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Protein Overview: Mcm2-PA

General Information:
Name(s) found: Mcm2-PA / FBpp0081317 [FlyBase]
Description(s) found:
Found 25 descriptions.
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  • The gene Minichromosome maintenance 2 is referred to in FlyBase by the symbol Dmel\Mcm2 (CG7538, FBgn0014861). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:4090565..4093653. It has the cytological map location 84F6. There is experimental evidence that it has the molecular function</span>: 3'-5' DNA helicase activity. There is experimental evidence that it is involved in the biological process</span>: chromosome condensation. 4 alleles are reported. The phenotypes of these alleles are annotated with: central nervous system; nuclear chromosome; imaginal disc. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 887 amino acids

    Gene Ontology:
    Cellular Component: pre-replicative complex [ISS][NAS]
    nucleus [NAS]
    Biological Process: cell proliferation [NAS]
    DNA replication initiation [IEA]
    DNA replication [IEA][NAS][TAS]
    chromosome condensation [IMP]
    pre-replicative complex assembly [ISS][NAS]
    Molecular Function: DNA binding [IEA][NAS]
    ATP binding [IEA]
    chromatin binding [ISS][NAS]
    3'-5' DNA helicase activity [IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDNPSSPPPN TPSDAAERRD LRAAMTSPVG DFEPFENEDE ILGDQTVRDE AEEEDGEELF  60
   61 GDNMENDYRP MPELDHYDPA LLDDEDDFSE MSQGDRFAAE SEMRRRDRAA GIHRDDRDLG 120
  121 FGQSDDEDDV GPRAKRRAGE KAAVGEVEDT EMVESIENLE DTKGHSTKEW VSMLGPRTEI 180
  181 ANRFQSFLRT FVDERGAYTY RDRIRRMCEQ NMSSFVVSYT DLANKEHVLA YFLPEAPFQM 240
  241 LEIFDKVAKD MVLSIFPTYE RVTTEIHVRI SELPLIEELR TFRKLHLNQL VRTLGVVTAT 300
  301 TGVLPQLSVI KYDCVKCGYV LGPFVQSQNT EIKPGSCPEC QSTGPFSINM EQTLYRNYQK 360
  361 ITLQESPGRI PAGRIPRSKD VILLADLCDQ CKPGDELEVT GIYTNNYDGS LNTDQGFPVF 420
  421 ATVIIANHVV VKDSKQVVQS LTDEDIATIQ KLSKDPRIVE RVVASMAPSI YGHDYIKRAL 480
  481 ALALFGGESK NPGEKHKVRG DINLLICGDP GTAKSQFLKY TEKVAPRAVF TTGQGASAVG 540
  541 LTAYVRRNPV SREWTLEAGA LVLADQGVCL IDEFDKMNDQ DRTSIHEAME QQSISISKAG 600
  601 IVTSLQARCT VIAAANPIGG RYDPSMTFSE NVNLSEPILS RFDVLCVVKD EFDPMQDQQL 660
  661 AKFVVHSHMK HHPSEEEQPE LEEPQLKTVD EIPQDLLRQY IVYAKENIRP KLTNIDEDKI 720
  721 AKMYAQLRQE SFATGSLPIT VRHIESVIRM SEAHARMHLR ENVMEADVSM AIRMMLESFI 780
  781 EAQKFSVMKK MRSTFQKYLS FQKDHSELLF FILRQLTLDQ LAYIRCKDGP GATHVEIMER 840
  841 DLIERAKQLD IVNLKPFYES DLFRTNGFSY DPKRRIILQI VVDGNTA

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..171] MSA 1.058978 View MSA. No confident structure predictions are available.
    2 View Details [172..393] PSI-BLAST 46.69897 DNA replication initiator (cdc21/cdc54) N-terminal domain
    3 View Details [394..471] PSI-BLAST 41.154902 Crystal structure of sigm54 activator (AAA+ ATPase) in the inactive state
    4 View Details [472..797] PSI-BLAST 31.69897 No description for 2r44A was found.
    5 View Details [798..887] PSI-BLAST 6.39794 DNA-binding domain of NTRC

