062009
  • MAP kinase activity
    		•  0.81943579965027 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.705905455086486 bayes_pls_golite062009
  • insulin receptor substrate binding
    		•  0.57617745233877 bayes_pls_golite062009
  • cyclin-dependent protein kinase activity
    		•  0.499492353295369 bayes_pls_golite062009
  • protein serine/threonine/tyrosine kinase activity
    		•  0.48345772948903 bayes_pls_golite062009
  • enzyme binding
    		•  0.46284745266176 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.450699332958421 bayes_pls_golite062009
  • magnesium ion binding
    		•  0.393328812780268 bayes_pls_golite062009
  • MAP kinase kinase kinase activity
    		•  0.37115026509016 bayes_pls_golite062009
  • transforming growth factor beta receptor activity, type II
    		•  0.365530951355731 bayes_pls_golite062009
  • fibroblast growth factor receptor activity
    		•  0.34434685718027 bayes_pls_golite062009
  • peptide hormone binding
    		•  0.312169974523858 bayes_pls_golite062009
  • glycoprotein binding
    		•  0.2984932537448 bayes_pls_golite062009
  • glycosaminoglycan binding
    		•  0.294256794094724 bayes_pls_golite062009
  • inhibin binding
    		•  0.29024207998068 bayes_pls_golite062009
  • inhibin beta-A binding
    		•  0.29024207998068 bayes_pls_golite062009
  • inhibin beta-B binding
    		•  0.29024207998068 bayes_pls_golite062009
  • protein complex binding
    		•  0.239339759110451 bayes_pls_golite062009
  • polysaccharide binding
    		•  0.229808864843639 bayes_pls_golite062009
  • cytokine binding
    		•  0.17817111033393 bayes_pls_golite062009
  • cell adhesion molecule binding
    		•  0.150740450460731 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.148194101970458 bayes_pls_golite062009
  • receptor serine/threonine kinase binding
    		•  0.0123645889643007 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.0040394359628233 bayes_pls_golite062009
  • SH2 domain binding
    		•  2.96656737540424E-4 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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