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • telomeric DNA binding
    		•  4.81350293592083 bayes_pls_golite062009
  • telomerase inhibitor activity
    		•  4.48082903165152 bayes_pls_golite062009
  • single-stranded telomeric DNA binding
    		•  4.34033743483519 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.29626483284963 bayes_pls_golite062009
  • DNA binding
    		•  3.71771169141041 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  3.51998515668903 bayes_pls_golite062009
  • structural molecule activity
    		•  3.29857127235306 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  3.06066809614422 bayes_pls_golite062009
  • single-stranded DNA binding
    		•  3.0183551365402 bayes_pls_golite062009
  • binding
    		•  2.83465364476231 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.10110937001387 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  1.9581702424972 bayes_pls_golite062009
  • DNA replication origin binding
    		•  1.84819558112187 bayes_pls_golite062009
  • translation regulator activity
    		•  1.46320772716954 bayes_pls_golite062009
  • translation factor activity, nucleic acid binding
    		•  1.40718318783582 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.30343463892105 bayes_pls_golite062009
  • translation initiation factor activity
    		•  1.27539679024898 bayes_pls_golite062009
  • transcription activator activity
    		•  1.24141936405635 bayes_pls_golite062009
  • protein binding
    		•  1.20309946451799 bayes_pls_golite062009
  • DNA-directed RNA polymerase activity
    		•  1.19766815287926 bayes_pls_golite062009
  • RNA polymerase activity
    		•  1.19766815287926 bayes_pls_golite062009
  • ribonuclease activity
    		•  1.19236946227657 bayes_pls_golite062009
  • transcription factor activity
    		•  1.14242112812892 bayes_pls_golite062009
  • DNA helicase activity
    		•  1.12203697857261 bayes_pls_golite062009
  • DNA-dependent ATPase activity
    		•  0.638831894247026 bayes_pls_golite062009
  • nuclease activity
    		•  0.57381531077345 bayes_pls_golite062009
  • aminoacyl-tRNA ligase activity
    		•  0.474251377131502 bayes_pls_golite062009
  • ligase activity, forming carbon-oxygen bonds
    		•  0.47336621289748 bayes_pls_golite062009
  • ligase activity, forming aminoacyl-tRNA and related compounds
    		•  0.47336621289748 bayes_pls_golite062009
  • nucleotidyltransferase activity
    		•  0.325774164899685 bayes_pls_golite062009
  • four-way junction helicase activity
    		•  0.31769813397725 bayes_pls_golite062009
  • exonuclease activity
    		•  0.28313884527829 bayes_pls_golite062009
  • RNA binding
    		•  0.18502033889261 bayes_pls_golite062009
  • exoribonuclease activity, producing 5'-phosphomonoesters
    		•  0.125256208482441 bayes_pls_golite062009
  • exoribonuclease activity
    		•  0.109774918833391 bayes_pls_golite062009
  • exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters
    		•  0.0954216620147701 bayes_pls_golite062009
  • DEAD/H-box RNA helicase binding
    		•  0.0627405398613412 bayes_pls_golite062009
  • ATP-dependent DNA helicase activity
    		•  0.0179535526984695 bayes_pls_golite062009
  • helicase activity
    		•  0.0121541775159524 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.
    5
    Term Confidence Notes
  • transcription regulator activity
    		•  5.13863038737912 bayes_pls_golite062009
  • DNA binding
    		•  4.66369707598026 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.51452285155271 bayes_pls_golite062009
  • transcription factor activity
    		•  4.06706589695599 bayes_pls_golite062009
  • transcription repressor activity
    		•  3.55154985983449 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  3.5139760613123 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  3.20235632037554 bayes_pls_golite062009
  • transcription activator activity
    		•  3.10621734076555 bayes_pls_golite062009
  • binding
    		•  3.02779747447702 bayes_pls_golite062009
  • telomeric DNA binding
    		•  2.58260058025381 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.26183812259792 bayes_pls_golite062009
  • protein binding
    		•  1.88087411289001 bayes_pls_golite062009
  • transcription corepressor activity
    		•  1.49423102874486 bayes_pls_golite062009
  • transcription factor binding
    		•  1.40653841901929 bayes_pls_golite062009
  • lysine N-acetyltransferase activity
    		•  1.40149699217445 bayes_pls_golite062009
  • histone acetyltransferase activity
    		•  1.40149699217445 bayes_pls_golite062009
  • protein deacetylase activity
    		•  1.23680480131205 bayes_pls_golite062009
  • histone deacetylase activity
    		•  1.18932416576802 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  1.14886080629275 bayes_pls_golite062009
  • chromatin binding
    		•  1.04132983826241 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.84983974758882 bayes_pls_golite062009
  • DNA-dependent ATPase activity
    		•  0.666799964992178 bayes_pls_golite062009
  • histone binding
    		•  0.557787598121402 bayes_pls_golite062009
  • deacetylase activity
    		•  0.530687254192222 bayes_pls_golite062009
  • transcription coactivator activity
    		•  0.2679415219517 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.236060274498333 bayes_pls_golite062009
  • N-acyltransferase activity
    		•  0.212884313176726 bayes_pls_golite062009
  • DNA helicase activity
    		•  0.187022204923867 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity, enhancer binding
    		•  0.13444271681002 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.105174598157041 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle